Cocktail of Ropivacaine, Morphine, and Diprospan Reduces Pain and Prolongs Analgesic Effects after Total Knee Arthroplasty: A Prospective Randomized Controlled Trial by Zhenyu Luo, Weinan Zeng, Xi Chen, Qiang Xiao, Anjing Chen, Jiali Chen, Haoyang Wang, Zongke Zhou

“…The purpose of this study was to evaluate the analgesic effect of a cocktail of ropivacaine, morphine, and Diprospan for TKA. Methods. A total of 100 patients from September 2018 to February 2019 were randomized into 2 groups. …”
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Socio-economic assessment of drought impacts in Lesotho: implications for early action by Relebohile Agnes Mojaki, Makoala Vitalis Marake, Evan Easton-Calabria, Joalane Rethabile Marunye, Erin Coughlan de Perez

“…Research limitations/implications – In any qualitative study, the researchers need to reflect on their positionality and how that may influence the research process, outcomes and the general limitations of the research methods (Quandt, 2021). Given that the research team has worked with humanitarian organisations in the study area after which development interventions were implemented, this might have led to interviewees exaggerating the negative impacts of drought hoping the team to bring assistance into the community. …”
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A comparative study of hospitalization costs of TKA inpatients before and after National Volume-based Procurement in Guangdong, China: an interrupted time-series analysis by Anqi Li, Gongduan Li, Dong Han, Manru Fu, Jinghui Chang, Jinghui Chang

“…BackgroundThis study aims to explore the impact of the National Volume-based Procurement Policy in Guangdong Province on hospitalization costs for total knee arthroplasty inpatients.MethodsInterrupted time-series analysis were used to examine the expenses associated with total knee arthroplasty for inpatients at a hospital in Guangzhou between May 10, 2021, and December 26, 2023. …”
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Measuring the uptake of clinic-based HIV treatment and prevention services following HIV testing and referral at private pharmacies in Kenya by Victor Omollo, Stephanie D. Roche, Shengruo Zhang, Magdalene Asewe, Bernard K. Rono, Benn Kwach, Greshon Rota, Patricia Ong’wen, Kendall Harkey, Josephine Odoyo, Daniel Were, Kenneth Ngure, Elizabeth A. Bukusi, Katrina F. Ortblad

“…To understand what uptake of HIV prevention and treatment services might look like if private pharmacies offered clients free HIV self-testing and referral to clinic-based HIV services, we conducted a pilot study in Kenya. Methods At 20 private pharmacies in Kisumu County, Kenya, pharmacy clients (≥ 18 years) purchasing sexual health-related products (e.g., contraception) were offered free HIV testing. …”
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Restoring coronal pre-arthritic alignment in mobile-bearing unicompartmental knee arthroplasty: mid- to long-term outcomes by Yankun Jiang, Changquan Liu, Qidong Zhang, Guoyuan Sun, Ran Ding, Nianfei Zhang, Cheng Huang, Weiguo Wang, Wanshou Guo

“…This study evaluated whether patients who achieve pre-arthritic alignment following mobile-bearing UKA with the kinematic alignment technique experience superior postoperative knee function compared with those who do not. Methods A retrospective analysis was conducted on 236 knee joints that underwent UKA using kinematic alignment techniques between May 2015 and November 2017. …”
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Sistem Pakar Diagnosa Penyakit Campak Rubella pada Anak Menggunakan Metode Certainty Factor Berbasis Website by Pujianti Wahyuningsih, Sitti Zuhriyah

“…The methodology to diagnose the rubella measles disease in this study used a Certainty Factor (CF) method. The CF value got from the calculation of the percentage input of Measure Belief (MB) and Measure Disbelief (MD), where the function of MB value is to measure and know the level of belief value and then the MD function is to measure and to see the level of disbelief value. …”
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Simulator training in focus assessed transthoracic echocardiography (FATE) for undergraduate medical students: results from the FateSim randomized controlled trial by Johannes Matthias Weimer, Franziska Marietta Sprengart, Thomas Vieth, Sebastian Göbel, Anna Dionysopoulou, Rebecca Krüger, Jan Beer, Andreas Michael Weimer, Holger Buggenhagen, Roman Kloeckner, Lukas Pillong, Johanna Helfrich, Elias Waezsada, Philipp Wand, Julia Weinmann-Menke

“…This study evaluates the effectiveness of simulator-based versus human-based training in Focused Assessed with Transthoracic Echocardiography (FATE). Materials and methods This single-centre, prospective, randomised controlled study was conducted during an extracurricular FATE workshop (approximately 420 min) for third-year medical students. …”
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Efficacy and Safety of Risankizumab in Patients with Psoriasis Showing Suboptimal Response to Secukinumab or Ixekizumab: Results from a Phase 3b, Open-Label, Single-Arm (aIMM) Stud... by Richard B. Warren, Lev Pavlovsky, Antonio Costanzo, Michael Bukhalo, Neil J. Korman, Yu-Huei Huang, Georgios Kokolakis, Andreas Pinter, Nadia Ibrahim, Yanbing Zheng, Leonidas Drogaris, Vassilis Stakias, Ahmed M. Soliman, Simone Rubant, Diamant Thaçi

“…We evaluated the efficacy and safety of directly switching patients with moderate-to-severe plaque psoriasis and a suboptimal response to interleukin (IL)-17 inhibitors (secukinumab or ixekizumab) to risankizumab. Methods This 52-week, phase 3b study enrolled patients (≥ 18 years) with moderate-to-severe plaque psoriasis who had previously been treated with the recommended dose of secukinumab or ixekizumab for ≥ 6 months but did not achieve an optimal response (static Physician's Global Assessment [sPGA] 2/3; body surface are [BSA] 3– < 10%). …”
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Kinomic profiling to predict sunitinib response of patients with metastasized clear cell Renal Cell Carcinoma by Jeannette C. Oosterwijk-Wakka, Liesbeth Houkes, Loes F.M. van der Zanden, Lambertus A.L.M. Kiemeney, Kerstin Junker, Anne Y Warren, Tim Eisen, Ulrich Jaehde, Marius T Radu, Rob Ruijtenbeek, Egbert Oosterwijk

“…The aim of this study was to investigate whether kinase activity analysis can predict sunitinib response and/or toxicity using tissue samples obtained from primary clear cell RCC (ccRCC) from a cohort of clinically annotated patients with mRCC receiving sunitinib as first-line treatment. Materials and Methods: EuroTARGET partners collected ccRCC and matched normal kidney tissue samples immediately after surgery, snap-frozen and stored at -80°C until use. …”
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D-mannose alleviates chronic periodontitis in rats by regulating the functions of neutrophils by Xue Li, Xueting Chen, Qingyu Zhu, Pengye Zhang, Shunxue Nan, Lei Lv, Shengcai Qi

“…The study aimed to explore the protective effects of D-mannose on chronic periodontitis and determine whether its underlying mechanisms is related to neutrophils. Methods To explore the protective effects of D-mannose on chronic periodontitis, the eight-week-old Sprague Dawley rat model of lipopolysaccharide (LPS)-induced periodontitis was established, followed by D-mannose treatment by oral gavage. …”
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Comparing cup placement, leg length, and offset discrepancy after total hip arthroplasty between CT-based robotic arm-assisted and navigation systems by Akira Shimizu, Satoshi Murakami, Takayuki Tamai, Yuuki Haga, Tatsuhiko Kutsuna, Tomofumi Kinoshita, Masaki Takao

“…This study aimed to determine whether a CT-based robotic arm-assisted system helps surgeons perform accurate cup placement, minimizes leg length, and offsets discrepancies more than a CT-based navigation system. Methods: We studied 60 hips from 54 patients who underwent rTHA between April 2021 and August 2023, and 45 hips from 44 patients who underwent nTHA between January 2020 and March 2021 with the same target cup orientation at the Department of Orthopedic Surgery at Ozu Memorial Hospital, Japan. …”
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Analysis of students' cognitive difficulties based on the revised Bloom's taxonomy in solving mathematics problems by Azis Azis, Imelda Tria Handayani, Ferniati Ferniati, Nurmarini Anggriana, Aisyah Aisyah

“…This research used a survey method. The subjects in this study were grade IX junior high school students in Baubau City in the 2020/2021 academic year. …”
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Immunohistochemical Expression of p53 Gene and Clinicopathological Assessment of Low-grade Serous Ovarian Cancer and High-grade Serous Ovarian Cancer: A Cohort Study by Geeta Bazard, Minakshi Vashist, Sunita Singh, Gulshan Rohilla, Nidhi Paliwal

“…Aim: To analyse the Immunohistochemical (IHC) expression of p53 gene and clinicopathological features of Low-grade Serous Ovarian Cancer (LGSOC) and High-grade Serous Ovarian Cancer (HGSOC). Materials and Methods: This cohort study was conducted on 37 histopathologically confirmed cases of serous carcinomas of ovary in Department of Genetics, Maharshi Dayanand University, Rohtak, in collaboration with Department of Pathology, Pandit Bhagwat Dayal Sharma University of Health Sciences, Rohtak, Haryana, India during the period 2019 to 2023. …”
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Community-based models of care for management of type 2 diabetes mellitus among non-pregnant adults in sub-Saharan Africa: A scoping review. by Emmanuel Firima, Lucia Gonzalez, Fabiola Ursprung, Elena Robinson, Jacqueline Huber, Jennifer M Belus, Fabian Raeber, Ravi Gupta, Gibrilla F Deen, Alain Amstutz, Bailah Leigh, Maja Weisser, Niklaus Daniel Labhardt

“…We further aimed to critically appraise the different models of care and compare community-based to facility-based care if data were available.<h4>Methods</h4>We searched Medline, Embase, Cumulative Index to Nursing and Allied Health Literature (CINAHL) and Scopus, supplemented with backward and forward citation searches. …”
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Percutaneous unilateral biportal endoscopic discectomy for symptomatic lumbar disc herniation in geriatric patients by Rongqing Qin, Rongqing Qin, Anhong Guan, Anhong Guan, Min Zhu, Pin Zhou, Bing Zhou, Bing Zhou, Ruihua Zhou, Ruihua Zhou, Zaiyong Guan, Zaiyong Guan

“…PurposeThe purpose of this study is to investigate the surgical efficacy and safety of percutaneous unilateral biportal endoscopic discectomy (UBED) for symptomatic lumbar disc herniation (LDH) in geriatric patients.MethodsSeventy-two geriatric patients, aged 65–86 years (mean age: 73.2 years), with single or two-level LDH who underwent UBED from January 2020 to September 2022 were retrospectively analyzed. …”
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Digital Transformation in Voluntary Sports Organizations: A Scoping Review on Multi-Level Drivers, Promoting Factors, Forms and Consequences by Pascal Stegmann, Grazia Lang

“…Therefore, this review aims to analyse the existing research on digital transformation in voluntary sports organizations to reconcile current approaches in the field of sport management research and identify research gaps. Methods: A scoping review methodology is employed to explore the current evidence and highlight knowledge gaps regarding digital transformation in voluntary sports organizations. …”
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Demographic variation and socioeconomic inequalities in all forms of malnutrition among children aged 6 months to 9 years: findings from the Vietnamese General Nutrition Survey 202... by J Bernadette Moore, Xiaodong Lin, Louise Dye, Van Khanh Tran, Yun Yun Gong, Xiaomian Tan, Pui Yee Tan, Somphos Vicheth Som, Son Duy Nguyen, Do Tranh Tran, Nga Thuy Tran, Samantha Caton, Hannah Ensaff, Geoffry Smith

“…This study examined the prevalence of population-level DBM, its demographic and socioeconomic determinants as well as the associations between anthropometric indicators of undernutrition and overnutrition, and micronutrient deficiencies (MNDs), among Vietnamese children, using the data from the nationally representative General Nutrition Survey 2020.Methods Data on anthropometric parameters, micronutrient biomarkers, demographic and socioeconomic indicators for 7289 children aged 6 months to 9 years were analysed. …”
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The cardioprotective effects of HTK solution and conventional blood cardioplegia in patients with atrial fibrillation undergoing valvular replacement and Cox maze III procedure by BingMei Qiu, Lei Zhang, Dan Wu, Qian Li, Lei Sun, AnLi Wang, Zhilong Xi, HaiWei Wu, ChangTian Wang, ShanWu Feng

“…Abstract Introduction The study was to assess the myocardial protection effects of the histidine-tryptophan-ketoglutarate (HTK) solution and the 4:1 blood cardioplegia (BC) in patients with atrial fibrillation (AF) who were subjected to valvular replacement concomitant with the Cox maze III surgery. Methods A cohort of 148 individuals afflicted with AF, who received valve replacement surgery in conjunction with the Cox maze III procedure at our clinic within the period extending from 2015 to 2023, were enrolled. …”
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Parents' perception of the promotion of physical activity as part of the Purzelbaum project in Swiss daycare centers by Bianca Celine Schmidli, Claudio R. Nigg

“…This study examines whether the participation and perception of PA by parents differs in daycare centers with or without Purzelbaum certification. Methods Between February and April 2024, parents from daycare centers in various Swiss cantons were invited to complete an online questionnaire about PA in daycare centers. …”
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The role of Anti-PAD4, Anti-CarP, and Anti-RA33 antibodies combined with RF and ACPA in predicting abatacept response in rheumatoid arthritis by Alberto Floris, Maria Maddalena Angioni, Mattia Fadda, Micaela Rita Naitza, Mattia Congia, Elisabetta Chessa, Matteo Piga, Alberto Cauli

“…Abstract Objectives To explore the role of newly emerging autoantibodies (AAbs) - peptidyl-arginine deiminase 4 (aPAD4), carbamylated proteins (aCarP), and anti-RA33 (aRA33) - alongside the traditionally assessed rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA), in predicting the response to abatacept (ABT) and its retention rate in rheumatoid arthritis (RA) patients. Methods Data from 121 consecutive ABT-treated RA patients were recorded. …”
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