Investigation of the effect of intravitreal bevacizumab treatment on left heart function using speckle tracking echocardiography by Mehmet Şahinbaş, İdris Buğra Çerik, Duygu Yalınbaş Yeter

“…In our study, we aimed to investigate the effects of anti-VEGF agents on left heart functions after intravitreal injection using speckle tracking echocardiography. Methods: In this prospectively designed study, 44 patients who were going to start intravitreal anti-VEGF treatment were included in the study. …”
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Deciphering the functional roles of PE18 and PPE26 proteins in modulating Mycobacterium tuberculosis pathogenesis and immune response by Aquib Ehtram, Mohd Shariq, Neha Quadir, Neha Quadir, Salma Jamal, Manjunath Pichipalli, Sheeba Zarin, Sheeba Zarin, Javaid Ahmad Sheikh, Nasreen Z. Ehtesham, Seyed E. Hasnain, Seyed E. Hasnain

“…Despite their importance, the roles and molecular interactions of PE18 and PPE26 in Mtb pathogenesis require further investigation.MethodsWe explored the roles of PE18 and PPE26 using recombinant Mycobacterium smegmatis (Msmeg) as a model organism. …”
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Effects of macitentan and selexipag across prognostic age groups in patients with pulmonary arterial hypertension by Richard Channick, MD, Sarah Medrek, MD, Marion Delcroix, MD, Sean Gaine, MD, Pavel Jansa, MD, PhD, Irene Lang, MD, Vallerie McLaughlin, MD, Sanjay Mehta, MD, Tomas Pulido, MD, Bhagavatula Sastry, MD, Rogerio Souza, MD, PhD, Adam Torbicki, MD, Carol Zhao, MS, Paul Strachan, MD, Peter Agron, PhD, Joseph Yen, PhD, Olivier Sitbon, MD, PhD

“…This post-hoc analysis identified prognostic age groups and associated macitentan/selexipag treatment effects. METHODS: Randomized trials evaluated macitentan (SERAPHIN; NCT00660179) and selexipag (GRIPHON; NCT01106014) versus placebo (primary endpoint: time to morbidity/mortality [M/M]). …”
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Estimation des rendements fourragers des pâturages dans les espaces climatiques du Burkina Faso à partir de données satellitaires by Wièmè Some, Antoine Denis, Amani Louis Kouadio, Bakary Djaby, Hassan Bismark Nacro, Adrien Marie Gaston Belem, Bernard Tychon

“… Contexte: L’évaluation des ressources fourragères est un élément clé de la gouvernance des crises alimentaires du bétail au Burkina Faso. Objectif-Méthodes: Cette étude visait l’évaluation, pour la première fois, de la possibilité d’estimer les rendements fourragers des pâturages dans les espaces climatiques du Burkina Faso via l’utilisation de modèles statistiques linéaires uni et multivariés construits à partir de données de biomasse végétale fourragère collectées sur le terrain en 2017, 2018 et 2019, de variables satellitaires phénologiques (indice de végétation de la différence normalisée [NDVI] et fraction de rayonnement photosynthétiquement actif absorbé [FAPAR]) et agroclimatiques (précipitations, humidité du sol, évapotranspiration, température de surface). …”
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Incidence of self-reported tuberculosis treatment with community-wide universal testing and treatment for HIV and tuberculosis screening in Zambia and South Africa: A planned analy... by L Telisinghe, S Floyd, D MacLeod, A Schaap, R Dunbar, J Bwalya, N Bell-Mandla, E Piwowar-Manning, D Donnell, K Shaunaube, P Bock, S Fidler, R J Hayes, H M Ayles, HPTN 071 (PopART) study team

“…Combining UTT with TB screening could therefore significantly impact TB control in sub-Saharan Africa, but to our knowledge there is no evidence for this combined approach.<h4>Methods and findings</h4>HPTN 071 (PopART) was a community-randomised trial conducted between November 2013 to July 2018; 21 Zambian and South African communities (with a total population of approximately 1 million individuals) were randomised to arms A (community-wide UTT and TB screening), B (community-wide universal HIV testing with treatment following national guidelines and TB screening), or C (standard-of-care). …”
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Navigating Emergency Management of Cancer Patients: A Retrospective Study on First-Time, End-Stage, and Other Established Diagnoses in a High Turnover Emergency County Hospital by Mihaela Corlade-Andrei, Radu-Alexandru Iacobescu, Viorica Popa, Alexandra Hauta, Paul Nedelea, Gabriela Grigorasi, Monica Puticiu, Roxana Elena Ciuntu, Andreea Ivona Sova, Diana Cimpoesu

“…This study aims to determine the burden of end-stage and first-time diagnosis of cancer on emergency care in a high-turnover emergency care center. <i>Materials and Methods</i>: A retrospective observational study was conducted to identify patients requesting emergent aid for cancer-related symptoms in the Emergency Department of “St. …”
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Depletion of myeloid-derived suppressor cells sensitizes murine multiple myeloma to PD-1 checkpoint inhibitors by Qiang Wang, Qing Yi, Wei Xiong, Rui Duan, Jianfei Qian, Liuling Xiao, Miao Xian, Pan Su, Chuanchao Zhang, Yabo Li, Ling Zhong, Chengyun Zheng

“…Therefore, investigating how TME components in MM influence ICB treatment is urgent.Methods We employed two well-established murine myeloma models, 5TGM1 and Vk*MYC, by intravenously injecting 5TGM1 or Vk*MYC cells into mice, respectively, to determine ICB therapeutic efficacy in MM. …”
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Mechanism of Delaying Cartilage Degeneration in Knee Osteoarthritis with Rongjin Niantong Recipe Based on lncRNA NEAT1 and Nrf2/ARE Pathway by FU Changlong, XIE Xinyu, QIU Zhiwei, HUANG Yanfeng, JIN Linglu, LI Xihai

“…ObjectiveTo evaluate the effect of Rongjin Niantong Recipe on knee osteoarthritis model rats, and to explore the mechanism of delaying cartilage degeneration in knee osteoarthritis based on long noncoding RNA (lncRNA) NEAT1 and Nrf2/ARE pathway.MethodsAfter adaptive feeding for one week, a total of 45 SPF SD rats aged two months were randomly divided into blank group and sodium iodoacetate group, with 15,30 cases in each group. …”
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Diversity and distribution of nitrifying bacteria play an important role in the nitrogen cycle in mangrove sediments by A. Mubaraq, M. Sembiring, E. Widiastuti, E. Fachrial, B. Utomo, M. Turjaman, F. Sidik, Y.I. Ulumuddin, V.B. Arifanti, E.S. Siregar, T. Kajita, S. Proches, M. Basyuni

“…The Preferred Reporting Items for Systematic Reviews and Meta-Analyses method is used as a guide to help report reviews systematically and has a flow chart to show the process of selecting relevant studies. …”
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Aerobic exercise alleviates statin-induced PCSK9 upregulation by increasing epoxyeicosatrienoic acid levels through the FoxO3a–Sirt6 axis by Jiahui Hu, Hao Lei, Jingyuan Chen, Leiling Liu, Yajun Gui, Kaijun Sun, Danyan Xu

“…Therefore, we investigated how aerobic exercise can ameliorate statin-induced increases in PCSK9 levels. Methods: Three-week-old male American Institute of Cancer Research (ICR) mice were fed a high-fat-cholesterol diet (HFD) for 12 weeks and then administered atorvastatin alone or atorvastatin combined with aerobic exercise (Statin + Ex). …”
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Incidence, Risk Factors, and Outcomes of Perioperative Atrial Fibrillation following Noncardiothoracic Surgery: A Systematic Review and Meta-Regression Analysis of Observational St... by Yamini Subramani, Omar El Tohamy, Daniil Jalali, Mahesh Nagappa, Homer Yang, Ashraf Fayad

“…The evidence on risk factors and complications associated with perioperative AF after noncardiothoracic surgery is limited. Methods. The primary objective was to determine demographic and clinical risk factors for new-onset atrial fibrillation associated with noncardiothoracic surgery. …”
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Global comparison of the economic costs of coronary heart disease: a systematic review and meta-analysis by Lan Gao, Susan Brumby, Crystal Man Ying Lee, George Mnatzaganian, Suzanne Robinson, Helen Brown, Rachel Huxley, Anna Peeters, Dan Xu, James Boyd, Sean Randall, Adrienne O’Neil, Sangita Shakya, Sarah Gauci, Anita Shrestha, James Lucas

“…Exploring advanced costing methods such as time-driven activity-based costing can optimise resource allocation and identify opportunities to reduce unnecessary costs and cost disparities.PROSPERO registration number CRD42023412044.…”
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Alterations in the polarization of liver M1/M2 macrophages upon long-term administration of triptorelin in rats by M.V. Rud, Y.V. Stetsuk, V.I. Shepitko, O.V. Vilkhova, L.B. Pelypenko, O.V. Voloshyna, A.G. Sydorenko, H.P. Pavlenko, N.M. Sharlai, O.V. Sych

“…The study employed a series of experimental periods, with the introduction of triptorelin and quercetin at varying stages. Materials and methods. The study was conducted on 35 sexually mature male rats. …”
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Placental trophoblast aging in advanced maternal age is related to increased oxidative damage and decreased YAP by Song Guo, Song Guo, Qihao Pan, Qihao Pan, Baokang Chen, Baokang Chen, Yijuan Huang, Yijuan Huang, Si Li, Si Li, Chenyu Gou, Chenyu Gou, Yu Gao, Yu Gao

“…Therefore, this study explored the relationship between trophoblast cell aging and oxidative injury and YAP in AMA pregnancy, which not only provided an insight into the mechanisms of trophoblast cell aging, but also provide valuable directions for healthcare during AMA pregnancy.MethodsIn this study, human term placentas were collected from AMA and normal pregnancies for the analysis of aging, oxidative damage and YAP level. …”
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Manifestaciones neurológicas asociadas a la vacuna contra COVID-19 by R. Alonso Castillo, J.C. Martínez Castrillo

“…Objective: To review the reported cases of neurological manifestations after the application of COVID-19 vaccines, describing clinical, analytical and neuroimaging findings and health outcomes. Methods: We carried out a review through bibliographic searches in PubMed. …”
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Analysis and comparison of the trends in burden of spinal cord injury in China and worldwide from 1990 to 2021: an analysis of the global burden of disease study 2021 by Hao Qin, Yuhang Diao, Mingyu Hao, Zhitan Wang, Minghao Xie, Xiaojun Hu, Tao Zhu

“…This study aimed to examine and compare trends in the burden of spinal cord injury—specifically incidence, prevalence, and years lived with disability (YLD)—in China and worldwide from 1990 to 2021, and to project these trends over the next 15 years.MethodsThis study analyzed the characteristics of the SCI burden in China and globally, examining changes in incidence, prevalence, and years lived with disability (YLD) using open data from the Global Burden of Disease database covering 1990 to 2021. …”
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液体脂肪酶催化制备甘油二酯油连续化工艺研究 Continuous preparation process of diacylglycerol oil catalyzed by liquid lipase by 王建芳1，李昕2，张蕊1 WANG Jianfang1，LI Xin2，ZHANG Rui1

“…In conclusion, the continuous preparation process of diacylglycerol oil catalyzed by liquid lipase can be realized by the microchannel reactor, and the method has good stability. …”
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Prevalence and Related Risk Factors of Intestinal Parasitosis among Private School-Going Pupils of Dharan Submetropolitan City, Nepal by Bijay Kumar Shrestha, Manita Tumbahangphe, Jenish Shakya, Anu Rai, Kabita Dhakal, Bidhya Dhungana, Romika Shrestha, Jyoti Limbu, Kabiraj Khadka, Santoshi Ghimire, Sujata Chauhan, Lata Chalise, Ashu Ghimire

“…This research is aimed at studying the prevalence and related risk factors of parasitic infections among private school-going pupils of Dharan Submetropolitan City. Methods and Materials. This was a cross-sectional laboratory-based study conducted from 13 November 2018 to 26 February 2019 among 400 private school pupils. …”
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Effects of L-carnitine supplementation in uremic patients receiving hemodialysis (尿毒症血液透析患者应用左卡尼汀临床效果观察) by YOU Huiqin (尤惠琴)

“…Objective To investigate the effects of L-carnitine supplementation in uremic patients receiving hemodialysis. Methods Totally100 uremic patients undergoing hemodialysis were randomly divided into the control group and observation group according to the random number table, with 50 cases in each group. …”
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Pengaruh Pemberian Berbagai Olahan Telur terhadap Kadar Kolesterol Total Darah Mencit by Putri Mira Magistri, Rismawati YaswiR, Yustini Alioes

“…</p><p><strong>Kata kunci:</strong> olahan telur, kadar kolesterol total darah, mencit</p><p> </p><p><strong><em>Abstract</em></strong></p><p><em>People use various methods of processing before consumption </em><em>eggs </em><em>which can affect the levels of nutrients contained in, including cholesterol content which can also affect the levels of total cholesterol in blood.…”
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