Validation study of synthetic models for esophageal atresia with tracheoesophageal fistula (EA/TEF): A simulation-based training in pediatric surgery by Zahradníková Petra, Hnilicová Silvia, Lindák Martin, Pechanová Rebeka, Števková Dominika, Vitovič Pavol, Laurovičová Miroslava, Horn František, Tvrdoň Tomáš, Babala Jozef

“…Furthermore, we aimed to validate two synthetic EA/TEF models. Method: A questionnaire focused on the degree of adoption of MIS among paediatric surgeons was proposed online to participants at the 68th Czech and Slovak Pediatric Surgery Congress in Slovakia in 2024. …”
Get full text

Impact of Bone-Modifying Agents on Post-Bone Metastasis Survival Across Cancer Types by Hironari Tamiya, Kazumi Nishino, Yuji Kato, Reina Nakahashi-Kato, Yurika Kosuga-Tsujimoto, Shota Kinoshita, Rie Suzuki, Makiyo Watanabe, Toru Wakamatsu, Shigeki Kakunaga, Satoshi Takenaka

“…In this study, we investigated whether BMA was involved in post-bone metastasis survival. Methods: A total of 539 cancer patients were retrospectively analyzed to identify significant independent factors in post-bone metastasis survival. …”
Get full text

Visualization analysis of knowledge graph of domestic self-regulated learning researches based on CiteSpace (基于CiteSpace的国内自我调节学习研究知识图谱可视化分析)... by CHEN Qiannan (陈倩楠), QIAN Zhigang (钱志刚), WANG Beibei (王贝贝), JIN Guifang (金桂芳), ZHANG Xueru (张雪茹)

“…Objective To analyze the development of self-regulated learning research in China based on CNKI database, and to provide reference for future research on the theory and practice of self-regulated learning. Methods "Self-regulated learning" was used as the search term, and the relevant literatures published on CNKI between January 1, 1994 and May 1, 2021 were searched. …”
Get full text

Clinical Characteristics and Optimization of Empirical Antimicrobial Therapy for Febrile Neutropenia in Patients With Hematologic Malignancies by Cui Y, Liu X, Feng S

“…The study aims to update and optimize empirical treatment strategies for hematological malignancy (HM) patients, a population particularly vulnerable to these evolving threats.Methods: A literature review was conducted on studies published between January 2010 and December 2023 regarding empirical treatment of FN in HM patients, focusing on pathogen characteristics, treatment regimens, and duration of therapy.Results: Approximately one-third of HM patients with FN experience fever of unknown origin (FUO), while 40– 50% have clinically documented infections (CDI), and 10– 30% present with microbiologically documented infections (MDI), with a predominance of Gram-negative bacteria (GNB). …”
Get full text

Comparison of the Impact of tNGS with mNGS on Antimicrobial Management in Patients with LRTIs: A Multicenter Retrospective Cohort Study by Li D, Li Q, Huang Z, Wu W, Fan X, Liu J, Li R, Zhang Q, Su X

“…However, the impact of tNGS and mNGS on antimicrobial stewardship in patients with LRTIs remains unclear.Methods: Patients diagnosed with LRTIs who underwent tNGS or mNGS between June 2021 and January 2024 were included. …”
Get full text

Limited Diagnostic Value of miRNAs in Early Trauma-Induced Liver Injury: Only miRNA-122 Emerges as a Late-Phase Marker by Jason-Alexander Hörauf, Amit Singh, Maika Voth, Hamed Moheimani, Cora Rebecca Schindler, Borna Relja, Liudmila Leppik, Ingo Marzi, Dirk Henrich

“…This study investigates whether specific liver-related microRNAs (miRNAs) are released into the circulation in trauma patients with liver injury and whether they can indicate liver damage in the early phase after major trauma. <b>Methods</b>: A retrospective analysis of prospectively collected data and blood samples from 26 trauma patients was conducted. …”
Get full text

The Prevalence of Celiac Disease-Specific Auto-Antibodies in Type 1 Diabetes in a Moroccan Population by Ider Oujamaa, Majda Sebbani, Lahcen Elmoumou, Aïcha Bourrahouate, Rabiy El Qadiry, Soufian El Moussaoui, Imane Ait Sab, Mohamed Sbihi, Laila Ennazk, Ghizlane El Mghari-Tabib, Nawal El Ansari, Hicham Baizri, Mohamed Amine, Brahim Admou

“…We aimed to determine the prevalence of specific auto-antibodies to celiac disease (CD) in Moroccan type 1 diabetic (T1D) patients and compare the clinical and biological characteristics of seropositive and seronegative cases. Patients and Methods. A cross-sectional study was carried out on 276 T1D patients including 109 adults and 167 pediatric cases. …”
Get full text

Peningkatan Performa Pengelompokan Pola Berpikir Siswa dalam Belajar pada Media Pembelajaran Menggunakan Direct Batch Growing Self Organizing Map by Mochammad Izzuddin, Ahmad Afif Supianto, Tibyani Tibyani, Hilman Ferdinandus Pardede, Asri Rizki Yuliani, Ade Ramdan

“…The comparison significance measurement was carried out using the Wilcoxon method which resulted in a test stat value of 8 and a critical value of 13. …”
Get full text

Defective Slc7a7 transport reduces erythropoietin compromising erythropoiesis by Judith Giroud-Gerbetant, Fernando Sotillo, Gonzalo Hernández, Irene Ruano, David Sebastián, Joana Fort, Mayka Sánchez, Günter Weiss, Neus Prats, Antonio Zorzano, Manuel Palacín, Susanna Bodoy

“…Given the limitations of current citrulline-based treatments and the unknown role of SLC7A7 in red blood cell production, there is an urgent need to investigate the pathways affected by SLC7A7 deficiency. Methods We employed total inducible and cell type-specific Slc7a7 knockout mouse models to determine whether the hematological abnormalities observed in LPI are due to the loss of Slc7a7 function in hematopoietic cells. …”
Get full text

Invasive aspergillosis in critically ill patients with diabetes mellitus: a systematic review and meta-analysis by Yuhua Liu, Zhaopei Zhang, Liang Zhou, Tianlai Lin, Rong Zhang, Manshu Li, Sihao Chen, Xiaoqing Liu, Xuesong Liu

“…We aimed to clarify the relationship between DM and IA among patients in the ICU in a systematic review and meta-analysis. Methods We retrieved all reports published in PubMed, EMBASE, and the Cochrane Library databases before July 12, 2023. …”
Get full text

When specific exercise is more effective than medication - Sensorimotor training is currently the most promising option to treat and prevent chemotherapy-induced peripheral neuropa... by Fiona Streckmann, Maryam Balke, Céline Hammadou, Bianca Schmidli, Oliver Faude, Sarah Koch

“…In our most recent study (Streckmann et al. 2024) we have been able to show that CIPN can even be prevented by up to 70%. Methods we performed a prospective multicenter randomized clinical trial (STOP) and followed up patients over 5 years (May 2014 – Nov. 2020) at 4 centers and around Cologne, Germany. …”
Get full text

Neural Correlates of Balance Skill Learning in Young and Older Individuals: A Systematic Review and Meta-analysis by Lisanne B. M. Bakker, Claudine J. C. Lamoth, Tomas Vetrovsky, Markus Gruber, Simone R. Caljouw, Ward Nieboer, Wolfgang Taube, Jaap H. van Dieën, Urs Granacher, Tibor Hortobágyi

“…The aim of this review is to determine the effects of age on the neural correlates of balance skill learning measured during static (standing) and dynamic (walking) balance tasks in healthy individuals. Methods We determined the effects of acute (1–3 sessions) and chronic (> 3 sessions) balance skill training on balance in the trained and in untrained, transfer balance tasks through a systematic review and quantified these effects by robust variance estimation meta-analysis in combination with meta-regression. …”
Get full text

Application of the procedural sedation protocol for patients with traumatic brain injury and related nursing management (颅脑损伤患者实施程序化镇静的效果及护理) by ZHANG Feiting (张飞婷), YANG Zhiying (杨智颖), YANG Ruinan (杨蕊南)

“…Objective To investigate the application effect of the procedural sedation protocol for patients with traumatic brain injury, and summarized related nursing management. Methods Totally 64 patients with traumatic brain injury were randomly divided into the control and study group, with 32 cases in each group. …”
Get full text

<i>Piriformospora indica</i> Enhances Rice Blast Resistance and Plant Growth by Manegdebwaoga Arthur Fabrice Kabore, Guanpeng Huang, Changqing Feng, Shuhong Wu, Jiayi Guo, Guofeng Wu, Yiqiong Sun, Samuel Tareke Woldegiorgis, Yufang Ai, Lina Zhang, Wei Liu, Huaqin He

“…Rice blast disease, caused by <i>Magnaporthe oryzae</i> (<i>M. oryzae</i>), is a significant threat to global rice production. Conventional methods for disease management face limitations, emphasizing the importance of sustainable alternatives. …”
Get full text

Recycling waste biosolids to forest propagation of Pinus leiophylla Schltdl. & Cham by Pedro Sinai Rivera-Torres, Jorge Flores-Velázquez, Miguel Ángel López-López, Abdul Khalil-Gardezi, Carlos Ramírez-Ayala, Erickson Basave-Villalobos

“… Purpose: Analyze the use of biosolids, mixed with substrates, as an alternative in the nursery and field production of forest species such as Pinus leiophylla. Method: Biosolids mixed with commercial substrates and chemical fertilizers were tested. …”
Get full text

Development of the early fetal human thalamus: from a protomap to emergent thalamic nuclei by Maznah Alhesain, Ayman Alzu’bi, Ayman Alzu’bi, Ayman Alzu’bi, Niveditha Sankar, Niveditha Sankar, Charles Smith, Charles Smith, Janet Kerwin, Ross Laws, Susan Lindsay, Gavin J. Clowry

“…Higher order thalamic nuclei, relaying information between cortical regions and important in higher cognitive function, are greatly expanded.MethodsThis study mapped the emergence of thalamic nuclei in human fetal development (8–16 post conceptional weeks; PCW) by revealing gene expression patterns using in situ hybridization and immunohistochemistry for previously established thalamic development markers.ResultsIn the proliferative thalamic ventricular zone, OLIG3 and NR2F1 immunoreactivity marked the extent of the thalamus, whereas PAX6 and NR2F2 were expressed in gradients, suggesting an early protomap. …”
Get full text

Early embryonic developmental toxicity of TPhP and CDP: Roles of PPARγ by Jing HUANG, Yunuo ZHAI, Boyang LI, Jing JI, Chuanhai LI, Shixin LIU, Yiman LIU, Junhua YUAN, Qixiao JIANG

“…ObjectiveTo evaluate potential developmental toxicities in early chicken embryos following exposure to triphenyl phosphate (TPhP) or cresyl diphenyl phosphate (CDP), to reveal TPhP and CDP’s capabilities to activate peroxisome proliferator-activated receptor γ (PPARγ) in vivo in an established chicken embryo gene reporter system, and to investigate the roles of PPARγ in TPhP/CDP-induced developmental toxicities with lentivirus-mediated in vivo gene silencing. MethodsFirstly, diverse doses of TPhP and CDP were injected into the air sacs of fertilized eggs to assess the development of chicken embryos after 6 d of incubation, and an optimal dose was chosen for subsequent experiments. …”
Get full text

Effect of nursing interventions on preventing side effects of azacitidine in patients with high-risk myelodysplastic syndrome (预防较高危骨髓增生异常综合征患者阿扎胞苷治疗所致不良反应的护理效果观察)... by WANG Xue (王雪), CAO Hongjing (曹红京), LI Ning (李宁), CHEN Siyu (陈思雨), REN Lixin (任利鑫), SONG Meijia (宋美佳)

“…Objective To investigate the effect of predictive nursing strategies on preventing side effects of azacitidine in patients with high-risk myelodysplastic syndrome. Methods Totally 40 patients undergoing subcutaneous injection therapy with azacitidine for high-risk myelodysplastic syndrome were randomly divided into the observation group and control group, with 20 cases in each group. …”
Get full text

Consecutive prediction of adverse maternal outcomes of preeclampsia, using the PIERS-ML and fullPIERS models: A multicountry prospective observational study. by Guiyou Yang, Tünde Montgomery-Csobán, Wessel Ganzevoort, Sanne J Gordijn, Kimberley Kavanagh, Paul Murray, Laura A Magee, Henk Groen, Peter von Dadelszen

“…This study evaluated the models' performance during such consecutive prediction.<h4>Methods and findings</h4>This multicountry prospective study used data of 8,843 women (32% white, 30% black, and 26% Asian) with a median age of 31 years. …”
Get full text

Mediterranean diet and dementia: MRI marker evidence from meta-analysis by Xiaojie Wang, Zhiyao Xin, Xiuwen Li, Keying Wu, Wanxin Wang, Lan Guo, Li Wang, Xin Mo, Xinjian Liu, Zhihui Guo, Jing Wang, Ciyong Lu

“…Objectives This systematic review and meta-analysis aimed to quantify the association between MeDi and dementia-related MRI markers. Methods A systematic search was conducted on PubMed, Embase, and Web of Science up to September 2024. …”
Get full text