CD4 T cell depletion increases memory differentiation of endogenous and CAR T cells and enhances the efficacy of Super2 and IL-33-armored CAR T cells against solid tumors by Chrystal Paulos, Mary Jo Turk, Megen C Wittling, Yina H Huang, Asmaa O Mohamed, David Tyler Boone, Shannon L Ferry, Melanie C Peck, Alicia M Santos, Haille E Soderholm

“…Here, we describe the intrinsic ability of CAR T cells to differentiate into memory T cells, the effect of cytokine armoring, and neoadjuvant CD4 depletion therapy on CAR and tumor-specific endogenous memory T cells.Methods TRP1-specific or NKG2D CAR T cells alone or with Super2+IL-33 (S233) armoring and/or CD4 depletion were evaluated in immunocompetent B16F10 melanoma or MC38 colon cell carcinoma models without preconditioning. …”
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Effectiveness of Different Intervention Modes in Lifestyle Intervention for the Prevention of Type 2 Diabetes and the Reversion to Normoglycemia in Adults With Prediabetes: Systema... by Yachen Wang, Xin Chai, Yueqing Wang, Xuejun Yin, Xinying Huang, Qiuhong Gong, Juan Zhang, Ruitai Shao, Guangwei Li

“…ObjectiveThis study aimed to assess the effectiveness of different intervention modes of digital health, face-to-face, and blended interventions, particularly the benefits of digital health intervention, in reducing T2DM incidence and facilitating the reversion to normoglycemia in adults with prediabetes compared to the usual care. MethodsWe conducted a comprehensive search in 9 electronic databases, namely MEDLINE, Embase, ACP Journal Club, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Cochrane Clinical Answers, Cochrane Methodology Register, Health Technology Assessment, and NHS Economic Evaluation Database through Ovid, from the inception to October 2024. …”
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Subjective Taste and Smell Changes in Conjunction with Anxiety and Depression Are Associated with Symptoms in Patients with Functional Constipation and Irritable Bowel Syndrome by Jie Liu, Chaolan Lv, Dandan Wu, Ying Wang, Chenyu Sun, Ce Cheng, Yue Yu

“…Therefore, there is a need to determine whether taste/smell disturbances and psychological abnormalities are present in patients with FC or IBS and whether these are related to the severity of lower gastrointestinal symptoms. Methods. A total of 337 subjects were recruited, including FC (n=115), IBS (n=126), and healthy controls (n=96). …”
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Cigarette Smoking Patterns Among Racial and Ethnic Groups With Chronic Lung Diseases During the COVID-19 Pandemic by Vijaya L. Seegulam, MPH, Caretia J. Washington, BS, Parvathy P. Surendran, BPT, Alyssa M. Falise, PhD, MSPH, Diana Gomez-Manjarres, MD, Catalina Lopez-Quintero, MD, MPH, PhD

“…This study investigates the association between race/ethnicity and current cigarette smoking among adults diagnosed with chronic obstructive pulmonary disease and/or asthma in the U.S. before, during, and after the COVID-19 pandemic. Methods: The authors analyzed data from 10,763 adults (aged ≥40 years) with a history of chronic obstructive pulmonary disease and/or asthma surveyed in the 2019, 2021, and 2023 National Health Interview Survey. …”
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Development of a real-time duplex PCR assay for simultaneously diagnosis of KHV and CEV in common carp and koi by Khumaira Puspasari, Adityawati Fajar Rini, Noviana Dewi, Ratih Ismayasari

“…For clinical validation, 18 KHV and CEV positive samples each, as well as 12 negative samples were tested with three different test methods, i.e., real-time duplex PCR, real-time simplex PCR, and conventional PCR. …”
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Gambaran Peningkatan Angka Kejadian Gangguan Afektif dengan Gejala Psikotik pada Pasien Rawat Inap di RSJ Prof. Dr. HB. Sa’anin Padang pada Tahun 2010 - 2011 by Aisyah Fithri Syafwan, Kurniawan Sedjahtera, Asterina .

“…This study was conducted in May 2013-August 2013. The research method was descriptive with sample of 199 people in 2010 and 205 people in 2011. …”
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Effect of Proprioceptive Neuromuscular Facilitation Technique Combined with Kinesio Taping on Upper Limb Motor Function of Patients with Stroke by XU Xuedi, ZHAO Kai, CHEN Yan, ZHANG Akang, GAO Xiaoping, CHEN Hemu

“…ObjectiveTo observe the effect of proprioceptive neuromuscular facilitation (PNF) technique combined with kinesio taping on upper limb motor function of patients with stroke.MethodsA total of 67 stroke patients hospitalized in the department of rehabilitation medicine of the First Affiliated Hospital of Anhui Medical University from January 2021 to January 2022 were randomly divided into control group, PNF group and combined group, with 22, 22, 23 cases in each group. …”
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Induction of phospholipase A2 group 4C by HCV infection regulates lipid droplet formation by Masahiko Ito, Jie Liu, Masayoshi Fukasawa, Koji Tsutsumi, Yumi Kanegae, Mitsutoshi Setou, Michinori Kohara, Tetsuro Suzuki

“…This study aimed to clarify the involvement of phospholipid metabolic pathways in the pathogenesis of HCV-induced steatosis. Methods: The expression and distribution of lipid species in the livers of human liver chimeric mice were analyzed using imaging mass spectrometry. …”
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The Factors That Influence The Financial Performance of Islamic Banks by Evi Maulida Yanti, Andi Syahrum, Agussalim M, Denni, Rahmah Yulianti, Boihaki, Ali Abdullah Amer Bin Al-Shaibah

“…The total population from 2017 to 2023 is 16 banks. The analytical method used in this research is panel data regression with the help of the Eviews application through the Chow, Hausman and Lagrange tests. …”
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Comparison of PD-L1 tumor cell expression with 22C3, 28-8, and SP142 IHC assays across multiple tumor types by Jeffrey S Ross, Richard S P Huang, Jake G Maule, Lani K Clinton, Ryon P Graf, Jinpeng Xiao, Geoffrey R Oxnard

“…Here we present 22C3, 28-8, and SP142 analysis of 418 tumor specimens encountered in routine clinical practice.Methods All specimens were tested with 22C3, 28-8, and SP142 assays following the manufacturer’s established staining protocols.Results The same PD-L1 status (defined as tumor cell expression (TC) scores with all three assays ≥1% or all <1%) was observed in 60.0% (251/418) tumor specimens (45.9% (192/418) were triple negative and 14.1% (59/418) were triple positive). …”
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Weighted EHR-based prevalence estimates for hypertension at the state and local levels in Louisiana by Wenjun Li, Meng Zhang, Jie Cheng, Sandra L. Jackson, Adam S. Vaughan, Michael Klompas, Thomas W. Carton, Elizabeth Nauman, Lee Mendoza, Arun Adhikari, Jeanie Donovan, Katherine H. Hohman

“…Statistical approaches are needed to adjust estimates to represent the underlying population and validate the results against independent estimates. Methods MENDS, the Multi-State-EHR-Based Network for Disease Surveillance, uses EHR data to calculate chronic disease and risk factor prevalence metrics. …”
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Confronting needlestick and sharp injuries in healthcare: a decade of struggle and progress in a university teaching hospital by Shuk-Ching Wong, Lithia Lai-Ha Yuen, Germaine Kit-Ming Lam, Monica Oi-Tung Kwok, Crystal Yuen-Ki Siu, Bella Hong-Yan Li, Jonathan Hon-Kwan Chen, Simon Yung-Chun So, Kelvin Hei-Yeung Chiu, Vincent Chi-Chung Cheng

“…This study analyzes the incidence and characteristics of NSIs at Queen Mary Hospital and assesses the effectiveness of targeted training programs for interns. Methods A retrospective analysis was conducted on NSI reports from 2014 to 2023, focusing on episodes involving medical, nursing, allied health, and other staff. …”
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Guidance and Counselling and Learners’ Discipline in Kasese District: A Case of Selected Government-Aided Secondary Schools in Bukonzo County. by Kule, Samson

“…The study adopted mixed-methods research that incorporated elements of both Qualitative and Quantitative approaches to provide deeper and wider insights in the data evaluation. …”
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The Contribution of the Hotel Industry on Youth Empowerment in Mbarara City: A Case Study of Hotel Triangle Mbarara City. by Owomuhangi, Emmanuel

“…A qualitative descriptive study design was employed as it allowed for straightforward and comprehensive explorations of participants’ experiences without imposing theoretical frameworks or preconceived categories. The methods that were used in data collection included questionnaires and interviews. …”
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Guidance and Counselling and Learners’ Discipline in Kasese District: A Case of Selected Government-Aided Secondary Schools in Bukonzo County. by Kule, Samson

“…The study adopted mixed-methods research that incorporated elements of both Qualitative and Quantitative approaches to provide deeper and wider insights into the data evaluation. …”
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Effects of Teenage Pregnancy on Girl Child Education in Buhunga Sub-County Uganda. by Twikirize, Edwig

“…This study was based on a mixed-method design with a descriptive survey approach incorporated. …”
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Student Manual Kabale University by Kabale University

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CircUCK2(2,3) promotes cancer progression and enhances synergistic cytotoxicity of lenvatinib with EGFR inhibitors via activating CNIH4–TGFα–EGFR signaling by Xindong Wei, Anfeng Si, Shuai Zhao, Yi Fu, Jilei Li, Kedeerya Aishanjiang, Yujie Ma, Chang Yu, Bo Yu, Chunhong Cui, Hui Wang, Xianming Kong, Shibo Li, Xiaoni Kong, Ying Tong, Hailong Wu

“…Nonetheless, the expression regulation, biological functions, and underlying mechanisms of circRNAs in mediating hepatocellular carcinoma (HCC) progression remain insufficiently elucidated. Methods We identified circUCK2(2,3) through circRNA sequencing, RT–PCR, and Sanger sequencing. …”
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Charlson comorbidity index has no incremental value for mortality risk prediction in nursing home residents with COVID-19 disease by Anum Zahra, Maarten van Smeden, Petra J. M. Elders, Jan Festen, Jacobijn Gussekloo, Karlijn J. Joling, Anouk van Loon, Kim Luijken, René J. F. Melis, Simon P. Mooijaart, Karel G. M. Moons, Geeske Peeters, Harmke A. Polinder-Bos, Fenne Wouters, Anne de Hond

“…We evaluated the incremental predictive value of the CCI for predicting 28-day mortality in NH residents with COVID-19, compared to prediction using age and sex only. Methods We included older individuals of ≥ 70 years of age in a large retrospective observational cohort across NHs in the Netherlands. …”
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Foot screening and customized health education program for patients with diabetic peripheral neuropathy: A nurse-led, real-world observational study by Shuhong Liu, Hexiao Ding, Dandan Li, Fen Lu, Gumei Luo, Yujin He, Hui Li, Xiuhong Zeng, Kaixin Li, Dong-E Gong, Xiling Hu, Yanming Chen, Xubin Yang

“…Nevertheless, there is an increasing recognition of the significance of nurse-led screening and health education in the early detection and slowing down of DPN. Method: The present study conducted a retrospective analysis of medical records of 10,191 diabetic patients from 2019 to 2023, who also regularly attended outpatient clinics. …”
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