CYP3A5 promotes glioblastoma stemness and chemoresistance through fine-tuning NAD+/NADH ratio by Wentao Hu, Xiaoteng Cui, Hongyu Liu, Ze Li, Xu Chen, Qixue Wang, Guolu Zhang, Er Wen, Jinxin Lan, Junyi Chen, Jialin Liu, Chunsheng Kang, Ling Chen

“…However, how GSCs leverage metabolic adaptation to obtain survival advantage remains elusive. Methods A multi-step process of machine learning algorithms was implemented to construct the glioma stemness-related score (GScore). …”
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A Navier–Stokes-Informed Neural Network for Simulating the Flow Behavior of Flowable Cement Paste in 3D Concrete Printing by Tianjie Zhang, Donglei Wang, Yang Lu

“…Moreover, the mean prediction time used in the NSINN, the ANN, and Computational Fluid Dynamics (CFD) are 0.039 s, 0.014 s, and 3.37 s, respectively. That means the method is more computationally efficient at performing simulations compared to CFD which is mesh-based. …”
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Association between physical activity, smartphone usage, and obesity risk among Korean adolescents: A cross-sectional study based on 2021 Korean adolescent health behavior survey by Haoyuan Li, Jaeyoung Choi, Aram Kim, Guifang Liu

“…This study explores the associations between physical activity (PA) levels, smartphone usage, and obesity risk among Korean adolescents, aiming to inform the design of targeted health promotion programs to mitigate obesity rates in this demographic. Methods: This cross-sectional analysis used data from 50,407 Korean adolescents who participated in the 2021 Adolescent Health Behavior Online Survey. …”
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Knowledge, attitudes, and practices among physicians and pharmacists toward antibiotic use in sepsis by Jingmin Zhang, Jingmin Zhang, Haipeng Shi, Haipeng Shi, Yanmei Xia, Yanmei Xia, Zhenghua Zhu, Yaojun Zhang

“…This study aimed to assess the knowledge, attitudes and practices (KAP) among physicians and pharmacists toward antibiotic use in sepsis.MethodsThis web-based cross-sectional study was conducted at Shanxi Bethune Hospital between June 2023 and October 2023. …”
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Bryostatin-1 enhances the proliferation and functionality of exhausted CD8+ T cells by upregulating MAP Kinase 11 by Ling Li, Manzhi Zhao, Marjan van Meurs, Inge Brouwers-Haspels, Renske J. H. den Dekker, Merel E. P. Wilmsen, Dwin G. B. Grashof, Harmen J. G. van de Werken, Shringar Rao, Casper Rokx, Yvonne M. Mueller, Peter D. Katsikis

“…Therefore, we further investigated how bryostatin-1 directly impacts exhausted CD8+ T cells.MethodsPBMCs from people with HIV (PWH) were treated with bryostatin-1 and tracked with proliferation dye for cell expansion. …”
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Therapeutic Effect of High-Definition Transcranial Direct Current Stimulation Combined with Suspension Exercise Training on Lower Limb Motor Function of Stroke Patients by ZHANG Haiquan, HU Chuan, HUANG Lei, LU Wei, WANG Xin

“…ObjectiveTo observe the effect of high-definition transcranial direct current stimulation combined with suspension exercise training on lower limb motor function of stroke patients.MethodsA total of 120 stroke patients treated in the department of rehabilitation medicine of the Shandong Provincial Third Hospital, Shandong University from January 2022 to February 2023 were randomly divided into control group, HD-tDCS group, suspension group and combined treatment group, with 30 cases in each group. …”
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Clinical characteristics and outcomes of surgical resection for brain metastases from lung adenocarcinoma by Ming Li, Zhiying Li, Hang Zhang, Hiroaki Wakimoto, Linlin Sun, Tiantian Wang, Shengli Zhou, Liyun Zhou

“…ObjectiveThe purpose of this study was to explore the clinical characteristics, survival time and prognostic factors of patients undergoing craniotomy for brain metastases (BM) from lung adenocarcinoma (LUAD).MethodsA total of 208 patients with BM from LUAD who underwent craniotomy at the Zhengzhou University People’s Hospital, Henan province, China from March 2005 to October 2022 were included in this retrospective study. …”
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Gender Incidence in the Salary of Informal Workers for the Management of Socioeconomic Strategies by E. Melendres Medina, M. Campaña Lara, B. Riera Riera, J. Orozco Carrillo

“…Qualitative and quantitative approaches were used using inductive and deductive methods. Data were collected through a survey and analyzed using the Chi square test. …”
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Tangeretin alleviates sepsis-induced acute lung injury by inhibiting ferroptosis of macrophage via Nrf2 signaling pathway by Hui Zhang, Yan Wang, Shenghua Wang, Xiaomei Xue, Kai Huang, Dunfeng Xu, Lai Jiang, Siyuan Li, Yunqian Zhang

“…However, whether tangeretin protects against sepsis-induced ALI and the potential mechanisms remain unclear. Methods We established an ALI model via intraperitoneally injected with 5 mg/kg lipopolysaccharides (LPS) for 12 h. …”
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In-vitro effect of the methanolic extract of Morinda citrifolia against the life cycle of Dermatobia hominis by Dumar Alexander Jaramillo Hernández, Rafael Felipe Quevedo Carrillo, Diego Arnaldo Cadena Franco, Angélica Elizabeth Gonzalez Reina, Lida Carolina Lesmes-Rodríguez, Luz Natalia Pedraza-Castillo

“…Objective: to assess the in-vitro effect of the methanolic extract of the M. citrifolia ripe fruit against the life cycle of D. hominis. Methods: D. hominis larvae were taken directly from naturally parasitized bovine skins. …”
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Reticulocyte hemoglobin content: a new frontier in iron deficiency diagnostics for major surgical patients by Suma Choorapoikayil, Mischa J. Kotlyar, Lisa Kawohl, Paul P. Pratz, Denana Mehic, Peter Kranke, Florian Rumpf, Lea V. Blum, Jan A. Kloka, Kai Zacharowski, Vanessa Neef, Patrick Meybohm

“…Recently, reticulocyte hemoglobin content (Ret-He) has been evaluated as an early marker for ID diagnosis. Method In this retrospective study, 2,966 major surgical patients from two University Hospitals were screened for the presence of ID and the significance of Ret-He in diagnosis ID was evaluated in both non-anemic and anemic patients. …”
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Role of Virtual iMRI in Glioblastoma Surgery: Advantages, Limitations, and Correlation with iCT and Brain Shift by Erica Grasso, Francesco Certo, Mario Ganau, Giulio Bonomo, Giuseppa Fiumanò, Giovanni Buscema, Andrea Maugeri, Antonella Agodi, Giuseppe M. V. Barbagallo

“…Moreover, the impact of brain shift on software reliability is assessed. <b>Methods</b>: This ambispective study included 80 patients with a diagnosis of glioblastoma. …”
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Proficiency, Clarity, and Objectivity of Large Language Models Versus Specialists’ Knowledge on COVID-19's Impacts in Pregnancy: Cross-Sectional Pilot Study by Nicola Luigi Bragazzi, Michèle Buchinger, Hisham Atwan, Ruba Tuma, Francesco Chirico, Lukasz Szarpak, Raymond Farah, Rola Khamisy-Farah

“…ObjectiveThis study aimed to assess LLMs’ proficiency, clarity, and objectivity regarding COVID-19’s impacts on pregnancy. MethodsThis study evaluates 4 major AI prototypes (ChatGPT-3.5, ChatGPT-4, Microsoft Copilot, and Google Bard) using zero-shot prompts in a questionnaire validated among 159 Israeli gynecologists and obstetricians. …”
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Application of nursing program in reducing the rate of unplanned extubation of nasogastric tube (护理专案模式在降低患者胃管非计划拔管发生率中的应用) by LI Lan (李兰), ZHOU Min (周敏)

“…Objective To investigate the effect of nursing program in reducing the rate of unplanned extubation (UEX)of nasogastric tube. Methods Totally 80 patients with placement of nasogastric feeding tube before implement of nursing program(Dec, 2019 to Dec, 2020) were included as the control group, and another 84 patients with placement of nasogastric feeding tube after implement of nursing program(Jan, 2021 to Jan, 2022) were recruited as the observation group. …”
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The additional impact of metabolic syndrome on left ventricular deformation and myocardial energetic efficiency impairment in ischemia with nonobstructive coronary arteries patient... by Chen-Yan Min, Yue Gao, Yuan Li, Yi-Ning Jiang, Ying-Kun Guo, Hua-Yan Xu, Rong Xu, Xi Liu, Li-Ting Shen, Zhi-Gang Yang

“…The study aimed to investigate the aggravating effect of MetS on left ventricular (LV) deformation and function impairment in INOCA patients. Materials and methods This study collected 104 INOCA patients (INOCA [MetS−]: n = 56; INOCA [MetS+]: n = 48) and 41 sex- and age-matched controls. …”
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Effects of exercise and exercise timing on energy intake and appetite control in Danish individuals with overweight or obesity with and without type 2 diabetes: a protocol for a ra... by Louise Groth Grunnet, Martin Bæk Blond, Jonas Salling Quist, Kristine Beaulieu, Graham Finlayson, Kristine Færch, Lea Jalking, Natja Poder Launbo, Marie Møller Jensen, Hanne Enghoff Pedersen, Marina Kjærgaard Gerstenberg

“…Introduction The aim of this study is to investigate the effects of acute exercise on appetite control and whether this differs between morning and late afternoon in individuals with overweight/obesity with or without type 2 diabetes (T2D).Methods and analysis The hedonic and homeostatic appetite control in obesity and type 2 diabetes in the context of meal and exercise timing (TIMEX) study is a randomised, controlled, cross-over trial. …”
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Cerebrospinal fluid β2-microglobulin promotes the tau pathology through microglia–astrocyte communication in Alzheimer's disease by Zehu Sheng, Lanyang Wang, Ming Chen, Fuxin Zhong, Shijing Wu, Shuyu Liang, Jiaqi Song, Lihua Chen, Yingxi Chen, Shiyu Chen, Weihua Yu, Yang Lü

“…However, more investigation is required to ascertain the relationship between β2M and glial activities in AD pathogenesis. Methods In this study, 211 participants from the Alzheimer’s disease Neuroimaging Initiative (ADNI) with CSF and Plasma β2M, CSF glial fibrillary acidic protein (GFAP), soluble triggering receptor expressed on myeloid cells 2 (sTREM2), Aβ42, phosphorylated-tau (P-tau) and total tau (T-tau) were divided into four groups, stage 0, 1, 2, and suspected non-AD pathology (SNAP) based on the National Institute on Aging- Alzheimer’s Association (NIA-AA) criteria. …”
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A novel nomogram based on the patient’s clinical data and CT signs to predict poor outcomes in AIS patients by Jingyao Yang, Fangfang Deng, Qian Zhang, Zhuyin Zhang, Qinghua Luo, Yeyu Xiao

“…Therefore, our objective was to combine patient clinical data with head CT signs to create a nomogram to predict poor outcomes in AIS patients. Methods A retrospective analysis was conducted on 161 patients with acute ischemic stroke who underwent mechanical thrombectomy at the Guangzhou Hospital of Integrated Traditional and Western Medicine from January 2019 to June 2023. …”
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Extracellular vesicles derived from creeping fat stem cells promote lymphatic function and restrain inflammation of Crohn's disease by Weigang Shu, Yongheng Wang, Mengfan Chen, Xiaoli Zhu, Fangtao Wang, Chunqiu Chen, Peng Du, Alexandra Bartolomucci, Xin Su, Xiaolei Wang

“…However, the regulating roles of ADSC‐EVs in CrF (CrF‐EVs) in CD, especially in modulating lymphatic function and mitigating the progression of mesenteritis and colitis, remains elusive. Methods To evaluate the regulative roles of CrF‐EVs on lymphatic functions, in vitro assays were performed using human lymphatic endothelial cells (HLECs). …”
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Protective effects and possible mechanisms of mesenchymal stem cells and mesenchymal stem cell-derived extracellular vesicles against kidney fibrosis in animal models: a systematic... by Yuanchen Lv, Zibo Hua, Xiaomei Lu

“…In light of these observations, we are undertaking a meta-analysis to elucidate the influence of hUCB-MSCs and MSC-Exos on kidney fibrosis.MethodsTo identify eligible trials, we conducted a comprehensive search of the CNKI, PubMed, Web of Science and Wanfang databases from inception to 24 October 2022. …”
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