Effects of a periodic intermittent theta burst stimulation in Alzheimer’s disease by Yue Wu, Lu Wang, Kai Wang, Shanshan Zhou, Pan Wu, Yibing Yan, Ling Wei, Bensheng Qiu, Yanghua Tian, Zhi Geng, Xingqi Wu, Panpan Hu, Guixian Xiao, Gongjun Ji, Hesheng Liu

“…However, the long-term effects of iTBS on cognitive decline and brain structure in patients with AD are unknown.Aims We aimed to explore whether repeating accelerated iTBS every three months could slow down the cognitive decline in patients with AD.Methods In this randomised, assessor-blinded, controlled trial, iTBS was administered to the left dorsolateral prefrontal cortex (DLPFC) of 42 patients with AD for 14 days every 13 weeks. …”
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Key prognostic risk factors linked to poor functional outcomes in cerebral venous sinus thrombosis: a systematic review and meta-analysis by Lili Lin, Senfeng Liu, Wei Wang, Xiao-kuo He, Muhammad Hibatullah Romli, Ruthpackiavathy Rajen Durai

“…This systematic review and meta-analysis assessed the overall effect size of all prognostic risk factors. Methods A systematic review was conducted to explore all prognostic risk factors in studies published from the initial to June 2024 among 5 Databases included PubMed / Medline, Scopus, EBSCOhost, Web of Science, and Cochran Library. …”
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Fifteen-second bouts of hyperoxia improve 5-minute time-trial performance in acute hypoxic conditions by Martin Faulhaber, Sina Schneider, Linda K. Rausch, Tobias Dünnwald, Verena Menz, Hannes Gatterer, Michael D. Kennedy, Wolfgang Schobersberger

“…Out study aimed to test the effects of repeated bouts of hyperoxia, each lasting fifteen seconds, on maximal 5-minute cycling performance under acute hypoxic conditions. Methods 17 healthy and recreationally trained individuals (7 females, 10 males, age 27 ± 4 years) participated in this randomized placebo-controlled cross-over trial. …”
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1990—2021年中国和全球归因于高BMI的缺血性卒中疾病负担变化趋势分析 Analysis of the Trend in the Burden of Ischemic Stroke Attributable to High BMI in China and Globally from 1990 to 2021... by 刘乾坤1，李鹏鹞1，马丽1，戴婧佼2，徐洋1，庞佳雪1，黄菊菊1，谢晖1 (LIU Qiankun1, LI Pengyao1, MA Li1, DAI Jingjiao2, XU Yang1, PANG Jiaxue1, HUANG Juju1, XIE Hui1 )

“…Abstract: Objective To analyze the current status and trend of the burden of ischemic stroke attributable to high BMI in China and globally from 1990 to 2021. Methods Based on the 2021 global burden of disease database, data on disability-adjusted life years (DALYs) and deaths related to ischemic stroke attributable to high BMI were extracted. …”
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Influence of cervical muscle strength and pain severity on functional balance and limits of stability in elderly individuals with chronic nonspecific neck pain: a cross-sectional s... by Shaker Hassan S. Alshehri, Ravi Shankar Reddy, Mohammad A. ALMohiza, Mastour Saeed Alshahrani, Batool Abdulelah Alkhamis, Hani Hassan Alnakhli, Ghada Mohammed Koura, Ajay Prashad Gautam, Debjani Mukherjee, Raee S. Alqhtani, Saeed Y. Al Adal, Abdullah Mohammed Alyami, Faisal M. Alyazedi

“…Additionally, it assessed the moderating effect of pain severity on the relationship between cervical muscle strength and these balance outcomes. Methods A prospective study included a total of 186 participants, including 93 with CNSNP and 93 asymptomatic individuals, were recruited. …”
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Impact of Sex-Related Differences in Infrarenal Aortic Neck Morphology on Outcomes of Endovascular Aneurysm Repair for Similar-Sized Aortic Aneurysm by Ombretta Martinelli, Antonio Marzano, Maria Irene Bellini, Roberto Gattuso, Luca Di Marzo, Valeria Gonta, Jihad Jabbour, Wassim Mansour, Simone Cuozzo

“…<b>Objectives</b>: This study aimed to evaluate whether gender-related anatomical differences in proximal aortic neck morphology affect the feasibility and outcomes of endovascular aortic aneurysm repair (EVAR) in women with abdominal aortic aneurysms (AAA). <b>Methods</b>: This study performed a retrospective analysis of patients electively treated by EVAR for infrarenal AAA between January 2019 and December 2023. …”
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Retrospective analysis of amantadine response and predictive factors in intensive care unit patients with non-traumatic disorders of consciousness by Corinna Blum, Constanze Single, Kornelia Laichinger, Anna Hofmann, Tim W. Rattay, Tim W. Rattay, Kamaldeen Adeyemi, Reimer Riessen, Michael Haap, Helene Häberle, Ulf Ziemann, Annerose Mengel, Katharina Feil

“…BackgroundDisorders of consciousness (DoC) in non-traumatic ICU-patients are often treated with amantadine, although evidence supporting its efficacy is limited.MethodsThis retrospective study analyzed non-traumatic DoC-patients treated with amantadine between January 2016 and June 2021. …”
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Risk factors associated with degenerative glenohumeral osteoarthritis by Ravi Prakash, Nitin B Jain, Ziyi Chen, Folefac D Atem, Michael S Khazzam, Rashmi Pathak, Daniel Tai, Ursa BezanPetric, Estefanie Garduno Rapp

“…This study aimed to identify risk factors for GH OA.Methods We used data from the Dallas Shoulder cohort, including individuals aged 40–85. …”
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Impact of Online Interactive Decision Tools on Women’s Decision-Making Regarding Breast Cancer Screening: Systematic Review and Meta-Analysis by Patricia Villain, Laura Downham, Alice Le Bonniec, Charlotte Bauquier, Olena Mandrik, Tom Nadarzynski, Lorie Donelle, Raúl Murillo, Eleni L Tolma, Sonali Johnson, Patricia Soler-Michel, Robert Smith

“…ObjectiveThis systematic review and meta-analysis aims to evaluate the scientific evidence on the impacts of these e-tools and to provide a comprehensive assessment of the factors associated with their increased utility and efficacy. MethodsWe followed the 2020 PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and conducted a search of MEDLINE, PsycINFO, Embase, CINAHL, and Web of Science databases from August 2010 to April 2023. …”
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Effect of bright light therapy combined with five-element music therapy on negative emotions and sleep quality of pregnant women (强光联合五音疗法对孕妇负面情绪及睡眠质量的影响)... by ZHANG Caixia (张彩霞), ZHANG Ping (张萍), CAI Donglin (蔡东林), AN Rongrong (安溶溶)

“…Objective To explore the effect of bright light therapy combined with five-element music therapy on negative emotions and sleep quality of pregnant women with depression. Methods Totally 70 cases of depressed pregnant women were selected and randomly divided into control group and study group, with 35 cases each. …”
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Long-term outcomes combined minimally invasive laser surgical technique for local rhegmatogenous retinal detachment by A.V. Doga, D.O. Shkvorchenko, L.A. Kryl, M.R. Taevere, D.A. Buryakov

“…</i> </p> <p> <i><b>Patients and Methods:</b> treatment results of 41 patients (41 eyes) with local RRD resulting from horseshoe retinal tear were analyzed. …”
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Discontinuation of immune checkpoint inhibitors for reasons other than disease progression and the impact on relapse and survival of advanced melanoma patients. A systematic review... by Konstantinos Lallas, Eftychia Chatziioannou, Derya Durak, Georg Frey, Lina Maria Serna-Higuita, Marie-Lena Rasch, Athanassios Kyrgidis, Eleni Timotheadou, Zoe Apalla, Ulrike Leiter, Lukas Flatz, Lukas Flatz, Aimilios Lallas, Teresa Amaral, Teresa Amaral

“…BackgroundDespite durable responses achieved with Immune Checkpoint Inhibitors (ICIs), data about optimal duration of treatment, especially in the context of adverse events, remain scarce.ObjectiveTo systematically review the evidence concerning the impact of treatment discontinuation with ICIs for reasons other than progressive disease (PD) on relapse rates and survival of melanoma patients.MethodsA systematic literature search was conducted in three electronic databases until July 2024. …”
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Anticholinergic burden and behavioral and psychological symptoms in older patients with cognitive impairment by Sabrina Pistorio, Gianluca Scotto di Tella, Vittoria Canzanella, Raffaella Merenda, Gianluigi Cuomo, Paola Iacotucci, Vincenzo Carnovale, Leonardo Bencivenga, Maria Vargas, Annalaura Manes, Mauro Cataldi, Giuseppe Rengo, Giuseppe Rengo, Michela Zanetti, Grazia Daniela Femminella, Grazia Daniela Femminella

“…The aim of this research is to report use of anticholinergic drugs in a clinical population and to investigate the correlation between the use of anticholinergic drugs and the risk of presenting with more severe behavioral and psychological symptoms (BPSD).MethodPatients with a diagnosis of subjective cognitive impairment, mild cognitive impairment (MCI) or dementia were recruited. …”
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Reproduction performance of climbing perch Anabas testudineus F1 and F2 broodstock with different dietary supplementation by Helmizuryani, Helmizuryani, Boby Muslimin, Khusnul Khotimah

“…The research was conducted on Fish Hatchery Unit Mulia Plaju, Palembang for three months and biology laboratory in Agriculture Faculty, University of Muhammadiyah Palembang. The research method used completely randomized design with three replications, began by rearing the female broodstock (F1 and F2) with adding dietary supplement for three treatments, they were P1: vitamin E (250 mg/kg dietary weight), P2: vitamin C (125 mg/kg dietary weight), and P3: Spirulina sp. (10% / dietary weight). …”
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Effectiveness of a Web-Based Self-Guided Intervention (MINDxYOU) for Reducing Stress and Promoting Mental Health Among Health Professionals: Results From a Stepped-Wedge Cluster Ra... by Yolanda López-del-Hoyo, Selene Fernández-Martínez, Adrian Perez-Aranda, Alicia Monreal-Bartolomé, Alberto Barceló-Soler, Loreto Camarero-Grados, Carilene Armas-Landaeta, José Guzmán-Parra, Vera Carbonell, Daniel Campos, Xinyuan Chen, Javier García-Campayo

“…ObjectiveThis study aimed to evaluate the effectiveness of the MINDxYOU program, a web-based self-guided intervention based on third-wave psychotherapy principles, to reduce perceived stress and promote mental health in a sample of health professionals. MethodsIn a stepped-wedge cluster randomized design, 357 health professionals from health centers in Aragon and Málaga, Spain, were recruited. …”
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Feasibility study of Omaha System in the construction of health education program for elderly patients with chronic obstructive pulmonary disease (奥马哈系统在老年慢性阻塞性肺疾病健康教育方案构建中的可行性研究)... by YANG Yuanqin (杨元琴), YIN Cuihong (尹翠红), SHEN Xiaohong (申晓红), WU Sichao (吴思超), WANG Anxiu (王安秀)

“…Objective To analysis the feasibility of building health education program for chronic obstructive pulmonary disease(COPD) in the elderly with the framework of Omaha System. Methods The medical records of 60 elderly COPD patients were analyzed retrospectively to classify and statistically compare the language of the medical records description with Omaha problem classification subsystem and intervention classification subsystem. …”
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Association of sodium–glucose cotransporter-2 inhibitors with mortality across the spectrum of myocardial infarction: a systematic review and meta-analysis by Michele Maremmani, Ramin Ebrahimi, Marco Centola, Felice Achilli, Valentina Capone, Eduardo Bossone, Christian Templin, Davide Di Vece

“…This meta-analysis aimed to assess the association of SGLT2 inhibitors with all-cause mortality in post-MI patients and to explore key moderators influencing this benefit. Methods PubMed, Embase, and Scopus were searched for randomized controlled trials (RTCs) and propensity score-matched (PSM) observational studies assessing SGLT2 inhibitors' impact on post-MI mortality. …”
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Potential pharmacological effect of Quercetin Phytosome™ in the management of hyperuricemia: results from real-life clinical studies by Francesco Di Pierro, Francesco Di Pierro, Francesco Di Pierro, Fazle Rabbani, Meherullah Tareen, Roohi Nigar, Amjad Khan, Nicola Zerbinati, Maria L. Tanda, Massimiliano Cazzaniga, Alexander Bertuccioli, Alexander Bertuccioli, Paolo Falasca, Gabriele Damiani, Nicola Villanova

“…Quercetin, a naturally occurring flavonoid, has shown potential as a hypouricemic agent through XO inhibition.ObjectiveThis study aims to evaluate the potential hypouricemic effect of Quercetin Phytosome™ (QP) supplementation across three cohort studies involving healthy adults with various metabolic health profiles, exploring its potential as a safe, effective intervention for hyperuricemia.MethodsClinical data collected in various clinics in Italy between September 2021 and April 2024 under real-life clinical settings from three distinct cohort studies, were analyzed. …”
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Natural Product Identification and Molecular Docking Studies of Leishmania Major Pteridine Reductase Inhibitors by Moses N. Arthur, George Hanson, Emmanuel Broni, Patrick O. Sakyi, Henrietta Mensah-Brown, Whelton A. Miller, Samuel K. Kwofie

“…While chemotherapy remains the primary treatment, its effectiveness is constrained by drug resistance, unfavorable side effects, and substantial associated costs. <b>Methods</b>: This study addresses the urgent need for novel, cost-effective drugs by employing in silico techniques to identify potential lead compounds targeting the PTR1 enzyme. …”
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Rationale and design of a multicentre randomised controlled trial on circulating tumour DNA-guided neoadjuvant treatment strategy for locally advanced rectal cancer (CINTS-R) by Bin Wu, Yi Xiao, Xiao Zhang, Tao Xu, Qian Liu, Wei Fu, Yang An, Yongheng Li, Guole Lin, Huadan Xue, Guoju Wu, Jiaolin Zhou, Hongwei Yao, Zhenjun Wang, Weijie Chen, Junyang Lu, Guannan Zhang, Xiaoyuan Qiu

“…Our previous study has shown that circulating tumour DNA (ctDNA) effectively reflects tumour burden and genetic characteristics and has significant predictive value for tumour recurrence, demonstrating great potential in guiding the choice of neoadjuvant strategies.Methods and analysis The CINTS-R trial is a multicentre, open-label, randomised controlled trial designed to evaluate the efficacy and safety of a ctDNA-guided neoadjuvant treatment strategy compared with conventional neoadjuvant therapy regime in patients with LARC. …”
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