Comparative Analysis of the Occurrence and Role of CX3CL1 (Fractalkine) and Its Receptor CX3CR1 in Hemophilic Arthropathy and Osteoarthritis by Piotr Wojdasiewicz, Łukasz A. Poniatowski, Andrzej Kotela, Marta Skoda, Michał Pyzlak, Aleksandra Stangret, Ireneusz Kotela, Dariusz Szukiewicz

“…Taking this into account, we have presented a study investigating the role of the CX3CL1/CX3XR1 axis in the course of hemophilic arthropathy, including the CX3CL1-dependent expression of CD56+, CD68+, and CD31+ cells along with evaluation of articular cartilage and synovial membrane morphology. Methods. The study was carried out using cases (n=20) of end-stage hemophilic arthropathy with a severe type of hemophilia A and control cases (n=20) diagnosed with osteoarthritis. …”
Get full text

Optimization of the management of pregnant women with new COVID-19 coronavirus infection: An open prospective cross-sectional study by Irina V. Medyannikova, Yuliya Ch. Kuklis, Irina V. Saveljeva, Galina B. Beznoshchenko, Elena G. Galyanskaya, Olga Yu. Tsygankova, Galina V. Krivchik, Elena A. Bukharova, Natalya V. Nosova, Pavel V. Davidov

“…To improve pregnancy and childbirth outcomes in women with COVID-19 by optimizing diagnostic and treatment interventions. Materials and methods. An open-label prospective continuous cross-sectional study enrolled 114 patients following SARS-CoV-2 infection. …”
Get full text

Preference for HIV testing among community residents in Yunnan Province, China: results from a discrete choice experiment by Jingwen Yang, Chenquan Qiu, Renhai Tang, Wenbin Dong, Enlong Yao, Huyunzhao Wang, Shuwen Lin, Minyang Xiao, Zuyang Zhang, Jin Niu, Liru Fu, Lijun Song, Xuehua Li, Yuhua Shi, Xiaowen Wang

“…This study aimed to elicit preferences regarding HIV testing among community residents to identify a model of community-based HIV testing services that would appeal to this population. Methods A discrete-choice experiment (DCE) was conducted in the communities of Yunnan Province, China. …”
Get full text

Effect of Acarbose on High Carohydrate Diet Induced Liver Injury in Largemouth Bass (Micropterus salmoides) by Yanhao CAO, Xiaolong BO, Hongli LIU, Xiaoli HUANG

“…【Objective】The study was conducted to investigate the effect of acarbose on high-carbohydrate dietinduced liver injury in largemouth bass and to detect similar functional therapeutic drugs in the initial screening.【Method】The largemouth bass (Micropterus salmoides) with an initial body weight of 7.25 (±1.67) g was taken as research object. …”
Get full text

Acupuncture for somatosensory deficits after stroke: a systematic review and meta-analysis by Shumeng Ren, Yuhang Chen, Yu Liu, Qiuyi Lv, Jing Peng, Lei Song, Yihuai Zou, Hua Zhang, Xing Chen

“…ObjectiveThis meta-analysis aimed to evaluate the randomized controlled trials (RCTs) of acupuncture for somatosensory deficits after stroke to provide the current best evidence for clinical practice.MethodsA systematic search was performed for eligible articles on the acupuncture for somatosensory deficits after stroke based on 14 databases. …”
Get full text

Profile of non-invasive physical health indicators associated with cognitive performance in Chinese older adults: evidence from the China Health and Retirement Longitudinal Study by Xiyu Wei, Chao Li, Dongyu Liu, Jieyi Chen, Yumeng Ju, Jin Liu, Bangshan Liu, Yan Zhang

“…Therefore, the current study aimed to establish a comprehensive physical health indicators profile in association with cognitive performance. Methods The present study utilized a three-year longitudinal cohort design, with data from the China Health and Retirement Longitudinal Study (CHARLS). 4,869 participants aged 60–97 years from CHARLS wave 2015 and 2018 who were cognitively and physically healthy were included in analysis. …”
Get full text

Corticosteroid use beyond 1-year post heart transplantation is associated with worse outcomes: A contemporary analysis of the ISHLT registry by Abhishek Jaiswal, MD, William L. Baker, Pharm.D, Ashwin Pillai, MD, Michelle Kittleson, MD, PhD, Balaphanidhar Mogga, MD, Zeina Jedeon, MD, Caroline Chen, David A. Baran, MD

“…We compared outcomes in adult HT recipients with or without steroid use in the large, international ISHLT Registry. Methods: We included adults who underwent their first heart-only transplant between January 2010 and June 2018. …”
Get full text

Pegloticase and Methotrexate Cotherapy in Patients With Uncontrolled Gout With Prior Pegloticase Monotherapy Failure: Findings of an Open‐Label Trial by Orrin M. Troum, John K. Botson, Katie Obermeyer, Bo Chao, Yang Song, Jennifer Zarzoso, Kjerstina Gutierrez, Supra Verma, Lissa Padnick‐Silver, Brian LaMoreaux

“…The ADVANCE open‐label trial examined pegloticase plus MTX cotherapy efficacy and safety following pegloticase monotherapy failure. Methods Patients with uncontrolled gout (SU levels ≥6 mg/dL, oral urate–lowering therapy failure or intolerance, and ≥1 gout sign or symptom) who previously lost SU‐lowering response to pegloticase monotherapy were included. …”
Get full text

Country economic status is strongly associated with burn survival - validation of the (modified) ABSI by Julia Elrod, Christoph Mohr, Ludvik Branski, Joshua M. Peterson, Fionna M. Wood, Dale W. Edgar, Pius Agbenorku, Shobha Chamania, Anant Sharma, Flavio N. Novaes, Jean Bosco Katabogama, Michael Boettcher, Konrad Reinshagen, Ingo Koenigs

“…This study compares burn mortality across countries with varying economic levels, as indicated by the Human Development Index (HDI), to assess if a modified ABSI (mABSI) offers enhanced predictive accuracy. Methods A retrospective study was performed, including over 90,000 patients from seven sources in five continents, including two burn registries and five referral burn centers. …”
Get full text

A Digital Parenting Intervention With Intimate Partner Violence Prevention Content: Quantitative Pre-Post Pilot Study by Moa Schafer, Jamie Lachman, Paula Zinser, Francisco Antonio Calderón Alfaro, Qing Han, Chiara Facciola, Lily Clements, Frances Gardner, Genevieve Haupt Ronnie, Ross Sheil

“…ObjectiveThis study aimed to assess parents’ and caregivers’ level of engagement with the IPV prevention material in the ParentText chatbot and explore preliminary changes in experiences and perpetration of IPV, attitudes toward IPV, and gender-equitable behaviors following the intervention. MethodsCaregivers of children aged between 0 and 18 years were recruited through convenience sampling by research assistants in Cape Town, South Africa, and by UNICEF (United Nations Children's Fund) Jamaica staff in 3 parishes of Jamaica. …”
Get full text

Machine learning models for dementia screening to classify brain amyloid positivity on positron emission tomography using blood markers and demographic characteristics: a retrospec... by Noriyuki Kimura, Kotaro Sasaki, Teruaki Masuda, Takuya Ataka, Mariko Matsumoto, Mika Kitamura, Yosuke Nakamura, Etsuro Matsubara

“…This study developed machine learning models to classify positron emission tomography (PET) Aβ-positivity in participants with preclinical and prodromal AD using data accessible to primary care physicians. Methods This retrospective observational study assessed the classification performance of combinations of demographic characteristics, routine blood test results, and cognitive test scores to classify PET Aβ-positivity using machine learning. …”
Get full text

Collagenase Chemonucleolysis for Treating Cervical Disc Herniation: An Exploratory, Single-Arm, Open-Label, Multicenter Clinical Trial by Zhijian Wang, Bifa Fan, Lili Gu, Xuexue Zhang, Tao Sun, Hui Liu, Rongchun Li, Likui Wang, Kaiqiang Wang, Shun Li, Yong Ma, Haibo You, Daying Zhang

“…This study aims to evaluate the efficacy and safety of collagenase chemonucleolysis for treating CDH. Methods Eligible patients with CDH underwent collagenase chemonucleolysis via anterior cervical intradiscal injection or epidural injection. …”
Get full text

Evaluasi Kombinasi Hipernin dan Sinonim untuk Klasifikasi Kebutuhan Non-Functional Berbasis ISO/IEC 25010 by Lukman Hakim, Siti Rochimah, Chastine Fatichah

“…The two training data will be compared using two testing models ie based on expert ground truth and systems using the KNN and SVM classification methods. The test results showed scenario 1 is proven to provide a better value than scenario 2 in both testing models, where the precision values of expert ground truth, KNN, and SVM  respectively 49.3%, 81.0%, and 74.6%. …”
Get full text

Feasibility of a Mobile App–Based Cognitive-Behavioral Perinatal Skills Program: Protocol for Nonrandomized Pilot Trial by Andrea B Temkin-Yu, Aliza Ayaz, Ella Blicker, Michael X Liu, Ace Oh, Isabelle E Siegel, Meredith J Seewald, Alison D Hermann, Soudebah Givrad, Lara M Baez, Lauren M Osborne, Cori M Green, Maddy M Schier, Alexandra M Davis, Shasha Zhu, Avital Falk, Shannon M Bennett

“…ObjectiveThis pilot study aims to assess the feasibility, acceptability, and usability of M-PSP and explore links between program use and symptoms of anxiety and low mood. MethodsThis single-arm trial will recruit 50 pregnant or postpartum individuals with mild-to-moderate anxiety or mood symptoms. …”
Get full text

Incidence and predictors of adverse birth outcomes among women who gave birth at Assosa general hospital, Northwest Ethiopia: a retrospective cohort study by Habtamu Tadesse Gudeta, Shalama Lekasa Nagari, Dessalegn Emana Jabana, Mustefa Aflegn Legese, Demekisa wondimu Biyena, Fantahun Cheklie Kassie

“…For this purpose, this study aimed to assess the incidence and predictors of adverse birth outcomes among women who gave birth at Assosa General Hospital. Methods An institution-based retrospective cohort study design was used to select 715 mothers who gave birth at the hospital. …”
Get full text

Restoring natural killer cell activity in lung injury with 1,25-hydroxy vitamin D3: a promising therapeutic approach by Johnny Amer, Ahmad Salhab, Mohammad Abuawad

“…We aimed to assess the impact of 1,25-hydroxy-vitamin-D3 [1,125(OH)2D] on ALI clinical outcome in a mouse model and effects on lung trNK cell activations.MethodsOleic acid (OA)-induced ALI in C57BL/6J mice and 1,25(OH)2D treatment 2×/2 weeks were performed. …”
Get full text

The Relationship between Body Mass Index and Incident Diabetes Mellitus in Chinese Aged Population: A Cohort Study by M. L. Tang, Y. Q. Zhou, A. Q. Song, J. L. Wang, Y. P. Wan, R. Y. Xu

“…We aimed to evaluate the value of BMI for the prediction of incident diabetes mellitus (DM) in the Chinese elderly population. Methods. A total number of 6,911 Chinese elderly people (4,110 men and 2,801 women, aged 71±6.0 years) were included in this cohort study. …”
Get full text

Can home care work be organized to promote musculoskeletal health for workers? Results from the GoldiCare cluster randomized controlled trial by Fredrik Klæboe Lohne, Marius Steiro Fimland, Javier Palarea-Albaladejo, Svend Erik Mathiassen, Andreas Holtermann, Skender Redzovic

“…Outcomes were pain in the neck/shoulder and lower back, and the implementation of the intervention was also evaluated. Methods A 16-week cluster randomized controlled trial was conducted with 125 workers from 11 home care units, divided into six intervention units and five control units. …”
Get full text

Confronting food insecurity through agricultural interventions: the Farmer FIRST program in India by Purushothaman Venkatesan, Nilakandan Sivaramane, Ch Srinivasa Rao, Ramanujam Venkattakumar, Sethuraman Sivakumar, Palanisamy Mooventhan, Rajarshi Roy Burman, Bommu Kalyani, Lalitha Navya Challa

“…This program envisages agricultural interventions ensuring national food security goals, with improved agricultural practices, enhanced food production, and increased access to nutritious food, especially for vulnerable populations.MethodsThis study aims to investigate the food security improvement resulting from implementing nutrition-sensitive interventions introduced under the Farmer FIRST Program (FFP) in 15 agroecological zones. …”
Get full text

Hubungan Tingkat Pengetahuan Dokter dengan Kualitas Visum et Repertum Perlukaan di Rumah Sakit Wilayah Sumatera Barat Periode Januari 2011 sampai Desember 2012 by Muhammad Ridho Azhari, Rika Susanti, Noza Hilbertina

“…The objective of this study was to investigate the relation between doctor’s knowledge level and the quality of VeR of injury by using Cross Sectional Study method. This study was conducted at eight hospitals in West Sumatera region that met the inclusion criteria. …”
Get full text