Psychological symptoms, quality of life and dyadic relations in family members of intensive care survivors: a multicentre, prospective longitudinal cohort study by Sumeet Rai, Dale M. Needham, Rhonda Brown, Teresa Neeman, Krishnaswamy Sundararajan, Arvind Rajamani, Rakshit Panwar, Mary Nourse, Frank M. P. van Haren, Imogen Mitchell, for the PRICE study investigators

“…The objective was to compare long-term psychological symptoms and QoL outcomes in family members of intubated versus non-intubated ICU survivors and to evaluate dyadic relationships between paired family members and survivors. Methods Prospective, multicentre cohort study among four medical-surgical ICUs in Australia. …”
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The Role of Bronchoalveolar Lavage in Therapeutic Antimicrobial Choices for Hematologic Patients with Pulmonary Infiltrates by Filippo Patrucco, Mattia Bellan, Davide Martinotti, Giuseppe Ielo, Paola Rebecca Iovine, Martina Mascheroni, Francesco Todisco, Martina Ubaldi, Nadia Castaldo, Francesco Gavelli, Alberto Fantin

“…This study aimed to determine the diagnostic yield of BAL in hematological patients for microbiological purposes and its influence on modifying the therapeutic strategy. <i>Material and Methods:</i> This multicenter, retrospective, observational study included data from 193 consecutive patients from two centers from January 2020 to October 2022. …”
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Geographic variation in modern contraceptive utilization among women of reproductive age in Mozambique: a multilevel analysis by Habtu Kifle Negash, Destaye Tirite Gelaw, Mihret Getnet, Hiwot Tezera Endale, Tseganesh Asefa, Fethiya Seid Hasen, Yihun Tefera Ayenew, Nebebe Demis Baykemagn, Trualem Zeleke Yehuala, Winta Tesfaye

“…This study investigates geographic variation in contraceptive use and the individual, community, and regional factors influencing it to guide equitable family planning interventions. Methods This study utilized data from the 2022/23 Mozambique Demographic and Health Survey, analyzing a weighted sample of 9,316 women aged 15–49. …”
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The miR-1269a/PCDHGA9/CXCR4/β-catenin pathway promotes colorectal cancer invasion and metastasis by Haitao Mei, Qingshan Luo, Junyong Weng, Jialing Hao, Jinfeng Cai, Runkai Zhou, Ce Bian, Yingzi Ye, Shengzheng Luo, Yugang Wen

“…This research focuses on investigating the impact and underlying molecular mechanisms of protocadherin gamma subfamily A, 9 (PCDHGA9) on the invasion and metastasis of CRC, aiming to identify more precise molecular markers for the diagnosis and prognosis of CRC. Methods PCDHGA9 expression was detected using quantitative real-time quantitative polymerase chain reaction (RT-qPCR) in 63 pairs of colorectal cancer tissues. …”
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Surgical nonunion treatment of large-sized defects of femur and tibia based on the diamond concept by Sebastian Findeisen, Louis Mennerat, Thomas Ferbert, Lars Helbig, Tim N. Bewersdorf, Tobias Großner, Christian Schamberger, Gerhard Schmidmaier, Michael Tanner

“…Aims: The aim of this study was to evaluate the radiological outcome of patients with large bone defects in the femur and tibia who were treated according to the guidelines of the diamond concept in our department (Centre for Orthopedics, Trauma Surgery, and Paraplegiology). Methods: The following retrospective, descriptive analysis consists of patients treated in our department between January 2010 and December 2021. …”
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Sex-related functional outcome after periacetabular osteotomy in mild to severe hip dysplasia by Maximilian Fischer, Lars Nonnenmacher, Andre Hofer, Alexander Zimmerer, Andreas Nitsch, Rico Großjohann, Sabrina Erdmann, Georgi I. Wassilew

“…Therefore, this study aimed to analyze the functional outcome and activity level in relation to patient sex with a minimum follow-up of two years after PAO for mild to severe hip dysplasia. Methods: A single-centre study was conducted, enrolling patients undergoing PAO and completing a preoperative and postoperative radiological and clinical outcome assessment. …”
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Impaired creatinine-based estimated glomerular filtration rate in Thai individuals switching to dolutegravir: illustrating the role of cystatin C testing to aid clinical decision m... by Carlo Sacdalan, Curtis Austin, Aswathy Varma, Suteeraporn Pinyakorn, Eugène Kroon, Donn J. Colby, Phillip Chan, Orlanda Goh, Krittaporn Pornpaisakul, Jintana Intasan, Tassanee Luekasemsuk, Merlin L. Robb, Nitiya Chomchey, Nittaya Phanuphak, Jintanat Ananworanich, Sandhya Vasan, Denise Hsu, the SEARCH 010/RV254 study group

“…RV254/SEARCH010 is a prospective observational cohort in Bangkok, Thailand with ART initiation during acute HIV infection (AHI) where participants switched to DTG-based ART. Methods Participants started Efavirenz (EFV)-based ART during AHI (n = 214) and switched to DTG-based ART after a median of 97 weeks (IQR 61–145). …”
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Loss of histone H3K27me3 up-regulates SLC7A11 in diffuse gastric cancer cells by REN Yuanfeng, LIU Wenkang, CHU Zhaole

“…Objective‍　‍To map the genome-wide distribution profile of histone H3K27me3 modification in diffuse gastric cancer tissues， identify target genes regulated by H3K27me3， and primarily explore the potential mechanism of its modification reprogramming in the occurrence and development of the tumor. Methods‍　‍Normal gastric mucosal tissues and diffuse gastric cancer tissues were harvested from the patients who underwent examinations or treatments in the departments of gastroenterology and gastrointestinal surgery of our medical center between 2021 and 2023. …”
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Penerapan Metode Association Rule Mining untuk Asosiasi Ulasan Terhadap Aspek Tempat Wisata Jawa Timur Park 3 by Aisyatul Maulidah, Fitra A. Bachtiar

“…The Association Rule Mining (ARM) technique is a text mining method that can support the knowledge discovery process in large document collections. …”
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The state of paediatric deceased-organ donation at a South African tertiary public- sector hospital: A 14-year analysis by T Siyotula, J Barrell, K Manning, D Thomson, M McCulloch, T du Toit

“…To identify in-hospital barriers to organ donation and gain a better understanding of the paediatric donor landscape. Methods. A retrospective descriptive study of consecutive deceased-donor referrals at Red Cross War Memorial Children’s Hospital over a 14-year period, from 1 January 2007 to 31 December 2020. …”
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Cloning and Expression Characteristics of BhARF4 Gene in Wax Gourd (Benincasa hispida) by Xiaoxin CHENG, Xuling ZHAI, Jinqiang YAN, Baochen WANG, Renliang MO, Wenrui LIU, Zhiming WU, Biao JIANG

“…【Objective】The ARF4 gene of wax gourd (Benincasa hispida) was cloned and its expression patterns in different tissues were studied by bioinformatics analysis, thereby providing a reference for further exploration of the function of BhARF4 in the development of wax gourd fruits.【Method】With the cDNA of the fruits of B227 on the day of flowering as template, specific cloning primers were designed according to the CDS sequence of BhARF4 in the reference gene. …”
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Diagnostic Value of Sodium, White Blood Cell, Neutrophil Levels; White Blood Cell/Sodium and Neutrophil/Sodium Ratios in Appendicitis in Pediatric Patients by Cem Kaya, Gökhan Arkan, Fatma Nur Aracıer Uçaner, Leyla Nur Türker, Alparslan Kapısız, Ramazan Karabulut, Zafer Türkyılmaz, Kaan Sönmez

“…This study aimed to evaluate the relationship between serum sodium levels, WBC and neutrophil counts, and their respective ratios with the diagnosis and severity of appendicitis. Methods: This retrospective analysis included 176 pediatric patients who underwent appendectomy. …”
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Antimicrobial Profiling of Bacteria Isolated from Fish Sold at Informal Market in Mufakose, Zimbabwe by Claudious Gufe, Tinashe Canaan Hodobo, Bernard Mbonjani, Otlia Majonga, Jerikias Marumure, Shuvai Musari, Gilbert Jongi, Pious Vengesayi Makaya, Jairus Machakwa

“…A cross-sectional study was carried out to (i) isolate and phenotypically identify bacteria from 36 fish samples from informal market in Mufakose, Harare, and (ii) determine the antibiotic sensitivity pattern of the isolated bacteria against ten available antibiotics (ampicillin 10 μg, gentamycin 30 μg, penicillin G 10 μg, erythromycin 15 μg, tetracycline 30 μg, kanamycin 30 μg, neomycin 10 μg, cloxacillin 5 μg, lincomycin 15 μg, and sulfamethoxazole 25 μg) using the Kirby–Bauer disk agar diffusion method. Eight bacterial genera were isolated and identified, and they were Escherichia, Aeromonas, Staphylococcus, Pseudomonas, Citrobacter, Klebsiella, Enterobacter, and Proteus. …”
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Smartphone-Based Telemonitoring for Better Oral Health With Toothbrushes: 6-Month Randomized Controlled Trial by Jaeyeon Kim, Yiseul Choi, Yoolbin Song, Wonse Park

“…ObjectiveThis 6-month prospective randomized controlled trial aimed to compare the clinical effectiveness, defined as improved oral hygiene measured by plaque reduction and halitosis control, of an interactive telemonitoring toothbrush (ITT), an oscillating-rotating power toothbrush (ORT), and a manual toothbrush (MT). MethodsParticipants were recruited offline from the Department of Advanced General Dentistry at Yonsei University Dental Hospital, South Korea. …”
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Ruthenium(II) Complex with 1-Hydroxy-9,10-Anthraquinone Inhibits Cell Cycle Progression at G0/G1 and Induces Apoptosis in Melanoma Cells by Júlia S. M. Dias, Guilherme A. Ferreira-Silva, Rommel B. Viana, João H. de Araujo Neto, Javier Ellena, Rodrigo S. Corrêa, Marília I. F. Barbosa, Marisa Ionta, Antônio C. Doriguetto

“…Objectives: Thus, two new ruthenium complexes with 1-hydroxy-9,10-anthraquinone were obtained: <i>trans-</i>[Ru(HQ)(PPh₃)₂(bipy)]PF₆ (<b>1</b>) and <i>cis-</i>[RuCl₂(HQ)(dppb)] (<b>2</b>), where HQ = 1-hydroxy-9,10-anthraquinone, PPh₃ = triphenylphospine, bipy = 2,2′-bipyridine, PF₆ = hexafluorophosphate, and dppb = 1,4-bis(diphenylphosphine)butane. Methods: The complexes were characterized by infrared (IR), UV–vis, ¹H, ¹³C{¹H}, and ³¹P{¹H} NMR spectroscopies, molar conductivity, cyclic voltammetry, and elemental analysis. …”
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Injectable Nanocomposite Hydrogel for Accelerating Diabetic Wound Healing Through Inflammatory Microenvironment Regulation by Chen Y, Li Y, Song H, Liu X, Zhang H, Jiang J, Liu H, Zhuo R, Cheng G, Fang J, Xu L, Qi Y, Sun D

“…Employing zeolitic imidazolate framework-8 (ZIF-8) as a drug delivery platform, integrated within a temperature-sensitive injectable hydrogel, presents an intriguing strategy for the closure of various irregular wounds, modulation of inflammatory responses, and promotion of angiogenesis.Methods: Herein, ZIF-8 loaded with curcumin (Cur) combined with methylcellulose/carboxymethyl chitosan (MCC) thermosensitive hydrogel was described. …”
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Gαi1/3 signaling mediates IL-5-induced eosinophil activation and type 2 inflammation in eosinophilic chronic rhinosinusitis by Huanxia Xie, Jiang Ji, Zhichen Liu, Ning Lu, Yuqian Wei, Aina Zhou, Jisheng Liu, Qingqing Jiao, Qingqing Jiao

“…Whether Gαi1/3 proteins have a role in the development of eCRS remains unknown.ObjectivesTo investigate the association between Gαi1/3 expression levels and CRS and the underlying mechanismsMethodsWestern blotting and immunohistology were used to detect Gαi1/3 expression. …”
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IMPLEMENTASI GREEN LIVING SEBAGAI UPAYA MENINGKATKAN SIKAP PEDULI LINGKUNGAN DI SEKOLAH ADIWIYATA (SMPN 2 SOLEAR KAB. TANGERANG) by Rizkia Suciati, Siti Djulaiha Ika Capricanilia

“…Technical analysis using descriptive qualitative analysis methods (data collection, data presentation, and conclusion). …”
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Exome sequencing reveals a rare damaging variant in GRIN2C in familial late-onset Alzheimer's disease by Elisa Rubino, Maria Italia, Elisa Giorgio, Silvia Boschi, Paola Dimartino, Tommaso Pippucci, Fausto Roveta, Clara Maria Cambria, Gabriella Elia, Andrea Marcinnò, Salvatore Gallone, Ekaterina Rogaeva, Flavia Antonucci, Alfredo Brusco, Fabrizio Gardoni, Innocenzo Rainero

“…This study investigates a large Italian family with late-onset autosomal dominant AD, identifying a novel rare missense variant in GRIN2C gene associated with the disease, and evaluates the functional impact of this variant. Methods Affected and unaffected members from a Northern Italian family were included. …”
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Impact of First- and Second-Generation Tyrosine Kinase Inhibitors on the Development of Graft-Versus-Host Disease in Individuals with Chronic Myeloid Leukemia: A Retrospective Anal... by Ugo Giordano, Agnieszka Piekarska, Witold Prejzner, Lidia Gil, Jan Maciej Zaucha, Joanna Kujawska, Zuzanna Dybko, Krzysztof Dudek, Sebastian Giebel, Jarosław Dybko

“…<b>Objectives</b>: The main endpoint of our research was to assess the impact of prior TKI treatment on acute graft-versus-host disease (aGvHD) and chronic graft-versus-host disease (cGvHD). <b>Methods</b>: In our retrospective analysis, we included 240 patients treated between 1993 and 2013 and divided them into three groups according to the therapy administered prior to haploidentical, matched-related, or matched-unrelated donor allo-HCT (imatinib group <i>n</i> = 41, dasatinib/nilotinib group <i>n</i> = 28, TKI-naïve group <i>n</i> = 171). …”
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