The Financial Implications of Pancreatic Surgery: The Hospital Is the Big Winner, Not the Surgeon! by Nitzan Zohar, MD, Avinoam Nevler, MD, Sean P. Maher, Matthew C. Rosenthal, Florence Williams, Wilbur B. Bowne, MD, FACS, Charles J. Yeo, MD, FACS, Harish Lavu, MD, FACS

“…A greater consideration of these financial aspects may in fact have implications for enhancing clinical care and for a broader sustainability of high-volume pancreatic surgery programs. Methods:. In this retrospective observational study, patients who underwent pancreaticoduodenectomy (PD), total pancreatectomy, or distal pancreatectomy at one academic medical center during the fiscal year 2021 were evaluated. …”
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Interpreting IGF-1 in children treated with recombinant growth hormone: challenges during early puberty by Helena-Jamin Ly, Helena-Jamin Ly, Carina Ankarberg-Lindgren, Hans Fors, Hans Fors, Staffan Nilsson, Jovanna Dahlgren, Jovanna Dahlgren

“…This study aimed to evaluate descriptively a group of 93 children treated per protocol with GH to assess the influence of pubertal signs and sex steroid levels on the interpretation of IGF-1.Methods93 (67 boys and 26 girls) prepubertal children who participated in a previous GH treatment trial were included. …”
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Shaoyao Gancao decoction alleviates paclitaxel-induced cognitive impairment by activating PTEN/PI3K/AKT pathway to inhibit NETs formation by Xu Ying, Su Yue, Hu Yuwen, Li Xiang, Zhou Ziyan, Yuan Ningning, Ji Xiaowei, Jiang Ruoyu, Wang Wenzhu, Zhang Yafeng, Zhai Guojie, Cheng Xiaolan

“…Herein, our work was set out to study the potential role and possible mechanism of SGD in PICI through network pharmacology, Mendelian analysis and animal experiments. Methods: First, network pharmacology analysis was performed to identify the potential active compounds and targets of SGD on PICI. …”
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IQUB mutation induces radial spoke 1 deficiency causing asthenozoospermia with normal sperm morphology in humans and mice by Tingwenyi Hu, Xiangrong Tang, Tiechao Ruan, Shunhua Long, Guicen Liu, Jing Ma, Xueqi Li, Ruoxuan Zhang, Guoning Huang, Ying Shen, Tingting Lin

“…To date, many components of RSs and their functions in human sperm flagella remain unclear. Methods We recruited a cohort of 323 infertile males with ASZ between August 2019 and June 2024. …”
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Phase I study of pembrolizumab in combination with ibrutinib for the treatment of unresectable or metastatic melanoma by Yuan Yao, Yiyi Yan, Vera J. Suman, Allan B. Dietz, Courtney L. Erskine, Anastasios Dimou, Svetomir N. Markovic, Svetomir N. Markovic, Robert R. McWilliams, Heather N. Montane, Matthew S. Block, Matthew S. Block

“…The primary aim of this phase I study was to evaluate the safety, tolerability, and determine the maximum tolerated dose (MTD) of ibrutinib in combination with pembrolizumab in patients with metastatic melanoma.MethodsA 3 + 3 phase I clinical trial was conducted in patients with unresectable Stage III or metastatic melanoma (stage IV) not amenable to local therapy. …”
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Characterization and dosimetric predictors for absolute lymphocyte count changes during neoadjuvant chemoradiotherapy with or without pembrolizumab for esophageal squamous cell car... by Wei-Xiang Qi, Shuyan Li, Shujun Zhang, Chao Li, Huan Li, Xiaomei Li, Chaofen Zhao, Gang Cai, Cheng Xu, Xuan Han, Yibin Zhang, Jiayi Chen, Shengguang Zhao

“…Abstract Aim To characterize the differences of dynamic changes for absolute lymphocyte count (ALC) among esophageal squamous cell carcinoma (ESCC) patients treated with neoadjuvant chemoradiotherapy (nCRT) with or without pembrolizumab, as well as to investigate the clinical and lymphocyte-related organs dosimetric parameters that would impact ALC nadir during nCRT. Materials and methods A total of 216 ESCC patients who received nCRT (with pembrolizumab 144; without pembrolizumab: 72) were identified from a prospective cohort. …”
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Seroprevalence of Malaria and Hepatitis B Coinfection among Pregnant Women in Tamale Metropolis of Ghana: A Cross-Sectional Study by Gideon Kofi Helegbe, Paul Armah Aryee, Baba Sulemana Mohammed, Anthony Wemakor, David Kolbila, Abdul-Wahid Abubakari, Salam Askanda, Rashid Alhassan, Collins Barnie, Afua Aboagyewaa Donkoh, Ernest Ofosu

“…The aim of this study was to assess the seroprevalence of coinfections of malaria, hepatitis B (HBV), human immunodeficiency virus (HIV), and syphilis among pregnant women attending antenatal clinics (ANC) in the Tamale Metropolis. Methods. By means of rapid diagnostic tests (RDTs), pregnant women attending the Tamale Teaching Hospital (TTH) were screened for malaria, HBV infection, HIV infection, and syphilis from March 2013 to February 2015. …”
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Improving the quality of primary healthcare in Kosovo: Impact of targeted training of Quality Coordinators by Ardita Baraku, Gordana Pavleković

“…The objective was to enhance the professional skills of QCs through targeted training, aiming to improve healthcare quality. Methods: The study involved determining the basic characteristics of QCs, assessing knowledge of quality standards before and after the training via a questionnaire; providing 2 training sessions; and, evaluating the impact of training on organizational adherence to healthcare quality standards. …”
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Assessment of Health-Related Quality of Life after TBI: Comparison of a Disease-Specific (QOLIBRI) with a Generic (SF-36) Instrument by Nicole von Steinbuechel, Amra Covic, Suzanne Polinder, Thomas Kohlmann, Ugne Cepulyte, Herbert Poinstingl, Joy Backhaus, Wilbert Bakx, Monika Bullinger, Anne-Lise Christensen, Rita Formisano, Henning Gibbons, Stefan Höfer, Sanna Koskinen, Andrew Maas, Edmund Neugebauer, Jane Powell, Jaana Sarajuuri, Nadine Sasse, Silke Schmidt, Holger Mühlan, Klaus von Wild, George Zitnay, Jean-Luc Truelle

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Application of iron-rich slag to capture carbon dioxide gas through direct gas-solid carbonation by F. Abdul, R.F. Rahman, K.A. Purwanto, F.I. Ma'ruf, Y. Setiyorini, V.A. Setyowati, S. Pintowantoro

“…The aim is to assess the feasibility of applying iron-rich slag from nickel smelters in the solid carbonation gas process for carbon dioxide capture, focusing on chemical reactions and overall kinetics.METHODS: The iron-rich slag analyzed in this study contains a significant amount of iron oxide. …”
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Treatment of chronic hepatitis C by cepeginterferon alpha-2b in combination to ribavirin by M. V. Mayevskaya, O. O. Znoyko, Ye. A. Klimova, S. L. Maximov, S. N. Kizhlo, N. A. Petrochenkova, F. I. Nagimova, Yu. N. Linkova

“…Comparative study of efficacy and safety of Algeron in dozes of 1,5 and 2,0 mkg/kg and PegIntron in combination to ribavirin within combined mode of treatment of patients with chronic hepatitis C (CHC) with subsequent assessment of therapeutic doze of Algeron.Material and methods. In open randomized «noninferiority» clinical study of II–III phase 150 previously untreated by interferon adult CHC patients (genotypes 1, 2, 3) were randomized in three medical groups: Algeron 1,5 mkg/kg, Algeron 2,0 mkg/kg and active control group — PegIntron 1,5 mkg/kg. …”
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The temporal change of heat exposure and adaptation capacity in Chinese adults from 1994 to 2023 by Xiaohui Ji, Haomin Tan, Shaoli Huang, Zhongguo Huang, Jianxiong Hu, Jianxiong Hu, Guanhao He, Fengrui Jing, Ziqiang Lin, Mengen Guo, Tao Liu, Wenjun Ma, Wenjun Ma

“…However, it is unclear whether heat exposure or temperature adaptation play an important role in this change.MethodsThis is a cross-sectional study. Data were collected from 3,094 respondents aged 31–64 years old based on online questionnaire. …”
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An artificial intelligence application to predict prolonged dependence on mechanical ventilation among patients with critical orthopaedic trauma: an establishment and validation st... by Weigang Jiang, Tao Liu, Baisheng Sun, Lixia Zhong, Zhencan Han, Minhua Lu, Mingxing Lei

“…The purpose of the study was to establish and validate an artificial intelligence (AI) platform to assess the prolonged dependence on mechanical ventilation among patients with critical orthopaedic trauma. Methods This study analyzed 1400 patients with critical orthopaedic trauma who received mechanical ventilation, and the prolonged dependence on mechanical ventilation was defined as not weaning from mechanical ventilation for ≧ 7 days. …”
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Le stress thermique environnemental dans l’espèce bovine : 2. Effets physiologiques, pathologiques, comportementaux, alimentaires, immunitaires et sur la production laitière by Christian Hanzen, Pauline Delhez, Jean-Luc Hornick, Françoise Lessire, Djellel Eddine Gherissi

“…Objectifs : Cette revue de littérature a pour objectif de décrire les effets physiologiques, pathologiques, comportementaux, alimentaires et immunitaires du stress thermique et son impact sur la production laitière. Méthode : À partir de la base PubMed, elle s’est concentrée dans un premier temps sur les articles de synthèse puis a été complétée par les références des articles identifiés. …”
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Olutasidenib in combination with azacitidine induces durable complete remissions in patients with relapsed or refractory mIDH1 acute myeloid leukemia: a multicohort open-label phas... by Jorge E. Cortes, Gail J. Roboz, Maria R. Baer, Brian A. Jonas, Gary J. Schiller, Karen Yee, P. Brent Ferrell, Jay Yang, Eunice S. Wang, William G. Blum, Alice Mims, Hua Tian, Aaron Sheppard, Stéphane de Botton, Pau Montesinos, Antonio Curti, Justin M. Watts, the Olutasidenib Combination Therapy Study Group

“…We present a pooled analysis from multiple cohorts of the phase 1/2 trial of patients with R/R AML who received combination olutasidenib and azacitidine therapy. Methods Adult patients with mIDH1 R132 AML received 150 mg olutasidenib twice daily plus standard-of-care azacitidine (OLU + AZA) and were evaluated for response and safety. …”
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Digital Home-Based Self-Monitoring System for People with Heart Failure: Protocol for Development of SmartHeart and Evaluation of Feasibility and Acceptability by Ralph Maddison, Rebecca Nourse, Reza Daryabeygikhotbehsara, Teketo Kassaw Tegegne, Paul Jansons, Jonathan Charles Rawstorn, John Atherton, Andrea Driscoll, Brian Oldenburg, Rajesh Vasa, Vassilis Kostakos, Tilman Dingler, Gavin Abbott, Paul Scuffham, Jo-Anne Elizabeth Manski-Nankervis, Dominika Kwasnicka, Finn Kensing, Sheikh Mohammed Shariful Islam, Anthony Maeder, Yuxin Zhang

“…ObjectiveThis study aims to provide an overview of the SmartHeart project by describing our approach to designing the SmartHeart system, outlining its features, and describing the planned pilot study to determine the feasibility of the system. MethodsWe used the Integrate, Design, Assess, and Share (IDEAS) framework to guide the development of the SmartHeart system, involving users (people with HF and their caregivers) and stakeholders (health care providers involved in the management of HF) in its design. …”
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Deciphering the oncogenic network: how C1QTNF1-AS1 modulates osteosarcoma through miR-34a-5p and glycolytic pathways by Yu Zhang, Hailong Lun, Naiqiang Zhu, Naiqiang Zhu, Ning Yang, Kaikai Ding, Bin Chen, Chengbing Chang, Haipeng Gu, Yanqi Liu

“…The aim of this study was to investigate the functions and underlying mechanisms of C1QTNF1-AS1 in the progression of osteosarcoma.MethodsThis investigation focused on elucidating the functional roles and mechanisms of C1QTNF1-AS1 in OS cells. …”
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Sedentary Behavior and Its Association With Psychological Well-Being and Sleep Quality in Adolescents: Evidence from a Propensity Score Analysis by Zhang L, Zhao S, Zhao S, Zheng H, Ke Y, Yang W, Lei M

“…This study aims to clarify the association between sedentary lifestyle and psychological and sleep health among adolescents through propensity scores matching analysis.Methods: A total of 2,846 adolescents from three universities participated in the study. …”
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Nymphaea pubescens Willd. extract and its flavonoid constituents vasodilate rat isolated pulmonary artery via NO-sGC-cGMP pathway by Teerapap Panklai, Prapapan Temkitthawon, Nungruthai Suphrom, Corine Girard, Perle Totoson, Kowit Hengphasatporn, Yasuteru Shigeta, Krongkarn Chootip, Kornkanok Ingkaninan

“…Our previous research demonstrated that the extract (WLE) derived from the petals of the water lily (Nymphaea pubescens Willd.) and its flavonoid constituents, 3-methyl ether 3´-O-β-xylopyranoside (1), quercetin (2), and kaempferol (3), exhibited PDE5 inhibitory property, suggesting that WLE and its constituents may contribute to PA vasodilation. Methods: Dried N. pubescens petals were extracted with 95 % ethanol to provide the WLE. …”
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KiKli Fit: Insights into the Development and Practice of a Physical Activity Program in Pediatric Cancer by Lisa Hillebrech, Lars Rehbein, Ann Christin Schneider, Sara Müller, Christina Schindera, Katharina Eva, Valentin Benzing

“…Therefore, the KiKli Fit project was initiated to design and implement a tailored PA program at the Department of Pediatric Oncology and Hematology at the University Hospital Bern. Methods First, a needs analysis was conducted through 14 qualitative interviews with patients to gather insights into their preferences and requirements for a PA intervention. …”
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