Plasma phospho-tau217 as a predictive biomarker for Alzheimer’s disease in a large south American cohort by Neetesh Pandey, Zikun Yang, Basilio Cieza, Dolly Reyes-Dumeyer, Min Suk Kang, Rosa Montesinos, Marcio Soto-Añari, Nilton Custodio, Lawrence S. Honig, Giuseppe Tosto

“…However, most studies have been conducted in non-Hispanic Whites, limiting our understanding of the performances and utility of these biomarkers across ethnicities. Methods We examined a cohort of Peruvians from the GAPP study, a recently established cohort of Peruvian mestizos from Lima and indigenous groups from Southern Peru (Aymaras and Quechuas). …”
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Single-Cell Transcriptome Analysis Reveals Different Immune Signatures in HPV- and HPV + Driven Human Head and Neck Squamous Cell Carcinoma by Simin Li, Yang Wang, Rui Sun, Debora Franceschi, Hongying Pan, Chenxuan Wei, Anthony Chukwunonso Ogbuehi, Bernd Lethaus, Vuk Savkovic, Sebastian Gaus, Rüdiger Zimmerer, Dirk Ziebolz, Gerhard Schmalz, Xiao Jiang

“…This current study aimed in the assessment of the viral- (especially human papilloma virus [HPV]) and carcinogen-driven head and neck squamous cell carcinoma (HNSCC) microenvironment based on single-cell sequencing analysis. Methods. Data were downloaded from GEO database (GSE139324), including 131224 cells from 18 HP- HNSCC patients and 8 HPV+ HNSCC patients. …”
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Risk Factors of Anaemia among Children under Five Years in the Hohoe Municipality, Ghana: A Case Control Study by Phyllis Atta Parbey, Elvis Tarkang, Emmanuel Manu, Hubert Amu, Martin Amogre Ayanore, Fortress Yayra Aku, Sorengmen Amos Ziema, Samuel Adolf Bosoka, Martin Adjuik, Margaret Kweku

“…We examined the risk factors of anaemia among children under five years in the Hohoe Municipality, Ghana. Methods. This facility-based matched case control study recruited 210 children (70 cases and 140 controls) aged 6 to 59 months. …”
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Predictors of long-term symptom burden and quality of life in patients hospitalised with chest pain: a prospective observational study by Tone Merete Norekvål, Jørund Langørgen, Torbjørn Omland, Øyvind Skadberg, Kjell Vikenes, Nasir Saeed, Ole-Thomas Steiro, Hilde Lunde Tjora, Rune Oskar Bjørneklett, Vernon Vijay Singha Bonarjee, Øistein Rønneberg Mjelva, Kristin Moberg Aakre

“…Objective To describe the magnitude and predictors of symptom burden (SB) and quality of life (QoL) 3 months after hospital admission for acute chest pain.Design Prospective observational study.Setting Single centre, outpatient follow-up.Participants 1506 patients.Outcomes Scores reported for general health (RAND-12), angina-related health (Seattle Angina Questionnaire 7 (SAQ-7)) and dyspnoea (Rose Dyspnea Scale) 3 months after hospital admission for chest pain.Methods A total of 1506 patients received questionnaires assessing general health (RAND-12), angina-related health (SAQ-7) and dyspnoea (Rose Dyspnea Scale) 3 months after discharge. …”
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Asiaticoside Attenuates Chronic Restraint Stress-Induced Hippocampal CA1 Neuronal Ferroptosis via Activating BDNF/Nrf2/GPX4 Signaling Pathway by Zhou A, Feng HY, Fan CN, Wang J, Yuan ZY, Xu GH, Li CF, Huang WF, Yi LT

“…Our research aims to elucidate the potential antidepressant mechanisms of asiaticoside, a bioactive compound known for its neuroprotective and immunomodulatory properties.Methods: The antidepressant-like properties of asiaticoside in a model of chronic restraint stress (CRS)-induced depression in mice, with a particular focus on its interaction with ferroptosis-related pathways.Results: The behavioral results revealed that asiaticoside significantly ameliorated CRS-induced depressive symptoms, as evidenced by increased sucrose preference and reduced immobility time. …”
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Composition and the predicted functions of fungal communities and the key drivers in acidic soils of Jiaodong Peninsula, China by Jing Liu, Zafran Gul Wazir, Guoqin Hou, Guizhen Wang, Fangxu Rong, Yuzhi Xu, Kai Liu, Mingyue Li, Aiju Liu, Hongliang Liu, Hongwen Sun

“…As being more tolerant than bacteria to soil acidification, so it would be more meaningful for agricultural management and crop yield to characterize fungal community in acidic soils and manifest its key drivers.MethodThis study investigated the composition and diversity of fungal communities and its key driving factors by collecting 90 soil samples from the acidic region of Jiaodong Peninsula China, spanning 3 × 104 km2.ResultsThe results indicated that most soil pH values ranged from 5.01 to 6.42, and the exchangeable acidity (EA) content raised significantly (p < 0.01) along with soil acidic degree increasing. …”
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Engagement With an Internet-Administered, Guided, Low-Intensity Cognitive Behavioral Therapy Intervention for Parents of Children Treated for Cancer: Analysis of Log-Data From the... by Christina Reuther, Louise von Essen, Mudassir Imran Mustafa, Markus Saarijärvi, Joanne Woodford

“…ObjectiveThis study aimed to (1) describe user engagement with the EJDeR intervention and examine whether (2) sociodemographic characteristics differed between adherers and nonadherers, (3) depression and anxiety scores differed between adherers and nonadherers at baseline, (4) user engagement differed between adherers and nonadherers, and (5) user engagement differed between fathers and mothers. MethodsWe performed a secondary analysis of ENGAGE data, including 71 participants. …”
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Characteristics and outcomes of out-of-hospital cardiac arrest among students under school supervision in Japan: a descriptive epidemiological study (2008–2021) by Kosuke Kiyohara, Mamoru Ayusawa, Masahiko Nitta, Takeichiro Sudo, Taku Iwami, Ken Nakata, Yuri Kitamura, Tetsuhisa Kitamura

“…We aimed to comprehensively describe the characteristics and outcomes of OHCA among students in elementary schools, junior high schools, high schools, and technical colleges in Japan. Methods: OHCA data from 2008–2021 were obtained from the SPIRITS study, which provides a nationwide database of OHCAs occurring under school supervision across Japan. …”
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PLL-g-HPA Hydrogel Loaded Human Umbilical Cord Mesenchymal Stem Cells Promote Burn Wound Healing in Rat Model by Regulating Inflammation Response by Tian L, Wang Z, Lei T, Feng L, Li Y, Wang K, Zhang Y, Zhang C, Liu J, Xing H, Ren W

“…Therefore, the aim of this study was to evaluate the therapeutic effect of hUC-MSCs combined with PLL-g-HPA hydrogel on full thickness burn injury in rat model.Methods: The PLL-g-HPA hydrogel was developed and characterized by Scanning Electron Microscopy (SEM), Fourier-Transform Infrared Spectroscopy (FTIR), Hydrogen-1 nuclear magnetic resonance (H-NMR). …”
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Deep learning-based CT radiomics predicts prognosis of unresectable hepatocellular carcinoma treated with TACE-HAIC combined with PD-1 inhibitors and tyrosine kinase inhibitors by Linan Yin, Ruibao Liu, Wei Li, Shijie Li, Xunbo Hou

“…Abstract Objective To develop and validate a computed tomography (CT)-based deep learning radiomics model to predict treatment response and progression-free survival (PFS) in patients with unresectable hepatocellular carcinoma (uHCC) treated with transarterial chemoembolization (TACE)-hepatic arterial infusion chemotherapy (HAIC) combined with PD-1 inhibitors and tyrosine kinase inhibitors (TKIs). Methods This retrospective study included 172 patients with uHCC who underwent combination therapy of TACE-HAIC with TKIs and PD-1 inhibitors. …”
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Predictors and prognosis of elderly hip fracture patients with perioperative atrial fibrillation: a nested case–control study by Wei Li, Aoying Min, Wei Zhao, Weining Li, Shuhan Li, Saidi Ran, Mingming Fu, Qili Yu, Junkai Kou, Zhiqian Wang, Zhiyong Hou

“…In addition, given the frequency and significant impact of AF in the perioperative period, therefore our aim was to identify prognosis and predictors of elderly hip fracture patients with perioperative AF. Methods An examination of hip fracture patients at the Third Hospital of Hebei Medical University, who had been hospitalized from January 2018 to October 2020 in succession, was conducted retrospectively. …”
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Remimazolam for the prevention of emergence agitation in adults following nasal surgery under general anesthesia: a prospective randomized clinical controlled trial by Yanfei Lu, Qiaomin Xu, Hong Dai, Jimin Wu, Mengting Ai, Haiyan Lan, Xiaoli Dong, Gongchen Duan

“…The purpose of this study was to evaluate the effectiveness of postoperative use of remimazolam in preventing emergence agitation (EA) in adults following nasal surgery. Methods Patients who underwent nasal surgery were randomly divided into Group R and Group C. …”
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Changes in levels of urokinase receptor and other components of fibrinolytic system in brain tissues in urokinase gene-knockout mice with B16/F10 melanoma growing together with chr... by E. M. Frantsiyants, V. A. Bandovkina, I. V. Kaplieva, N. D. Cheryarina, E. I. Surikova, I. V. Neskubina, Yu. A. Pogorelova, L. A. Nemashkalova

“…An analysis of the changes in components of the urokinase system in the brain of urokinase gene-knockout mice (uPA-/-) with B16/F10 melanoma growing alone and together with chronic neurogenic pain (CNP).Materials and methods. The study included male and female C57BL/6-PlautmI.IBug-ThisPlau6FDhu/GFDhu mice (uPA-/-) (n = 48) and C57BL/6 mice (uPA+/+) (n = 80) with transplanted B16/F10 melanoma growing solitarily and together with CNP. …”
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Effects of Honey Supplementation in Female Brood Feed on Male and Female Percentages, Growth, and Survival Rate of Crayfish Red Claw (Cherax quadricarinatus) Seed by Akhmad Taufiq Mukti

“… The aim of this study was to know effects of honey supplementation in female brood feed on male and female percentages, growth, and survival rate of crayfish red claw seed. The method that used in this study was laboratory scale experiment. …”
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Effect of differences in vascular anatomy on surgical outcomes of left pancreatectomy: a retrospective study by Masahiro Fukada, Noriki Mitsui, Takeshi Horaguchi, Yuji Hatanaka, Itaru Yasufuku, Yuta Sato, Jesse Yu Tajima, Shigeru Kiyama, Yoshihiro Tanaka, Katsutoshi Murase, Nobuhisa Matsuhashi

“…In this study, we aimed to evaluate the effect of vascular anatomical variations on surgical outcomes and identify factors that influence open and minimally invasive surgery (MIS) outcomes. Methods This was a single-center retrospective study involving 123 patients who underwent left pancreatectomy (LP). …”
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Association Between Liver Fibrosis and Risk of Incident Stroke and Mortality: A Large Prospective Cohort Study by Zijie Wang, Zhitao Gong, Jianshang Wen, Shanyu Zhang, Xiao Hu, Wenliang Guo, Yanghua Tian, Qi Li

“…However, uncertainty persists regarding the contribution of liver fibrosis to major stroke types including ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage at the population level. Methods In this large prospective cohort study, participants without previous stroke or coronary heart disease at baseline from the UK Biobank were included. …”
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Metal complexes in cells: from design of catalytic antioxidants to imaging metal ions and designing metal-based probes in X-ray fluorescence and IR-imaging, a multidisciplinary col... by Policar, Clotilde, Delsuc, Nicolas, Bertrand, Hélène Charlotte

“…The effect of the hydration level and inertness with regard to metal ion release have also been explored. Methods to quantify the SOD-like activity, out of cellular context and in cells, and analysis of the integrity of the metal-based antioxidant in cells (through ion mobility coupled with mass spectrometry) will be described. …”
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Ciphertext policy hidden access control scheme based on blockchain and supporting data sharing by Ruizhong DU, Tianhe ZHANG, Pengliang SHI

“…Objectives: Although the traditional attribute-based encryption scheme achieves one-to-many access control,there are still challenges such as single point of failure,low efficiency,no support for data sharing,and privacy leakage.To solve these problems,a ciphertext policy hidden access control scheme based on blockchain and supporting data sharing is proposed. Methods:Firstly,an efficient attribute vector and policy vector generation algorithm is proposed using vector compression technology, which judges whether user attributes satisfy the access policy through the inner product operation result of attribute vector and policy vector.Afterwards, the prime order bilinear group and attribute encryption technology were used to achieve fine-grained access control while avoiding the leakage of user attribute values; using the interstellar file system to store the ciphertext and storing the hash address of the ciphertext on the blockchain through a smart contract,it realizes distributed and reliable access control and reduces the storage overhead of the blockchain. …”
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First detection and molecular characterization of porcine epidemic diarrhea virus (PEDV) in India: evidence of a new variant in Karnataka by Jagadish B. Hiremath, M. Swathi, R. Ramamoorthy, M. Shijili, Damini Sharma, Divakar Hemadri, H. B. Chethankumar, K. P. Suresh, Sharanagouda S. Patil, Shivasharanappa Nayakvadi, S. P. Satheesha, B. R. Shome, Baldev Raj Gulati

“…This study reports the first clinical outbreak of PED in India, followed by the detection and genetic characterization of PED virus (PEDV) during 2022-23. Methods The outbreak was characterized, and fecal samples (n = 21) were collected from affected pigs. …”
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Clinical observation of Baduanjin exercise on bed in relief of constipation among patients with acute myocardial infarction (床上八段锦改善急性心肌梗死患者便秘的效果观察)... by LI Fengyan (李丰艳), GONG Zhencui (宫振翠), SHI Yu (时玉)

“…Objective To observe the effect of Baduanjin exercise on bed (abdominal acupoint massage with Shuangtong Qihai technique) in relief of constipation among patients with acute myocardial infarction(AMI). Methods Totally 80 AMI patients with constipation were randomly divided into control group and intervention group, with 40 cases in each group. …”
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