Long-Term Results of Cabergoline Add-on Long-Acting Somatostatin Analogue Therapy in Acromegaly Patients by Mehmet Muhittin Yalçın, Gizem Bedir Keser, Meriç Coşkun, Afruz Babayeva, Emrah Çeltikçi, Mehmet Arda İnan, Emetullah Cindil, Aylar Poyraz, Ethem Turgay Cerit, Alev Eroğlu Altınova, Müjde Aktürk, Füsun Baloş Törüner, Mehmet Ayhan Karakoç, İlhan Yetkin

“…Objective: To investigate the efficacy of the dopamine agonist cabergoline in uncontrolled acromegaly despite long-acting somatostatin analog (SSA). Methods: Thirty-five patients with acromegaly who were followed up in the department of endocrinology and metabolism of our university were analyzed. …”
Get full text

Effects of fine particulate matter and its chemical constituents on influenza-like illness in Guangzhou, China by Keyi Wu, Weidong Fan, Jing Wei, Jianyun Lu, Xiaowei Ma, Zelin Yuan, Zhiwei Huang, Qi Zhong, Yining Huang, Fei Zou, Xianbo Wu

“…This study aims to explore this effect in Guangzhou, China. Methods: Daily data on ILI cases, PM2.5 levels, and specific PM2.5 constituents (black carbon [BC], chlorine [Cl−], ammonia [NH4+], nitrate [NO3−], and sulfate [SO42−]) in Guangzhou, China, were collected for the period of 2014–2019. …”
Get full text

Phenotypic diversity of CTCs and tdEVs in liquid biopsies of tumour-draining veins is linked to poor prognosis in colorectal cancer by Stefan A. Cieslik, Andrés G. Zafra, Christiane Driemel, Monica Sudarsanam, Jan-Philipp Cieslik, Georg Flügen, Levent Dizdar, Andreas Krieg, Sascha Vaghiri, Hany Ashmawy, Stephen Fung, Miriam Wilms, Leon W. M. M. Terstappen, Afroditi Nanou, Hans Neubauer, Nuh N. Rahbari, Wolfram T. Knoefel, Nikolas H. Stoecklein, Rui P. L. Neves

“…In this study, we explored the presence of CTCs and tdEVs collected intraoperatively from a tumour-draining vein (DV) and via a central venous catheter (CVC) prior to tumour resection. Methods CellSearch analyses of 395 blood samples from 306 patients with gastrointestinal tumours and 93 blood samples from healthy donors were used to establish and validate gates for the automated detection of CTCs and tdEVs with ACCEPT software and R scripts. …”
Get full text

Assessing intrinsic capacity for person‐centred HIV care: a cross‐sectional study in ageing populations in Malaysia and Hong Kong by Reena Rajasuriar, Syaza Hisham, John Son Lim, Jean Yi Cheong, Wen Ying Ho, Siew Hwei Yap, Nurul Syuhada Zulhaimi, Malinee Neelamegam, Catherine Cheung, Vivian Wong, Ruhana Che Yusof, Kejal Hasmukharay, Shahrul Bahyah Kamaruzzaman, Sharifah Faridah Syed Omar, Meng Li Chong, Pui Li Wong, Grace Chung‐Yan Lui

“…However, to date, its utility within the context of HIV has not been assessed. Methods Participants included 200 PWH attending out‐patient care (2021−2023) in Universiti Malaya Medical Centre, Malaysia and 101 community controls aged 35 years and above. …”
Get full text

Oncolytic virus OH2 extends survival in patients with PD-1 pretreated melanoma: phase Ia/Ib trial results and biomarker insights by Juan Li, Xuan Wang, Li Zhou, Jun Guo, Lu Si, Bixia Tang, Chuanliang Cui, Xiaoting Wei, Xinan Sheng, Siming Li, Zhihong Chi, Lili Mao, Bin Lian, Xieqiao Yan, Yan Kong, Caili Li, Xiangyong Gu, Binlei Liu, Hui Tian, Han Hu

“…A phase Ia/Ib clinical trial in China was conducted in patients with unresected stage III–IV melanoma, the majority of whom had the acral type, to assess the safety and preliminary efficacy of OH2.Methods The trial enrolled patients with histologically confirmed unresectable stage III or advanced stage IV melanoma. …”
Get full text

Electroacupuncture attenuates ferroptosis by promoting Nrf2 nuclear translocation and activating Nrf2/SLC7A11/GPX4 pathway in ischemic stroke by Xi-chen Yang, Ya-ju Jin, Rong Ning, Qiu-yue Mao, Peng-yue Zhang, Li Zhou, Cheng-cai Zhang, Yi-chen Peng, Na Chen

“…In the present study, we wanted to explore whether electroacupuncture could inhibit ferroptosis by promoting nuclear factor erythroid-2-related factor 2 (Nrf2) nuclear translocation. Methods The ischemic stroke model was established by middle cerebral artery occlusion/reperfusion (MCAO/R) in adult rats. …”
Get full text

Efficacy of brain stimulation therapies across psychiatric, movement, and cognitive disorders: an umbrella review synthesizing meta-analyses of randomized controlled trialsResearch... by Zhenyue Zu, Fenglan Chen, Linxi Yang, Wenzhuo Wei, Mi Zhang, Limin Huang, Ni Li, Zihan Lv, He Du, Xinrong Xue, Lijun Ma, Huixue Wang, Kai Wang, Xiaoming Li

“…Given the high prevalence of comorbidities among these disorders, we conducted an umbrella review to comprehensively assess the efficacy of BSTs in treating the core symptoms across these three categories of disorders. Methods: We systematically searched for meta-analyses and network meta-analyses of randomized controlled trials with sham controls up to September 25, 2024, from databases including PubMed, PsycINFO, Embase, and the Cochrane Library. …”
Get full text

TP53 germline testing and hereditary cancer: how somatic events and clinical criteria affect variant detection rate by Paula Rofes, Carmen Castillo-Manzano, Mireia Menéndez, Álex Teulé, Sílvia Iglesias, Elisabet Munté, Mireia Ramos-Muntada, Carolina Gómez, Eva Tornero, Esther Darder, Eva Montes, Laura Valle, Gabriel Capellá, Marta Pineda, Joan Brunet, Lidia Feliubadaló, Jesús del Valle, Conxi Lázaro

“…Here we aim to assess the relevance and impact of these issues on the diagnostic routine, and to evaluate the sensitivity of the different LFS clinical criteria to identify hTP53rc. Methods TP53 was analyzed in 6161 suspected hereditary cancer non-related patients categorized into three subgroups: (1) 495 patients fulfilling any LFS/Chompret clinical criteria; (2) 2481 patients diagnosed with early-onset breast/colorectal cancer; (3) 3185 patients without clinical criteria suggestive of hTP53rc. …”
Get full text

Reflecting on the impact of the COVID pandemic on patient management and its subsequent influence on long-term outcomes: a case–control study in the field of esophago-gastric cance... by Mohamed Alasmar, Nadia Matias, Norah Ali M. Alhamed, Omneya Alwani, Brogan Rudge, Terngu David Moti, Muhammad Ossama Yassin Abdelwahab, Jennifer Stockton, Charef Raslan, Jess Cairney-Hill, Mohammad Altarawni, Bilal Alkhaffaf, on behalf Greater Manchester Oesophago-Gastric Service

“…This study aimed to describe changes in presentations, assess the change in recommendations by the MDT during the pandemic, and describe the subsequent long-term impact of these changes on survival rates in patients with EG cancer. Methods A retrospective cohort study was designed comparing three patient groups of those referred to EG MDT in the same 6-month period pre-pandemic (PP;2019) during the initial phase of the pandemic (P1;2020) and the year after the initial phase (P2;2021). …”
Get full text

FAecal micRobiota transplantation in primary sclerosinG chOlangitis (FARGO): study protocol for a randomised, multicentre, phase IIa, placebo-controlled trial by Laith Alrubaiy, Rachel Cooney, Tariq Iqbal, Mohammed Nabil Quraishi, Susan Manzoor, Christopher Quince, Palak J Trivedi, Andrew D Beggs, Alexandra Vince, Chris Weston, Benjamin Mullish, Sahida Shabir, Nicola Jackson, Anna Rowe, Victoria Homer, Willem van Schaik, Peter Rimmer, Sarah Al-Shakhshir, Arzoo Patel, Derick Gyimah, Miriam Hares, Elena Efstathiou

“…The aim of this clinical trial is to determine the effects of repeated FMT as a treatment for PSC-IBD.Methods and analysis FAecal micRobiota transplantation in primary sclerosinG chOlangitis (FARGO) is a phase IIa randomised placebo-controlled trial to assess the efficacy and safety of repeated colonic administration of FMT in patients with non-cirrhotic PSC-IBD. …”
Get full text

Bidirectional effect modifications of temperature and PM2.5 on myocardial infarction morbidity and mortality in Beijing, China from 2007 to 2021 by Piaopiao Hu, Qinghui Zeng, Jie Chang, Moning Guo, Feng Lu, Yue Qi, Zhao Yang, Pingping Jia, Qiuju Deng, Jing Liu

“…Objectives: To investigate bidirectional effect modifications of temperature and PM2.5 on MI morbidity and mortality. Methods: A time-stratified case-crossover study was conducted utilizing high-resolution data of temperature and PM2.5, along with 498,077 MI cases from the citywide registry in Beijing, China from 2007 to 2021. …”
Get full text

The implementation of genome sequencing in rare genetic diseases diagnosis: a pilot study from the Hong Kong genome projectResearch in context by Wai Kei Jacky Lam, Chak Sing Lau, Ho Ming Luk, Lisa Wing Chi Au, Gary C.P. Chan, Will Yap Hang Chan, Shirley Sze Wing Cheng, Timothy Hua Tse Cheng, Li Li Cheung, Yiu Fai Cheung, Josephine Shuk Ching Chong, Annie Tsz Wai Chu, Claudia Ching Yan Chung, Kin Lai Chung, Cheuk Wing Fung, Eva Lai Wah Fung, Yuan Gao, Stephanie Ho, Shirley Pik Ying Hue, Chi-Ho Lee, Tsz Leung Lee, Philip Hei Li, Hei Man Lo, Ivan Fai Man Lo, Herbert Ho Fung Loong, Becky Mingyao Ma, Wei Ma, Shirley Yin Yu Pang, Wai-Kay Seto, Steven Wai Kwan Siu, Ho So, Yuk Him Tam, Wenshu Tang, Rosanna Ming Sum Wong, Desmond Yat Hin Yap, Maggie Lo Yee Yau, Brian Hon Yin Chung, Su-Vui Lo

“…This study evaluated the impact of short read GS (srGS), complemented by long read GS (lrGS) in a subset, on individuals recruited in the pilot phase of the HKGP. Methods: GS was performed on a prospective cohort of patients with suspected genetic disease recruited by territory-wide referrals to the HKGP. …”
Get full text

Dietary steviol glycosides mixture supplementation modulates the gene expression of gut chemoreceptors and enhances the antioxidant capacity in weaned piglets by Yunxia Xiong, Zhentao He, Qiwen Wu, Hao Xiao, Shuting Cao, Xuefen Yang, Yajing Li, Zongyong Jiang, Cui Zhu, Li Wang

“…This study aimed to investigate the effect of dietary SGs mixture supplementation on growth performance, gene expression of gut chemoreceptors, and antioxidant capacity in weaned piglets. Methods A total of 216 weaned piglets (Duroc × Landrace × Yorkshire, 7.36 ± 0.04 kg body weight) were randomly assigned to 6 groups (6 pens/group with 6 piglets/pen), and were fed with the basal diet supplemented with 0, 100, 150, 200, 250, or 300 mg/kg SGs mixture for 42 days. …”
Get full text

Phase I study of efineptakin alfa (NT-I7) for the treatment of Kaposi sarcoma by Leonard D’Amico, Martin Cheever, Steven P Fling, Anna Wright, Kathryn Lurain, Ramya Ramaswami, Irene Ekwede, Thomas S Uldrick, Robert Yarchoan, Judith C Kaiser, Angela Shaulov Kask, Manoj P Menon, Paul Couey, Eli Burnham, Allysson Angeldekao, Byung Ha Lee, Li-Lian Kwok, Chia-Ching Jackie Wang

“…In PWH, IL-7 administration leads to increased numbers of circulating central memory and naïve T-cell phenotypes.Methods In this multicenter phase I study with a 3+3 dose escalation design, participants with KS with or without HIV received up to four intramuscular injections of IL-7 (NT-I7) every 9 weeks. …”
Get full text

Liver transcriptome analysis reveals PSC-attributed gene set associated with fibrosis progression by Alena Laschtowitz, Eric L. Lindberg, Anna-Maria Liebhoff, Laura Anne Liebig, Christian Casar, Silja Steinmann, Adrien Guillot, Jun Xu, Dorothee Schwinge, Michael Trauner, Ansgar Wilhelm Lohse, Stefan Bonn, Norbert Hübner, Christoph Schramm

“…We here aimed to identify a PSC-specific gene signature associated with biliary fibrosis development. Methods: We performed RNA-sequencing of 47 liver biopsies from people with PSC (n = 16), primary biliary cholangitis (PBC, n = 15), and metabolic dysfunction-associated steatotic liver disease (MASLD, n = 16) with different fibrosis stages to identify a PSC-specific gene signature associated with biliary fibrosis progression. …”
Get full text

The prognostic association of triglyceride-glucose index and its derived indicators with stable coronary artery disease patients undergoing percutaneous coronary intervention by Yu Shan, Yu Shan, Maoning Lin, Maoning Lin, Fangfang Gu, Duanbin Li, Duanbin Li, Qiongjun Zhu, Qiongjun Zhu, Zhezhe Chen, Zhezhe Chen, Wenbin Zhang, Wenbin Zhang, Guosheng Fu, Guosheng Fu, Min Wang, Min Wang

“…Therefore, this study aims to investigate the association of the TyG index and its derived indicators, including the baseline TyG index, the baseline triglyceride glucose-body mass index (TyG-BMI), the mean TyG index, and the triglyceride glucose index-standard deviation (TyG-SD), with the prognosis of SCAD patients undergoing percutaneous coronary intervention (PCI).MethodsThis retrospective study enrolled 2,306 patients. …”
Get full text

Sex disparity in the association between alcohol consumption and sarcopenia: a population-based study by Longbao Yang, Longbao Yang, Qiuju Ran, Qiuju Ran, Yee Hui Yeo, Zhang Wen, Zhang Wen, Shuyue Tuo, Shuyue Tuo, Yong Li, Yong Li, Jia Yuan, Jia Yuan, Shejiao Dai, Shejiao Dai, Jinhai Wang, Jinhai Wang, Fanpu Ji, Fanpu Ji, Fanpu Ji, Fanpu Ji, Xinxing Tantai, Xinxing Tantai

“…Therefore, this study comprehensively investigated the association of alcohol consumption with sarcopenia in a nationally representative sample of US adults.MethodsThis population-based study included adults aged 18 years and older from the National Health and Nutrition Examination Survey (NHANES) III. …”
Get full text

Sex and outcomes of patients with microsatellite instability-high and BRAF V600E mutated metastatic colorectal cancer receiving immune checkpoint inhibitors by Michael Hoffmeister, Hermann Brenner, Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio, Julien Taieb, David Tougeron, Robyn L Ward, Marco Vitellaro, Thierry André, Pierre Laurent-Puig, Jitendra Jonnagaddala, Francesca Bergamo, Raghav Sundar, Claire Gallois, Michael J Overman, Jakob Nikolas Kather, Lisa Salvatore, Romain Cohen, Rossana Intini, Priya Jayachandran, Miriam Koopman, Javier Ros, Marwan Fakih, Vincenzo Nasca, Giacomo Mazzoli, Jeanine M L Roodhart, Filippo Ghelardi, Elena Elez, Durgesh Wankhede, Marta Ligero, Joseph Zhao, Koen Zwart, Jeroen Derksen, Nicholas Hawkins, Javier Carmona

“…Growing evidence supports the role of sex in determining susceptibility to anticancer therapies, but data is lacking for patients with MSI-H CRC.Methods In this real-world cohort comprising 624 patients with MSI-H mCRC receiving ICIs, we investigated the impact of sex on patients’ outcomes, overall and according to RAS-BRAF mutational status or type of treatment (anti-PD-(L)1 with or without anti-CTLA-4 agents). …”
Get full text

Long-term safety of dexamethasone sodium phosphate encapsulated in autologous erythrocytes in pediatric patients with ataxia telangiectasia by Mary Kay Koenig, Vincenzo Leuzzi, Riadh Gouider, Riadh Gouider, Eppie M. Yiu, Eppie M. Yiu, Barbara Pietrucha, Asbjørg Stray-Pedersen, Susan L. Perlman, Steve Wu, Trudy Burgers, Rupam Borgohain, Rukmini Mridula Kandadai, Isabelle Meyts, Giorgia Bucciol, Anaita Udwadia-Hegde, Ravi Yadav, Donna Roberts, Aaron Dane, Maureen Roden, Dirk Thye, Biljana Horn, Howard M. Lederman, William P. Whitehouse

“…The primary objective of this report is to describe the safety of long-term use of EryDex in treatment of pediatric patients with ataxia telangiectasia.MethodsThis is a post-hoc analysis of patients treated with EryDex for a minimum of 24 months in two prospective clinical trials. …”
Get full text

Virtual reality-based cognitive–behavioural therapy for the treatment of anxiety in patients with acute myocardial infarction: a randomised clinical trial by Jiajun Weng, Junbo Ge, Jiajia Liu, Juying Qian, Xiao Huang, Yuanyuan Li, Juan Peng, Yan'e Lu, Dong Huang, Pingyuan Yang, Shikun Xu, Lihua Guan, Qibing Wang, Zexin Zhao, Yabin Wei

“…Providing timely and easily accessible psychological interventions using virtual reality-based cognitive–behavioural therapy (VR-CBT) could potentially improve both acute and long-term symptoms affecting their mental health.Aims We aim to examine the effectiveness of VR-CBT on anxiety symptoms in patients with AMI who were admitted to the intensive care unit (ICU) during the acute stage of their illness.Methods In this single-blind randomised clinical trial, participants with anxiety symptoms who were admitted to the ICU due to AMI were continuously recruited from December 2022 to February 2023. …”
Get full text