Noninvasive respiratory support following extubation in critically ill adults with obesity: a systematic review and network meta-analysisResearch in context by Joris Pensier, Arthur Naudet-Lasserre, Clément Monet, Mathieu Capdevila, Yassir Aarab, Inès Lakbar, Gérald Chanques, Nicolas Molinari, Audrey De Jong, Samir Jaber

“…Discrepancies were found in the results of recent randomized controlled trials (RCTs) regarding the roles of noninvasive ventilation (NIV), high flow nasal cannula (HFNC) and conventional oxygen therapy (COT) to prevent extubation failure in critically ill patients with obesity. Methods: In this systematic review and network meta-analysis, we searched MEDLINE, Cochrane Center Register of Controlled Trials and Web of Science from 1 January 1998 to 1 July 2024 for RCTs evaluating noninvasive respiratory support therapies (NIV, HFNC, COT, NIV + HFNC) after extubation in critically ill adults with obesity. …”
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Single Dose of Attenuated Vaccinia Viruses Expressing H5 Hemagglutinin Affords Rapid and Long-Term Protection Against Lethal Infection with Highly Pathogenic Avian Influenza A H5N1... by Fumihiko Yasui, Keisuke Munekata, Tomoko Fujiyuki, Takeshi Kuraishi, Kenzaburo Yamaji, Tomoko Honda, Sumiko Gomi, Misako Yoneda, Takahiro Sanada, Koji Ishii, Yoshihiro Sakoda, Hiroshi Kida, Shosaku Hattori, Chieko Kai, Michinori Kohara

“…Although these vaccines are well tolerated, their immunogenicity and cross-reactivity with viruses of different clades can be improved. Methods: To address this aspect, we generated recombinant influenza vaccines against H5-subtype viruses using two different strains of highly attenuated vaccinia virus (VACV) vectors. …”
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Target trial emulation to evaluate the effect of immune-related adverse events on outcomes in metastatic urothelial cancer by Renate Pichler, Josef Fritz, Sarah Maier, Melanie R. Hassler, Johanna Krauter, David D`Andrea, Ekaterina Laukhtina, Kilian Gust, Keiichiro Mori, Karl H. Tully, Dora Niedersuess-Beke, Lea Korber, Jasmin Alija Spiegelberg, Thomas Bauernhofer, José D. Subiela, Roman Mayr, Andreas Kronbichler, Marco Moschini, Jeremy Teoh, Benjamin Pradere, Shahrokh F. Shariat, Hanno Ulmer, Laura S. Mertens, European Association of Urology–Young Academic Urologists (EAU-YAU): Urothelial Carcinoma Working Group

“…The aim of this study was to assess the effect of irAEs on outcomes while correcting for immortal time bias, using target trial emulation (TTE). Methods TTE was contrasted to adjusted naïve and time-updated Cox models. …”
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Epithelial NSD2 maintains FMO‐mediated taurine biosynthesis to prevent intestinal barrier disruption by Yue Xu, Xiuying Xiao, Chunxiao Ma, Ziyi Wang, Wenxin Feng, Hanyu Rao, Wei Zhang, Ningyuan Liu, Rebiguli Aji, Xiangjun Meng, Wei‐Qiang Gao, Li Li

“…However, the precise role of NSD2 in IBD remains unexplored. Methods Colon tissues from IBD mice, SW620 cells and MC38 cells, were used as research subjects. …”
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Therapeutic role of miR-26a on cardiorenal injury in a mice model of angiotensin-II induced chronic kidney disease through inhibition of LIMS1/ILK pathway by Weijie Ni, Yajie Zhao, Jinxin Shen, Qing Yin, Yao Wang, Zuolin Li, Taotao Tang, Yi Wen, Yilin Zhang, Wei Jiang, Liangyunzi Jiang, Jinxuan Wei, Weihua Gan, Aiqing Zhang, Xiaoyu Zhou, Bin Wang, Bi-Cheng Liu, Yuanyuan Ji

“…Therefore, this study focused on the molecular mechanism of heart and kidney injury in CKD. Methods:. We generated an microRNA (miR)-26a knockout (KO) mouse model to investigate the role of miR-26a in angiotensin (Ang)-II-induced cardiac and renal injury. …”
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Microwave ablation vs. single-needle radiofrequency ablation for the treatment of HCC up to 4 cm: A randomized-controlled trial by Katsutoshi Sugimoto, Kento Imajo, Hidekatsu Kuroda, Go Murohisa, Kazue Shiozawa, Kentaro Sakamaki, Takuya Wada, Hirohito Takeuchi, Kei Endo, Tamami Abe, Takashi Matsui, Takahiro Murakami, Masato Yoneda, Atsushi Nakajima, Shigehiro Kokubu, Takao Itoi

“…Therefore, we evaluated and compared the effectiveness of MWA and RFA in managing HCC tumors up to 4 cm in size. Methods: In this multicenter randomized controlled trial conducted across five centers in Japan, eligible participants had up to 4 tumors, each up to 4 cm in size, and were not considered for surgery. …”
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Impact of Immune Checkpoint Inhibitors and Local Radical Treatment on Survival Outcomes in Synchronous Oligometastatic NSCLC by Mandy Jongbloed, MD, Valentina Bartolomeo, MD, Martina Bortolot, MD, Shahan Darwesh, MD, Jarno W.J. Huijs, MD, Safiye Dursun, MD, Juliette Degens, MD, PhD, Ben E.E.M. van den Borne, MD, PhD, Maggy Youssef-El Soud, MD, PhD, Marcel Westenend, MD, PhD, Cordula Pitz, MD, PhD, Dirk K.M. De Ruysscher, MD, PhD, Lizza E.L. Hendriks, MD, PhD

“…Introduction: The impact of an immune checkpoint inhibitor (ICI)–based systemic treatment strategy with or without local radical treatment (LRT) on outcomes for patients with NSCLC and synchronous oligometastatic disease (sOMD) is unknown. Methods: Multicenter retrospective study including adequately staged patients, with sOMD NSCLC (maximum five metastases in three organs [European Organization for Research and Treatment of Cancer definition]) between January 1, 2015 and December 31, 2022, treated with a first-line ICI-based versus chemotherapy-only regimen. …”
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Brucea javanica oil inhibited the proliferation, migration, and invasion of oral squamous carcinoma by regulated the MTFR2 pathway by Yihan Lai, Yihan Lai, Mingkang Li, Mingkang Li, Juan Zhan, Juan Zhan, Lin Jiang, Lin Jiang, Yuan Wu, Zhiyi Fang, Jianhan Zhou, Jianhan Zhou, Yujie Ma, Yisen Shao, Yisen Shao, Wei Wang, Wei Wang

“…Studies have shown that Brucea javanica oil (BJO) extracts have anti-cancer effects against a variety of cancers, but little research has been reported on OSCC. MethodsCCK8, Colony formation, Scratch test and Transwell invasion assays were applied to determine the effects of BJO on the proliferation, migration, and invasion ability of OSCC cells in vitro. …”
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Serial measurements in COVID-19-induced acute respiratory disease to unravel heterogeneity of the disease course: design of the Maastricht Intensive Care COVID cohort (MaastrICCht) by Steven J R Meex, Walther N K A van Mook, Iwan C C van der Horst, Jeanette Tas, Coen D A Stehouwer, Rob J J van Gassel, Serge J H Heines, Mark M G Mulder, Nanon F L Heijnen, Melanie J Acampo-de Jong, Julia L M Bels, Frank C Bennis, Marcel Koelmann, Rald V M Groven, Moniek A Donkers, Frank van Rosmalen, Ben J M Hermans, Otto Bekers, Astrid M L Oude Lashof, Fabian H Tijssen, Jan-Willem E M Sels, Chahinda Ghossein-Doha, Rob G H Driessen, Pieter L Kubben, Marcus L F Janssen, Gerry A F Nicolaes, Ulrich Strauch, Zafer Geyik, Thijs S R Delnoij, Kim H M Walraven, Jeanine A M C F Verbunt, Susanne van Santen, Ronny M Schnabel, Marcel J H Aries, Marcel C G van de Poll, Bas C T van Bussel, Joachim E Wildberger, Sander M J van Kuijk, Dennis C J J Bergmans, Paul H M Savelkoul, Alma M A Mingels, Wolfgang F F A Buhre

“…The study aims to investigate the heterogeneity of the natural course of critically ill patients with a SARS-CoV-2 infection.Methods and analysis Mechanically ventilated patients admitted to the intensive care with a SARS-CoV-2 infection will be included. …”
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Residence-based disparities of composite index of anthropometric failures in East African under five children; multivariate decomposition analysis by Aznamariam Ayres, Yawkal Tsega, Abel Endawkie, Shimels Derso Kebede, Eyob Tilahun Abeje, Ermias Bekele Enyew, Chala Daba, Lakew Asmare, Amare Muche, Fekade Demeke Bayou, Mastewal Arefaynie, Asnakew Molla Mekonen, Abiyu Abadi Tareke, Awoke Keleb, Kaleab Mesfin Abera, Natnael Kebede, Endalkachew Mesfin Gebeyehu

“…Hence, identifying the main contributors of these disparities will help health policy makers, program designers and implementers for the reduction of composite index of anthropometric failures in children under-5 years old in the study areas. Methods The most recent and nationally representative samples of demographic and health surveys of five East African countries data were used for the current study. …”
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Visual analysis of Traditional Chinese Medicine nursing for lung cancer patients with chemotherapy induced nausea and vomiting based on CiteSpace (基于CiteSpace的肺癌患者化疗相关性恶心呕吐中医护理研究热点... by LIN Haiqing (林海青), CHEN Yang (陈扬), LIU Jie (刘杰), HOU Yanli (侯燕丽), BAI Xue (白雪), CHEN Mengna (陈梦娜), TANG Xinyu (唐新宇)

“…Objective To explore research hotspots and development trend of Traditional Chinese Medicine (TCM) nursing interventions in the treatment of chemotherapy-induced nausea and vomiting(CINV) in lung cancer patients by using CiteSpace software. Methods Relevant literatures on TCN nursing interventions in the treatment of CINV from CNKI database were retrieved from the Jan 1, 2004 to Jan 1, 2024 and visualized by the CiteSpace 6. 3. …”
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Identification of strengths and weaknesses of the healthcare system for persons living with rare diseases in Catalonia (Spain), and recommendations to improve its comprehensive att... by José Hernández-Rodríguez, Fernando Martínez-Valle, Xènia Acebes, Carmen Alerany, Jordi Antón, Gonzalo Calvo, Marian Corral, Jordi Cruz, M. Antònia Mangues-Bafalluy, José Mateo, Josefa Rivera, Albert Salazar, Roser Francisco, Cristina Mallol, Rita Reig-Viader, Ariadna Tigri-Santiña, Assumpta Ricart, Francesc Palau

“…The additional primary aim was to propose recommendations to solve or improve the limitations found. Methods A task force of 13 participants with multidisciplinary expertise on RDs completed a questionnaire and participated in two focus groups. …”
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Initial treatment with a single capsule containing half-dose quadruple therapy vs standard-dose dual therapy in hypertensive patients (QUADUAL): a randomized, blinded, crossover tr... by Xiexiong Zhao, Tao Liu, Qiong Yang, Guoping Yang, Xingli Li, Xiaohong Tang, Jingle Li, Zhongshu Liang, Anying Li, Lixiong Zeng, Juan Wen, Xiaoyan Wang, Liping Peng, Wenjuan Wang, Jingjing Cai, Ye Chen, Miao Huang, Ruixuan Li, Ru Fu, Lin Zhao, Xiaogang Li, Weihong Jiang

“…However, whether low-dose quadruple therapy is better than dual combination is unknown. Methods A randomized blinded crossover trial was conducted to compare the efficacy and safety of low-dose quadruple antihypertensives (irbesartan 75 mg + metoprolol 23.75 mg + amlodipine 2.5 mg + indapamide 1.25 mg) with standard-dose dual antihypertensives (irbesartan 150 mg + amlodipine 5 mg), both in a single pill, in the initial treatment of patients with mild to moderate hypertension. …”
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Prevalence and characterization of IncQ1α-mediated multi-drug resistance in Proteus mirabilis Isolated from pigs in Kunming, Yunnan, China by Hongmei Liu, Hongmei Liu, Hongmei Liu, Na Xia, Fanan Suksawat, Bundit Tengjaroenkul, Yue Hu, Xiaofeng Zhou, Xiaojiang Li, Cuiqin Huang, Yinli Bao, Qiong Wu, Chunrong Zhang, Sunpetch Angkititrakul, Bin Xiang, Xin Wu

“…This study aims to investigate the presence of Inc plasmid types in pig-derived Proteus mirabilis in Kunming, Yunnan, China.MethodsFecal samples were collected from pig farms across six districts of Kunming (Luquan, Jinning, Yiliang, Anning, Songming, and Xundian) from 2022 to 2023. …”
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Progressive systemic inflammation precedes decompensation in compensated cirrhosis by Rubén Sánchez-Aldehuelo, Càndid Villanueva, Joan Genescà, Juan Carlos García-Pagán, Elisa Castillo, José Luis Calleja, Carles Aracil, Rafael Bañares, Luis Téllez, Lorena Paule, Rosa María Morillas, María Poca, Beatriz Peñas, Salvador Augustin, Juan G. Abraldes, Edilmar Alvarado-Tapias, Jaume Bosch, Agustín Albillos

“…We evaluated inflammation and bacterial translocation markers in compensated cirrhosis and their dynamics in relation to the first decompensation. Methods: This study is nested within the PREDESCI trial, which investigated non-selective beta-blockers for preventing decompensation in compensated cirrhosis and clinically significant portal hypertension (CSPH: hepatic venous pressure gradient ≥10 mmHg). …”
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Prevalence of peptic ulcer disease and its associated factors in Jeddah Saudi Arabia by Muazzam Sheriff Maqbul, Reem Saleh Alzaki, Reema Sami Meeralam, Norah Abdulmajeed Alqutami, Bayan Mohammed Alturki, Lina Sultan Alhazmi, Reem Mamdouh Alaseeri, Lama Saad Alghamdi, Reem Khalid bin Brik, Shaima Tariq Mansoor Beig, Muath Saeed Alamri, Wjood Abdullah A. Alshehri, Turki Ayed Almutairi, Maha Abdullah Alqurashi, Ahmed Jamal Nasef

“…Data was collected through an online survey using convenience sampling and analyzed with SPSS and Excel, employing both descriptive and inferential statistical methods. Result: The survey in Jeddah, Saudi Arabia, examined peptic ulcer disease (PUD) prevalence and associated factors. …”
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Correlates of mental health of people living with HIV co-infected with SARS-CoV-2: findings from the COVIDHIV study in France by Issifou Yaya, Issifou Yaya, Yvenie Amboise, Yvenie Amboise, Guillaume Roucoux, Guillaume Roucoux, Lisa Yombo-Kokule, Lisa Yombo-Kokule, Fabienne Marcellin, Claudine Duvivier, Claudine Duvivier, Karine Lacombe, Karine Lacombe, James W. Griffith, James W. Griffith, Marie Préau, Antoine Cheret, Antoine Cheret, Martin Duracinsky, Martin Duracinsky, Martin Duracinsky

“…This study aimed to investigate the mental well-being repercussions faced by PLWHA co-infected with SARS-CoV-2 in France.MethodsCOVIDHIV is a French multicenter cohort of PLWHA co-infected with SARS-CoV-2, which collected sociodemographic, clinical, and mental health data. …”
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Determinants of the Continuum of Maternal Healthcare Services in Northwest Ethiopia: Findings from the Primary Health Care Project by Asmamaw Atnafu, Adane Kebede, Bisrat Misganaw, Destaw Fetene Teshome, Gashaw Andargie Biks, Getu Debalkie Demissie, Haileab Fekadu Wolde, Kassahun Alemu Gelaye, Mezgebu Yitayal, Tadesse Awoke Ayele, Telake Azale, Terefe Derso, Tsegaye Gebremedhin, Endalkachew Dellie

“…This study aimed to assess the factors associated with the completion of a continuum of maternal healthcare services among mothers who gave birth in the past five years. Methods. A community-based cross-sectional study was conducted from May 01 to June 29, 2019, among 565 randomly selected mothers who gave birth in five years before the study in primary healthcare project implementation districts of north Gondar zone, Amhara National Regional State, Ethiopia. …”
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Steatohepatitis-induced vascular niche alterations promote melanoma metastasis by Johannes Hoffmann, Julia Schüler, Bianca Dietsch, Sina Wietje Kürschner-Zacharias, Carsten Sticht, Felix A. Trogisch, Maren Schreitmüller, Tinja Baljkas, Kai Schledzewski, Manuel Reinhart, Sebastian A. Wohlfeil, Manuel Winkler, Christian David Schmid, Joerg Heineke, Cyrill Géraud, Sergij Goerdt, Philipp-Sebastian Reiners-Koch, Victor Olsavszky

“…Given the increase in metabolic liver diseases such as metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH), this study investigated the impact of liver sinusoidal endothelial cell (LSEC)-specific alterations in MASLD/MASH on hepatic melanoma metastasis. Methods Mice were fed a choline-deficient L-amino acid-defined (CDAA) diet for ten weeks to induce MASH-associated liver fibrosis, or a CDAA diet or a high fat diet (HFD) for shorter periods of time to induce early steatosis-associated alterations. …”
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Inter-rater reliability and prognostic value of baseline Radiographic Assessment of Lung Edema (RALE) scores in observational cohort studies of inpatients with COVID-19 by Andrew I Kim, William Bain, Alison Morris, Barbara Methe, Bryan J McVerry, Georgios D Kitsios, Daniel Kotok, Janet S Lee, Nameer Al-Yousif, Christine E Girard, Jana J Jacobs, Konstantin Golubykh, Hafiz Qurashi, Michael Lu, Saketram Komanduri, Anatoliy Korzhuk, Halimat O Lawal, Nicholas Abourizk, Caitlin Schaefer, Kevin J Mitchell, Catherine M Dietz, Ellen K Hughes, Clara S Brandt, Georgia M Fitzgerald, Robin Joyce, Asmaa S Chaudhry, Jose D Rivera, Shruti Shettigar, Allen Lavina, Samantha R Gillenwater, Anas Hadeh, Faraaz A Shah, Matthew Bittner, Niall Prendergast, John Evankovich, Navitha Ramesh, Cathy Kessinger

“…We replicated the significant associations of RALE scores with baseline disease severity and mortality in the independent validation data set.Conclusions With a reproducible method to measure radiographic severity in COVID-19, we found significant associations with clinical and physiologic severity, host inflammation and clinical outcomes. …”
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