Intratumoral BO-112 in combination with radiotherapy synergizes to achieve CD8 T-cell-mediated local tumor control by Helena Escuin-Ordinas, Ignacio Melero, Marisol Quintero, Jose Luis Perez-Gracia, Maite Alvarez, Maria E Rodriguez-Ruiz, Miguel F Sanmamed, Paloma Sanchez-Mateos, Inmaculada Rodríguez López, Irantzu Serrano-Mendioroz, Celia Barrio-Alonso, Eneko Garate-Soraluze, Victor Diaz Pascual, Leire Arbea Moreno

“…BO-112 and focal irradiation were used to make the proof-of-concept for local immunotherapy plus radiation therapy combinations.Methods Murine transplantable tumor cell lines (TS/A, MC38 and B16-OVA) were used to show increased immunogenic features under irradiation, as well as in bilateral tumor models in which only one of the lesions was irradiated or/and injected with BO-112. …”
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Effects of population aging on quality of life and disease burden: a population-based study by Jun-Yan Xi, Bo-Heng Liang, Wang-Jian Zhang, Bo Yan, Hang Dong, Yuan-Yuan Chen, Xiao Lin, Jing Gu, Yuan-Tao Hao

“…Therefore, our study proposed to develop a systematic attribution framework to comprehensively evaluate the health impacts of population aging. Methods We used health-adjusted life expectancy (HALE) to measure quality of life and disability-adjusted life years (DALY) to quantify the burden of disease for the population of Guangzhou. …”
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Optimization and Evaluation of Conditions for Orthotopic Nude Mouse Models of Human Liver Tumor Cells by MENG Yu, LIANG Dongli, ZHENG Linlin, ZHOU Yuanyuan, WANG Zhaoxia

“…Objective The study aims to optimize the conditions for constructing orthotopic nude mouse models of liver cancer by injecting human liver tumor cell lines and to explore appropriate timings for drug administration. Methods Human hepatocellular carcinoma Hep3B and hepatoblastoma HepG2 cell lines, which stably expressing the luciferase reporter gene (LUC), were selected. …”
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Beta-hydroxy-beta-methylbutyrate (HMB) improves daily activity and whole-body protein metabolism in Duchenne muscular dystrophy dogs: a pilot study by Peter P. Nghiem, Alexis M. Rutledge, Kyle Tehas, Corine Kaderli, Meredith Poling, Sidney Arnim, Vitaliy Dernov, Celine van Sas, Macie L. Mackey, Gabriella A. M. ten Have, Mariëlle P. K. J. Engelen, Nicolaas E. P. Deutz

“…In this pilot study, we studied the effect of daily supplementation of the anabolic substrate beta-hydroxy-beta-methylbutyrate (HMB) on whole body protein and amino acid kinetics using novel isotope methods and daily activity in a canine model of DMD. …”
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TiMON: a real-time integrated monitor for improving the placement and wear of emergency tourniquets by John Quan Nguyen, Avery Goss, Helen Keshishian, Francis Berchard, Jonathan Parks, Conor Evans

“…Here, we present the results of two studies in which the TiMON was tested among a group of soldiers participating in the Army Expeditionary Warrior Experiments (AEWE) as well as in a group of untrained civilians from Massachusetts General Hospital. Methods In the first study, 30 soldiers with prior tourniqueting experience were asked to apply a TiMON equipped CAT tourniquet onto a leg mannequin with (unblinded) and without (blinded) assistance from the TiMON’s output. …”
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Effect of sun dry brewer spent yeast on chemical composition, in vitro digestibility, and ruminal degradation kinetics of wheat straw by Geberemariyam Terefe, Mulugeta Walelgne, Dereje Fekadu, Getu Kitaw, Mesfin Dejene, Aeimro Kehaliu, Bethlehem Mekonnen, Yohannse Habteyesus

“…This study was conducted to evaluate the effect of DBSY on the chemical composition, in vitro digestibility, and in situ degradability of wheat straw (WS). Methods Liquid brewer spent yeast (BSY) and water was mixed at a ratio of 1:5, respectively. …”
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Evaluation of the Efficacy of Stem Cell Therapy in Ovariectomized Osteoporotic Rats Based on Micro-CT and Dual-Energy X-Ray Absorptiometry: A Systematic Review and Meta-Analysis by Zhencheng Xiong, Ping Yi, Jialiang Lin, Shengfeng Qiu, Li Shu, Chi Zhang

“…The purpose of this work is to carry out a systematic review and meta-analysis of the efficacy of stem cell therapy in ovariectomized (OVX) osteoporotic rats. Methods. PubMed, Cochrane Library, ScienceDirect, Embase, CNKI, and Wanfang Databases were used to search for articles that met the inclusion criteria. …”
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Comprehensive coronary CT angiography in people living with HIV: a systematic review and meta-analysis by Binh T Nguyen, Edward Hulten, Venkatesh L Murthy, Tarin Phillips, Gregory M Blake, Jonathan A Aun, Lisa M Conte, Ritika Gadodia, Aakash Tuli, Sara L Robinson, Travis E Harrell

“…This systematic review and meta-analysis summarise and estimate pooled effect sizes for observational studies among PLWH using comprehensive coronary CT angiography (CTA).Design Preferred Reporting Items for Systematic Review and Meta-analysis reporting guidelines were used.Data sources PubMed, Embase, Web of Science, CINAHL, Cochrane Clinical Trials and EBM were searched from inception to 23 February 2024.Eligibility criteria We included studies evaluating coronary atherosclerosis in adult PLWH with controls and CTA results for plaque prevalence, extent, severity and high-degree stenosis.Data extraction and synthesis Two independent reviewers used standardised methods to screen for relevance by title, abstract and full-text review. …”
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Influencing factors of survival rate after replantation of severed palm and fingers and related nursing strategies (断指断掌再植术后成活率影响因素分析及护理对策)... by WEI Suhui (韦素惠), MO Julian (莫菊莲), TENG Lichu (滕立初)

“…Objective To investigate the influencing factors of survival rate after replantation of severed palm and fingers and related nursing strategies. Methods The clinical data of 68 patients undergoing replantation of severed palm or severed finger were retrospectively analyzed. …”
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Network Design and Route Analysis Using Outside Plant by Isaac Adjaye Aboagye, Nii Longdon Sowah, Wiafe Owusu-Banahene, Aryee Shaelijah, Margaret Ansah Richardson, Emmanuel Baah-Boadi

“…A high-level design was produced to realize the optimum structural design and implementation of the backend framework of the fiber system. This method helped to tidy the utility corridors and tackle the problem associated with improper planning and design of passive OSP routes. …”
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Short-term variability of Alzheimer’s disease plasma biomarkers in a mixed memory clinic cohort by Frederikke Kragh Clemmensen, Mathias Holsey Gramkow, Anja Hviid Simonsen, Nicholas J. Ashton, Hanna Huber, Kaj Blennow, Henrik Zetterberg, Gunhild Waldemar, Steen Gregers Hasselbalch, Kristian Steen Frederiksen

“…In this study we investigated short-term intra- and inter-individual variability of AD biomarkers in the intended use population, memory clinic patients. Methods In a consecutive sample of memory clinic patients (AD n = 27, non-AD n = 20), blood samples were collected on three separate days within a period of 36 days and analysed for plasma Aβ40, Aβ42, p-tau181, p-tau217, p-tau231, T-tau, neurofilament light (NfL), and glial fibrillary acidic protein (GFAP). …”
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Risk of neonatal SARS-CoV-2 infection: a retrospective cohort study based on infected mothers with gestational diabetes mellitus by Jing Ni, Yongfei Zheng, Jiaqi Tian, Jiaqi Tian, Jiaqi Tian, Lin Zhang, Lin Zhang, Lin Zhang, Shuyin Duan

“…However, little is known about the impact of maternal SARS-CoV-2 infection on neonatal outcomes, particularly in the context of coexisting gestational diabetes mellitus (GDM).MethodsHospitalized pregnant women with SARS-CoV-2 infection were retrospectively enrolled between November 2022 and January 2023, and matched with pregnant subjects free of SARS-CoV-2 infection based on their propensity scores. …”
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Modelling the health, financial protection and equity impacts of upscaling the ACT NOW early intervention breast cancer pilot program in the Philippines: an extended cost-effective... by Blake Angell, Stephen Jan, Mark Woodward, Sanne Peters, Merel Kimman, Alexander Chye, Nirmala Bhoo Pathy, Herdee Gloriane C Luna, Soledad B Lim, Helen Monaghan, Corazon A Ngelangel

“…This study aims to model the health and economic impacts of ACT NOW (a pilot breast cancer programme that navigates women through free early detection to treatment) through an extended cost-effectiveness analysis.Methods A microsimulation decision tree model was used to model the ACT NOW intervention (including annual clinical breast examination (CBE) and biannual breast ultrasound for women at high risk of breast cancer) over 5 years for healthy women 40–69 years old. …”
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The Multifaceted Roles of Myrrha in the Treatment of Breast Cancer: Potential Therapeutic Targets and Promises by Anwar Shams MD, MSc, PhD, Abdullah Ahmed Alzahrani, Taghreed A Ayash MSc, PhD, Shadi Tamur MD, FRCPC, FAAP, Majed AL-Mourgi MD, FRCS, FCCP, FACS

“…Purpose: Herein, we use a network pharmacology platform to identify the potential genes targeted by myrrh-active molecules in breast cancer. Method: The identified targets’ expression profiles were determined at the mRNA and protein levels using The Breast Cancer Gene-Expression Miner v5.0 (bcGen-ExMiner v5.0) and The Human Protein Atlas datasets, respectively. …”
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Proton therapy versus conventional radiotherapy for the treatment of cavernous sinus benign meningioma, a randomized controlled phase III study protocol (COG-PROTON-01) by Paul Lesueur, Benedicte Clarisse, Justine Lequesne, Idlir Licaj, Loic Feuvret, Dinu Stefan, Damien Ricard, Georges Noel, Jacques Balosso, Marie Lange, Aurelie Capel, Isabelle Durand-Zaleski, Marie Castera, Berenice Legrand, Nicolas Goliot, Camille Hedou, Jean Michel Grellard, Samuel Valable

“…Thus, according to its ballistic advantage, an improvement of patient functional outcomes and a reduction of neurocognitive long-term toxicity are expected if tissue sparing proton-therapy is used .Randomized trial seems crucial to further assess proton-therapy indication for patients with cavernous sinus meningioma. Methods COG-PROTON-01 is the first worldwide randomized phase III prospective study evaluating long-term toxicity of these two irradiation modalities (PRT and XRT)for the treatment of cavernous sinus meningioma. …”
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Effects of Exergaming on Morphological Variables, Biochemical Parameters, and Blood Pressure in Children and Adolescents with Overweight/Obesity: A Systematic Review with Meta-Anal... by Jordan Hernandez-Martinez, Joaquín Perez-Carcamo, Hassan Melki, Izham Cid-Calfucura, Edgar Vasquez-Carrasco, Pedro Delgado-Floody, Claudio Romero, Tomás Herrera-Valenzuela, Braulio Henrique Magnani Branco, Pablo Valdés-Badilla

“…Objectives: This systematic review with meta-analysis aimed to evaluate the available body of published peer-reviewed studies on the effects of exergaming (EXG) compared to the control group (CG) on morphological variables, biochemical parameters, and blood pressure in children and adolescents with overweight/obesity. Methods: A systematic literature search was conducted until September 2024 using five databases: PubMed, Medline, CINAHL Complete, Scopus, and Web of Science. …”
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A meta-analysis of the effects of acupuncture on limb function, depression and quality of life in stroke patients (针灸对卒中患者肢体功能、抑郁症状和生活质量影响的Meta分析)... by LEI Hong (雷宏), SUN Xinyu (孙新雨), LANG Yanru (郎艳茹), YIN Anchun (尹安春)

“…Objective To evaluate the effects of acupuncture on physical function, depression and quality of life in stroke patients. Methods A systematic search of the publicly available databases such as the Cochrane Library, PubMed, Embase, China Knowledge Network (CNKI), Wan Fang Data, VIP Database (VIP) and China Biomedical Literature Database (CBM) was conducted, and randomized controlled trials on the use of acupuncture in stroke patients from its inception to April 10, 2023 were included for the Meta analysis. …”
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Characterizing populations prioritized for PrEP in 19 African countries: a review of national guidance by Lauren A. Graybill, Caroline N. McKay, Jiayu Wang, Nadia A. Sam‐Agudu, Marcel Yotebieng, Friday Saidi, Linda‐Gail Bekker, Bonnie E. Shook‐Sa, Benjamin H. Chi, Nora E. Rosenberg

“…We reviewed national guidance to characterize populations prioritized for PrEP in Africa. Methods Between January and June 2023, we searched for current National HIV Treatment and Prevention Guidelines, National HIV Strategic Plans, and the United States President's Emergency Plan for AIDS Relief (PEPFAR) Country Operational Plans (COPs) for all African countries implementing PrEP programmes supported by PEPFAR in 2022. …”
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An outbreak within an outbreak: The impact of Infection Prevention and Control strategies on hospital-acquired infections and the occurrence of multi-drug resistant organisms durin... by B Mashigo, A Parker, U Lalla, B W Allwood, M S Moolla, T Lovelock, C F N Koegelenberg

“…To report these outbreaks, compare the rate of CRE and A. baumannii infections with the first COVID-19 wave and to analyse its impact on patient outcomes. Method. We retrospectively analysed data from a prospectively collected registry involving all adult patients with severe COVID-19 admitted to the dedicated COVID-19 ICU from May 2021 to September 2021. …”
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Effect of Benson’s relaxation training on fatigue and sleep quality of elderly patients after surgery for with glioma (本森放松训练对老年胶质瘤术后患者疲乏程度与睡眠质量的影响)... by GAO Yan (高严), HUANG Na (黄娜), DENG Lan (邓岚)

“…Objective Using Benson’s relaxation training to reduce the physical tension and anxiety of elderly patients with glioma after surgery, improve the quality of sleep, relieve fatigue, and improve the satisfaction of patients during hospitalization. Methods A total of 100 elderly glioma patients admitted to the hospital from April to October 2022 were studied. …”
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