Unraveling the association and regulatory role of miR-146b-5p in coronary artery disease by Xiaozhu Ma, Shuai Mei, Yi He, Qidamugai Wuyun, Li Zhou, Ziyang Cai, Qiushi Luo, Yi Wen, Jiangtao Yan

“…In the study, we focus on the expression of miR-146b-5p in peripheral blood mononuclear cells (PBMCs) of patients with CAD and preliminarily investigate its function and underlying mechanism. Methods and results The study encompassed a total of 452 participants, consisting 295 patients with CAD and 157 individuals without CAD. …”
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Provincial distribution and predictors of desire for more children among married and cohabiting women in Sierra Leone by Augustus Osborne

“…This study, therefore, examined the desire for more children and its predictors among women in Sierra Leone. Methods The study analysed the 2019 Sierra Leone Demographic and Health Survey data. …”
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Role of preconception nutrition supplements in maternal anemia and intrauterine growth: a systematic review and meta-analysis of randomized controlled trials by Sumera Aziz Ali, Jeanine Genkinger, Ka Kahe, Linda Valeri, Nayab Khowaja, Nancy F. Krebs, Louise Kuhn

“…We synthesized the evidence on the role of preconception nutrition supplements in reducing maternal anemia and improving intrauterine growth. Methods We undertook a review of the randomized controlled trials (RCTs) assessing the effect of preconception nutrition supplements on maternal hemoglobin, an indicator to estimate maternal anemia, and markers of intrauterine growth including birth weight, length, head circumference, and small for gestational age. …”
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The work-related well-being of social service workers post COVID-19 pandemic: The psychosocial impact of remote vs in-person work by Venusia COVELLI, Morena TAFFARELLO, Marina Angela VISCO, Francesco CHIRICO, Pietro CRESCENZO, Luca COPPETA, Kavita BATRA, Alessandra MARELLI

“…Therefore, the current research aims to compare the remote working situation during the pandemic with the return to in-person work to evaluate how these two models affected the SSW’s job satisfaction and well-being. Methods: SSW working in social service delivery organizations were recruited to participate in an online semi-structured survey comprising the Job Satisfaction Scale, Psychological General Well-Being Index-S, Work-Related Stress Indicator Tool, Organizational Identification Scale, and Positive and Negative Affect Schedule. …”
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Serum Pharmacochemistry and Network Pharmacology Reveal Active Compounds and Mechanisms of the Huaxian Formula in Alleviating Radiation-Induced Pulmonary Fibrosis by Gong C, Chen J, Zou P, Fang Z, Quan L, Wang J, Yin J, Lin B, Lang J, Chen M

“…The Huaxian formula (HXF), a traditional Chinese herbal remedy, shows promise in alleviating RIPF; however, its active ingredients and underlying mechanisms remain poorly understood.Methods: Through serum pharmacochemistry, network pharmacology, molecular docking, and experimental validation, we investigate the potential mechanisms of HXF in the prevention and treatment of radiation-induced pulmonary fibrosis (RIPF).Results: Histological examination and non-invasive computed tomography (CT) scans in animal experiments revealed that HXF improved extracellular matrix collagen deposition in the lung tissue of irradiated mice and reduced fibrosis manifestations on CT images. …”
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Active biomonitoring in streams by using multimarker approaches of mussels by T. Ukasha, N.U.H. Faisal, B.K. Adji, A.P. Nugroho

“…This study evaluates the ecosystem health of Code Stream, Yogyakarta, Indonesia, through active biomonitoring by transplanting mussels Anodonta woodiana into cages at three stations, representing mild (station 1), moderate (station 3), and severe (station 2) polluted ecosystem conditions based on human activities around the stream.METHODS: The mussels were transplanted into the Code Stream. …”
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Systematic preclinical evaluation of CD33-directed chimeric antigen receptor T cell immunotherapy for acute myeloid leukemia defines optimized construct design by Haiying Qin, Nirali N Shah, Terry J Fry, Lila Yang, John A Chukinas, Samiksha Tarun, Marie Pouzolles, Christopher D Chien, Lisa M Niswander, Anthony R Welch, Sarah K Tasian, Naomi A Taylor

“…However, the impact of costimulatory domains on the efficacy of myeloid antigen-directed CAR T cell immunotherapy remains unknown.Methods In this preclinical study, we developed six CAR constructs targeting CD33, a highly expressed and validated AML target, comprised of one of three single-chain variable fragments with CD3ζ and either CD28 or 4-1BB costimulatory domains. …”
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HEALING LANDSCAPES: THE EFFECTS OF ITS PARAMETERS ON DIFFERENT GENDER (CASE STUDY: ERAM GARDEN & AZADI PARK OF SHIRAZ-IRAN) by Mina Razmara, Hajar Asadpour, Malihe Taghipour

“…Since men and women behave differently in dealing with their surroundings, this research evaluates how Persian gardens and urban parks effect (with two different structural patterns) among men and women. The research method was quantitative, and data gathered by the questionnaire technique. …”
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Towards water-conscious green hydrogen and methanol production: A techno-economic review by Henrik Wenzel, Gian Müller, Freia Harzendorf, Thomas Schöb, Felix Kullmann, Jann Michael Weinand, Detlef Stolten

“…In this review, we reveal a significant research gap regarding comprehensive assessments of such production methods. We present an innovative process chain, consisting of adsorption-based direct air capture, solid oxide electrolysis, and methanol synthesis to address this issue. …”
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Systematic multiomics analysis and in vitro experiments suggest that ITGA5 could serve as a promising therapeutic target for ccRCC by Xiangxian Che, Xi Tian, Zhenda Wang, Shuxuan Zhu, Shiqi Ye, Yue Wang, Yihan Chen, Yiyun Huang, Aihetaimujiang Anwaier, Peifeng Yao, Yijia Chen, Keting Wu, Yifei Liu, Wenhao Xu, Hailiang Zhang, Dingwei Ye

“…Abstract Background Integrin alpha 5 (ITGA5) was previously confirmed to be related to prognosis in several cancer types; however, its function in clear cell renal cell carcinoma (ccRCC) and how this molecule regulates tumor progression and the tumor microenvironment (TME) remain to be elucidated. Methods We investigated the prognostic implications of ITGA5 with a machine learning model and evaluated biological behaviors of different levels of ITGA5 expression in vitro. …”
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Internalizing and externalizing symptoms in individuals with neurofibromatosis type 1: a systematic review and meta-analysis by Dan Liu, Liyan Yu, Xian Wu, Julia Moreira, Benjamin Felipe Mujica, Elora Shelly Mukhopadhyay, Angelena Novotney, André B. Rietman, Yang Hou

“…Thus, this systematic review and meta-analysis was conducted to synthesize existing findings on the degree to which individuals with NF1 experience internalizing and externalizing symptoms, compared with the unaffected population, and explore moderators of the group disparities. Methods Scopus, PsycINFO, Web of Science, PubMed, and ProQuest were searched from inception to March 26th, 2024, which identified 59 eligible studies (N of NF1 = 3182, mean ages 2.38 to 46.4 years). …”
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The Effect of Cysteine on the Removal of Cadmium in Paddy Soil by Combination with Bioremediation and the Response of the Soil Microbial Community by Emmanuel Konadu Sarkodie, Kewei Li, Ziwen Guo, Jiejie Yang, Yan Deng, Jiaxin Shi, Yulong Peng, Yuli Jiang, Huidan Jiang, Hongwei Liu, Yili Liang, Huaqun Yin, Xueduan Liu, Luhua Jiang

“…However, the Cd removal efficacy achieved through this method remains unsatisfactory and is accompanied by a marginally higher cost. …”
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Functional Near-Infrared Brain Network Characteristics Analysis in Patients with Cognitive Impairment after Stroke by JIN Tao, LI Haozheng, BAO Chunrong, ZHUANG Min, CAI Weiqiang, HU Ruiping, WU Yi

“…ObjectiveTo observe the differences in brain network activation and functional connectivity of patients with post-stroke cognitive impairment (PSCI) of different severity using functional near-infrared spectroscopy (fNIRS).MethodsA total of 40 stroke patients in the outpatient and inpatient Rehabilitation Department in the Pudong District of Huashan Hospital, Fudan University from April to November 2020 were recruited and divided into normal group (<italic>n</italic>=14), mild to moderate group (<italic>n</italic>=11) and severe group (<italic>n</italic>=15) according to the mini-mental state examination (MMSE) score. …”
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Predicting survival rates: the power of prognostic nomograms in distal cholangiocarcinoma by Jiangfeng Hu, Yuping Shi, Lihua Jin, Suhong Yi, Jinsuo Chen, Dadong Wan, Weixin Ye, Jingnan Chen, Yajing Zhang, Yang Jiang, Bensong Duan, Yuwei Dong

“…ObjectiveThe purpose of this research is to establish a prognostic nomogram for patients with distal cholangiocarcinoma (dCCA).MethodsWe obtained clinical data from 2401 patients diagnosed with distal cholangiocarcinoma (dCCA) between 2010 and 2020 from the Surveillance, Epidemiology, and End Results database. …”
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Walnut oil prevents hyperlipidemia induced by high-fat diet and regulates intestinal flora and liver metabolism by Rui Yang, Dan Chen, Yanling Chen, Yage Ma, Chaoyin Chen, Shenglan Zhao

“…ObjectiveThis study aims to investigate the preventive effect of walnut oil as medicinal food on abnormal lipid metabolism and its influence on liver metabolites and intestinal flora.MethodsThe rat model of abnormal lipid metabolism was established by feeding high-fat diet and administering a high-fat emulsion via gavage. …”
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Pembentukan Daftar Stopword Menggunakan Term Based Random Sampling Pada Analisis Sentimen Dengan Metode Naïve Bayes (Studi Kasus: Kuliah Daring Di Masa Pandemi) by Raditya Rinandyaswara, Yuita Arum Sari, Muhammad Tanzil Furqon

“…So this research is aimed at finding the best combination of these 3 parameters and comparing the Term Based Random Sampling stopword with the stopword tuning and without the stopword removal process in the analysis of tweet sentiment regarding online lectures using the Naïve Bayes method. The results of the evaluation with the Term Based Random Sampling stopword get the highest accuracy with X, Y, L of 10, 10, 40 with a macroaverage accuracy of 0.758, a macroaverage precision of 0.658, a macroaverage recall of 0.636, and a macroaverage f-measure of 0.647. …”
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Magnesium ions regulate the Warburg effect to promote the differentiation of enteric neural crest cells into neurons by Qiongqian Xu, Xixi He, Yaru Mou, Dong Sun, Xintao Zhang, Jichang Han, Xiaoyang Liu, Xingjian Liu, Xue Ren, Dongming Wang, Jian Wang, Chuncan Ma, Qiangye Zhang, Aiwu Li

“…This study explores how magnesium ions regulate the glycolytic pathway to enhance ENCCs differentiation into neurons. Materials and methods We used polymerase chain reaction, western blot, immunofluorescence, and multielectrode array techniques to assess magnesium ions' impact on ENCCs differentiation. …”
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A Novel Telehealth Exercise Program Designed for Rural Survivors of Cancer With Cancer-Related Fatigue: Single-Arm Feasibility Trial by Ryan J Marker, Andrew J Kittelson, Jared J Scorsone, Ian A Moran, John C Quindry, Heather J Leach

“…ObjectiveThe purpose of this investigation was to assess the feasibility of a novel telehealth exercise program designed specifically for rural survivors of cancer with CRF. MethodsA single-arm clinical trial of the BfitBwell Telehealth Program was performed. …”
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Myofibrillogenesis Regulator-1 in Smooth Muscle Cells Modulates Inflammation Signaling Pathways via Regulating ROCK1 Ubiquitination and Degradation to Impact Aortic Dissection by Yin H, Li X, Lu D, Zhao X, Yang Z, Wang Z, Xu F, Chen Y, Li C

“…This study aimed to investigate the role of MR-1 and ROCK1 in the regulation of inflammation in AD and their potentialities as therapeutic targets.Methods: Researchers performed protein immunoblotting on aortic wall tissue from 10 patients who underwent aortic arch replacement and 10 patients who underwent coronary artery bypass grafting to examine the expression levels of MR-1, ROCK1, and inflammatory pathways in the aortas. …”
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Correlation analysis between preoperative odontoid incidence and clinical outcomes 2 years after anterior cervical discectomy and fusion by Yan Gong, Hao Liu, Yanchi Gan, Jiahui He, Zelin Zhou, Hang Zhuo, Yu Liu, De Liang, Hui Ren, Xiaobing Jiang, Zhaojun Cheng

“…Abstract Objective This study presents a novel odontoid parameter, the odontoid incidence (OI), to examine the correlation between OI on preoperative cervical sagittal radiographs and 2-year clinical outcomes following short-segment anterior cervical discectomy and fusion (ACDF) in patients with cervical spondylotic myelopathy (CSM). Methods A retrospective analysis of the clinical data of 87 patients with CSM who underwent ACDF surgery from January 2018 to December 2023 was conducted. …”
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