Preclinical model for evaluating human TCRs against chimeric syngeneic tumors by Olivier Michielin, Philippe Guillaume, Melita Irving, Patrick Reichenbach, Vincent Zoete, Elise Gray-Gaillard, Evangelos Stefanidis, Aikaterini Semilietof, Julien Pujol, Alessia D'Esposito

“…Here, we have developed a chimeric syngeneic tumor model in which A2Kb transgenic C57BL/6 mice are engrafted with B16 expressing A2Kb:NY as a single chain trimer (SCT) and treated by ACT with murine T cells expressing A2/NY TCRs comprising human variable fused to mouse constant regions.Methods We compared the function of a supraphysiological affinity A2/NY TCR (wtc51m), a computationally designed TCR in an optimal affinity range (DMβ), and a near non-binding TCR (V49I), engineered in both primary human and murine T cells by lentiviral and retroviral transduction, respectively. …”
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Explorando el potencial de la inteligencia artificial en traumatología: respuestas conversacionales a preguntas específicas by F. Canillas del Rey, M. Canillas Arias

“…These bots can engage in dialogue using natural language indistinguishable from humans and are a potential source of information for patients.The aim of this study is to examine the performance of these bots in solving specific issues related to orthopedic surgery and traumatology using questions from the Spanish MIR exam between 2008 and 2023. Material and methods: Three «chatbot» models (ChatGPT, Bard and Perplexity) were analyzed by answering 114 questions from the MIR. …”
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Genomic detection of Panton-Valentine Leucocidins encoding genes, virulence factors and distribution of antiseptic resistance determinants among Methicillin-resistant S. aureus iso... by Masoud A. Juma, Tolbert Sonda, Boaz Wadugu, Davis Kuchaka, Mariana Shayo, Petro Paulo, Patrick Kimu, Livin E. Kanje, Melkiory Beti, Marco Van Zwetselaar, Blandina Mmbaga, Happiness Kumburu

“…This study aimed at detecting the presence of pvl genes and determining the distribution of antiseptic resistance genes in Methicillin-resistant Staphylococcus aureus isolates through whole genome sequencing technology. Materials and methods A descriptive cross-sectional study was conducted across six regional referral hospitals-Dodoma, Songea, Kitete-Kigoma, Morogoro, and Tabora on the mainland, and Mnazi Mmoja from Zanzibar islands counterparts using the archived isolates of Staphylococcus aureus bacteria. …”
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Cesarean section in Suriname using robson classification: a two-year nationwide cross-sectional study on rates, risk factors and perinatal outcomes of cesarean section by Zita D. Prüst, Josephine A. I. Dupont, Safir Liesdek, Kitty W. M. Bloemenkamp, Thomas van den Akker, Kim J. C. Verschueren, Lachmi R. Kodan

“…This study aims to (1) determine the facility-based CS rate in Suriname and explore which women are most likely to undergo a CS and (2) classify all CS by the WHO Robson classification and analyze the perinatal outcomes. Methods An observational, cross-sectional study in Suriname, using nationwide birth registry data that included all hospital births in 2020 and 2021 (≥ 27 weeks of gestation). …”
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Predictive Value of Urinary KIM-1, TIMP-2 and sTREM-1 for Contrast-Induced Acute Kidney Injury in Elderly Patients After Percutaneous Coronary Intervention by Huang W, Wang R, Zhang P

“…Wu Huang, Rong Wang, Ping Zhang Department of Geriatric Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, People’s Republic of ChinaCorrespondence: Rong Wang, Department of Geriatric Medicine, The Second Xiangya Hospital of Central South University, 139 Renmin Middle Road, Changsha, Hunan, 410011, People’s Republic of China, Tel +86-0731-85295173, Email Wangrong5913@163.comObjective: We aimed to address the predictive value of urinary kidney injury molecule-1 (KIM-1), tissue inhibitor of metalloproteinases-2 (TIMP-2) and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) for contrast-induced acute kidney injury (CI-AKI) in elderly patients after percutaneous coronary intervention (PCI).Methods: One hundred thirty-six patients who underwent PCI were separated into the CI-AKI group (n = 36) and the non-CI-AKI group (n = 100) based on CI-AKI occurrence after operation, and their general data were collected. …”
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Therapeutic Effect of Cardiac Exercise Rehabilitation Program Based on Cardiopulmonary Exercise Test on Patients with Stable Coronary Heart Disease Complicated with Hypertension by TONG Yiman, GAO Min, WANG Xinyu, CAO Yuhan, CHEN Wei

“…ObjectiveTo observe the effect of cardiac exercise rehabilitation program based on cardiopulmonary exercise testing (CPET) on patients with stable coronary heart disease complicated with hypertension.MethodsA total of 80 patients with stable coronary artery disease complicated with hypertension in the Xuzhou Central Hospital from February to September 2023 were randomly divided into control group and observation group, with 40 cases in each group. …”
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The Potential Proallergenic Activity of Tranzschelia pruni-spinosae and Phragmidium rubi-idaei in vitro Studies by Sztandera-Tymoczek M, Wdowiak-Wróbel S, Świderska U, Palusińska-Szysz M, Szuster-Ciesielska A

“…This study aimed to investigate the potential of two common rust fungi, Tranzschelia pruni-spinosae and Phragmidium rubi-idaei, to trigger a proinflammatory response in vitro models representing the upper and lower respiratory tract.Materials and Methods: The BEAS-2B and A549 cell lines simulated upper and lower respiratory endothelial cells. …”
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Dynamics of epidemiological indicators of glaucoma in the Republic of Bashkortostan for the period of 2010–2016 by M.M. Bikbov, A.E. Babushkin, I.I. Khusnitdinov, L. Kh. Murova, E.N. Matyukhina

“…<br> <b>Patients and Methods:</b> studies were conducted on the basis of data from the annual statistical reports of ophthalmologists of cities and districts of the RB, as well as of the Ufa Eye Research Institute of the Academy of Sciences and the “Main Bureau of Socio-Medical Expertising on the Republic of Bashkortostan”.…”
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Identification of EARS2 as a Potential Biomarker with Diagnostic, Prognostic, and Therapeutic Implications in Colorectal Cancer by Wang L, Deng X, Tang J, Gong Y, Bu S, Li Z, Liao B, Ding Y, Dai T, Liao Y, Li Y

“…This study identifies key genes associated with lactic acid metabolism and explore their impact on CRC.Patients and Methods: This study utilized data from The Cancer Genome Atlas, Gene Expression Omnibus, other public databases, and our institutional resources. …”
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Enhanced Safety and Efficacy of O‐Arm Navigation Over C‐Arm Guidance in Percutaneous Kyphoplasty for Patients With Osteoporotic Vertebral Compression Fractures and Spinal Deformity... by Zhong‐Wei Ji, Min‐Jie Shen, Jia‐Jia Sun, Jia‐Le Wang, Yong‐Kang Deng, Yao Zhang, Xie‐Xing Wu, Kang‐Wu Chen, Hai‐Qing Mao

“…ABSTRACT Objective Although percutaneous kyphoplasty (PKP) under C‐arm guidance is an effective treatment for osteoporotic vertebral compression fractures (OVCF), obtaining high‐definition images in patients with OVCF and spinal deformities can be challenging or insufficient using traditional C‐arm guidance, prompting our institution to adopt the O‐arm navigation system—which offers comprehensive 3D imaging and precise navigation—and this study compares its safety and efficacy with conventional C‐arm‐assisted PKP. Methods This was a retrospective study. From February 2019 to February 2022, we enrolled 28 patients with OVCF (44 vertebrae) with spinal deformity treated with O‐arm navigation‐assisted PKP and 30 patients with OVCF (42 vertebrae) with spinal deformity treated with C‐arm‐guided PKP. …”
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DETERMINATION OF TECHNOPARK ACTIVITY BY REGULATORY AND LEGISLATIVE ACTS by Nikolay S. Novikov, Irina V. Karpova

“…Purpose, materials and methods. Among the unprocessed regulations are issues related to the drafting of contracts between partners regarding in which financial, intellectual, material, production, professional and performing parts the partners record their participation in joint activities. …”
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Effect of rapamycin-eluting stents on in-stent restenosis and early inflammatory response in coronary artery narrowing animal models by Jianbing Zhang, Jingyi Zhu, Baiping Sui, Ying Wang, Bingxue Zhang

“…Abstract Objective it was to evaluate the efficacy and safety of rapamycin-eluting stents at different doses in the treatment of coronary artery narrowing in miniature pigs. Methods a total of 20 miniature pigs were randomly assigned into four groups: S1 group (low-dose rapamycin-coated stent, 55 µg/mm2), S2 group (medium-dose rapamycin-coated stent, 120 µg/mm2), S3 group (high-dose rapamycin-coated stent, 415 µg/mm2), and D0 group (bare metal stent). …”
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Distinguishable Immunologic Characteristics of COVID-19 Patients with Comorbid Type 2 Diabetes Compared with Nondiabetic Individuals by Ruxing Zhao, Yujing Sun, Yongyuan Zhang, Weili Wang, Shouyu Wang, Chuang Wang, Jinbo Liu, Ling Gao, Zhao Hu, Jianchun Fei, Xinguo Hou, Huizhen Zheng, Li Chen

“…Here, we make efforts to examine whether comorbidity with type 2 diabetes (T2D) affects the immunological response in COVID-19 patients. Methods. We conducted a retrospective pilot study investigating immunological characteristics of confirmed cases of COVID-19 with or without comorbid T2D. …”
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Transcriptomic and metabolomic analysis of recalcitrant phosphorus solubilization mechanisms in Trametes gibbosa by Yulan Chen, Akasha Farooq, XieLuyao Wei, Leitao Qin, Yong Wang, Lingzi Zhang, Quanju Xiang, Ke Zhao, Xiumei Yu, Qiang Chen, Xue Gao, Tashi Nyima, Petri Penttinen, Yunfu Gu

“…Although the phosphorus-solubilizing mechanisms of phosphate-solubilizing bacteria (PSB) have been well characterized, the mechanisms utilized by phosphate-solubilizing fungi (PSF) remain largely unexplored.MethodsThis study isolated a PSF strain, Trametes gibbosa T-41, from soil and evaluated its phosphorus solubilizing capacity with organic (calcium phytin; Phytin-P) and inorganic (tricalcium phosphate; Ca-P) phosphorus sources. …”
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Prediction of Pathologic Response in Unresectable Hepatocellular Carcinoma After Downstaging with Locoregional and Systemic Combination Therapy by Yang C, Chen Y, Sheng L, Wang Y, Zhang X, Yang Y, Ronot M, Jiang H, Song B

“…Chongtu Yang,1,2,&ast; Yidi Chen,1,2,&ast; Liuji Sheng,1,2 Yanshu Wang,1,2 Xiaoyun Zhang,3 Yang Yang,4 Maxime Ronot,5 Hanyu Jiang,1,2 Bin Song1,2,6 1Department of Radiology, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 3Division of Liver Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 4Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 5Department of Radiology, Hôpital Beaujon (Université de Paris), Clichy, France; 6Department of Radiology, Sanya People’s Hospital, Sanya, Hainan, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Hanyu Jiang; Bin Song, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, People’s Republic of China, Email hanyu_jiang@foxmail.com; songlab_radiology@163.comBackground: The combination of locoregional and systemic therapy may achieve remarkable tumor response for unresectable hepatocellular carcinoma (HCC).Objective: We aimed to investigate the correlation between radiologic and pathologic responses following combination therapy, evaluate their prognostic values, and to establish a non-invasive prediction system for pathologic response.Methods: This single-center retrospective study included 112 consecutive patients with HCC who underwent locoregional and systemic combination therapy followed by liver resection or transplantation. …”
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Realization of a cascade treatment algorithm for glaucoma in St. Petersburg by A.V. Antonova, V.P. Nikolaenko, V.V. Brzheskiy

“…</i> </p> <p> <i><b>Patients and Methods:</b> this study included 500 consecutively enrolled patients who underwent surgery for uncontrolled glaucoma in 2016–2020 and were followed up for 6–24 months. …”
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Prevalence and factors associated with female genital mutilation/cutting among Tanzanian women who gave birth in the five years prior to the survey: A population-based study. by Fabiola Vincent Moshi

“…The study aimed to determine the prevalence and factors associated with FGM/C among Tanzanian women who had given birth within five years preceding the Survey.<h4>Method</h4>This study utilized an analytical cross-sectional design based on data from the 2015-2016 Tanzania Demographic and Health Survey and Malaria Indicators Survey (TDHS-MIS). …”
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Club Cell Protein 16 Attenuates CD16brightCD62dim Immunosuppressive Neutrophils in Damaged Tissue upon Posttraumatic Sepsis-Induced Lung Injury by Nils Becker, Philipp Störmann, Andrea Janicova, Kernt Köhler, Klemens Horst, Ildiko Rita Dunay, Claudia Neunaber, Ingo Marzi, Jan Tilmann Vollrath, Borna Relja

“…To understand their local and remote distribution after trauma, PMNL-subsets and the impact of immunomodulatory Club Cell protein (CC)16 that correlates with pulmonary complications were assessed. Methods. C57BL/6N mice were divided into three groups, receiving isolated blunt chest trauma (TxT), undergoing TxT followed by cecal ligation and puncture (CLP, TxT+CLP) after 24 h, or sham undergoing analgosedation (n=18/group). …”
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Differential impact of TyG and TyG-BMI indices on short- and long-term mortality in critically ill ischemic stroke patients by Yufan Pu, Na Xing, Ying Wang, Huihuang Wang, Jiang Xu, Xuejing Li

“…However, the comparative impact of these indices on short- and long-term mortality among critically ill ischemic stroke patients remains unclear. Methods This retrospective cohort study analyzed data from the Medical Information Mart for Intensive Care IV (MIMIC-IV 3.0) database, including 1,334 critically ill ischemic stroke patients. …”
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汉麻仁抗血栓活性肽的制备工艺优化 "Preparation process optimization of hemp kernel antithrombotic active peptide" by 石杰，张正海，魏连会，杨庆丽，李国巍，董艳，姬妍茹 "SHI Jie, ZHANG Zhenghai, WEI Lianhui, YANG Qingli, LI Guowei, DONG Yan, JI Yanru"

“…In summary, the hemp kernel antithrombotic active peptide prepared and purified by this method has high thrombin inhibitory activity. …”
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