The effects of altitude training on hormonal response in professional cyclists by Raphael Faiss, Bastien Krumm, Basile Moreillon, Lena Mettraux, Julian Wackernell, James Spragg, Martin Faulhaber

“…While the impact of prolonged sojourns at altitude on hematological variations is increasingly well understood, research is very limited on the hormonal responses to altitude, and the underlying mechanisms underpinning putative anabolic and erythropoietic adaptations in elite endurance athletes. Methods 21 professional cyclists (25.4 ± 3.3 yrs, 69.8 ± 5.0 kg, maximal aerobic power 560 ± 34 W) underwent a 3-weeks altitude training camp at an altitude of 2050 m (inspired oxygen pressure 115 mmHg, Kühtai, Austria) while training between 500 and 2500 m of altitude (Live-High Train-Low (LHTL) approach). …”
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Study on the Regulated Cell Death of Hypertrophic H9c2 Cells Induced by Au:Ag Nanoparticles by Galindo-Padrón AG, Lorenzo-Anota HY, Rueda-Munguía M, García-Carrasco A, Gaitán López M, Vázquez-Garza E, Campos-González E, Lozano O, Cholula-Díaz JL

“…The main objective of this work is to explore the susceptibility of cells due to exposure to Au:Ag NPs in conditions representing cardiometabolic diseases.Methods: Au:Ag NPs were synthesized in different molar ratios (Au:Ag, 100:0, 75:25, 50:50, 25:75, 0:100) using starch as a capping and reducing agent. …”
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Acceptability of intermittent preventive treatment of malaria in pregnancy with sulfadoxine-pyrimethamine plus dihydroartemisinin-piperaquine in Papua New Guinea: a qualitative stu... by Elvin Lufele, Sophie Pascoe, Alice Mengi, Alma Auwun, Nalisa Neuendorf, John W. Bolnga, Moses Laman, Stephen J. Rogerson, Kamala Thriemer, Holger W. Unger

“…The present qualitative study assessed the acceptability of IPTp-SP plus dihydroartemisinin-piperaquine (DP) in Papua New Guinea, where IPTp-SP was implemented in 2009. Methods Individual in-depth interviews (IDIs) and focus group discussions were conducted at health facilities where a clinical trial evaluated IPTp-SP plus DP (three-day regimen) versus IPTp-SP plus DP-placebo. …”
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Association Between Urinary Metal Levels and Chronic Kidney Dysfunction in Rural China: A Study on Sex-Specific Differences by Kaisheng Teng, Qinyi Guan, Qiumei Liu, Xiaoting Mo, Lei Luo, Jiahui Rong, Tiantian Zhang, Wenjia Jin, Linhai Zhao, Songju Wu, Zhiyong Zhang, Jian Qin

“…The relationship between urinary metal exposure and chronic kidney disease (CKD) remains contentious, particularly within specific demographic groups. Methods: This cross-sectional study included 2919 rural Chinese adults recruited between 2018 and 2019. …”
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Kidney failure-related excess mortality during the first three years of the COVID-19 pandemic in the United States: a nation-wide, population-based analysis by Zhenhu Chen, Pingping Jia, Di Xie, Jingyu Xie, Juan Liu, Wangnan Cao, Lefei Han, Jinjun Ran, Shengzhi Sun, Shi Zhao, Yang Ge, Leonardo Martinez, Xin Chen, Peihua Cao

“…In this study, we investigated temporal trends in excess kidney failure-related mortality during the first three years of the pandemic in the United States. Methods We aim to estimate time-varying excess kidney failure-related mortality, which is defined as the difference between observed mortality and expected mortality predicted by a Poisson log-linear regression model, in the United States (March 2020—March 2023). …”
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Sex Differences in Computed Tomography Coronary Stenosis Severity Versus Flow Impairment and Impact on Revascularization, Clinical Events and Health Care Costs: A FORECAST Substudy by Lavinia Gabara, Jonathan Hinton, Mohamed Kira, James Shambrook, Ausami Abbas, Sam Wilding, Jonathon A. Leipsic, Pamela S. Douglas, Nick Curzen

“…Background The impact of sex‐related differences in coronary atheroma and flow impairment severity on clinical events and costs remains unclear. Methods and Results This is a secondary analysis of patients with stable coronary artery disease who underwent both coronary computed tomography angiography  and fractional flow reserve derived from computed tomography as part of the FORECAST (Fractional Flow Reserve Derived From Computed Tomography Coronary Angiography in the Assessment and Management of Stable Chest Pain) trial, investigating (1) the relationship between coronary stenosis severity on coronary computed tomography angiography and fractional flow reserve derived from computed tomography FFRCT by sex and (2) the association with revascularization, resource usage, and adverse clinical events. …”
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Systemic Immune-Inflammation Index (SII) and Neutrophil-to-Lymphocyte Ratio (NLR): A Strong Predictor of Disease Severity in Large-Artery Atherosclerosis (LAA) Stroke Patients by Liu K, Yang L, Liu Y, Zhang Y, Zhu J, Zhang H, He Z

“…This study aimed to verify the predictive value of the clinical parameters such as systemic immune-inflammation index (SII) and neutrophil-to-lymphocyte ratio (NLR) for the severity in Large Artery Atherosclerosis (LAA) stroke patients.Methods: The SII is defined as platelet × (neutrophil count/lymphocyte count), the NLR is defined as neutrophil count/lymphocyte count. …”
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Clinicopathologic characteristics, therapeutic modalities and survival outcomes of plasmablastic lymphoma: A real-world study by Yan-Hua Zheng, Kun Xie, Hong-Yuan Shen, Zhuo Wan, Shan Gao, Wen-Rui Sun, Guang-Xun Gao, Li Liu, Juan Feng

“…Neither a standardized regimen nor a consensus for PBL treatment has been established. Material and methods We retrospectively analyzed the clinicopathologic characteristics, therapeutic modalities and survival outcomes of 418 patients registered in the Surveillance, Epidemiology, and End Results (SEER) database from 2008 to 2016 and 21 (19 treated) patients in our institution. …”
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Brimonidine as an additional treatment for moderate glaucoma by I.R. Gazizova, V.E. Korelina

“…</i> </p> <p> <i><b>Patients and Methods:</b> 99 patients (121 eyes) aged 62–73 years with moderate glaucoma were enrolled. …”
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Impact of Changes in Rainfall and Temperature on Production of Darjeeling Tea in India by Netrananda Sahu, Rajiv Nayan, Arpita Panda, Ayush Varun, Ravi Kesharwani, Pritiranjan Das, Anil Kumar, Suraj Kumar Mallick, Martand Mani Mishra, Atul Saini, Sumat Prakash Aggarwal, Sridhara Nayak

“…These results underline how susceptible the tea sector in Darjeeling is to climate change adversities and the necessity of adopting adaptive methods to lessen these negative consequences. The results carry significance not only for regional stakeholders but also for the global tea industry, which encounters comparable obstacles in other areas.…”
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Achieving reliable patient reported outcomes collection to measure health care improvement in a learning health network: lessons from pediatric rheumatology care and outcomes impro... by Nancy Pan, Nancy Pan, Esi M. Morgan, Meghan Ryan, Beth Gottlieb, Beth Gottlieb, Julia G. Harris, Julia G. Harris, Tzielan Lee, Tzielan Lee, Y. Ingrid Goh, Y. Ingrid Goh

“…The objective of this study was to better understand the practices of collecting PROs at PR-COIN sites.MethodsA REDCap survey was sent to the lead representative for each PR-COIN site. …”
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Magnitude of female child sexual abuse in Ethiopia: A systematic review and meta-analysis by Gemeda Wakgari Kitil, Dagne Deresa Dinagde, Fikadu Wake Butta, Melese Adugna Tola, Gizu Tola Feyisa, Shambel Negesse Marami, Wakuma Wakene Jifar, Geleta Nenko Dube, Adamu Ambachew Shibabaw, Chernet Desalegn Gebeyehu, Alex Ayenew Chereka

“…This study aims to fill this gap by conducting a meta-analysis and systematic review to explore the current prevalence and contributing factors of female child sexual abuse in Ethiopia. Methods: This study followed the PRISMA checklist, focusing on Ethiopian studies. …”
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Postpartum depression and associated factors among childbearing women from the recent Demographic and Health Survey data of Mozambique: Multilevel analysis by Mamaru Melkam, Bezawit Melak Fente, Yohannes Mekuria Negussie, Zufan Alamrie Asmare, Hiwot Altaye Asebe, Beminate Lemma Seifu, Alemayehu Kasu Gebrehana, Sintayehu Simie Tsega, Meklit Melaku Bezie, Angwach Abrham Asnake

“…Depression during childbirth can have several detrimental effects, including increased risk of complication and decreased satisfaction with birth, decreased trust in medical facilities, and decreased women's participation in maternity and newborn healthcare units.Therefore, this study amid to reveal the prevalence of postpartum depression and associated factors at individual and community levels among women who give birth in Mozambique's recent data Demographic and Health Survey (DHS). Method: Multilevel logistic regression analysis was carried out from the recent Demographic and Health Survey data. …”
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High Detection Rates for Prostate-specific Membrane Antigen–avid Prostate Cancer Recurrence at Low Prostate-specific Antigen levels on Extended Axial Field-of-view Positron Emissio... by Sarah Thomas, Jason Callahan, Paul Conway, Daniel Moon, Hugh Morgan, Johanna Ingbritsen, Melissa Munro, Robert E. Ware, Phil Dundee, Rodney J. Hicks

“…Our aim was to assess whether the enhanced signal-to-noise ratios achieved on the Quadra scanner improve detection of low-volume disease and thereby increase detection of PC at low PSA levels. Methods: We analysed data for the first 300 consecutive patients who underwent clinically indicated PSMA PET/CT for BCR using a Quadra scanner. …”
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Findings from the Tushirikiane-4-MH (supporting each other for mental health) mobile health–supported virtual reality randomized controlled trial among urban refugee youth in Kampa... by Carmen H. Logie, Moses Okumu, Zerihun Admassu, Frannie MacKenzie, Lesley Gittings, Jean-Luc Kortenaar, Naimul Khan, Robert Hakiza, Daniel Kibuuka Musoke, Aidah Nakitende, Brenda Katisi, Peter Kyambadde, Richard Lester, Lawrence Mbuagbaw

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The Effect of “Carvacrol” on Ischemia-Reperfusion Injury in the Skeletal Muscles of Rats by Barış Mardin, Abdullah Özer, Başak Koçak, Ayşegül Küçük, Mustafa Hakan Zor, Şaban Cem Sezen, Mustafa Kavutçu, Mustafa Arslan, Gürsel Levent Oktar

“…In this study, we formulated a hypothesis suggesting that carvacrol (Car), an aromatic hydrocarbon present in some plant species, might decrease I/R injury by implication of its antioxidant, anti-apoptotic, and anti-inflammatory functions. Methods: We planned our study with 18 rats, randomly divided into three groups: control group, I/R group, and I/R + Car group. …”
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Randomized, observer-blind, controlled Phase 1 study of the safety and immunogenicity of the Na-GST-1/Alhydrogel hookworm vaccine with or without a CpG ODN adjuvant in hookworm-naï... by David J Diemert, Maria Zumer, Mark Bova, Christina Gibbs-Tewary, Elissa M Malkin, Doreen Campbell, Lara Hoeweler, Guangzhao Li, Maria Elena Bottazzi, Peter J Hotez, Jeffrey M Bethony

“…Phase 1 trials have demonstrated the safety of Na-GST-1 formulated on Alhydrogel, but further optimization of the vaccine adjuvant formulation may improve humoral immune responses, thereby increasing the likelihood of vaccine efficacy.<h4>Methods</h4>A randomized, observer-blind, dose escalation Phase 1 trial was conducted in 24 healthy, hookworm-naïve adults. …”
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Factors influencing repeat blood donor lapsing in Guangzhou: based on the zero-inflated poisson regression model by KE Rongrong, XIE Guiyun, ZHENG Xiaoxiao, XU Yingying, HONG Xiaochun, LI Shijie, DENG Yongshi, SHEN Jinyu, CHEN Jinyan, OUYANG Jian

“…[Objective] To analyze the influencing factors of repeat blood donor lapsing using a zero-inflated poisson regression model (ZIP). [Methods] The blood donation behavior of 12 498 whole blood donors from 2020 was tracked until December 31, 2023. …”
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Amélioration des conditions de vie de lémuriens issus du commerce illégal et ayant subi différents traumatismes à Madagascar by Emeline Lempereur, Delphine Roullet, Emmanuelle Pouydebat

“…Une étude a ainsi été réalisée entre le 2 février et le 20 juin 2015, au sein du Refuge Reniala à Mahajanga, afin de relever les activités comportementales (budget temps) par la méthode d’échantillonnage instantané « scan sampling » (Altman, 1974) pour 3 espèces de lémuriens (Eulemur rufus, Eulemeur mongoz, Propithecus coquereli, soit 9 individus au total). …”
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B7-H3 CAR-T cell therapy combined with irradiation is effective in targeting bulk and radiation-resistant chordoma cancer cells by Kun Wang, Gianpietro Dotti, Soldano Ferrone, Yufeng Wang, Yin P Hung, Tao Ma, Giulia Cattaneo, Xinhui Wang, David O Osei-Hwedieh, Tara A Walhart, Joseph H Schwab

“…This study explores the efficacy of B7-H3 chimeric antigen receptor T (CAR-T) therapy in vitro and in vivo.Methods Chordoma cancer stem cells (CCSCs) were identified using flow cytometry, sphere formation, and western blot analysis. …”
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