Deep learning-based synthetic CT for dosimetric monitoring of combined conventional radiotherapy and lattice boost in large lung tumors by Hongwei Zeng, Xiangyu E, Minghe Lv, Su Zeng, Yue Feng, Wenhao Shen, Wenhui Guan, Yang Zhang, Ruping Zhao, Jingping Yu

“…This study aimed to develop an integrated treatment plan that combines CRT with lattice boost radiotherapy (LRT) and monitors its dosimetric characteristics. Methods This study employed cone-beam computed tomography from 115 lung cancer patients to develop a U-Net +  + deep learning model for generating synthetic CT (sCT). …”
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High Ki67 expression, HER2 overexpression, and low progesterone receptor levels in high-grade DCIS: significant associations with clinical practice implications by Hossein Schandiz, Hossein Schandiz, Lorant Farkas, Lorant Farkas, Daehoon Park, Yan Liu, Yan Liu, Solveig N. Andersen, Torill Sauer, Jürgen Geisler, Jürgen Geisler

“…Additionally, we investigated the associations between Ki67 expression, PR levels, and human epidermal growth factor receptor 2 (HER2) in high-grade DCIS among various subtypes (Luminal (Lum) A, LumB HER2-, LumB HER2+, HER2-enriched, and triple-negative)).MethodsUsing histopathological specimens from 484 patients diagnosed with DCIS between 1996 and 2018, we implemented the 2013 St. …”
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Computational analysis of reproducibility and image quality of 2011 and 2017 models of Heidelberg Spectralis SD-OCT machines by Kyoung A Viola Lee, Corey Tesdahl, Keith Zimmerman, Kimberly Jun, Sabrina Khalil, Alexander Shahin, Abdullah Abou-Samra, Ramesh Ayyala, Radouil Tzekov

“…Subjects and participants: Fourteen healthy individuals (28 eyes, age range: 22-54 years) underwent TRT measurements using both Old and New OCT models, with each eye receiving three consecutive scans per visit. Methods and testing: TRT measurements were performed using the Posterior Pole Algorithm (PPA) and Early Treatment Diabetic Retinopathy Study (ETDRS) grid protocols. …”
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Association of the Triglyceride-Glucose Index and Obesity Indicators with Multiple Chronic Diseases: A Longitudinal Cohort Study Based on CHARLS by Lan Y, Qi G, Li B, Sooranna SR, Chen D, Rao W, Lin Y, Pang Y

“…Yincai Lan,1,* Guangzi Qi,1,* Boya Li,1 Suren Rao Sooranna,2 Dongshun Chen,3 Wenlian Rao,3 Yinxia Lin,1 Yaqin Pang4– 7 1School of Public Health, Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, People’s Republic of China; 2Life science and clinical research center, Youjiang Medical University for Nationalities, Baise 533000, Guangxi, China and Department of metabolism, digestion and reproduction, Imperial College London, Chelsea & Westminster Hospital, London, SW10 9NH, UK; 3School of Basic Medicine, Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, People’s Republic of China; 4School of Medical Laboratory Medicine, Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, People’s Republic of China; 5Key Laboratory of Environmental and Population Health Research, Ecological Aluminum Industrial Base of Guangxi Universities, Baise, Guangxi, 533000, People’s Republic of China; 6Key Laboratory for Environmental Pollution and Health Risk Assessment, Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, People’s Republic of China; 7Modern Industrial College of Biomedicine and Great Health, Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yinxia Lin; Yaqin Pang, Email lin1837731@163.com; pangyaqin@126.comObjective: To explore the relationship between triglyceride glucose (TyG) and the obesity combined indexes and the occurrence of multiple chronic diseases (MCD), which will help to provide a basis for the prevention and treatment of this condition.Methods: 3037 participants in the China Health and Retirement Longitudinal Study, which was conducted from 2011 to 2015 were selected for this study. …”
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Green synthesis of nano-copper oxide using Sargassum sp. functionalized in cellulose acetate membrane for dye adsorption by U. Yanuhar, H. Suryanto, M. Amin, J.S. Binoj, I. Casuarina

“…The objective of the current study is to assess the properties of the green synthesis product of nano-copper oxide by employing Sargassum sp. macroalgae and its functionalized cellulose acetate membrane for the purpose of dye adsorption.METHODS: The preparation of Sargassum sp. extract involved utilizing quantities of 2.5, 5.0, and 10.0 grams, which were subsequently combined with a copper sulphate solution to yield nano-copper oxide. …”
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Alchornea cordifolia leaf-extract ameliorates bisphenol A-induced obesity in male Wistar rats by Abdulhakeem Rotimi Agboola, Ako Hogan Itam, Chinedum Martins Ekeleme, Eyuwa Ignatius Agwupuye, Zuwairatu Oyiza Ahmed, Godswill Peter Igiakong, Gideon Bassey Agbor, Asmau Niwoye Abubakar, Zainab Adamu, Esien David-Oku, Item Justin Atangwho

“…Objective To evaluate the obesity attenuation effect of Alchornea cordifolia ethanol extract (ACEE) and other associated macrovascular health risks in BPA-induced obesity rat model. Methods Thirty (30) young male Wistar rats (80–100 g) divided into five groups of six rats each, were administered BPA (50 mg/kg), once a day, p.o. for four weeks in order to induce obesity. …”
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Refraction in adolescents with various severity of Internet addiction and intensity of device use by T.R. Mukhamadeev, R.R. Akhmadeev, E.F. Shaykhutdinova, A.R. Khusniyarova

“…</p> <p> <b>Patients and Methods: </b>84 adolescents (66 girls and 18 boys, mean age 16.0±0.2 years) underwent psychometric and ophthalmic examinations to determine Internet addiction (IA) and duration and experience of using devices and to measure spherical equivalent (SE) (Righton Speedy-K). …”
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Kajian Strategi Pendidikan Vokasi Bidang Teknologi Informasi dan Komunikasi Menghadapi Bonus Demografi by Faizatul Amalia, Waras Kamdi, R. Machmud Sugandi

“…For graduates from Vocational High School (SMK) to be well absorbed, a strategy or method is needed to equip graduates with the competencies needed by the industry. …”
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Disparate and shared transcriptomic signatures associated with cortical atrophy in genetic behavioral variant frontotemporal degeneration by Ting Shen, Jacob W. Vogel, Vivianna M. Van Deerlin, EunRan Suh, Laynie Dratch, Jeffrey S. Phillips, Lauren Massimo, Edward B. Lee, David J. Irwin, Corey T. McMillan

“…Abstract Background Cortical atrophy is a common manifestation in behavioral variant frontotemporal degeneration (bvFTD), exhibiting spatial heterogeneity across various genetic subgroups, which may be driven by distinct biological mechanisms. Methods We employed an integrative imaging transcriptomics approach to identify both disparate and shared transcriptomic signatures associated with cortical thickness in bvFTD with C9orf72 repeat expansions or pathogenic variants in GRN or MAPT. …”
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Evaluation of seasonal variation, effect of extraction solvent on phytochemicals and antioxidant activity on Rosmarinus officinalis grown in different agro-ecological zones of Kiam... by Zelipha N. Kabubii, James M. Mbaria, Mbaabu P. Mathiu, John M. Wanjohi, Evans N. Nyaboga

“…The study also aimed at comparing different extraction solvents to establish the best extraction system for the bioactive compounds. Methods The leaves of R. officinalis were harvested from six purposively selected sites in four agro-ecological zones of Kiambu County, Kenya both in the wet and the dry seasons. …”
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Immunoregulatory programs in anti‐N‐methyl‐D‐aspartate receptor encephalitis identified by single‐cell multi‐omics analysis by Xinhui Li, Yicong Xu, Weixing Zhang, Zihao Chen, Dongjie Peng, Wenxu Ren, Zhongjie Tang, Huilu Li, Jin Xu, Yaqing Shu

“…This study aimed to characterize immune cell interactions and dysregulation in anti‐NMDARE by leveraging single‐cell multi‐omics sequencing technologies. Methods Peripheral blood mononuclear cells (PBMCs) from patients in the acute phase of anti‐NMDARE and healthy controls were sequenced using single‐cell joint profiling of transcriptome and chromatin accessibility. …”
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Time-restricted feeding improves metabolic syndrome by activating thermogenesis in brown adipose tissue and reducing inflammatory markers by Yueling Gong, Yueling Gong, Honghui Zhang, Jiang Feng, Li Ying, Mengmeng Ji, Shiyin Wei, Shiyin Wei, Qiming Ma

“…This study aims to investigate the impact of TRF on weight management, glucose metabolism, insulin resistance, and lipid metabolism in male C57BL/6J mice, particularly in the context of metabolic disorders induced by a high-fat diet (HFD).MethodsC57BL/6J mice were divided into two groups: a normal diet (ND) group and a high-fat diet (HFD) group. …”
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Comprehensive Analysis of m5C RNA Methylation Regulator Genes in Clear Cell Renal Cell Carcinoma by Jiajin Wu, Chao Hou, Yuhao Wang, Zhongyuan Wang, Pu Li, Zengjun Wang

“…This study is aimed at investigating the predictive and clinical value of these m5C-related genes in ccRCC. Methods. Based on The Cancer Genome Atlas (TCGA) database, the expression patterns of twelve m5C regulators and matched clinicopathological characteristics were downloaded and analyzed. …”
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Hand size association with ulnar collateral ligament reconstruction in professional baseball players by Michael T. Freehill, MD, Michael Walsh, MD, Nathan Richards, DO, John Morasso, DO, Traci A. Ackron, DO, MPH, Emily Lau, MD, Chaoyang Richard Chen, MD, Corey S. Tremble, ATC, Richard K. Ryu, MD, Stephen E. Lemos, MD, PhD

“…We hypothesize that a smaller hand size will be correlated with higher UCL reconstruction (UCLR) rates in professional baseball players. Methods: One-hundred and eighty-nine professional players from one Major League Baseball organization were recruited in this retrospective study. …”
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Pilot study of a comprehensive multidisciplinary inpatient-based approach to smoking cessation in patients with vascular disease by Tanner Kim, MD, Anand Brahmandam, MBBS, Dana Alameddine, MD, Rachel Forman, MD, Amin Hardik, MD, Lisa Fucito, PhD, Carlos Mena-Hurtado, MD, Raul Guzman, MD, Cassius Iyad Ochoa Chaar, MD, MS, MPH

“…This pilot study aims to evaluate the efficacy of a multidisciplinary inpatient smoking cessation intervention that leverages surgery as a teachable moment and the postoperative inpatient recovery period to initiate smoking cessation counseling and pharmacotherapy. Methods: Adult smokers with occlusive or aneurysmal arterial disease admitted after vascular surgery in a tertiary care center were enrolled. …”
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Efficacy and Safety of Non-Vitamin K Anticoagulants for Atrial Fibrillation in Relation to Different Renal Function Levels: A Network Meta-Analysis by Hao Jin, Kongbo Zhu, Lina Wang, Yifan Li, Jingjun Meng, Hong Zhi

“…We performed a network meta-analysis (NMA) comparing the efficacy (stroke or systemic embolism) and safety (major bleeding) among different non-vitamin K antagonist oral anticoagulants (NOACs) in patients with atrial fibrillation (AF) and renal impairment, with the aim of recommending the proper drug and the dose based on renal function. Methods. We searched PubMed, EMBASE, Web of Science, and Cochrane Library with the items “dabigatran, edoxaban, apixaban, rivaroxaban, warfarin, and atrial fibrillation” through August 2019. …”
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Occupational skin diseases among bricklayers and brick masons in a resource poor setting, Southwest Nigeria: prevalence and correlates – a case–control study by Michael Gbenga Israel, Oluwaseyi Kikelomo Israel, Adeolu Oladayo Akinboro, Peter Kehinde Uduagbamen, Sebastien S Oiwoh, Olanrewaju Olayemi, Fatai O Olanrewaju, Mufutau M Oripelaye, Stephen Olawale Aiyedun, Olumayowa Oninla, Olayinka Olasode, Olaniyi Onayemi

“…We determined the prevalence of OSDs and their correlates among bricklayers and brick masons.Design This was a comparative case–control study which involved 200 bricklayers/brick masons and 200 healthy non-bricklayers/non-brick masons.Settings This study was carried out in two local governments (LGAs) in Ogbomoso community.Methods Respondents were selected using a multistage random sampling technique. …”
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Pengaruh Diet Tinggi Minyak Sawit Terhadap Sel Hepatosit Tikus by Susila Sastri, Husnil Kadri

“…The objective of this studi was to determine the effect of high palm oil diet on fat vacuole in liver parenchymal cells of rat. Method: This was a post test experiment design in laboratorium. …”
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Based on CT scans at the 12th thoracic spine level, assessing the impact of skeletal muscle and adipose tissue index on one-year postoperative mortality in elderly hip fracture pat... by En-li Li, Jia-sen Hu, Zi-hao Chen, Run-xun Ma, Chen Jin, Yi-tian Bu, Si-xiang Feng, Cheng-bin Huang, Ya-ping Jin, Lei Yang

“…Therefore, this study aimed to prove whether skeletal muscle and adipose tissue index measured by computed tomography (CT) images based on a single layer are associated with one-year postoperative mortality in elderly hip fracture patients. Methods A total of 334 participants from two institutions were enrolled in this study to obtain skeletal muscle index (SMI), subcutaneous fat index (SFI), visceral fat index (VFI), and the visceral-to-subcutaneous ratio of the fat area (VSR) at T12 levels and divide them into death and survival groups based on the results of follow-up after 1 year. …”
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Safety and efficacy of CD33-targeted CAR-NK cell therapy for relapsed/refractory AML: preclinical evaluation and phase I trial by Ruihao Huang, Xiaoqi Wang, Hongju Yan, Xu Tan, Yingying Ma, Maihong Wang, Xiao Han, Jia Liu, Li Gao, Lei Gao, Guangjun Jing, Cheng Zhang, Qin Wen, Xi Zhang

“…We have developed a new CAR construct that targets CD33 and modified NK cells, specifically eliminating AML cells while reducing severe side effects on stem cells. Methods The CD33-targeting domain was selected by CAR-T cells, and this optimized CAR construct was subsequently transduced into umbilical cord-derived NK cells via a retroviral vector. …”
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