Pharmacodynamic characteristics and influencing factors of tapentadol for chronic pain relief under dose titration by Liang Xin, Haoxiang Zhu, Haoxiang Zhu, Suping Niu, Xie Han, Hongxian Pang, Jiangfan Li, Ye Hu, Xuhong Wang, Lujin Li, Lujin Li, Yi Fang

“…This model is intended to provide a pharmacodynamic reference for designing rational tapentadol dose titration schemes in clinical research.MethodsRandomized controlled trials assessing the efficacy of tapentadol in the management of chronic pain were retrieved from public databases (PubMed and EMBASE). …”
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Finite element investigation for improving chest wall reconstruction process using ceramic and polymeric implants by Yomna H. Shash

“…This research aims to explore alternatives to metallic implants in order to overcome their drawbacks and enhance the performance of chest wall reconstruction using the finite element method. In this research, customized implants for the ribs and cartilages are used to repair the defective portion of the chest wall. …”
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Role of emotional disorders, personality features and disorders of intraceptive sensation in development of somatic symptoms at irritable bowel syndrome by Ye. A. Poluektova, A. A. Kurbatova, G. Ye. Rupchev, A. A. Sheptulin, V. T. Ivashkin

“…To estimate emotional disorders, personality features and features of intraceptive sensations in patients with irritable bowel syndrome (IBS), as well as the effect of revealed changes on disease severity.Material and methods. Overall 30 patients with confirmed diagnosis of IBS were studied. …”
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The hidden crisis: double burden of malnutrition among refugee children in South Asia – a systematic review and meta-analysis from observational studies by Pooja Panchal, Mohd Usman, Tajung Longkumer, Reshma Susan Babu, Mahalaqua Nazil Khatib, Shariza Abdul Razak, Kavitha Menon

“…The study aims to assess the prevalence of malnutrition among refugee children in South Asia.MethodsThis systematic review and meta-analysis followed the standard Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines using CoCoPop mnemonic approach. …”
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Partial Stereotactic Ablative Radiotherapy Boost Before Conventional Radiotherapy (P‐SABR) for Large (> 5 cm) Unresectable Stage III Nonsmall Cell Lung Cancer by Yun Bai, Xianshu Gao, Shangbin Qin, Shanshi Li, Mingwei Ma, Xi Cao, Feng Lyu, Jiayan Chen, Xin Qi, Siwei Liu, Yan Gao, Hongzhen Li, Xiaomei Li, Xiaoying Li, Xueying Ren, Lei Huang

“…This study aims to evaluate the efficacy and safety of partial SABR boost before conventional radiotherapy (P‐SABR) for the treatment of large (> 5 cm) unresectable stage III nonsmall cell lung cancer (NSCLC). Methods From April 2014 to January 2024, 44 patients with > 5 cm unresectable T3‐4N0‐3M0 stage III NSCLC were analyzed. …”
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The effects of the positioning of a bolt in the femoral neck system on the short-term outcomes of middle-aged and young adults with displaced femoral neck fractures by Yujie Jin, Xiaoqiang Zhou, Zhiqiang Li, Yubo Liu, Renjie Xu, Jun Shen, Xiangxin Zhang, Xiao Yu

“…Abstract Background To analyze the effects of the positioning of a bolt in the femoral neck system (FNS) on the short-term outcomes of middle-aged and young adults with displaced femoral neck fractures (FNFs). Methods This was a retrospective study involving 114 middle-aged and young adults with displaced FNFs who were surgically treated with internal fixation via the FNS in the Department of Orthopedics, Suzhou Municipal Hospital, from December 2019 to January 2023. …”
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Dose-response associations of device-measured sleep regularity and duration with incident dementia in 82391 UK adults by Wenxin Bian, Raaj K. Biswas, Matthew N. Ahmadi, Yu Sun Bin, Svetlana Postnova, Andrew J. K. Phillips, Nicholas A. Koemel, Jean-Philippe Chaput, Shantha M. W. Rajaratnam, Peter A. Cistulli, Emmanuel Stamatakis

“…To evaluate the associations of device-measured sleep duration and regularity with incident dementia and explore whether sleep regularity moderates the association of sleep duration with dementia. Methods Population-based prospective cohort study of 82,391 adults aged 43 to 79 years from the UK Biobank accelerometry subsample, collected between 2013 and 2015, followed up to 2022. …”
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Identification of patient demographic, clinical, and SARS-CoV-2 genomic factors associated with severe COVID-19 using supervised machine learning: a retrospective multicenter study by Kuganya Nirmalarajah, Patryk Aftanas, Shiva Barati, Emily Chien, Gloria Crowl, Amna Faheem, Lubna Farooqi, Alainna J. Jamal, Saman Khan, Jonathon D. Kotwa, Angel X. Li, Mohammad Mozafarihashjin, Jalees A. Nasir, Altynay Shigayeva, Winfield Yim, Lily Yip, Xi Zoe Zhong, Kevin Katz, Robert Kozak, Andrew G. McArthur, Nick Daneman, Finlay Maguire, Allison J. McGeer, Venkata R. Duvvuri, Samira Mubareka

“…Therefore, we aimed to establish a COVID-19 patient dataset with linked clinical and viral genomic data to then examine associations between SARS-CoV-2 genomic signatures and clinical disease phenotypes. Methods A cohort of adult patients with laboratory confirmed SARS-CoV-2 from 11 participating healthcare institutions in the Greater Toronto Area (GTA) were recruited from March 2020 to April 2022. …”
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Systematic Evaluation of Clinical Efficacy of Shiyiwei Shenqi (Ginseng and Astraglus, Eleven Ingredients) Preparation in Adjuvant Chemotherapy for Malignant Tumor by Bowei HUANG, Yuhui ZENG, Lisha LU, Huijuan GAN

“…Objective:To evaluate the clinical efficacy and safety of Shiyiwei Shenqi preparation adjuvant chemotherapy in the treatment of malignant tumors by Meta analysis.Methods:Data were search from the databases of CBM, CNKI, Wanfang Data, VIP, PubMed, Web of Science, Cochrane Library and EMbase. …”
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Similar Survival Between Non-Western Immigrant Patients and Danish-Born Patients with Lymphoma: A Danish Population-Based Study by Simonsen MR, Maksten EF, Jakobsen LH, Severinsen MT, Dann EJ, Frederiksen H, Niemann CU, Jørgensen JM, Clausen MR, Starklint J, Johnsen SP, El-Galaly TC, Baech J

“…Furthermore, differences in clinical and socioeconomic variables were compared, and mediators of OS differences were explored to explain possible outcome differences.Patients and Methods: The study included a total of 540 non-Western patients and 16,294 Danish-born patients diagnosed with lymphoma in the period 2000– 2020. …”
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Inappropriate prescribing of drugs for peptic ulcer and gastro-esophageal reflux disease remains a matter of concern: Results from the LAPTOP-PPI cluster randomized trial by Manuela Casula, Manuela Casula, Ilaria Ardoino, Laura Pierini, Lara Perrella, Stefano Scotti, Sara Mucherino, Valentina Orlando, Enrica Menditto, Carlotta Franchi

“…This study aims to assess the effectiveness of a low-cost and easily implementable informative intervention directed at GPs to enhance the appropriate prescription of PPIs.MethodsThe LAPTOP-PPI study is a pragmatic, cluster-randomized controlled trial designed to improve the appropriateness of PPI prescriptions among community-dwelling individuals aged ≥65 years. …”
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Hospitalizations, emergency medical care utilization, and contacts with the regional on-call medical services among nursing home residents in Germany: a cross-sectional study in 44... by Paula Lienesch, Heinz Rothgang, Ansgar Gerhardus, Karin Wolf-Ostermann, Falk Hoffmann, Jonas Czwikla

“…We quantified hospitalizations, emergency medical care utilization, and contacts with the regional on-call medical services among nursing home residents, and investigated individual characteristics that may be associated with the utilization of these medical care types. Methods Cross-sectional data from the “Needs-based provision of medical care to nursing home residents” (MVP-STAT) study were analyzed, which were collected in 44 German nursing homes from 442 residents in 2018/2019. …”
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Optimizing oral 3-hydroxybutyrate dosage using pharmacokinetic model to improve cognitive function and mood in healthy subjects by Kentaro Nishioka, Kentaro Nishioka, Kentaro Nishioka, Takahiro Ishimoto, Mariko Sato, Ruki Yasuda, Yumi Nakamura, Hiroshi Watanabe, Toshihide Suzuki, Yudai Araragi, Yukio Kato, Ken-ichi Yoshida, Norihito Murayama

“…Previous studies indicated that achieving a maximum concentration (Cmax) of 3-HB in plasma at 0.28 mM could initiate ketone metabolism in the brain; we hypothesized that attaining this Cmax would improve brain health.MethodsWe aimed to demonstrate the efficacy of an optimized single oral dose of 3-HB on cognitive function and mood through two clinical studies: a pharmacokinetic study and an efficacy study. …”
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Determinants of Parental Attitudes towards Children’s Vaccination in Lithuania: An Online Survey by Kamilė Čeponytė, Eglė Narkevičiūtė, Aušra Beržanskytė, Sigita Burokienė

“…Therefore, the aim of our study was to determine the impact of parental attitudes on children’s vaccination.Materials and Methods: A web-based cross-sectional study was made in Lithuania from October 20th to November 3rd, 2020, using Google Forms. …”
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Methodological challenges using routine clinical care data for real-world evidence: a rapid review utilizing a systematic literature search and focus group discussion by Michelle Pfaffenlehner, Max Behrens, Daniela Zöller, Kathrin Ungethüm, Kai Günther, Viktoria Rücker, Jens-Peter Reese, Peter Heuschmann, Miriam Kesselmeier, Flavia Remo, André Scherag, Harald Binder, Nadine Binder, for the EVA4MII project

“…This study focuses on additional limitations frequently reported in the literature, providing an overview of the challenges and biases inherent to analyzing routine clinical care data, including health claims data (hereafter: routine data). Methods We conducted a literature search on routine data studies in four high-impact journals based on the Journal Citation Reports (JCR) category “Medicine, General & Internal” as of 2022 and three oncology journals, covering articles published from January 2018 to October 2023. …”
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Feasibility of HIV self-test implementation among Mizo youths: a field investigation from Northeast India bordering Myanmar by Amrita Rao, Henry Zodinliana Pachuau, Samiran Panda, Richard L. Chawngthu, Rita Zomuanpuii, Pranoti Hemade, Amit Nirmalkar

“…They also provided valuable insights on the optimal locations and methods for making HIVST kits accessible. Among the youths who used HIVST, the majority were first-time testers (1,772/2,101; 84.3%). …”
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Mechanism of warmed malate ringer’s solution in fluid resuscitation in improving the lethal triad of severe trauma by WU Yinyu, SHE Han, SHE Han, DU Yunxia, DU Yunxia

“… ‍Objective‍　‍To explore the role and mechanism of warm malate ringer’s solution (MR) in resuscitation of the lethal triad caused by severe trauma. Methods‍　‍A rat model of severe trauma was established in SPF-grade SD rats (half male and half female, weighing 200~220 g) using combined multiple injuries and hemorrhagic shock, and the rats were randomly divided into 8 groups (n=8): Sham group, only arterial and venous catheterization; Trauma (Tra) groups with different time points (10, 30, 60, 90, 120, 180 min) and a Trauma group that were observed without any treatment for 180 min after model establishment. …”
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Implementasi Web Push Notification pada Sistem Informasi Manajemen Arsip Menggunakan PUSHJS by Alam Rahmatulloh, Andi Nur Rachman, Fahmi Anwar

“…This feature is available in the HTML5 Push API by using a Push Service or Messaging server that sends notifications to subscribed web browsers without opening the website so that it can broadcast and the HTML5 Notification API does not require a Push Service or Messaging server but must open a website, but not supported all web browsers so that this paper discusses Push Notification Web Implementation in archive management information systems using PushJS, the development method used is the Rational Unified Process (RUP). …”
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Time-frequency characterization of acoustic emission signals from bending damage of corroded reinforced concrete beams in high- temperature saline environment by Dazhong Zhang, Shiyi Zhang, SM Chayan, Yingfang Fan, Surendra P. Shah, Junjie Zheng

“…Additionally, the study uses the Abaqus finite element numerical analysis method to simulate and verify the flexural failure process of the concrete beams under three conditions. …”
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The antiarthritic effect of CBR‐470‐1 in hypoxic environment is to increase the level of NOD‐like receptor family pyrin domain containing 3 ubiquitination by decreasing phosphoglyc... by Ao Duan, Zemeng Ma, Xiaolong Shao, Zhencheng Xiong, Chaoyi Zhang, Wenzheng Liu, Guanglin Wang, Shouye Hu, Wei Lin

“…Specifically, the activation of the NOD‐like receptor family pyrin domain containing 3 (NLRP3) in macrophages induces the secretion of a series of inflammatory factors, accelerating the progression of OA. Methods The effects of CBR‐470‐1 were assessed in a mouse model of OA induced by destabilization of the medial meniscus (DMM) by micro‐computed tomography imaging, Safranin‐O and Fast Green staining, immunofluorescence staining and enzyme‐linked immunosorbent assay. …”
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