uN2CpolyG-mediated p65 nuclear sequestration suppresses the NF-κB-NLRP3 pathway in neuronal intranuclear inclusion disease by Yu Shen, Kaiyan Jiang, Dandan Tan, Min Zhu, Yusen Qiu, Pencheng Huang, Wenquan Zou, Jianwen Deng, Zhaoxia Wang, Ying Xiong, Daojun Hong

“…This study aimed to elucidate the molecular interaction between uN2CpolyG and the NF-κB-NLRP3 pathway. Methods Single-cell RNA sequencing was conducted on the skin tissues of NIID patients to assess changes in the expression of genes involved in inflammatory pathways. …”
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Use of rituximab in mature, high-grade and advanced-stage pediatric B-lineage non-Hodgkin lymphomas: a systematic review, meta-analysis and the Brazilian reality by Alejandra Adriana Cardoso de Castro, Alejandra Adriana Cardoso de Castro, Alejandra Adriana Cardoso de Castro, Liana Alves de Oliveira, Liana Alves de Oliveira, Diancarlos Pereira de Andrade, Edna Kakitani Carbone, Edna Kakitani Carbone, Roberto Rosati, Roberto Rosati, Roberto Rosati

“…Since access to this medication in public health systems in low- and middle-income countries is complex, we were also interested in mapping access to it in Brazil.MethodsWe conducted a systematic review and meta-analysis on the survival of pediatric patients with mature, high-grade and advanced-stage B-NHL treated with rituximab in combination with chemotherapy in first-line treatment or later. …”
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Perancangan User Experience Portal Media Interaksi Komunitas Kampus dengan Pendekatan Social Media Platform by Asyora Dewi Prabandani, Herman Tolle, Retno Indah Rokhmawati

“…The media portal is designed using the Human Centered Design method. There are 4 stages, namely determining the user context, requirements specification, design solution, and design evaluation. …”
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Salvia deserti Decne., an endemic and rare subshrub from Arabian desert: antidiabetic and antihyperlipidemic effects of leaf hydroethanolic extracts by Arbi Guetat, Slimen Selmi, Abdelrhman T. Abdelwahab, Marwa A. Abdelfattah, Abd Ealrhman M. Elhaj, Roaa T. Mogharbel, M. J. A. Abualreish, Abdullah F. Alanazi, Karim Hosni, Naceur Mejri, Abdennacer Boulila

“…Many plant species of the genus Salvia L. such as “Arabian desert sage” (Salvia deserti) should began to be the focus of phytochemical and bioactivity studies.MethodsThe study aims to investigate, first-ever, the antidiabetic and antihyperlipidemic effects of the leaf hydroethanolic extract of S. deserti, an endemic and rare subshrub from Arabian desert. …”
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Effect of adding concentrated myofibrillar proteins of silver carp (Hypophthalmichthys molitrix) on the qualitative and nutritional characteristics of pasta by Mahsa Karami Charvadeh, Eshagh Zakipour Rahimabadi, Parva Safari

“…In this study, concentrated myofibrillar proteins of silver carp, Hypophthalmichthys molitrix were used to increase the product protein and improve the amino acid profile of pasta. Materials and methods: This study was carried out to examine the effect of adding concentrated myofibrillar proteins of silver carp on the qualitative and nutritional characteristics of pasta. …”
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Rescue of Mutant CFTR Channel Activity by Investigational Co-Potentiator Therapy by Mafalda Bacalhau, Filipa C. Ferreira, Marcelo Folhadella M. F. Azevedo, Talita P. Rosa, Camilla D. Buarque, Miquéias Lopes-Pacheco

“…We previously identified <b>LSO-24</b>, a hydroxy-1,2,3-triazole-based compound, as a modest potentiator of p.Arg334Trp-CFTR, a variant with a conductance defect for which no modulator therapy is currently approved. <b>Objective/Methods:</b> We synthesized a new set of LSO-24 structure-based compounds, screened their effects on p.Arg334Trp-CFTR activity, and assessed the additivity of hit compounds to VX-770, ABBV-974, ABBV-3067, and apigenin. …”
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Oxidative Stress, Antioxidant Capacity, and Inflammatory Markers in Patients with Idiopathic Complete Heart Block by Shobhit Shah, Monika Bhandari, Pravesh Vishwakarma, Wahid Ali, Mohammad Kaleem Ahmad, Abhishek Singh, Ayush Shukla, Akhil Kumar Sharma, Gaurav Chaudhary, Akshyaya Pradhan, Sharad Chandra, Rishi Sethi, S. K. Dwivedi

“…In this study, we sought to evaluate the etiological characteristics of patients with CHB. Materials and Methods: Sixty patients with CHB, ranging in age from 30 to 80 years, who were admitted as inpatients to the emergency room made up the study population. …”
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Long-term effects of linear versus macrocyclic GBCAs on gene expression in the central nervous system of mice by Chuanbing Wang, Yuxia Tang, Jiajia Tang, Jie Zhang, Siqi Wang, Feiyun Wu, Shouju Wang

“…Abstract Background We examined chronic gadolinium retention impact on gene expression in the mouse central nervous system (CNS) after injection of linear or macrocyclic gadolinium-based contrast agents (GBCAs). Methods From 05/2022 to 07/2023, 36 female mice underwent weekly intraperitoneal injections of gadodiamide (2.5 mmol/kg, linear), gadobutrol (2.5 mmol/kg, macrocyclic), or saline. …”
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Changing trends in the global burden of polycystic ovarian syndrome-related infertility over the past 30 years: retrospective data analysis of the global burden of disease study 20... by Ming Huo, Yixiang Wang, Xianbin Yuan, Yue Yuan, Xuehong Zhang

“…The aim of this study was to evaluate the global, regional, and national burden of PCOS-related infertility from 1990 to 2019. Methods The data utilized in this study were derived from the Global Burden of Disease Study 2019. …”
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Tofacitinib Efficacy/Safety in Patients with Ankylosing Spondylitis by Baseline Body Mass Index: A Post Hoc Analysis of Phase 2/3 Trials by Hillary Norton, Paula Sliwinska-Stanczyk, Tomas Hala, Bassel El-Zorkany, Lori Stockert, Rajiv Mundayat, Lisy Wang, Christopher T. Ritchlin

“…Abstract Introduction We assessed tofacitinib efficacy and safety in ankylosing spondylitis (AS) by body mass index (BMI) category. Methods Data were pooled from phase 2/3 trials; analyses included patients with active AS randomized (1:1) to tofacitinib 5 mg twice daily or placebo, who were stratified by baseline BMI into < 25, ≥ 25 to < 30, and ≥ 30 kg/m2 categories. …”
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Tobacco Treatment Disparities Among California Medicaid Members With and Without Chronic Disease Who Smoke by Nan Wang, PhD, Melanie S. Dove, ScD, Cindy V. Valencia, PhD, Elisa K. Tong, MD

“…As Medi-Cal transforms to improve population health and health equity, this study aimed to understand both the prevention and treatment of tobacco-related disease by comparing health professional advice and assistance among all Medi-Cal members with and without chronic disease who smoke. Methods: Using data from the California Health Interview Survey (2014, 2016–2018), the authors examined 3,517 Medi-Cal current smokers (age ≥18 years) who consulted a health professional and reported about having a chronic disease. …”
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Genetically Engineered Bacterial Ghosts as Vaccine Candidates Against <i>Klebsiella pneumoniae</i> Infection by Svetlana V. Dentovskaya, Anastasia S. Vagaiskaya, Alexandra S. Trunyakova, Alena S. Kartseva, Tatiana A. Ivashchenko, Vladimir N. Gerasimov, Mikhail E. Platonov, Victoria V. Firstova, Andrey P. Anisimov

“…The practical use of BGs in vaccine development for humans is limited because of concerns about the preservation of viable bacteria in BGs. <b>Methods:</b> To increase the efficiency of <i>Klebsiella pneumoniae</i> BG formation and, accordingly, to ensure maximum killing of bacteria, we exploited previously designed plasmids with the lysis gene <i>E</i> from bacteriophage φX174 or with holin–endolysin systems of λ or L-413C phages. …”
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PENGARUH PENDEKATAN INTERACTIVE CONCEPTUAL INSTRUCTION (ICI) BERBANTUAN SIMULASI PHET TERHADAP HASIL BELAJAR SISWA by Ega Prastika, Andik Purwanto, Nirwana Nirwana

“…The subject matter discussed was Newton's law of gravity. The method used in this research was the quasi experiment with the design of non-equivalent control group design research. …”
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Smoking cessation is a protective factor for lung cancer onset and mortality: a population-based prospective cohort study by Wei Yin, Zhuochen Lin, Wei-Jie Gong, Wen-Xuan Wang, Ying-Ying Zhu, Yi-Lin Fu, Han Yang, Jin-Xin Zhang, Peng Lin, Ji-Bin Li

“…We aimed to comprehensively investigate the association of smoking cessation-related behaviors on the AAO of LC, LC-specific and all-cause mortality. Methods A total of 2671 smokers with LC as the primary site from the UK Biobank were included in this study, with a 7:3 ratio assigned randomly to a discovery set (n = 1872) and a validation set (n = 799). …”
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INTERNATIONAL AND NATIONAL LEGAL MECHANISMS OF JUDICIAL LIABILITY IN THE CONDITIONS OF ECONOMIC GLOBALISATION OF MODERN SOCIETY by Konul Akhundova

“…This is a scientific development that is indicative of the legal mechanism for holding judges to disciplinary liability. The formal-legal method established the foundations for formulating conclusions regarding the effectiveness of existing national legal regimes for holding judges accountable. …”
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Hydrogen-oxygen mixture inhalation as an adjunctive treatment to home-based exercise in older patients with knee osteoarthritis: an open-label, blinded-endpoint, randomized control... by Chenhui Wang, Mengwei Yan, Yuru Li, Lei Han, Hongqian Wang, Shufeng Jia, Xingchen Liu, Yang Liu, Fan Wu, Baoguo Wang

“…Our study aims to assess the therapeutic potential of hydrogen-oxygen mixture (H2-O2) inhalation for KOA.MethodsIn this randomized controlled trial, eligible elderly KOA patients were randomly assigned to either Group H or Group C. …”
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Machine learning for predicting severe dengue in Puerto Rico by Zachary J. Madewell, Dania M. Rodriguez, Maile B. Thayer, Vanessa Rivera-Amill, Gabriela Paz-Bailey, Laura E. Adams, Joshua M. Wong

“…This study aims to evaluate machine learning (ML) model performance compared to WHO-recommended warning signs in predicting severe dengue among laboratory-confirmed cases in Puerto Rico. Methods We analyzed data from Puerto Rico’s Sentinel Enhanced Dengue Surveillance System (May 2012–August 2024), using 40 clinical, demographic, and laboratory variables. …”
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Toward Understanding of Quiet Human Resource Management Theory in Iranian Organizations: Theoretical Origins, Conceptual Narration and its Consequences by Abbas Nargesian, Sajjad Sadpoor

“…This study aims to establish a theoretical framework that describes and explains the emerging phenomenon of quiet HRM within Iranian organizations.MethodsThis research was conducted within an interpretive philosophical paradigm, utilizing semi-structured interviews to uncover the core dimensions and components of quiet HRM. …”
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The miR-146a SNP Rs2910164 and miR-155 SNP rs767649 Are Risk Factors for Non-Small Cell Lung Cancer in the Iranian Population by Neda K. Dezfuli, Ian M. Adcock, Shamila D. Alipoor, Sharareh Seyfi, Babak Salimi, Maryam Mafi Golchin, Neda Dalil Roofchayee, Mohammad Varhram, Esmaeil Mortaz

“…Thus, the aim of this study was to detect any correlation between those SNPs in Iranian NSCLC patients. Methods. In a small cohort study, 165 NSCLC patients and 147 noncancer controls were enrolled between Apr 2015 and Sep 2019 at the Masih Daneshvari Hospital, Tehran, Iran. …”
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Evaluation of bone mineral density and its influencing factors in patients infected with HIV under antiretroviral therapy by Alireza Azarboo, Mahboobeh Hemmatabadi, Noushin Fahimfar, Zahra Faghihi, SeyedAhmad SeyedAlinaghi, Nooshin Shirzad, Ladan Abbasian

“…Objective The purpose of this cross-sectional study was to assess the BMD status and low BMD risk factors in patients with HIV under ART living in Iran. Methods Data were collected from individuals diagnosed with HIV aged 30–50, receiving ART for at least 6 months. …”
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