Effect of trilaciclib administered before chemotherapy in patients with extensive-stage small-cell lung cancer: A pooled analysis of four randomized studies by Ying Liu, Lin Wu, Dingzhi Huang, Qiming Wang, Chen Yang, Li Zhou, Shuguang Sun, Xiaomei Jiang, Ying Cheng

“…Moreover, myeloprotection effect in 1 L, 2 L/3 L population and effect by risk category were explored. Materials and Methods: Patients with ES-SCLC who received trilaciclib were included. …”
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Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD by Shaowei Wang, Boyang Li, Jie Li, Zhiheng Cai, Cristelle Hugo, Yi Sun, Lu Qian, Julia TCW, Helena C. Chui, Dante Dikeman, Isaac Asante, Stan G. Louie, David A. Bennett, Zoe Arvanitakis, Alan T. Remaley, Bilal E. Kerman, Hussein N. Yassine

“…However, the role of ABCA1 trafficking in cellular senescence associated with APOE4 and AD remains unclear. Methods We examined the association between cellular senescence and ABCA1 expression in human postmortem brain samples using transcriptomic, histological, and biochemical analyses. …”
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Umbilical Cord Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles Modulate Skin Matrix Synthesis and Pigmentation by Kee LT, Foo JB, How CW, Nur Azurah AG, Chan HH, Mohd Yunus MH, Ng SN, Ng MH, Law JX

“…Therefore, this study aims to evaluate the impact of UC-MSC-sEVs on the synthesis of the skin’s extracellular matrix (ECM) and pigmentation using in vitro models.Methods: The study investigated the impact of characterized UC-MSC-sEVs on various aspects including the proliferation, migration, antioxidant activity, and ECM gene expression of human dermal fibroblasts (HDF). …”
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Effect observation of standardized nursing intervention after transjugular intrahepatic portosystemic shunt (经颈静脉肝内门体静脉分流术后规范化护理效果观察) by WANG Chenlu (王晨璐), ZHANG Ting (张婷)

“…Objective To investigate the effect of standardized nursing intervention after transjugular intrahepatic portosystemic shunt (TIPS). Methods Totally 66 patients undergoing TIPS for liver cirrhosis were randomly divided into the observation group and the control group, with 33 cases in each group. …”
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Liver Transplantation from Voluntary Organ Donor System in China: A Comparison between DBD and DCD Liver Transplants by Wei Chen, Dipesh Kumar Yadav, Xueli Bai, Jianying Lou, Risheng Que, Shunliang Gao, Guogang Li, Tao Ma, Ji Wang, Bingfeng Huang, Tingbo Liang

“…The objective of our research was to investigate the early postoperative and late long-term outcomes of LT from donation after brain death (DBD) and donation after circulatory death (DCD) according to the current organ donation system in China. Methods. Sixty-two consecutive cases of LT from donation after citizens’ death performed in our hospital between February 2012 and June 2017 were examined retrospectively for short- and long-term outcomes. …”
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Biliary atresia susceptibility gene EFEMP1 regulates extrahepatic bile duct elastic fiber formation and mechanics by Kapish Gupta, Jessica Llewellyn, Emilia Roberts, Chengyang Liu, Ali Naji, Richard K. Assoian, Rebecca G. Wells

“…Fibulin-3 is deposited in most tissues and Efemp1 null mice have decreased elastic fibers in visceral fascia; however, fibulin-3 does not have a role in the development of large elastic fibers and its overall function in the extrahepatic bile ducts remains unclear. Methods: We used staining and histology to define the amount and organization of key extracellular matrix components in the extrahepatic bile ducts. …”
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Polymorphic variants of the genes for enzymes of the antioxidant system, apoptosis and inflammation as potential predictors of myocardial infarction by T. R. Nasibullin, V. V. Erdman, Y. R. Timasheva, I. A. Tuktarova, A. A. Petinseva, G. F. Korytina

“…Using the Monte Carlo method and Markov chains (APSampler), combinations of alleles/ genotypes of the studied polymorphic loci associated with a high risk of MI were obtained, which, in addition to those identified during single-locus analysis, contained polymorphic variants of the genes CASP8, TP53, CAT, PON2, CRP, IL6, GSTP1. …”
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Can exercise as a complementary technique manage inflammatory markers in women with breast cancer who are overweight and obese? A systematic review and meta-analysis by Liang Tan, Jinyu Mei, Ruihong Tang, Duo Huang, Kai Qi, Zbigniew Ossowski, Xiaoning Wang

“…Objective: A systematic review and meta-analysis were used to study the effects of exercise on inflammatory markers in women with breast cancer who are overweight and obese. Method: Literature up to May 2024 was searched from databases such as Cochrane, Embase, Pubmed, Web of Science, and EBSCO, and English-language randomized controlled trials (RCTs) that met the inclusion criteria were screened. …”
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Lower limb coordination patterns following anterior cruciate ligament reconstruction: A longitudinal study by Cortney Armitano-Lago, Elizabeth Bjornsen, Caroline Lisee, Ashley Buck, Christin Büttner, Adam W. Kiefer, Todd A. Schwartz, Brian Pietrosimone

“…The purpose of this study was twofold: to determine differences in lower limb coordination patterns during gait in ACLR individuals 2, 4, and 6 months post-ACLR and to compare the coordination profiles of the ACLR participants at each timepoint post-ACLR to uninjured matched controls. Methods: We conducted a longitudinal assessment to quantify lower limb coordination at 3 timepoints post-ACLR and compared the ACLR coordination profiles to uninjured controls. …”
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Comparison of retinal vascular abnormalities in the fellow eyes of children with Coats’ disease and normal subjects using ultra-widefield fundus fluorescein angiography by Shenshen Yan, Haixia Ji, Yuzhu Liu, Haicheng She, Haiying Zhou

“…Purpose: To investigate retinal vascular abnormalities in the affected and fellow eyes of children with Coats’ disease using Optos® ultra-widefield fundus fluorescein angiography (UWFFA) and compare the peripheral vascular abnormalities between fellow eyes and normal control eyes. Methods: Children diagnosed with Coats’ disease who underwent UWFFA were retrospectively reviewed. …”
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Migrasi Data Hasil Optimalisasi Pemuatan Kontainer Pada Legacy System ke SAP untuk Mempercepat Pembuatan Surat Jalan dengan Batch Data Communication (BDC) by Rehulina Tarigan, Ely Nuryani, Susy Katarina Sianturi, Nur Hidayanti, Widyawati Widyawati

“…The solution to overcome this problem is to migrate the order data resulting from loading optimization in CSO to SAP so that the order data is integrated with the delivery note data. The BDC method is used to migrate to SAP, namely by transferring order data resulting from loading optimization from CSO to SAP and automating the picking and packing process in SAP to produce delivery note. …”
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Overview of preclinical and phase II clinical studies on Pegmolesatide’s long-term erythropoiesis stimulating effect via EPOR-mediated signal transduction by Xiaoying Ma, Zhen Li, Lu Zhang, Hui Qian, Qinkai Chen, Ye Tao, Yunfan Li, Dandan Wang, Zhizhen Hu, Weili Luo, Ping Li, Hai Yu, Changlin Mei, Xueqing Yu, Yuanfeng Zhou

“…This paper aimed to explore the long-acting erythropoiesis stimulating molecular mechanism of Pegmolesatide. Methods In vitro assays were utilized to assess Pegmolesatide erythropoietin receptor (EPOR) affinity, competitive binding, cell proliferation/survival, apoptosis, cell surface receptor expression, and signal transduction. …”
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Research on time–frequency characteristics of electromagnetic signals from coal and rock blasting based on DBO-VMD filtering by Litao WANG, Liming QIU, Menghan WEI, Dazhao SONG, Rentao GOU, Lin LIU, Shiqiang ZHONG, Tianyi XIE

“…This paper explores the use of electromagnetic radiation signals for blasting monitoring, introducing a noise reduction method for these signals and examining the time–frequency characteristics of the pure signals. …”
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Investigation of the Effects and Degradation Mechanism of Low-oxygen on the Stability of Blueberry Anthocyanins in Juice Simulation system by Zhouyang SHENG, Gengsheng XIAO, Lijuan ZHANG, Yujuan XU, Jijun WU, Yuanshan YU, Tenggen HU, Bo ZOU

“…The study aims to investigate the effect of low-oxygen conditions on the stability of anthocyanin in the simulated system of fruit juice, in hopes of providing a theoretical basis for improving the stability of anthocyanin in fruit juice.【Method】Four individual anthocyanins of blueberries (Cy-gal: cornflowerin-galactoside, Pn-glu: paeoniflorin-glucoside, Pn-ara: paeoniflorin-arabinose glycoside, Ma-gal: mallowin-galactoside) were adopted as research objects, and a citric acid buffer saline solution simulation system (pH=3.0, close to the blueberry juice system) was prepared to study the changes of anthocyanins in the juice simulation system during storage at 37℃ under nitrogen-inflated (low oxygen group) and non-nitrogen-inflated (conventional group) conditions. …”
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Bone marrow mesenchymal stem cell-derived extracellular vesicles alleviate diabetes-exacerbated atherosclerosis via AMPK/mTOR pathway-mediated autophagy-related macrophage polariza... by Libo Liu, Ziyu An, Huan Zhang, Xueqi Wan, Xin Zhao, Xueyao Yang, Jinfan Tian, Xiantao Song

“…Here, we aimed to characterize BMSC-EV-mediated regulation of autophagy and macrophage polarization. Methods EVs were isolated from the supernatant of cultured BMSCs and characterized with transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), and western blotting. …”
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Skullcapflavone II suppresses TGF-β-induced corneal epithelial mesenchymal transition in vitro by Meng-Xi Li, Zhen Zhang, Yue Zhang, Fan-Ru Zhao, Yu-Fan Li, Yu-Fei Dang, Yang-Yang Yue, Li Li

“…AIM: To investigate the effect of skullcapflavone II (SCF-II) on the epithelial-mesenchymal transition (EMT) induced by transforming growth factor beta (TGF-β) in human corneal epithelial cells (HCECs), as well as to identify the signaling pathways that may be involved. METHODS: HCECs were cultured in vitro. At a SCF-II (5, 10 µmol/L) dose, cell viability was analysed with a cell counting kit-8 (CCK-8) assay, and cell migration was monitored with wound healing and Transwell migration assays. …”
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Impacts of alfalfa nutrient concentrate on pellet physical attributes, growth performance, metabolism and nutritional quality of rainbow trout, Oncorhynchus mykiss by Hu Chen, Patrick C. Blaufuss, Dong-Fang Deng, Fabio Casu, Emma K. Kraco, Brian Shepherd, Wendy M. Sealey, Aaron M. Watson, Matthew F. Digman, Deborah A. Samac

“…Test diets contained varying ANC levels (0%, 5%, 10%, 15%, and 20%) to replace fishmeal (32% in the 0% ANC diet) to achieve equal digestible protein and were processed using a cooking extrusion method. Analysis of feed pellets showed that pellet density increased with ANC levels (P < 0.001), resulting in sinking pellets at 20% ANC. …”
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Toward a circular carbon economy: Production of green C1 compounds through high-temperature CO2 electrolysis by Nan Zheng, Jing Zhu, Haitao Zhu, Jin Xuan, Haoran Xu, Meng Ni

“…It offers insights into system design and operational strategies aimed at enhancing the safety and efficiency of these conversions. Furthermore, methods for reducing system costs and the conceptual integration of a circular economy model are explored, assessing its broader implications for sustainable development.…”
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A novel nomogram for predicting mortality risk in young and middle-aged patients undergoing maintenance hemodialysis: a retrospective study by Lei Sun, Lei Sun, Yue Zhang, Yue Zhang, Xinliang Zuo, Xinliang Zuo, Yongmei Liu

“…This research seeks to explore the critical determinants impacting mortality risk in young and middle-aged MHD patients and to construct a prediction model accordingly.MethodsThis study involved 127 young and middle-aged patients undergoing MHD in the Blood Purification Center of Chaohu Hospital of Anhui Medical University from January 2019 to January 2022. …”
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Factors associated with early childhood development: results from the Brazilian National Survey on Child Nutrition (ENANI-2019) by Gilberto Kac, Nadya Helena Alves-Santos, Dayana Rodrigues Farias, Nathalia Cristina Freitas-Costa, Raquel Scincaglia, Paula Normando, Inês Rugani, Elisa Maria de Aquino Lacerda, Sandra Crispim, Alexandra Valeria Maria Brentani, Claudia Regina Lindgren Alves

“…Introduction The full achievement of early childhood development (ECD) is a human right and adhering to the nurturing care framework may facilitate it.Objective To evaluate the association between distal and proximal variables and developmental quotient (DQ).Methods Data from 14 159 children &lt;5 years were evaluated in the Brazilian National Survey on Child Nutrition. …”
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