Several factors that predict the outcome of large B‐cell lymphoma patients who relapse/progress after chimeric antigen receptor (CAR) T‐cell therapy can be identified before cell a... by Alice Sýkorová, František Folber, Kamila Polgárová, Heidi Móciková, Juraj Ďuraš, Kateřina Steinerová, Aleš Obr, Adriana Heindorfer, Miriam Ladická, Ľubica Lukáčová, Erika Čellárová, Ivana Plameňová, David Belada, Andrea Janíková, Marek Trněný, Tereza Jančárková, Vít Procházka, Andrej Vranovský, Margaréta Králiková, Jan Vydra, Lukáš Smolej, Ľuboš Drgoňa, Martin Sedmina, Eva Čermáková, Robert Pytlík

“…Abstract Aim The aim of this study was to analyse the outcomes of patients with large B‐cell lymphoma (LBCL) treated with chimeric antigen receptor T‐cell therapy (CAR‐Tx), with a focus on outcomes after CAR T‐cell failure, and to define the risk factors for rapid progression and further treatment. Methods We analysed 107 patients with LBCL from the Czech Republic and Slovakia who were treated in ≥3rd‐line with tisagenlecleucel or axicabtagene ciloleucel between 2019 and 2022. …”
Get full text

Patient-reported quality of life and adherence outcomes after integrating exclusive liquid meal replacement in patients with head and neck cancer undergoing chemoradiation: results... by Luca F. Valle, Fang-I Chu, Xiaoyan Wang, Andrew Erman, Jackie Hernandez, Elizabeth Kaoh, Nicolas Edgar, Ann C. Raldow, Deborah J. Wong, Michael L. Steinberg, Amar U. Kishan, Robert K. Chin, John V. Hegde

“…We sought to assess patient-reported QOL outcomes after integrating exclusive liquid meal replacement with Soylent, a novel meal replacement agent, in patients with head and neck cancer undergoing CRT.MethodsPatients undergoing definitive or adjuvant concurrent CRT for locally advanced head and neck cancer enrolled on our single-institution, prospective phase II protocol evaluating nutritional replacement with Soylent. …”
Get full text

Multi-omics dissection of metabolic dysregulation associated with immune recovery in people living with HIV-1 by Lin-Yu Wan, Sin Man Lam, Hui-Huang Huang, Wen-Jing Cao, Xiang-Yi Cao, Xue-Meng Li, Li-Ping Zhang, Jia-Min Gao, Chao Zhang, Xing Fan, Yan-Mei Jiao, Guanghou Shui, Fu-Sheng Wang, Jin-Wen Song

“…Abstract Background Despite the success of antiretroviral therapy (ART) in suppressing HIV-1 replication, some people living with HIV-1 (PLWH) fail to achieve an optimal recovery of CD4 T cells, and precise metabolic regulation underlying immune recovery remained poorly understood. Methods In this cross-sectional study, mass spectrometry was used for quantitative analysis of plasma metabolome and lipidome in 24 treatment-naïve PLWH (TNs), 33 immunological responders (IRs), 35 immunological non-responders (INRs), and 16 healthy controls (HCs). …”
Get full text

Anthropometric measurements as markers of elevated blood pressure among Portuguese children and adolescents by Edmar Mendes, Paulo Farinatti, Alynne Andaki, Susana Vale, Andreia Pizarro, Maria Paula Santos, Clarice Martins, Jorge Mota

“…Abstract Purpose This cross-sectional study investigated the association between anthropometric measurements and age-related blood pressure (BP) in a large cohort of Portuguese children and adolescents. Methods We included 2972 individuals aged 2–18 years, drawn from previous study databases. …”
Get full text

Lipids as key biomarkers in unravelling the pathophysiology of obesity-related metabolic dysregulation by Anis Adibah Osman, Siok-Fong Chin, Lay-Kek Teh, Noraidatulakma Abdullah, Nor Azian Abdul Murad, Rahman Jamal

“…This study was aimed to discern unique metabolite signatures in obese and lean individuals using liquid chromatography-mass spectrometry quadruple time-of-flight (LC-MS/Q-TOF), with the goal of elucidating their roles in obesity. Methods: A total of 160 serum samples (Discovery, n = 60 and Validation, n = 100) of obese and lean individuals with stable Body Mass Index (BMI) values were retrieved from The Malaysian Cohort biobank. …”
Get full text

Knowledge, attitudes and practices of healthcare workers towards COVID-19 in three states of Nigeria in 2022 by Alash’le Abimiku, Nifarta Andrew, Elima Jedy-Agba, Rita Okonkwo, Olumide Okunoye, Oyewole Oyedele, Martin Edun, Ugochi Ezenwelu, Asmau Aminu-Alhaji, Aondoakura Kombu, Timothy Attah, Jibreel Jumare, Kenneth Enwerem, Sophia Osawe, Victor Ejeh, Michaela Udioh, Okame Okah-Avae, Elonna Obak, Olusola Anuoluwapo Akanbi, Mary Okoli, Nnaemeka C Iriemenam, McPaul Okoye

“…This study assessed KAP towards COVID-19 among HCWs (laboratorians, doctors, nurses and pharmacists) in Nigeria from August to December 2022.Method A facility-based cross-sectional study was conducted on 1341 HCWs (laboratorians, doctors, nurses and pharmacists) in 7 healthcare facilities across 3 states in Nigeria. …”
Get full text

Orbital cycle records in shallow unconsolidated sediments: implications for global carbon cycle and hydrate system evolution in deep-sea area sediments of the Qiongdongnan Basin by Yang Dong, Yang Dong, Ren Wang, Ren Wang, Jinqiang Liang, Yulin He, Jinfeng Ren, Wanzhong Shi, Wanzhong Shi, Xiaosong Wei, Xiaosong Wei, Hao Du, Hao Du, Xiangyang Xie, Arthur B. Busbey

“…Cyclostratigraphic analysis of the Quaternary unconsolidated sediments can help identify climate and sea level changes that correspond to orbital cycles and improve our understanding of the dynamic evolution of hydrates.MethodsUsing the natural gamma-ray log data from the deepwater area well W01 in the Qiongdongnan Basin, Milankovitch cycle analysis was conducted to identify the primary astronomical period in W01. …”
Get full text

Exploring the allometry between ear saturated water accumulation and dry mass for diagnosing winter wheat water status during the reproductive growth by Tingxuan Zhuang, Ben Zhao, Syed Tahir Ata-Ul-Karim, Gilles Lemaire, Xiaojun Liu, Yongchao Tian, Yan Zhu, Weixing Cao, Qiang Cao

“…However, it remains uncertain whether this method is applicable to the ear of winter wheat during its reproductive growth phase. …”
Get full text

A qualitative process evaluation of SBIRT implementation in pediatric trauma centers using the Science to Service Laboratory implementation strategy by Kelli Scott, Michael J. Mello, Geraldine Almonte, Emely Arenas Lemus, Julie R. Bromberg, Janette Baird, Anthony Spirito, Mark R. Zonfrillo, Karla Lawson, Lois K. Lee, Emily Christison-Lagay, Stephanie Ruest, Jeremy Aidlen, Andrew Kiragu, Charles Pruitt, Isam Nasr, Robert Todd Maxson, Beth Ebel, Sara J. Becker

“…This manuscript aimed to assess trauma center staff preferences and experience with the didactic training, performance feedback, and ongoing coaching elements of the SSL via a retrospective qualitative process evaluation. Methods Nurses, social workers, and site leaders that participated in IAMSBIRT were recruited to complete qualitative exit interviews guided by the Consolidated Framework for Implementation Research. …”
Get full text

“Space to see the future”? A political economy analysis of child and adolescent mental health and well-being in Ethiopia including routes for change by Kibur Engdawork, Kibur Engdawork, Kibur Engdawork, Lucia D’Ambruoso, Lucia D’Ambruoso, Lucia D’Ambruoso, Lucia D’Ambruoso, Lucia D’Ambruoso, Lucia D’Ambruoso, Tsion Hailu, Tsion Hailu, Tsion Hailu, Mahlet Yared, Mahlet Yared, Girma M. Geletu, Girma M. Geletu, Semere G. Baraki, Semere G. Baraki, Elias Sebsibe, Pamela Abbott

“…The aims were to describe the political, economic, social and policy contexts in which mental well-being exists; analysing power, interests, and the influence and resources key stakeholders bring to bear on decision-making processes related to child and adolescent well-being.MethodsWe used a Political Economy Analysis framework to identify structural and institutional features, networks of influence, and routes for change. …”
Get full text

Construction of "One Syndrome and One Product" Traditional Chinese Medicine nursing service in the specialized spine department (脊柱专科“一证一品”中医特色护理服务品牌建设思路)... by AN Ying (安影), HAO Juntao (郝俊涛), GAO Xinxia (高新霞), XU Huirong (许慧荣), JIANG Tingjie (姜婷杰), JIA Xin (贾昕)

“…This paper explored the the method, path and content of "One Syndrome and One Product" Traditional Chinese Medicine (TCM) nursing service in the specialized spine department, and summarized the construction and practice of "One Syndrome and One Product" nursing plan. …”
Get full text

Long-Term Clinical Outcomes for Non-ST Elevation Acute Coronary Syndrome Patients with High-Risk Angiographic Findings Undergoing Percutaneous Coronary Intervention by Sida Jia, Ce Zhang, Yue Liu, Deshan Yuan, Xueyan Zhao, Runlin Gao, Yuejin Yang, Bo Xu, Zhan Gao, Jinqing Yuan

“…However, long-term outcome in patients undergoing percutaneous coronary intervention (PCI) with HRCA is still unknown. Method. NSTE-ACS patients undergoing PCI in Fuwai Hospital in 2013 were prospectively enrolled and subsequently divided into HRCA and low-risk coronary anatomy (LRCA) groups according to whether angiography complies with the HRCA definition. …”
Get full text

Web-based mindfulness and skills-based distress reduction for patients with cancer: study protocol of the multicentre, randomised, controlled confirmatory intervention trial Reduct by Dirk Schadendorf, Peter Martus, Stephan Zipfel, Yesim Erim, Alexander Bäuerle, Martin Teufel, Caterina Schug, Johanna Graf, Wolfgang Bethge, Andreas Dinkel, Anja Neumann, Jasmin Steinbach, Jana Heinen, Julia Barbara Krakowczyk, Mirjam Damerau, Sebastian Dries, Anja Mehnert-Theuerkauf, Mitra Tewes, Jörg Wiltink, Alexander Wünsch

“…We expect the Make It Training to be superior to treatment as usual optimised (TAU-O) in terms of reducing distress after completing the intervention (T1, primary endpoint).Methods and analysis The study comprises a multicentre, prospective, randomised controlled confirmatory interventional trial with two parallel arms. …”
Get full text

Proteomic Analysis of Hypoxia-Induced Senescence of Human Bone Marrow Mesenchymal Stem Cells by Liping Mai, Guodong He, Jing Chen, Jiening Zhu, Shaoxian Chen, Xinghua Hou, Hui Yang, Mengzhen Zhang, Yueheng Wu, Qiuxiong Lin, Min Yang, Xiaohong Li

“…Here, we performed an investigation on the pathogenesis of hypoxia-induced senescence through proteomic analyses and aimed to explore the mechanisms of stem cell senescence. Methods. Hypoxia in hBMSCs was induced for 0, 4, and 12 hours, and cellular senescence was evaluated by senescence-associated β-galactosidase (SA-β-gal) staining. …”
Get full text

Surgery for Patients With cT3/4N2M0, Stage IIIB NSCLC. Is It Time to Redefine Resectability? by J. Humberto Rodriguez-Quintero, MD, MPH, Rajika Jindani, MD, MPH, MS, Roger Zhu, MD, Isaac Loh, Mohamed K. Kamel, MD, Anne Montal, MD, Marc Vimolratana, MD, MS, Neel P. Chudgar, MD, Nitin Ohri, MD, MS, Balazs Halmos, MD, MS, Brendon M. Stiles, MD

“…We sought to assess survival outcomes after surgery as part of a multimodality treatment regimen for these patients. Methods: Patients with cT3/T4N2M0 NSCLC who received surgery (S) as part of a multimodality approach and patients receiving multimodality treatment without surgery (chemoradiation [CRT] or systemic therapy only) were identified in the National Cancer Database (2010–2019). …”
Get full text

Long term outcomes associated with the use of perioperative systemic chemotherapy on low grade appendiceal mucinous neoplasms with pseudomyxoma peritonei treated with cytoreductive... by Samantha M. Ruff, Gyulnara Kasumova, Manoj Palavalli, Oliver S. Eng, Laura Lambert, Callisia Clarke, Sameer Patel, Jula Veerapong, Keith Fournier, Daniel Abbott, Charles Staley, Travis Grotz, Fabian Johnston, Mustafa Raoof, Sean Dineen, Jordan M. Cloyd, Alex C. Kim

“…We evaluated outcomes for individuals with LAMN who did and did not receive systemic chemotherapy in combination with CRS+HIPEC.MethodsA multicenter retrospective cohort study was performed using the US HIPEC Collaborative that included patients with LAMN who underwent CRS+HIPEC. …”
Get full text

TERTp Mutation and its Prognostic Value in Glioma Patients Under the 2021 WHO Classification: A Real‐World Study by Hao Xing, Delin Liu, Junlin Li, Yulu Ge, Xiaopeng Guo, Wenlin Chen, Dachun Zhao, Yixin Shi, Yilin Li, Yaning Wang, Yuekun Wang, Yu Xia, Jiaming Wu, Tingyu Liang, Hai Wang, Qianshu Liu, Shanmu Jin, Tian Qu, Siying Guo, Huanzhang Li, Tianrui Yang, Kun Zhang, Yu Wang, Wenbin Ma

“…Aims Given the changes in the entities included in each subtype under the new classification, this research investigated the distribution, prognostic value, and correlations with other molecular alterations of TERTp mutation in different subgroups under this latest classification. Methods All glioma patients admitted to Peking Union Medical College Hospital for surgical resection or biopsy from 2011 to 2022 were included. …”
Get full text

<i>Vismia guianensis</i> Improves Survival of <i>Tenebrio molitor</i> and Mice During Lethal Infection with <i>Candida albicans</i> by Arthur André Castro Costa, Elizangela Pestana Motta, Aluísio Silva Oliveira, Pamela Gomes Santos, Josivan Regis Farias, Danielle Cristine Gomes Franco, Mayara Cristina Pinto Silva, Nicolle Teixeira Barbosa, Simone Batista Muniz, Luís Douglas Miranda. Silva, Lucilene Amorim Silva, Claudia Quintino Rocha, Flavia Raquel Fernandes Nascimento, Rosane Nassar Meireles Guerra

“…This study evaluated the anti-<i>Candida</i> effect of <i>V. guianensis</i> extract after <i>C. albicans</i> lethal infection in <i>Tenebrio molitor</i> larvae and mice. <b>Methods and Results</b>: The chemical profile analysis of a hydroethanolic extract of the leaves of <i>V. guianensis</i> (EHVG) identified 14 compounds. …”
Get full text

DNGR-1 limits Flt3L-mediated antitumor immunity by restraining tumor-infiltrating type I conventional dendritic cells by Ignacio Melero, Ruth Conde-Garrosa, David Sancho, Santos Mañes, Alfonso R Sanchez-Paulete, Francisco J Cueto, Carlos del Fresno, Paola Brandi, Alexis J. Combes, Elena Hernández-García, Michel Enamorado, Christian P Bromley, Manuel J Gomez, Santiago Zelenay, Salvador Iborra, Matthew F. Krummel

“…DNGR-1 has been involved in both cross-presentation of dead cell-associated antigens and processes of disease tolerance, but its role in antitumor immunity has not been clarified yet.Methods B16 and MC38 tumor cell lines were inoculated subcutaneously into wild-type (WT) and DNGR-1-deficient mice. …”
Get full text

The MyLungHealth study protocol: a pragmatic patient-randomised controlled trial to evaluate a patient-centred, electronic health record-integrated intervention to enhance lung can... by Rachel Hess, Angela Fagerlin, Devin Mann, Tanner Caverly, Yue Zhang, Guilherme Del Fiol, Jorie Butler, Michael Flynn, Kensaku Kawamoto, Douglas Martin, Chelsey R Schlechter, Haojia Li, Polina Kukhareva, Christian Balbin, Elizabeth Stevens, Victoria Tiase, Kim Kaphingst, Chakravarthy Reddy, Phillip Warner, Joshua Choi, Claude Nanjo, Quyen Metzger

“…The intervention is designed to improve LCS rates through increased identification of eligible patients and informed decision-making.Methods and analysis MyLungHealth is a multisite pragmatic trial, involving University of Utah Health and New York University Langone Health primary care clinics. …”
Get full text