Physicians’ Perceptions of the Quality of Palliative Care and of the Importance of Collaboration in Interdisciplinary Teams in Norwegian Nursing Homes by Skomakerstuen Ødbehr L, Hov R, Sanaker H, Sandsdalen T

“…The aim of the study was thus to investigate physicians’ perceptions of factors that influence the quality of palliative care in Norwegian nursing homes and their descriptions of the importance of the team’s collaboration.Materials and Methods: The study has a qualitative research design based on interviews with twelve nursing home physicians in Eastern Norway. …”
Get full text

Keamanan Data Menggunakan Secure Hashing Algorithm (SHA)-256 dan Rivest Shamir Adleman (RSA) pada Digital Signature by Juniar Hutagalung, Puji Sari Ramadhan, Sarah Juliana Sihombing

“…After using the SHA-256 and RSA methods, the final result is "09C6423CF09C9E61BC09B29966DE6CB569A7DE2C4349FA2B52F 08EF39D07140F". …”
Get full text

Phenotypic and Genotypic Characterization of Extended Spectrum Beta-Lactamase-Producing Clinical Isolates of Escherichia coli and Klebsiella pneumoniae in Two Kenyan Facilities: A... by Sylvia M. Maveke, Gabriel O. Aboge, Laetitia W. Kanja, Alfred O. Mainga, Naftaly Gachau, Beatrice W. Muchira, Gervason A. Moriasi

“…The aim of this study was to assess the phenotypic and genetic determinants of antimicrobial resistance of ESBL-producing Escherichia coli and Klebsiella pneumoniae isolates from patient samples in two Kenyan Hospitals. Methods. We collected 138 E. coli and 127 K. pneumoniae isolates from various clinical specimens at the two health facilities from January 2020 to February 2021. …”
Get full text

Identification of key miRNAs and target genes in extracellular vesicles derived from low-intensity pulsed ultrasound-treated stem cells by Xin Yin, Xin Yin, Jialian Yi, Fugang Mao, Qisheng Tang, Xinyu Zhang, Xiaoyu Yang, Hongqing Xie, Linping Wang, Shuifen Sun, Xin Yu, Xin Yu, Jie Liu, Lihong Jiang, Lihong Jiang

“…Specifically, it sought to identify key miRNAs and their target mRNAs associated with enhanced therapeutic efficacy in LIPUS-treated stem cell-derived EVs.MethodsUtilizing miRNA deep-sequencing data from the Gene Expression Omnibus database, differential gene analysis was performed. …”
Get full text

Perceptions paysannes de la dynamique des parcours naturels et stratégies d’adaptation dans la vallée du Mandoul au Tchad by Terei Massa Mabilo, Ali Brahim Bechir, Adi Mama, Koussou Mian Oundanang, Sedjro Antoine Tranquillin Affossogbe, Luc Hippolyte Dossa

“…Objectif : La présente étude a eu pour objectifs de cerner les perceptions par les éleveurs de la vallée du Mandoul au Tchad des changements climatiques et de leurs incidences sur les pâturages, et de comprendre les stratégies d’adaptation de ces éleveurs. Méthodes : Cette analyse s’est appuyée sur le diagnostic agropastoral. …”
Get full text

Knowledge, Attitude, and Barriers Influencing Seasonal Influenza Vaccination Uptake by Mazin A. Barry, Khalid I. Aljammaz, Abdulaziz A. Alrashed

“…To measure the influenza vaccine uptake among residents of Riyadh Province, Saudi Arabia, that determines their attitude, knowledge, and beliefs regarding the vaccine. Methods. A cross-sectional study was conducted using a self-administered structured questionnaire distributed online targeting residents of Riyadh Province, Saudi Arabia, from 1st of August 2019 till 30th of September 2019. …”
Get full text

Construction of a diagnostic model for chronic mountain sickness among young male migrants to high-altitude areas by ZHANG Quan, CHEN Jian, LIU Bao

“…Objective‍　‍To analyze the risk factors for chronic mountain sickness （CMS） in young male migrants living in high-altitude areas and to construct a diagnostic model and evaluate its diagnostic efficacy. Methods‍　‍From June 10 to December 29， 2023， a cross-sectional study was conducted on young male migrants subjected with convenience sampling who had been living in high-altitude areas （4 500~5 000 m） for 6 months or longer. …”
Get full text

Feasibility and Acceptability of Antenatal Hepatitis C Screening: A Pilot Study by Joseph Valamparampil, Jaswant Sira, Maxine Brown, Saket Singhal, Deirdre Kelly

“…The aim of this study was to collect qualitative data on the feasibility and acceptability of antenatal HCV screening in pregnant women at the time of routine antenatal screening at 12 weeks, to estimate patient knowledge about HCV and identify the prevalence of HCV infection in antenatal women. Methods. This was a pilot study targeting a single hospital-based antenatal clinic in Birmingham, initially conducted for eight weeks with a further extension of the study period to enhance recruitment to meet the feasibility target of 500 patients. …”
Get full text

Rat Model of Cystic Neutrophilic Granulomatous Mastitis by Corynebacterium Kroppenstedtii by Wang M, Zeng Y, Liu M, Zhang D, Zhao D, Wang J, Liu Y, Zhao W

“…Developing an appropriate animal model will help further study the pathogenesis of CNGM.Methods: Seventy-two rats were randomly assigned to seven groups: group A (n=12, tissue suspension 0.2mL), group B (n=12, 1× 10^8 CFU/mL Corynebacterium kroppenstedtii (CK) suspension 0.1mL), group C (n=12, 1× 10^9 CFU/mL CK suspension 0.1mL), group D (n=12, tissue suspension 0.1mL + 1× 10^8 CFU/mL CK suspension 0.1mL), group E (n=12, tissue suspension 0.1mL + 1× 10^9 CFU/mL CK suspension 0.1mL), group F (n=6, phosphate buffer saline solution 0.1mL), and group G (n=6, physiological saline 0.1mL + Complete Freund’s adjuvant suspension 0.1mL). …”
Get full text

Digital Surveillance of Mental Health Care Services in Saudi Arabia: Cross-Sectional Study of National e-Referral System Data by Abdullah A Alharbi, Nawfal A Aljerian, Meshary S Binhotan, Hani A Alghamdi, Ali K Alsultan, Mohammed S Arafat, Abdulrahman Aldhabib, Yasser A Alaska, Eid B Alwahbi, Mohammed A Muaddi, Ahmad Y Alqassim, Ronnie D Horner

“…This study also aims to demonstrate how digital health technology can inform and improve mental health care delivery and policy making. MethodsThis retrospective, cross-sectional study used secondary data from SMARC on 10,033 psychiatric e-referrals in Saudi Arabia during 2020‐2021. …”
Get full text

Non-small Cell Lung Cancer Cell Line PC-9 Drug-resistant Mutant Cell Line 
Establishment and Validation of Their Sensitivity to EGFR Inhibitors by Tao HU, Yang LOU, Mingbo SU

“…This model aims to investigate the inhibitory effects of small-molecule EGFR-TKIs and to provide a cellular platform for developing a new generation of innovative drugs that target resistance associated with EGFR mutations. Methods Clustered regularly interspaced short palindromic repeats/CRISPR-associated nuclease 9 (CRISPR/Cas9) technology was employed to knock in the EGFRT790M/C797S mutant fragment into NSCLC PC-9 cells, originally harboring the EGFRD19 mutation, to generate the PC-9 EGFRD19/T790M/C797S cell model. …”
Get full text

Occupational exposures and coronary heart disease in the Hamburg City Health Study (HCHS) – a cross-sectional study by Franziska Labe, Raphael Twerenbold, Betül Toprak, Peter Koch, Birgit-Christiane Zyriax, Sarah Affolderbach, Lukas Damerau, Hanno Hoven, Hajo Zeeb, Robert Herold, Volker Harth

“…The aim of this study is to identify occupations that are associated with CHD and to elaborate on occupational exposures associated with CHD by using the job exposure matrix (JEM) BAuA-JEM ETB 2018 in a German study population. Methods Cross-sectional data from 8,070 participants, members of the first sub-cohort of the Hamburg City Health Study (HCHS), was used. …”
Get full text

Survey Report Analysis on Parasitic and Microbial Quality of Laboratory Animals in Sichuan Province, 2017-2023 by LIU Lida, CHEN Bing, XIE Na, LIU Li, ZHUANG Siqi, ZOU Yixing

“…ObjectiveTo provide reference for further strengthening the management of laboratory animals in Sichuan Province by reviewing and analyzing the results of parasitic and microbial quality inspections of laboratory animals from 2017 to 2023. Methods Sichuan Province has 31 licensed laboratory animal production units, with the main species including mice, rats, guinea pigs, rabbits, dogs, monkeys, and pigs. …”
Get full text

NPT100-18A rescues mitochondrial oxidative stress and neuronal degeneration in human iPSC-based Parkinson’s model by Julian E. Alecu, Veronika Sigutova, Razvan-Marius Brazdis, Sandra Lörentz, Marios Evangelos Bogiongko, Anara Nursaitova, Martin Regensburger, Laurent Roybon, Kerstin M. Galler, Wolfgang Wrasidlo, Beate Winner, Iryna Prots

“…NPT100-18A and structurally similar compounds (such as NPT200-11/UCB0599, currently being assessed in clinical studies) point towards a promising new approach for disease-modification. Methods Induced pluripotent stem cell (iPSC)-derived mDANs from PD patients with a monoallelic SNCA locus duplication and unaffected controls were treated with NPT100-18A. αSyn aggregation was evaluated biochemically and reactive oxygen species (ROS) levels were assessed in living mDANs using fluorescent dyes. …”
Get full text

Hubungan Kualitas Tidur dengan Prestasi Akademik Mahasiswa Program Studi Pendidikan Dokter Angkatan 2010 FK Universitas Andalas by Hanafi Nilifda, Nadjmir ., Hardisman .

“…</em><em>This research used analytic methods with cross sectional design. Total of 177 respondents were selected by random sampling technique. …”
Get full text

Prognostic factors in patients with localized and metastatic alveolar rhabdomyosarcoma. A report from two studies and two registries of the Cooperative Weichteilsarkom Studiengrupp... by Ewa Koscielniak, Sabine Stegmaier, Gustaf Ljungman, Bernarda Kazanowska, Felix Niggli, Ruth Ladenstein, Bernd Blank, Erika Hallmen, Christian Vokuhl, Claudia Blattmann, Monika Sparber‐Sauer, Thomas Klingebiel

“…The objective of this analysis was to evaluate survival outcomes of patients with localized and metastatic aRMS and its association with fusion status and subtype (PAX3/7::FOXO1, FOXO1 break), and clinical prognostic factors. Methods A total of 470 patients with aRMS ≤21 years of age enrolled in two CWS‐trials and two registries was eligible for the analysis. …”
Get full text

Voxelwise characterization of noise for a clinical photon-counting CT scanner with a model-based iterative reconstruction algorithm by Luigi Masturzo, Patrizio Barca, Luca De Masi, Daniela Marfisi, Antonio Traino, Filippo Cademartiri, Marco Giannelli

“…This study aimed to carry out a voxelwise noise characterization for a clinical PCD-CT scanner with a model-based iterative reconstruction algorithm (QIR). Methods Forty repeated axial acquisitions (tube voltage 120 kV, tube load 200 mAs, slice thickness 0.4 mm) of a homogeneous water phantom and CTP404 module (Catphan-504) were performed. …”
Get full text

Krebs von den Lungen-6 surveillance in immune checkpoint inhibitor-induced pneumonitis by Isamu Okamoto, Kazuya Tsubouchi, Ryosuke Matsukane, Shoji Nakamura, Haruna Minami, Yasuto Yoneshima, Kojiro Hata, Sai Yasukochi, Kimitaka Suetsugu, Takeshi Hirota

“…We evaluated the feasibility of using Krebs von den Lungen-6 (KL-6), a marker for interstitial pneumonitis, as a screening tool for pneumonitis.Methods We examined 500 patients with cancer divided into two groups: those with cancer other than non-small cell lung cancer (NSCLC) (Group 1, n=382) and those with NSCLC (Group 2, n=118). …”
Get full text

Evaluation of primary HPV-based cervical screening among older women: Long-term follow-up of a randomized healthcare policy trial in Sweden. by Qingyun Yao, Jiangrong Wang, K Miriam Elfström, Björn Strander, Joakim Dillner, Karin Sundström

“…We conducted a long-term follow-up of the first phase of a randomized healthcare policy trial in cervical screening, targeting women aged 56 to 61 years old, to investigate the effectiveness of primary HPV-based screening in preventing invasive cervical cancer (ICC) and the safety of extending screening interval.<h4>Methods and findings</h4>The randomized healthcare policy trial of primary HPV-based cervical screening targeted women residing in Stockholm-Gotland region during 2012 to 2016, aged 30 to 64 years. …”
Get full text

Probiotic Bacillus pumilus LV149 enhances gut repair, modulates microbiota, and alters transcriptome in DSS-induced colitis mice by Xinyu Sun, Long Yun, Keming Xie, Renhui Liu, Xinyue Ren, Bokun Zeng, Xudong Cao, Zhi Li, Guihao Zhou, Bang Liu, Luo Peng, Lihong Yuan

“…This study evaluated the effects of different doses of Bacillus pumilus LV149, an aquatic-derived probiotic, on gut injury repair in male C57BL/6 mice with dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) and investigated the underlying mechanisms.MethodsUC was induced by allowing mice free access to a 3% DSS solution for 7 days, with concurrent daily oral gavage of either a low (LV149-L, 1 × 108 CFU/day/mouse) or high (LV149-H, 1 × 109 CFU/day/mouse) dose of LV149. …”
Get full text