Baseline 18F-FDG PET/CT parameters in predicting the efficacy of immunotherapy in non-small cell lung cancer by Lu Zheng, Lu Zheng, Yanzhu Bian, Yanzhu Bian, Yujing Hu, Congna Tian, Xinchao Zhang, Shuheng Li, Xin Yang, Yanan Qin

“…ObjectiveTo analyse positron emission tomography/ computed tomography (PET/CT) imaging and clinical data from patients with non-small cell lung cancer (NSCLC), to identify characteristics of survival beneficiaries of immune checkpoint inhibitors (ICIs) treatment and to establish a survival prediction model.MethodsA retrospective analysis was conducted on PET/CT imaging and clinical parameters of 155 NSCLC patients who underwent baseline PET/CT examination at the Department of Nuclear Medicine, Hebei General Hospital. …”
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Perancangan User Experience Pada Aplikasi Mobile HomeCare Rumah Sakit Semen Gresik Menggunakan Metode Design Thinking by Fara Regina Isadora, Buce Trias Hanggara, Yusi Tyroni Mursityo

“…Design thinking is a method used to design user experiences on the HomeCare application by defining problems and providing design solutions that can solve these problems. …”
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Artificial intelligence analysis of thermal energy for convectively heated ternary nanofluid flow in radiated channel considering viscous dissipations aspects by Hamid Qureshi, Amjad Ali Pasha, Muhammad Asif Zahoor Raja, Zahoor Shah, Salem Algarni, Talal Alqahtani, Waqar Azeem Khan, Moinul Haq

“…The use of AI in creating the simulations is more accurate for prediction than traditional numerical methods with an improved MSE of up to 10−14 through the Python model. …”
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Healthcare practitioners as accomplices: a qualitative study of gender affirmation in a context of ambiguous regulation in Indonesia by Benjamin Hegarty, Alegra Wolter, Amalia Puri Handayani, Kevin Marian, Jamee Newland, Dede Oetomo, Ignatius Praptoraharjo, Angela Kelly-Hanku

“…In light of the challenges associated with medical and legal gender affirmation in Indonesia, we conducted a qualitative study to understand the views of trans people, healthcare providers, and legal practitioners. Methods In this qualitative study, we drew on a participatory methodology to conduct 46 semi-structured interviews between October and December 2023, with trans people (10 trans feminine people and 10 trans masculine people, each interviewed twice) and key informants (three healthcare providers and three lawyers and paralegals). …”
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Determining whether ethnic minorities with severe obesity face a disproportionate risk of serious disease and death from COVID-19: outcomes from a Southern California-based retrosp... by Qiaowu Li, Hemesh Mahesh Patel, Shefali Khandwala, Poonam Somani, Stephanie Tovar, Alejandra Montano

“…We aim to determine if ethnic minorities with severe obesity—defined as a body mass index (BMI) above 40 kg/m²—experience higher rates of hospitalisation, invasive ventilation and death.Design and setting Retrospective cohort study from 1 March 2020 to 28 February 2021 within an integrated healthcare organisation in Southern California.Participants We identified 373 831 patients by COVID-19 diagnosis code or positive laboratory test.Methods Multivariable Poisson regression with robust error variance estimated adjusted risks of hospitalisation, invasive ventilator use and death within 30 days. …”
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A Multi‐Center Prospective Study on the Healing of Neuro‐Ischemic Ulcers in Singapore: A Prospective Cohort Study by Lingyan Meng, Priya Bishnoi, Zhiwen Joseph Lo, Enming Yong, Tze Tec Chong, David Carmody, Rajesh Babu Dharmaraj, Yi Zhen Ng, Keith Harding, Pei Ho

“…This study aims to evaluate their healing rate, associated healthcare resource utilization, and prognostic factors influencing healing. Methods Consecutive patients attended specialist clinics or admitted to wards in three tertiary hospitals for new or existing NIUs from November 2019 to November 2021 were eligible for this study. …”
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Use of artificial intelligence for gestational age estimation: a systematic review and meta-analysis by Sabahat Naz, Sahir Noorani, Syed Ali Jaffar Zaidi, Abdu R. Rahman, Saima Sattar, Jai K. Das, Jai K. Das, Zahra Hoodbhoy

“…The aim of this meta-analysis is to assess the accuracy of AI models in assessing GA against US as the gold standard.MethodsA literature search was performed in PubMed, CINAHL, Wiley Cochrane Library, Scopus, and Web of Science databases. …”
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The impact of marriage on breastfeeding duration: examining the disproportionate effect of COVID-19 pandemic on marginalized communities by Anna Charlotta Kihlstrom, Tara Stiller, Nishat Sultana, Grace Njau, Matthew Schmidt, Anastasia Stepanov, Andrew D. Williams

“…This study examined how marriage affects breastfeeding duration across socioeconomic and racially minoritized groups during COVID-19, aiming to inform social support strategies for vulnerable families in public health crises. Methods For this cross-sectional study, data were drawn from the 2017–2021 North Dakota Pregnancy Risk Assessment Monitoring System (weighted n = 41433). …”
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IL-8 Downregulation Mediates the Beneficial Effects of Infection-Induced Fever on Breast Cancer Prognosis by Li H, Liang X, Ma J, Liu Q, Lin Y, Tang J, Ren Z, Liang Z

“…However, the key cytokines and the underlying mechanisms through which fever exerts its anti-tumor effects remain unclear.Patients and Methods: A total of 794 breast cancer patients were recruited between 2008 and 2017, with follow-up extending until October 31st, 2023. …”
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Food for thought: a qualitative assessment of medical trainee and faculty perceptions of nutrition education by Olivia Kunitsky, Mahdi Taye, Karla Feeley, Hugh Johnson, Abigail Glynn, Avery Stivale, Matthew Hamers, Alexis Notarianni, Sireesha Mamillapalli, Gabi Waite, Sonia Lobo

“…This study aimed to examine the perceptions of key stakeholders regarding the role of nutrition in medicine and to identify barriers, opportunities for improvement, and roles/responsibilities for innovative implementation of nutrition education. Methods This exploratory, qualitative study employed a phenomenological approach and inductive coding process. …”
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Real-World Persistence and Effectiveness of Upadacitinib versus Other Janus Kinase Inhibitors and Tumor Necrosis Factor Inhibitors in Australian Patients with Rheumatoid Arthritis by Peter Youssef, Sabina Ciciriello, Talib Tahir, Joanna Leadbetter, Belinda Butcher, Miriam Calao, Nicole Walsh, Catherine O’Sullivan, Tegan Smith, Geoffrey Littlejohn

“…Abstract Introduction This study sought to describe treatment patterns, persistence, and effectiveness of upadacitinib (UPA) alone and compared to other Janus kinase inhibitors (JAKis) or tumor necrosis factor inhibitors (TNFis) in patients with rheumatoid arthritis (RA). Methods This retrospective, non-interventional study used the OPAL dataset, derived from electronic medical records. …”
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Association between exposure to ambient air pollutants and metabolic syndrome in the vicinity of the Taklamakan Desert by Zhe Wang, Weidong Ji, Yushan Wang, Lin Li, Kai Wang, Hongze Liu, Yining Yang, Yi Zhou

“…Background: Air pollution is a recognized contributor to metabolic syndrome (MetS); but studies in developing regions, including China, remain limited, especially in severely polluted areas near the Taklamakan Desert. Methods: Health data from 2,689,455 individuals aged ≥ 18 years in five regions near the Taklamakan Desert were analyzed. …”
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Distinct sex differences in ethanol consumption and operant self-administration in C57BL/6J mice with uniform regulation by glutamate AMPAR activity by Sara Faccidomo, Sara Faccidomo, Vallari R. Eastman, Taruni S. Santanam, Katarina S. Swaim, Seth M. Taylor, Clyde W. Hodge, Clyde W. Hodge

“…This study aims to elucidate SABV in ethanol (EtOH) consumption by evaluating its reinforcing effects and regulation by glutamate AMPA receptor activity in male and female mice.MethodsC57BL/6J mice (male and female) were assessed for EtOH intake under continuous and limited access conditions in the home cage. …”
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Activation of Hippocampal Microglia Mediates Chronic Stress-induced Depression-like Behavior in Rats with Ischemic Stroke by TAO Xi, YANG Chen, TANG Wenjing, WU Siyuan, DENG Jinggui

“…ObjectiveTo explore the role of hippocampal microglia activation and related proinflammatory factors in depression-like behavior induced by chronic stress in rats with ischemic stroke.MethodsA total of seventy-five healthy male Sprague-Dawley rats were used to establish a right middle cerebral artery occlusion (MCAO) model with 70 min ischemia. …”
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Preventable hospitalizations through ED: does the number of hospital beds matter under the global budget in a single-payer system in Taiwan? by Hsueh-Fen Chen, Hsueh-Fen Chen, Hsueh-Fen Chen, Hui-Min Hsieh, Hui-Min Hsieh, Hui-Min Hsieh, Wei-Shan Chang

“…The present study aimed to examine the relationship between the supply of hospital beds and hospitalizations following an emergency department (ED) visit (called ED hospitalizations) by using diabetes-related ambulatory care sensitive conditions (ACSCs) that are preventable and discretionary as an example.MethodsThe study was a pooled cross-sectional design analyzing 2011–2015 population-based claims data in Taiwan. …”
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Levodopa Challenge Test Predicts STN-DBS Outcomes in Various Parkinson’s Disease Motor Subtypes: A More Accurate Judgment by Zijian Zheng, Zixiao Yin, Bohan Zhang, Houyou Fan, Dan Liu, Yuancheng Zhou, Jian Duan, Dongwei Zhou, Xi Wu, Guohui Lu

“…We aim to evaluate the value of total levodopa response (TLR) and symptom levodopa response (SLR) in predicting postoperative improvement in different PD motor subtypes. Methods. Studies were split into a training set (147 patients) and a validation set (304 patients). …”
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Joint fluid multi-omics improves diagnostic confidence during evaluation of children with presumed septic arthritis by Yolanda Peña-López, Naureen G. Tareen, Bo Zhang, Indu Raman, Carlos A. Arana, Chengsong Zhu, Yang Liu, Pratibha Selvakumar, Nicolai S. C. van Oers, Simrat Morris, Lora V. Hooper, Lawson A. B. Copley, Prithvi Raj

“…A multi-omics strategy comprising metagenomic and proteomic technologies were undertaken for children diagnosed with presumed septic arthritis to advance clinical diagnoses and care for affected individuals. Methods Twelve children with suspected septic arthritis were prospectively enrolled to compare standard of care tests with a rapid multi-omics approach. …”
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Reciprocal regulation between DNMT3A/3B and microRNAs miRs-299-3p/-30e is a causal factor for the downregulation of microRNAs targeting androgen receptor in prostate cancer by Kavya Ganapathy, Christian F. Harrs, Samuel Harris, Stephen J. Staklinski, Ayman Khatib, Jong Y. Park, Ratna Chakrabarti

“…Here we report that miR-34c, an AR targeting miRNA and miR-299-3p, both are differentially downregulated in PCa cells from African American (AA) and Caucasian American (CA) patients due to disparate promoter hypermethylation in these miRNA genes. Methods: We performed bisulfite sequencing based promoter methylation analysis with or without treatment with DNA methyl transferase (DNMT) inhibitor 5-Aza-2′-deoxycytidine (AzaC). …”
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Laryngeal recurrence sites in patients previously treated with transoral laser microsurgery for squamous cell carcinoma by P. Horwich, M. H. Rigby, C. MacKay, J. Melong, B. Williams, M. Bullock, R. Hart, J. Trites, S. M. Taylor

“…Our project objective is to describe laryngeal SCC recurrence patterns and overall survival in patients requiring total laryngectomy (TL) after TLM. Methods Patients undergoing TLM for laryngeal SCC requiring salvage TL were identified from a prospective CO2 laser database containing all patients undergoing TLM for head and neck malignancies at the QEII Health Sciences Center in Halifax, Nova Scotia between March 2002 – May 2014. …”
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Robotic Assistance is Associated With No Intraoperative Fluoroscopy or Radiation Exposure During Direct Anterior Total Hip Arthroplasty by Sean Sequeira, MD, Alan Brett, PhD, Joseph Nessler, MD, Benjamin Frye, MD, Michael A. Mont, MD

“…The purpose of this study was to evaluate the difference in radiation exposure from CT-based RA-THA DAA vs fluoroscopy-guided conventional THA DAA based on values from a cadaver study. Methods: There were 2 surgeons who had previous extensive experience with the DAA, as well as conventional and RA-THA. …”
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