Single-cell profiling reveals a reduced epithelial defense system, decreased immune responses and the immune regulatory roles of different fibroblast subpopulations in chronic atro... by Lin Lin, Tingxuan Huang, Lizhi Li, Yang Lin, Feng Chen, Ziyi Zheng, Jie Zhou, Yizhe Wang, Weihao You, Yujie Duan, Yawen An, Shiwei He, Weimin Ye

“…Abstract Purpose To identify key cellular changes and molecular events in atrophic mucosa, we aimed to elucidate the molecular mechanisms driving the occurrence of chronic atrophic gastritis (CAG). Methods We used single-cell RNA sequencing (scRNA-seq) to characterize changes in the epithelial state and tissue microenvironment associated with CAG. …”
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An Evidence summary of postoperative pain management in spinal surgery (脊柱外科术后患者疼痛管理的证据总结) by XIANG Tingting (向婷婷), ZHENG Su (郑苏), XIE Xiaomin (谢晓敏)

“…Objective To search and evaluate the evidence of postoperative pain management in spinal surgery so as to promote the standardized management of postoperative pain in patients with spinal surgery. Methods According to the "6S" evidence model, evidence of management of postoperative pain in spinal surgery were systematically searched from BMJ Best Practice, UpToDate, Cochrane library, Joanna Briggs Institute (JBI), National Guideline Clearinghouse(NGC), National Institute for Health and Clinical Excellence(NICE), Scottish Intercollegiate Guidelines Network(SIGN), Guidelines International Network(GIN), Registered Nurses’ Association of Ontario(RNAO), China Medical Network, PubMed, Web of science, Embase, EBSCO, Chinese Biomedical Medicine(CBM), China National Knowledge Infrastructure(CNKI), WanFang Data. …”
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Development of an in vitro model to study muscle maladaptation to overtraining by Giuseppe Sirago, Clément Lanfranchi, Justin Carrard, Vincent Gremeaux, Nadège Zanou, Nicolas Place

“…The aim of the present project is to determine the molecular mechanisms underlying skeletal muscle maladaptation’s in response to simulated exercise in vitro. Methods Using a model developed in our laboratory (Zanou et al., 2021), we electrically stimulated C2C12 myotubes (a mouse skeletal muscle cell line) to simulate endurance exercise (Zanou et al., 2021). …”
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Effect of following-up nursing guided by timing theory on rehabilitation and quality of life of elderly patients with acute myocardial infarction treated with percutaneous coronary... by Zhang Keke (张珂珂)

“…Objective To explore the effect of following-up nursing guided by timing theory on rehabilitation and quality of life of elderly patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI) . Methods Totally 96 elderly AMI patients treated with PCI were randomly divided into two groups, with 48 cases in each group . …”
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A 4-Week Mobile App–Based Telerehabilitation Program vs Conventional In-Person Rehabilitation in Older Adults With Sarcopenia: Randomized Controlled Trial by Lu Zhang, Ying Ge, Wowa Zhao, Xuan Shu, Lin Kang, Qiumei Wang, Ying Liu

“…ObjectiveWe aimed to compare the effects of a digital rehabilitation program with those of traditional therapist-supervised rehabilitation training on older adults with sarcopenia. MethodsIn total, 58 older adults with sarcopenia were recruited offline and randomized (1:1) into 2 groups: the telerehabilitation group (TRG, n=29, 50%) and the in-person rehabilitation group (IRG, n=29, 50%). …”
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Occurrence of Alternaria Toxins, Ochratoxin A and Aflatoxins B1 in Green Arabic Coffee (Coffea arabica) in Saudi Arabia: Risk Assessment on HepG-2 Cell Line and Male Albino Rats by Ahmed Hashim Almusallam, Ahmed Mahmoud Ismail

“…Cytotoxicity of the detected toxins was investigated utilizing the MTT assay method toward HepG-2 cells and male albino rats. Cytotoxic properties of the detected mycotoxins were investigated at doses of 31.25, 62.50, 125, 250 and 500 µg/ml following exposure durations of 24 and 48 h in comparison with control. …”
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Maternal Macronutrient Intake and Associated Risk for Gestational Diabetes Mellitus: Results from the BORN2020 Study by Antigoni Tranidou, Ioannis Tsakiridis, Emmanuela Magriplis, Aikaterini Apostolopoulou, Violeta Chroni, Eirini Tsekitsidi, Ioustini Kalaitzopoulou, Nikolaos Pazaras, Michail Chourdakis, Themistoklis Dagklis

“…Therefore, we evaluated these intakes both before and during pregnancy, comparing macronutrient data against the European Food and Safety Authorities’ (EFSA) Dietary Reference Values (DRVs). <b>Methods:</b> Data were prospectively collected from the Greek BORN2020 epidemiologic pregnant cohort, which included 797 pregnant women, of whom 14.7% were diagnosed with GDM. …”
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Clinical Characteristics and Treatment Options of Peripheral Spondyloarthritis by ZENG Lulu, JI Xiaojian, HU Lidong, HU Jiawen, ZHANG Yinan, ZHANG Jiaxin, LIU Xingkang, YANG Shiwei, HUANG Feng

“…ObjectiveTo compare the differences in clinical features and treatment choices between peripheral spondyloarthritis(pSpA) and axial spondyloarthritis(axSpA), and better understand the clinical characteristics and medication needs of pSpA.MethodsOur study is a retrospective cohort study. …”
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Health care utilization patterns of patients enrolled in an interdisciplinary program for back pain by Sara Davin, Psy.D., MPH, Brittany Lapin, PhD., MPH, Belinda Udeh, PhD, Sarah Rispinto, PhD, Nicolas R. Thompson, MS, Ryan Honomichl, PhD, Andre Machado, MD, Irene L. Katzan, MD

“…The aim of this study was to describe healthcare patterns of patients participating in a interdisciplinary pain program (IPP) for chronic low back pain. Methods: This observational cohort study describes the healthcare utilization of a group of adult patients (N=143) who participated in an IPP for chronic back pain compared to patients who did not complete the entire program (N=112), and those who were eligible for the program but chose not to participate (N=76). …”
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Role of sphingolipid metabolism signaling in a novel mouse model of renal osteodystrophy based on transcriptomic approach by Yujia Wang, Yan Di, Yongqi Li, Jing Lu, Bofan Ji, Yuxia Zhang, Zhiqing Chen, Sijie Chen, Bicheng Liu, Rining Tang, Yuanyuan Ji

“…To address this gap, we established a stable mouse model of ROD using an optimized adenine-enriched diet and conducted exploratory analyses through ribonucleic acid sequencing (RNA-seq). Methods:. Eight-week-old male C57BL/6J mice were randomly allocated into three groups: control group (n = 5), adenine and high-phosphate (HP) diet group (n = 20), and the optimized adenine-containing diet group (n = 20) for 12 weeks. …”
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Response mechanism of water status and photosynthetic characteristics of Cotoneaster multiflorus under drought stress and rehydrated conditions by Qiu-liang Huang, Miao-miao Zhang, Chang-shun Li, Chang-shun Li, Bo-yang Li, Sheng-lan Zhuo, Yu-shan Yang, Yu-da Chen, An-na Zhong, Hao-yang Liu, Wen-feng Lai, Zhen-bei Huang, Ming-hui Cao, Zong-sheng Yuan, Guo-fang Zhang

“…Therefore, exploring the physiological response mechanisms, molecular mechanisms and adaptive strategies of C. multiflorus in response to drought is important for its growth in arid and semi-arid regions.MethodsWe investigated the response and coupling mechanisms of water status, photosynthetic properties and chloroplast fluorescence parameters in C. multiflorus in response to drought and rehydrated after drought, especially the importance of nocturnal sap flow and nocturnal water refilling to maintain its own water balance in response to drought stress. …”
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Perceived healthiness of sugary drinks and related social norms among adults in five countries: evidence from the International Food Policy Study by Virginie Drolet-Labelle, Christine M. White, Jean Adams, Sharon I. Kirkpatrick, Alejandra Jáuregui, Lilia S. Pedraza, Véronique Provencher, Gary Sacks, James F. Thrasher, Gabriela C. Armendariz, Simón Barquera, David Hammond, Lana Vanderlee

“…This study examined differences in perceived healthiness of sugary drinks and related social norms between countries, over time, and sociodemographic groups and associations with sugary drink intake. Methods This study used annual cross-sectional data from the International Food Policy Study from 2018 to 2021 in Australia, Canada, the United Kingdom, the United States, and Mexico. …”
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A compilation of surface inherent optical properties and phytoplankton pigment concentrations from the Atlantic Meridional Transect by T. M. Jordan, G. Dall'Olmo, G. Tilstone, R. J. W. Brewin, F. Nencioli, R. Airs, C. S. Thomas, L. Schlüter

“…The compilation includes coincident high-performance liquid chromatography (HPLC) phytoplankton pigment concentrations, which are used to calibrate transects of total chlorophyll <span class="inline-formula"><i>a</i></span> (Tot_Chl_a) concentrations derived from the <span class="inline-formula"><i>a</i>_p(<i>λ</i>)</span> line-height method. The IOP data are processed using a consistent methodology and include propagated uncertainties for each IOP variable, uncertainty quantification for the Tot_Chl_a concentrations based on HPLC match-ups, application of consistent quality-control filters, and standardization of output data fields and formats. …”
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Relationship between regional relative theta power and amyloid deposition in mild cognitive impairment: an exploratory study by Jaesub Park, Jaesub Park, Woo Jung Kim, Woo Jung Kim, Han Wool Jung, Han Wool Jung, Jae-Jin Kim, Jae-Jin Kim, Jin Young Park, Jin Young Park, Jin Young Park

“…This study aimed to explore the relationship between regional EEG abnormalities and amyloid deposition in patients with mild cognitive impairment (MCI).MethodsWe recruited 24 older adults with MCI from a community center for dementia prevention, and 21 participants were included in the final analysis. …”
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Studying the Digital Intervention Engagement–Mediated Relationship Between Intrapersonal Measures and Pre-Exposure Prophylaxis Adherence in Sexual and Gender Minority Youth: Second... by Michael P Williams, Justin Manjourides, Louisa H Smith, Crissi B Rainer, Lisa B Hightow-Weidman, Danielle F Haley

“…ObjectiveThis study is a secondary analysis of the primary efficacy randomized controlled trial (RCT) of Prepared, Protected, Empowered (P3), a digital PrEP adherence intervention that used causal mediation to quantify whether and to what extent intrapersonal behavioral, mental health, and sociodemographic measures were related to effective engagement for PrEP adherence in YSGMMSM. MethodsIn May 2019, 264 YSGMMSM were recruited for the primary RCT via social media, community sites, and clinics from 9 study sites across the United States. …”
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Perbandingan Efektivitas Daya Hambat Kotrimoksazol Generik dan Paten terhadap Pertumbuhan Bakteri Escherichia coli sebagai Penyebab Infeksi Saluran Kemih secara In Vitro by Puti Anggun Sari, Erly ., Dessy Arisanty

“…These samples specified by minimal adequate sample size and using disc diffusion method. Then they were observed the comparison between germ-free zone established by the generic and the patent drugs. …”
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The Effect of Wheat Residues and Vermicompost on the Quality Characteristics of Corn (Zea mays L.) Forage and Soil Fertility by Hasanali Pooresmaeil, Mehdi Dahmradeh, Ahmad Ghanbari

“…Vermicomposting is one of the promising processes for producing organic fertilizer with high nutritional value, which not only increases agricultural productivity but is also a cost-effective strategy for waste management without pollution. Materials and MethodsThe corn (Zea mays L.) variety Fajr or K.S.C 260 was used in this study. …”
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Two-stage surgical treatment of cataracts with weakness of the lenticular zonular apparatus and uncompensated glaucoma by E.A. Ivachev, S.A. Kochergin

“…</p> <p> <b>Patients and Methods: </b>all the patients were divided into 3 groups: Group 1 (n=24) - the first stage was trabeculectomy, the second one represented phacoemulsification with an intraocular lens (IOL) implantation; Group 2 (n=29) initially underwent lensectomy followed by trabeculectomy; Group 3 (n=39) experienced lensectomy and, then, trabeculectomy as per the proposed technique. …”
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Nitrogen uptake and remobilization from pre- and post-anthesis stages contribute towards grain yield and grain protein concentration in wheat grown in limited nitrogen conditions by Sandeep Sharma, Tarun Kumar, M. John Foulkes, Simon Orford, Anju Mahendru Singh, Luzie U. Wingen, Venkatesh Karnam, Lekshmy S. Nair, Pranab Kumar Mandal, Simon Griffiths, Malcolm J. Hawkesford, Peter R. Shewry, Alison R. Bentley, Renu Pandey

“…We assessed the genetic variation in wheat recombinant inbred lines (RILs) for uptake, partitioning, and remobilization of N towards grain, its association with grain protein concentration (GPC) and grain yield. Methods We used the nested association mapping (NAM) population (195 lines) derived by crossing Paragon (P) with CIMMYT core germplasm (P × Cim), Baj (P × Baj), Watkins (P × Wat), and Wyalkatchem (P × Wya). …”
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Effect of chemoradiotherapy on the dynamics of circulating lymphocyte subsets in patients with non-metastatic nasopharyngeal carcinoma by Lilan Yi, Lilan Yi, Yinfang Gu, Yinfang Gu, Longhua Guo, Longhua Guo, Xiaofang Zou, Xiaofang Zou, Guowu Wu, Guowu Wu

“…This study aimed to characterize the dynamics of the proportions and absolute counts of peripheral circulating lymphocyte subsets in non-metastatic NPC before and after CRT, and to elucidate their association with clinical responses.MethodsA total of 91 patients with non-metastatic NPC were enrolled. …”
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