Long-term safety and sustained efficacy of bimekizumab in patients with ankylosing spondylitis (radiographic axial spondyloarthritis): 5-year results from BE AGILE (phase 2b) and i... by Sofia Ramiro, Désirée van der Heijde, Atul Deodhar, Xenofon Baraliakos, Denis Poddubnyy, Lianne S Gensler, Helena Marzo-Ortega, Natasha de Peyrecave, Victoria Navarro-Compán, Tetsuya Tomita, Carmen Fleurinck, Ute Massow, Thomas Vaux

“…Objective Assess long-term safety, tolerability and efficacy of bimekizumab in ankylosing spondylitis (radiographic axial spondyloarthritis (r-axSpA)).Methods Patients with active r-axSpA completing the dose-ranging 48-week randomised controlled trial could enrol in the open-label extension, where patients received bimekizumab 160 mg every 4 weeks. …”
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First clinical cases of leishmaniosis in meerkats (Suricata suricatta) housed in wildlife parks in Madrid, Spain by Pablo Moraleda-Berral, Rosa Gálvez, Eva Martínez-Nevado, Lino Pérez de Quadros, Juncal García, Manuel de la Riva-Fraga, Juan Pedro Barrera, Efrén Estévez-Sánchez, Lourdes Cano, Rocío Checa, María Ángeles Jiménez-Martínez, Ana Montoya, Guadalupe Miró

“…Some of these zoological parks are in endemic areas for both human and animal leishmaniosis, thus it should be very important to include this zoonosis in the differential diagnosis. Methods The study was carried out in two zoological parks in Madrid, Madrid Zoo and Faunia, and analyzed seven meerkats. …”
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Metal mixtures exposure with risk of elevated serum neurofilament light chain concentrations in U.S. general adults, NHANES 2013–2014 by Yan Wang, Keyi Zhang, Hao Li, Si Liu, Linyao Ying, Lu Xiang, Na Liang, Liangkai Chen, Lin Xiao, Gang Luo

“…Objective: This study seeks to elucidate the potential impact of metal mixtures exposure on sNfL concentrations in a representative sample of U.S. general adults. Methods: Twelve urinary metal levels, including barium (Ba), cadmium (Cd), cobalt (Co), cesium (Cs), molybdenum (Mo), lead (Pb), antimony (Sb), tin (Sn), strontium (Sr), thallium (Tl), tungsten (W) and uranium (U), were analyzed in U.S. general adults recruited from the 2013–2014 National Health and Nutrition Examination Survey using inductively coupled plasma mass spectrometry (ICP-MS) after a simple dilution step. …”
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Is the Use of Tourniquets More Advantageous than Other Bleeding Control Techniques in Patients with Limb Hemorrhage? A Systematic Review and Meta-Analysis by Roberto Cirocchi, Dominica Prigorschi, Luca Properzi, Matteo Matteucci, Francesca Duro, Giovanni Domenico Tebala, Bruno Cirillo, Paolo Sapienza, Gioia Brachini, Sara Lauricella, Diletta Cassini, Antonia Rizzuto, Andrea Mingoli

“…The aim of this systematic review and meta-analysis was to summarize data from the available scientific literature on the effectiveness of prehospital tourniquet use for extremity bleeding. <i>Materials and Methods:</i> A systematic review and meta-analysis was performed between March 2022 and March 2024, adhering to PRISMA guidelines, to determine whether prehospital tourniquets are clinically effective. …”
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Effect of Repetitive Transcranial Magnetic Stimulation Combined with Exercise Therapy on the Motor Function in Stroke Patients with Hemiplegia by Wani ZHOU, Lei ZHANG, Rundong LI, Kaiquan XU, Chengji WU

“…Objective:To discuss the effect of repetitive transcranial magnetic stimulation (rTMS) combined with exercise therapy on the motor function in stroke patients with hemiplegia.Methods:A total of 100 stroke patients with hemiplegia were selected from September 2016 to September 2018, according to the random number table, and they were divided into excitation group and exercise group, with 50 cases in each group. …”
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Sacubitril/valsartan on right ventricular-pulmonary artery coupling and albumin-bilirubin score in heart failure in Chinese patients with reduced ejection fraction by Yanan Shi, Chuanyu Gao, Yu Xu, Fang Yuan

“…This study aimed to assess whether angiotensin receptor-neprilysin inhibitor (ARNI) affects the TAPSE /PASP in patients with HFrEF, and whether there is a correlation between changes in the ALBI score and ARNI treatment. Methods A retrospective observational study was conducted on 305 patients with HFrEF and RVD who were hospitalized between June 2020 and December 2021. …”
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Black posterior vitreous detachment: A 10-year historical cohort of pigmented uveal tumors by Vicktoria Vishnevskia-Dai, Hila Goldberg, Michael Ostrovsky, Ofira Zloto, Rachel Shemesh

“…Participants: Eight patients who were diagnosed with pigmentary PVD associated with a uveal tumor or optic nerve pigmented tumors in a tertiary medical center. Methods: Demographics, clinical data, type of uveal lesion, treatment, multimodal images, and follow-up information were retrieved.The main outcome measures were tumor recurrence, vitreous spread, and the patient's prognosis. …”
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Prevalence of Salmonella and Shigella species and their multidrug resistance patterns among pediatric populations in Ethiopia: a systematic review and meta-analysis by Mihret Tilahun, Melaku Ashagrie Belete, Alemu Gedefie, Habtu Debash, Ermiyas Alemayehu, Daniel Gebretsadik Weldehana, Hussein Ebrahim, Ousman Mohammed, Bruktawit Eshetu, Saba Gebremichael Tekele, Zewudu Mulatie, Agumas Shibabaw

“…Thus, this systemic review and meta-analysis aimed to investigate the prevalence of Salmonella and Shigella species and their multidrug resistance patterns in pediatric populations in Ethiopia. Methods The articles were searched extensively in the electronic databases and grey literature using entry terms or phrases. …”
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Whole systems approaches to diet and healthy weight: A scoping review of reviews. by Gavin Breslin, Olujoke Fakoya, Wendy Wills, Nigel Lloyd, Charis Bontoft, Amander Wellings, Sian Harding, John Jackson, Katherine Barrett, Adam P Wagner, Lisa Miners, Honey-Anne Greco, Katherine E Brown

“…This scoping review of reviews aims to: determine how WSAs to diet and healthy weight have been implemented and evaluated nationally and internationally; to determine what models or theories have been used to implement WSAs; describe how WSAs have been evaluated; determine if WSAs are effective; and to identify the contribution of the public and/or service users in the development of WSAs.<h4>Method</h4>Systematic searches were carried out using CINAHL, Scopus, PsycINFO (ProQuest), the Cochrane Library, and MEDLINE. …”
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Correlated factors of posttraumatic growth in patients with colorectal cancer: A systematic review and meta-analysis by Dingyuan Wei, Xue Wang, Mengxing Wang, Jiayan Wang, Fangping Chen, Luyang Jin, Xuemei Xian

“…Objectives: This systematic review and meta-analysis aimed to identify and synthesize the factors correlated with posttraumatic growth (PTG) in patients with colorectal cancer (CRC). Methods: PubMed, Web of Science, Embase, PsycINFO, CINAHL, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang database, China Science and Technology Journal Database (VIP) and SinoMed were searched for studies that reported data on the correlated factors associated with PTG in patients with CRC from inception to September 3, 2024. …”
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Risk factors of aspiration in neurocritical care patients with enteral nutrition (神经重症肠内营养支持患者误吸危险因素分析) by WANG Dan (王丹), KUANG Hongmei (况红梅), LIU Weichen (刘韦辰)

“…Objective To analyze the influencing factors of aspiration in neurocritical care patients with enteral nutrition, and to provide a reference for formulating strategies to prevent the incidence of aspiration. Methods From July 2020 to July 2021, 527 neurocritical care patients with enteral nutrition in a tertiary hospital in Jiangxi Province were selected, and they were divided into aspiration group and non-aspiration group according to whether aspiration occurred. …”
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Promotional tone in reviews of menopausal hormone therapy after the Women's Health Initiative: an analysis of published articles. by Adriane Fugh-Berman, Christina Pike McDonald, Alicia M Bell, Emily Catherine Bethards, Anthony R Scialli

“…The goal of this study was to determine whether promotional tone could be identified in narrative review articles regarding menopausal hormone therapy and whether articles identified as promotional were more likely to have been authored by those with conflicts of interest with manufacturers of menopausal hormone therapy.<h4>Methods and findings</h4>We analyzed tone in opinion pieces on hormone therapy published in the four years after the estrogen-progestin arm of the WHI was stopped. …”
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Enhancing the understanding of safety and the quality of patient care among medical and health sciences students in interprofessional climate: an interventional study by Salman Yousuf Guraya, Nabil Sulaiman, Ahmed Hasswan, Vida Abdolhamid Salmanpour, Feras Jassim Jirjees, Mohamed Hassan Taha, Jennat Alamara, Sausan A.L. Kawas, Manal Awad, Jacqueline Maria Dias, Leena R. David, Mohamed Aly Haider, Shaista Salman Guraya, Nihar Ranjan Dash, Amal Al-Qallaf, Sarra Shorbagi, Ibrahim Eltayeb Mahmoud

“…This study aimed to foster the understanding of senior medical, dental, pharmacy and health sciences students about PS and quality of care at the University of Sharjah (UoS) in UAE. Methods Using a convenience sampling technique, we recruited students from the College of Medicine (CoM), College of Pharmacy (CoP), College of Dental Medicine (CDM), and College of Health Sciences (CHS) of UoS. …”
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Enhanced therapeutic effects of hypoxia-preconditioned mesenchymal stromal cell-derived extracellular vesicles in renal ischemic injury by Fei Yuan, Jie Liu, Liang Zhong, Pengtao Liu, Ting Li, Kexin Yang, Wei Gao, Guangyuan Zhang, Jie Sun, Xiangyu Zou

“…In this study, we investigated the alterations occurring in MSCs and the production of MSC-EVs following hypoxia pre-treatment, and further explored the key intrinsic mechanisms underlying the therapeutic effects of hypoxic MSC-EVs in the treatment of renal IRI. Methods Human umbilical cord MSCs were cultured under normoxic and hypoxic conditions. …”
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Correlation Between Dynamic Contrast-Enhanced CT Imaging Signs and Differentiation Grade and Microvascular Invasion of Hepatocellular Carcinoma by Liu Y, Zhou Y, Liao C, Li H, Zhang X, Gong H, Pu H

“…., Ltd, Beijing, People’s Republic of China; 5School of Computer Science and Engineering, University of Electronic Science and Technology, Sichuan, People’s Republic of ChinaCorrespondence: Hong Pu, Department of Radiology, Sichuan Academy of Medical Sciences, Sichuan Provincial People’s Hospital; School of Medicine, University of Electronic Science and Technology, Chengdu, Sichuan Province, 610000, People’s Republic of China, Email ph196797@163.com Haigang Gong, School of Computer Science and Engineering, University of Electronic Science and Technology, Chengdu, Sichuan Province, 610000, People’s Republic of China, Email hggong@uestc.edu.cnObjective: This study aimed to investigate how dynamic contrast-enhanced CT imaging signs correlate with the differentiation grade and microvascular invasion (MVI) of hepatocellular carcinoma (HCC), and to assess their predictive value for MVI when combined with clinical characteristics.Methods: We conducted a retrospective analysis of clinical data from 232 patients diagnosed with HCC at our hospital between 2021 and 2022. …”
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Effect of humanistic care combined with risk management nursing model on the incidence of venous thromboembolism in critically ill patients with cancer (人文关怀联合风险管理干预重症肿瘤患者静脉血栓栓塞症的效... by ZHEN Yuhong (郑玉红), PEI Xiaolu (裴晓璐)

“…Objective To investigate the effect of humanistic care combined with risk management nursing model on the incidence of venous thromboembolism in critically ill patients with cancer. Methods Totally 100 critically ill patients with cancer were randomly divided into the study group and the control group, with 55 cases in each group. …”
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Searching for new genes associated with the familial hypercholesterolemia phenotype using whole-genome sequencing and machine learning by D. E. Ivanoshchuk, A. B. Kolker, O. V. Timoshchenko, S. E. Semaev, E. V. Shakhtshneider

“…The aim of this work was to search for new genes associated with the familial hypercholesterolemia phenotype by modern high-tech methods of sequencing and machine learning. On the basis of a group of patients with familial hypercholesterolemia (enrolled according to the Dutch Lipid Clinic Network Criteria and including cases confirmed by molecular genetic analysis), decision trees were constructed, which made it possible to identify cases in the study population that require additional molecular genetic analysis. …”
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The incremental value of aspartate aminotransferase/alanine aminotransferase ratio combined with CURB-65 in predicting treatment outcomes in hospitalized adult community-acquired p... by Huamei Zhou, Xuelei Zhu, Yi Zhang, Wenjuan Xu, Shiqun Li

“…This study aims to spot a routinely tested parameter with discriminative, predictive and prognostic value to enhance CURB-65’s prognostic accuracy in CAP patients with T2DM. Methods We retrospectively studied consecutive CAP patients from 2020 to 2021, comparing laboratory parameters between patients with and without T2DM. …”
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Efficacy and Safety of Low-Dose Lenvatinib and Toripalimab in Patients With Recurrent Platinum-Resistant Ovarian Cancer: Study Protocol of a Multicenter, Open-Label, Single-Arm, Ph... by Su H, Shang X, Liu H, Wang Y, Yu Y, Xu Y, Jiang K, Feng F

“…This study is designed to further validate the efficacy and safety of the combination therapy of low-dose lenvatinib and PD-1 inhibitor toripalimab in patients with recurrent PROC.Study Design and Methods: The study is designed as a multicenter, open-label, single-arm, prospective phase II study. …”
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DESAIN RUMAH YANG BERKOMPROMI DENGAN SITUASI PANDEMI COVID-19 by Muhammad Zakaria Umar, Fahri Ramadhan

“…This research uses a case study method with a qualitative approach. Sources of secondary data in this study include the concept of a room, the concept of a house, light circulation, access to hygiene, and a minimalist modern house. …”
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