Chemical Composition Analysis of the Patented Naoxueshuan Formula Based on UPLC-Q-TOF MS and GC-MS by Chang LIU, Hui-qin WU, Jiang-bo QI, Hong-ling LIANG, Zhi-hua LIU, Hua-qiang HUANG, Su-ming YANG, Xi ZHOU, Fang HUANG, Hui-tai LUO

“…This study provides an effective and comprehensive method for qualitative analysis of the chemical components in the Patented Naoxueshuan formula, and also provides data support for clarifying effective substances and establishing a quality evaluation system.…”
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Association between gestational weight gain and adverse pregnancy outcomes: cohort analysis from South Asia and Sub-Saharan Africa by Anisur Rahman, Fyezah Jehan, Gary M Shaw, Sunil Sazawal, Salahuddin Ahmed, Abdullah H Baqui, David K Stevenson, Monjur Rahman, Jesmin Pervin, Shaki Aktar, Rasheda Khanam, Sayedur Rahman, Nitya Wadhwa, Ge Zhang, Huan Xu, Usma Mehmood, Shinjini Bhatnagar, Jeffrey S A Stringer, Bellington Vwalika, Waqasuddin Khan, Nabidul Haque Chowdhury, Imran Nisar, Javairia Khalid, Nima Aghaeepour, U Tin Nu, Yuri V Sebastião, Ramachandran Thiruvengadam, Ayushi, Bapu Koundinya Desiraju, Fatma Kabole, Muhammad Farrukh Qazi, Margaret Kasaro, Bihila Abdalla Bakari

“…We examined GWG patterns and adverse pregnancy outcomes in a consortium of pregnancy cohorts from LMICs.Methods We analysed data from five observational pregnancy cohorts in Bangladesh (two cohorts), India, Pakistan and Zambia. …”
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Characteristics of adherent and non-adherent patients with hypertension in a Norwegian cross-sectional study by Eirik Olsen, Lene V. Halvorsen, Stine Rognstad, Arleen Aune, Karl Marius Brobak, Ola Undrum Bergland, Vibeke N. Kjær, Knut Liestøl, Marit D. Solbu, Rune Mo, Eva Gerdts, Morten Rostrup, Sverre E. Kjeldsen, Aud Høieggen, Mimi S. Opdal, Anne Cecilie K. Larstorp, Camilla L. Søraas

“…We also identified characteristics associated with non-adherence. Methods: Patients with hypertension using ≥ 2 antihypertensive agents were invited to participate in this national study performed in a semi-blinded fashion. …”
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Long-term Impact of Carotid Endarterectomy on Choroidal and Choriocapillaris Perfusion: The INFLATE Study by Alessandro Berni, MD, Yi Zhang, PhD, Sandy Zhou Wenting, MD, Natalie Noam, MD, David Rabinovitch, BSc, Basheer Sheick Yousif, MD, Gissel Herrera, MD, Mengxi Shen, MD, PhD, Robert O’Brien, PhD, Giovanni Gregori, PhD, Ruikang K. Wang, PhD, Philip J. Rosenfeld, MD, PhD, Omer Trivizki, MD

“…Participants: Patients with clinically significant CAS undergoing unilateral CEA. Methods: Swept-source OCT angiography scans were performed on both eyes at baseline (before CEA), within 1 week post-CEA (short-term follow-up [FU]), and ≥30 days post-CEA (long-term FU). …”
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Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy by James Dooley, Bart Neyns, Elizabeth Allen, Frank Tacke, Louis Boon, Damya Laoui, Julia Katharina Schwarze, Helena Van Damme, Bruno Dombrecht, Máté Kiss, Heleen Roose, Eva Van Overmeire, Daliya Kancheva, Liesbet Martens, Aleksandar Murgaski, Pauline Madeleine Rachel Bardet, Gillian Blancke, Maude Jans, Evangelia Bolli, Maria Solange Martins, Yvon Elkrim, Kiavash Movahedi, Niels Vandamme, Sebahat Ocak, Isabelle Scheyltjens, Lars Vereecke, Frank Aboubakar Nana, Pascal Merchiers, Jo Agnes Van Ginderachter

“…Background Modulation and depletion strategies of regulatory T cells (Tregs) constitute valid approaches in antitumor immunotherapy but suffer from severe adverse effects due to their lack of selectivity for the tumor-infiltrating (ti-)Treg population, indicating the need for a ti-Treg specific biomarker.Methods We employed single-cell RNA-sequencing in a mouse model of non-small cell lung carcinoma (NSCLC) to obtain a comprehensive overview of the tumor-infiltrating T-cell compartment, with a focus on ti-Treg subpopulations. …”
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Development and usability testing of a multifaceted intervention to reduce low-value injury care by Mélanie Bérubé, Alexandra Lapierre, Michael Sykes, Jeremy Grimshaw, Alexis F. Turgeon, François Lauzier, Monica Taljaard, Henry Thomas Stelfox, Holly Witteman, Simon Berthelot, Éric Mercier, Catherine Gonthier, Jérôme Paquet, Robert Fowler, Natalie Yanchar, Barbara Haas, Paule Lessard-Bonaventure, Patrick Archambault, Belinda Gabbe, Jason R. Guertin, Yougdong Ouyang, Lynne Moore, the Canadian Traumatic Brain Injury Research Consortium

“…The aim of our study was to develop and assess the usability of a multifaceted intervention to reduce low-value injury care. Methods We used the Consolidated Framework for Implementation Research and the Expert Recommendations for Implementing Change tool as theoretical foundations to identify barriers and facilitators, and strategies for the reduction of low-value practices. …”
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Unraveling the immunological landscape and gut microbiome in sepsis: a comprehensive approach to diagnosis and prognosisResearch in context by Yali Luo, Jian Gao, Xinliang Su, Helian Li, Yingcen Li, Wenhao Qi, Xuling Han, Jingxuan Han, Yiran Zhao, Alin Zhang, Yan Zheng, Feng Qian, Hongyu He

“…Summary: Background: Comprehensive and in-depth research on the immunophenotype of septic patients remains limited, and effective biomarkers for the diagnosis and treatment of sepsis are urgently needed in clinical practice. Methods: Blood samples from 31 septic patients in the Intensive Care Unit (ICU), 25 non-septic ICU patients, and 18 healthy controls were analyzed using flow cytometry for deep immunophenotyping. …”
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Biological activities of Usnea lethariiformis lichen extracts and UHPLC-ESI-QTOF-MS analysis of their secondary metabolites by Mauricio Piñeiro, Mauricio Piñeiro, Sofía Manrique, Jessica Gómez, Jessica Gómez, Juan Manuel Rodriguez, Patricia Barrera, Duilio Caballero, Miguel A. Sosa, Gabriel Vargas-Arana, Gabriel Vargas-Arana, Alejandro Tapia, Beatriz Lima, Beatriz Lima, Mario J. Simirgiotis

“…The total phenolic content of lichen extracts was determined by the Folin–Ciocalteu method. Antioxidant properties were assessed through 2,2-diphenyl-1-picrylhydrazyl (DPPH), Trolox equivalent antioxidant activity (TEAC), ferric-reducing antioxidant power (FRAP), and inhibition of lipid peroxidation in erythrocytes (ILP) assays, and the extracts exhibited robust antioxidant activity. …”
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Dietary protein intake and PM2.5 on ovarian cancer survival: A prospective cohort study by He-Li Xu, Yi-Fan Wei, Qi Bao, Ya-Li Wang, Xiao-Ying Li, Dong-Hui Huang, Fang-Hua Liu, Yi-Zi Li, Yue-Yang Zhao, Xin-Xin Zhao, Qian Xiao, Song Gao, Ren-Jie Chen, Ling Ouyang, Xia Meng, Xue Qin, Ting-Ting Gong, Qi-Jun Wu

“…Objective: The objective of this study was to explore the association of dietary protein, PM2.5, and their interaction with the survival of OC patients. Methods: A prospective cohort study was carried out, which encompassed 658 newly diagnosed OC patients (18–79 years) residing in China. …”
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Prevalence of overweight and obesity among preschool children in Hainan: a cross-sectional study in China's largest free-trade zone by Wei-Jia Wu, Wei-Jia Wu, Ping-Hao Chen, Ping-Hao Chen, Zhen-Ning Huang, Zhen-Ning Huang, Xue-Lu Lei, Xue-Lu Lei, Chen Wang, Chen Wang, Chun-hui Zhang, Chun-hui Zhang, Ping Wang, Ping Wang, Chui-can Huang, Qing Luo, Qing Luo, Li-Chun Fan, Li-Chun Fan

“…Additionally, the potential factors influencing overweight and obesity among preschool children in Hainan Island were further explored.MethodsWe conducted a cross-sectional survey of children aged 3–6 years covering 18 cities and counties in China's largest free trade zone. …”
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Anxiety and depression in people with epilepsy during and one year after the COVID‐19 pandemic by Iris E. Martínez‐Juárez, Jimena Gonzalez‐Salido, Jimena Colado‐Martinez, Irving Fuentes‐Calvo, Santiago Philibert‐Rosas, E. Rodrigo Velásquez‐Coria, Salvador Martínez‐Medina, Mijail A. Rivas‐Cruz, Eithel Valenzuela‐Mendivil, Karen E. Guzmán‐Sánchez, Elizabeth M. Ruiz‐Peñaflor, Arnold R. Thomson‐Cerna, Emilia M. González‐Villagómez, Jimena Armenta‐Báez, Andrea Santos‐Peyret, Aurelio Jara‐Prado, Adriana Ochoa‐Morales, Daniel Crail‐Meléndez, Ángel Ruiz‐Chow, Mario A. Sebastián‐Díaz

“…Abstract Objective Compare the prevalence and severity of anxiety and depression among people with epilepsy (PWE) evaluated by telemedicine during the initial stages of the COVID‐19 pandemic and follow up on their status 15 months later. Methods We conducted a prospective, observational, and analytical study at the Epilepsy Clinic of the National Institute of Neurology and Neurosurgery (NINN) in Mexico City during the COVID‐19 pandemic. …”
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Biochemical, Histological, and Multi-Omics Analyses Reveal the Molecular and Metabolic Mechanisms of Cold Stress Response in the Chinese Soft-Shelled Turtle (<i>Pelodiscus sinensis... by Liqin Ji, Qing Shi, Chen Chen, Xiaoli Liu, Junxian Zhu, Xiaoyou Hong, Chengqing Wei, Xinping Zhu, Wei Li

“…Herein, plasma biochemical, hepatic morphological, apoptotic, transcriptomic, and metabolomic detection methods were performed to investigate the response of <i>P. sinensis</i> to acute cold stress. …”
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Breastfeeding support as predictors of sustainable breastfeeding practices of nursing mothers with common mental disorders in tertiary hospital nurseries in Nigeria: a cross sectio... by Michael Abel Alao, Olayinka Rasheed Ibrahim, Sakiru Abiodun Yekinni, Sikirat Adetoun Sotimehin, Udochukwu Michael Diala, Datonye Christopher Briggs, Aishatu Zaidu Musa, Zainab Oluwatosin Imam, Esther Oluwatoyin Famutimi, Adedeji Abiodun Idris, Adaeze C. Ayuk, Kenechukwu Kosisochukwu Iloh, Chioma Laura Odimegwu, Ayomide Toluwanimi Adeyemi, Patricia F. Medupin, Yetunde C. Adeniyi, Kenechi Ogbodo Nnamani, Olukemi Oluwatoyin Tongo

“…This study aimed to determine the breastfeeding support provided to mothers whose infants were hospitalised in Nigerian tertiary hospital nurseries and the prevalence of common mental health disorders among this population. Methods This was a national cross-sectional study involving mothers of hospitalised infants from eleven Nigerian tertiary hospitals between May and August 2022. …”
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體驗教育對建構大學生心理資本之研究 Effect of Experiential Education on College Students’ Psychological Capital Development by 陳淑媛 Shu-Yuan Chen, 許于仁 Yu-Ren Hsu

“…Accordingly, the present study explores methods for enhancing the PsyCap of college students while they navigate crucial social and career transitions. 2. …”
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Meta-synthesis of drivers of the circular business model by Atieh Khodaei, Mahdi Hosseinpour, Mohammad javad Jamshidi, Yoosof Mohamadifar

“…The findings of 42 previous studies related to the research objectives were reviewed, aggregated, combined, and interpreted by means of the seven-step model of Sandelowski and Barroso. Using the coding method, the number of 27 codes, 8 concepts, and 3 components were identified and validated through Cohen's kappa test, and the model of the drivers of circular business model was presented and drawn. …”
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Overexpression of the <i>GmPM35</i> Gene Significantly Enhances Drought Tolerance in Transgenic Arabidopsis and Soybean by Xinyu Wang, Yao Sun, Rui Wang, Xinyang Li, Yongyi Li, Tianyu Wang, Zhaohao Guo, Yan Li, Wenxi Qiu, Shuyan Guan, Qi Zhang, Piwu Wang, Mingze Li, Siyan Liu, Xuhong Fan

“…To further investigate the drought tolerance function of this gene in soybeans, nine overexpression lines of the T₃ generation soybean <i>GmPM35</i> gene and two editing lines of the T₃ generation soybean <i>GmPM35</i> gene were obtained by Agrobacterium-mediated method using a wild-type soybean strain (JN28) as a receptor. …”
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Non-Immersive Virtual Reality Exercise Can Increase Exercise in Older Adults Living in the Community and in Long-Term Care: A Randomized Controlled Trial by Sheehy L, Bharadwaj L, Nissen KA, Estey JL

“…Lisa Sheehy,1 Lalita Bharadwaj,2 Kelsey Annie Nissen,2 Justine L Estey2 1Bruyère Health Research Institute, Ottawa, Ontario, Canada; 2Centre for Innovation and Research in Aging, Fredericton, New Brunswick, CanadaCorrespondence: Lisa Sheehy, Bruyère Health Research Institute, 43 Bruyère St, Ottawa, ON, K1N 5C8, Canada, Tel +01 613 562 6262 ext. 1593, Email lsheehy@bruyere.orgPurpose: To assess the impact of an 8-week non-immersive virtual reality exercise program for older adults on 1) balance, physical function, community integration and quality of life; 2) falls, emergency room visits, hospital and long-term care admissions; 3) quantity of exercise performed; and 4) acceptance of non-immersive virtual reality.Patients and Methods: This prospective, assessor-blinded, randomized controlled trial was carried out on two separate samples of older adults: those living in their own homes (“home-based”) and those living in long-term care (“facility-based”). …”
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Durvalumab and tremelimumab in patients with advanced rare cancer: a multi-centre, non-blinded, open-label phase II basket trialResearch in context by Abha A. Gupta, Anna Tinker, Derek Jonker, Rahma Jamal, Hal Hirte, Eric W. Winquist, Quincy Chu, Christian Kollmannsberger, Ralph Wong, Thierry Alcindor, Torsten O. Nielsen, Ming Tsao, Tricia R. Cottrell, Diane Provencher, John Hilton, Monika K. Krzyżanowska, Christine Elser, Sebastien Hotte, Joana Sederias, Siwei Zhang, Wei Tu, Janet Dancey

“…We sought to determine the objective response rate of combination durvalumab (D) plus tremelimumab (TM) in parallel cohorts of patients with carefully selected rare cancer types in which these agents had not previously been evaluated in phase II trials and for which there was clinical or biological rationale for dual immune checkpoint inhibitor therapy to be active. Methods: We designed a multi-centre, non-blinded, open-label phase II basket trial with each of the following 8 rare cancers considered a separate phase II trial: salivary carcinoma, carcinoma of unknown primary (CUP) with tumour infiltrating lymphocytes and/or expressing PD-L1, mucosal melanoma, acral melanoma, osteosarcoma, undifferentiated pleomorphic sarcoma, clear cell carcinoma of the ovary (CCCO) or squamous cell carcinoma of the anal canal (SCCA). …”
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Innovación en sueño by Laura Vigil, Toni Zapata, Andrea Grau, Marta Bonet, Montserrat Montaña, María Piñar

“…This disorder affects one billion people worldwide and traditionally, diagnosis is based on polysomnography (PSG), a laborious method that requires specialized personnel. However, the integration of artificial intelligence (AI) in sleep medicine has made it possible to automate the analysis of sleep phases and respiratory events with high accuracy.Machine learning algorithms and neural networks have proven to be effective in automatic sleep coding, with hit rates comparable to those of human experts. …”
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Evolución del paciente hospitalizado con gripe durante 2016–2020 según su estado vacunal by Jacobo Martín Ramos, Francisco Javier Cuevas Fernández, Álvaro Torres Lana, Armando Aguirre Jaime

“…The objective of this study is to quantify the effectiveness of influenza vaccination in patients hospitalized for influenza to prevent its evolution to severity, considering other known factors that influence such severity. Methods: Cross-sectional study of the 2016–2017 to 2019–2020 influenza epidemiological seasons with patients hospitalized at the Nuestra Señora de la Candelaria University Hospital in Tenerife diagnosed with influenza. …”
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