Spinal neuromodulation using ultra low frequency waveform inhibits sensory signaling to the thalamus and preferentially reduces aberrant firing of thalamic neurons in a model of ne... by Martyn G. Jones, Martyn G. Jones, Liam A. Matthews, Liam A. Matthews, Scott Lempka, Scott Lempka, Scott Lempka, Nishant Verma, James P. Harris, Stephen B. McMahon

“…Here, we show that in anesthetized rats, epidural ULF current reversibly inhibits activation of neurons in the thalamus receiving sensory spinothalamic input.MethodsIn naïve, neuropathic and sham-operated rats, recordings of ongoing and evoked activity were made from thalamic neurons, targeting the ventral posterolateral (VPL) nucleus.ResultsResponses to electrical stimulation of hind limb receptive fields were reduced in 25 of 32 (78%) neurons tested with lumbar epidural ULF neuromodulation. …”
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Association of lower-limb strength with different fall histories or prospective falls in community-dwelling older people: a systematic review and meta-analysis by Ringo Tang-Long Zhu, Jenny Jing-Jing Zuo, Ke-Jing Li, Freddy Man Hin Lam, Arnold Yu Lok Wong, Lin Yang, Xue Bai, Man Sau Wong, Timothy Kwok, Yong-Ping Zheng, Christina Zong-Hao Ma

“…., those with a fall history or prospective falls). Methods This systematic review searched six databases, including PubMed, Web of Science, EMBASE, Scopus, CINAHL, and Cochrane CENTRAL. …”
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Retrospective Analysis of the Prevalence and Risk Factors of Retinopathy of Prematurity in a Single-Center Cohort in Romania and Comparison with National and European Data by Zsuzsánna Simon-Szabó, Sándor Pál, Aliz Pándi, Zsuzsanna Gáll, Hajnal Finta, Zsuzsánna Incze-Bartha, Cristina Maki, Manuela Cucerea

“…<i>Background and Objectives:</i> This study investigated and compared with European literature data the incidence, severity, and perinatal risk factors of retinopathy of prematurity (ROP) in preterm infants admitted to the Premature Department of Mureş County Clinical Hospital over a two-year period (January 2022–December 2023). <i>Materials and Methods</i>: ROP screening was performed in 96 infants (76.8%) according to professional guidelines. …”
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The Forgotten Hemodynamic (PCO2 Gap) in Severe Sepsis by Zouheir Ibrahim Bitar, Ossama Sajeh Maadarani, AlAsmar Mohammed El-Shably, Ragab Desouky Elshabasy, Tamer Mohamed Zaalouk

“…We also investigated the chest ultrasound pattern A or B. Method. We performed a prospective observational study and recruited 28 patients with severe sepsis and septic shock in a mixed ICU. …”
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Unraveling the Role of Oxygen Pulse Variability in Endurance Exercise Training in Individuals with COPD: A Novel Approach to Response of Oxygen Pulse and Quality of Life in Pulmona... by Huang SY, Hsieh PC, Huang KL, Yang MC, Jao LY, Tzeng IS, Lan CC, Wu YK

“…Cardiopulmonary exercise testing (CPET) measures oxygen pulse (O2P), an indicator of stroke volume, yet the impact of baseline O2P on PR effectiveness remains unclear.Methods: This retrospective study included 97 participants with COPD who had received PR, of whom 48 were classified as Group 1 (normal O2P) and 49 as Group 2 (low O2P). …”
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Implementasi Data Mining untuk Deteksi Penyakit Ginjal Kronis (PGK) menggunakan K-Nearest Neighbor (KNN) dengan Backward Elimination by Ikhsan Wisnuadji Gamadarenda, Indra Waspada

“…The process of this research uses work methods of Data Mining Knowledge Data Discovery (KDD). …”
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Clinical assessment of urinary prostate cancer antigen 3 in Chinese population: a large-scale, prospective and multicenter study by Xuan Shu, Jiaming Wang, Wen Cai, Shen Lin, Jiangfeng Li, Xueyou Ma, Yufan Ying, Yat Sai Terry Wang, Xiao Wang, Hong Chen, Chunyu Jin, Ben Liu, Liping Xie, Jindan Luo

“…Abstract Background To assess the clinical utility of PCA3 in the diagnostic accuracy, the correlation between PCA3 and biopsy or pathological characteristics and the performance of PCA3 to reduce the unnecessary biopsies in Chinese population. Methods A prospective study including patients with indication of prostate biopsies from 4 centers was conducted. …”
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Efficient Therapeutic Function and Mechanisms of Human Polyclonal CD8+CD103+Foxp3+ Regulatory T Cells on Collagen-Induced Arthritis in Mice by Juan Sun, Yiming Yang, Xiaona Huo, Beibei Zhu, Zhenhua Li, Xueyu Jiang, Rufeng Xie, Li Gao, Ying Sun, Huahua Fan, Yongming Zhu, Jie Yang

“…To investigate the potential therapeutic effect in a rheumatoid arthritis model of stable human CD8+ regulatory T cells (hCD8+Tregs) induced by TGF-β1 and rapamycin (RAPA) in vitro. Methods. Human CD8+T cells were isolated from human peripheral blood mononuclear cells and induced/expanded with TGF-β1 and RAPA along with anti-CD3/28 beads and IL-2 in vitro and harvested as hCD8+Tregs. …”
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Endothelial and neuronal engagement by AAV-BR1 gene therapy alleviates neurological symptoms and lipid deposition in a mouse model of Niemann-Pick type C2 by Charlotte Laurfelt Munch Rasmussen, Signe Frost Frederiksen, Christian Würtz Heegaard, Maj Schneider Thomsen, Eva Hede, Bartosz Laczek, Jakob Körbelin, Daniel Wüstner, Louiza Bohn Thomsen, Markus Schwaninger, Ole N. Jensen, Torben Moos, Annette Burkhart

“…We hypothesized that an adeno-associated virus (AAV-BR1) encoding the Npc2 gene could cure neurological symptoms in Npc2−/− mice through transduction of BECs, and possibly neurons via viral passage across the BBB. Methods Six weeks old Npc2−/− mice were intravenously injected with the AAV-BR1-NPC2 vector. …”
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Global, regional, national prevalence, mortality, and disability-adjusted life-years of cutaneous squamous cell carcinoma and trend analysis from 1990 to 2021 and prediction to 204... by Chengling Liu, Xingchen Liu, Pengjuan Cao, Xin Li, Haiming Xin, Sailin Zhu

“…For the purpose of creating focused strategies, it is essential to comprehend geographical variations in cSCC prevalence and trends.MethodsThis study utilized data from the 2021 Global Burden of Diseases (GBD) survey to analyze cSCC across 204 countries and territories. …”
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Health-related adverse work outcomes associated with post COVID-19 condition: a cross-sectional study by Peter M Smith, Hind Sbihi, Wei Zhang, Adeera Levin, Naveed Z Janjua, Hiten Naik, Bingyue Zhu, Lee Er, Karen Tran

“…This study aimed to assess health-related adverse work outcomes in individuals with a PCC history compared with others who had COVID-19.Methods This was a cross-sectional study in which participants in British Columbia (BC) completed an online questionnaire. …”
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Single-cell RNA sequencing and immune microenvironment analysis reveal PLOD2-driven malignant transformation in cervical cancer by Zhiheng Lin, Fengxin Wang, Renwu Yin, Shengnan Li, Yuquan Bai, Baofang Zhang, Chenlin Sui, Hengjie Cao, Dune Su, Lianwei Xu, Honghong Wang

“…Therefore, it is crucial to investigate the tumor microenvironment in advanced cervical cancer in order to identify possible treatment targets.Materials and methodsIn order to better understand malignant cervical cancer epithelial cells (EPCs), this study used bulk RNA-seq data from UCSC in conjunction with single-cell RNA sequencing data from the ArrayExpress database. …”
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Masculinization of Nile tilapia (Oreochromis niloticus) by administration of bull testes meal by Muslim Muslim, M. Zairin Junior, Nur Bambang Priyo Utomo

“…This study was conducted to evaluate the effect of natural testosterone hormone in bull testes meal (BTM) on the masculinization of Nile tilapia using validated aceto carmine squash method of gonads of the fish. Experimental design was utilized two factors experiments in completely randomized design. …”
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Efficacy of Moringa oleifera Seed Husk as Adsorptive Agent for Trihalomethanes from a Water Treatment Plant in Southwestern, Nigeria by Aderonke Adetutu Okoya, Olasunkanmi Olalekan Olaiya, Abimbola Bankole Akinyele, Nnenneh Oruada Ochor

“…The physicochemical properties of both the treated and raw surface water were determined using standard methods, and the concentration of THMs was determined from the water treatment plant at different stages of treatment using gas chromatography with flame ionization detector (GC-FID). …”
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Effect of pelvic floor muscle training combined with hydrotherapy on postoperative rehabilitation of patients undergoing for sphincter preservation rectal cancer (盆底肌锻炼联合水疗促进直肠癌患者保... by HUANG Liming (黄丽明), WU Lifang (吴丽芳)

“…Objective To investigate the effect of pelvic floor muscle training combined with hydrotherapy on postoperative rehabilitation of patients undergoing for sphincter preservation rectal cancer. Methods Totally 66 patients undergoing for sphincter preservation rectal cancer were randomly divided into the control group and observation group, with 33 cases in each group. …”
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The clinical features and risk factors of coagulopathy associated with cefoperazone/sulbactam: a nomogram prediction model by Changjing Xu, Junlong Zhu, Kun Tu, Hui Tang, Xinxin Zhou, Qiuyu Li, Kun Chen, Xuping Yang, Yilan Huang

“…This study aimed to explore the risk factors and developed a nomogram model for predicting the risk of coagulopathy in patients undergoing CPZ/SAM treatment.MethodsA total of 1719 patients who underwent CPZ/SAM in the Affiliated Hospital of Southwest Medical University from August 2018 to August 2022, were recruited as the training cohort. …”
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Physical activity, fatigue severity, and health-related quality of life of community-dwelling stroke survivors: a cross-sectional study by Marufat Oluyemisi Odetunde, Ayomide Felix Makinde, Olamide Mary Jimoh, Chidozie Emmanuel Mbada, Faatihah Niyi-Odumosu, Francis Fatoye

“…This study was aimed to determine the relationships among PA, FS, and HRQL in community-dwelling SSV and to predict the association with selected socio-demographic and clinical variables. Methods This analytical cross-sectional correlation study involved 102 consented community-dwelling SSV. …”
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Effect of Soft Rehabilitation Robot Gloves on Upper Limb and Hand Function of Stroke Patients：A Meta-Analysis by YU Tingting, SHEN Yuwei, WAN Guomeng, LI Jianan

“…ObjectiveTo evaluate the effect of soft rehabilitation robot gloves (SRG) on upper limb, hand motor function and activities of daily living of stroke patients by meta-analysis.MethodsData were searched and retrieved from the PubMed, Web of Science, The Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), Wanfang Data, Chinese Biomedical Literature Service System (CBMdisc), Chinese Science and Technology Periodical Database (VIP). …”
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Repeatability and reproducibility of a new spectral-domain optical coherence tomography biometer and agreement with swept-source optical coherence tomography based biometer by Xin Li, Chak Seng Lei, Rui Ning, Luze Liu, Aodong Chen, Xinning Yang, Giacomo Savini, Domenico Schiano-Lomoriello, Xingtao Zhou, Jinhai Huang

“…Abstract Background To assess the repeatability and reproducibility of the Colombo IOL biometer (Moptim, China), which utilizes spectral-domain optical coherence tomography (SD-OCT), in measuring ocular parameters of normal subjects and to compare its agreement with the swept-source optical coherence tomography (SS-OCT)-based IOLMaster 700 biometer (Carl Zeiss Meditec AG, Germany). Methods This prospective study included 91 eyes from 91 normal subjects. …”
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Efficacy, safety, and biomarker analysis of TACE combined with lenvatinib plus sintilimab in unresectable hepatocellular carcinoma: a real-world study by Lingzhan Meng, Hu Li, Yingjie Ji, Peng Yu, Zizheng Wang, Li Cao, Bin Shi, Yanling Shao, Jin Yan, Yinjie Gao, Zhenyu Zhu

“…This study aims to assess the efficacy and safety of TACE combined with lenvatinib and sintilimab in unresectable HCC patients. Methods Unresectable HCC patients who received TACE in combination with sintilimab plus Lenvatinib as first-line treatment from 1 January 2020 to 31 March 2023 were included for the analysis. …”
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