Artificially Cultivated Ophiocordyceps sinensis Alleviates Diabetic Nephropathy and Its Podocyte Injury via Inhibiting P2X7R Expression and NLRP3 Inflammasome Activation by Chao Wang, Xiao-xia Hou, Hong-liang Rui, Li-jing Li, Jing Zhao, Min Yang, Li-jun Sun, Hong-rui Dong, Hong Cheng, Yi-Pu Chen

“…It is known that chronic low-grade inflammation contributes to the initiation and development of both diabetes and diabetic nephropathy (DN), so we designed this study to investigate the role of P2X7R and NLRP3 inflammasome in DN pathogenesis and the antagonistic effects of artificially cultivated Ophiocordyceps sinensis (ACOS). Methods. A rat model of DN caused by high-fat-diet feeding and low-dose streptozotocin injection and a mouse podocyte injury model induced by high-glucose (HG) stimulation were established, and the intervention effects of ACOS on them were observed. …”
Get full text

Remote Lifestyle Intervention to Reduce Postpartum Weight Retention: Protocol for a Community-Engaged Hybrid Type I Effectiveness-Implementation Randomized Controlled Trial by Lindsay M Martin, Christine D McKinney, Lia Escobar Acosta, Janelle W Coughlin, Noelene K Jeffers, Alexandra Solano-Umaña, Kathryn A Carson, Nae-Yuh Wang, Wendy L Bennett, Kelly M Bower

“…Facilitators and barriers to implementation of the intervention within home visiting will be examined. MethodsWe describe the rationale and protocol for this hybrid type I effectiveness-implementation randomized controlled trial. …”
Get full text

Improved Mechanical Performances of Hastelloy C276 Composite Coatings Reinforced with SiC by Laser Cladding by Yuqing Tang, Zheng Lu, Xuan Zhang, Xihuai Wang, Shengbin Zhao, Mingdi Wang

“…The phase compositions, elemental distribution, microstructural characteristics, hardness, wear resistance and corrosion resistance of the composite coatings were analyzed using X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), Vickers hardness testing, friction-wear testing and electrochemical methods. The coatings have no obvious pores, cracks or other defects. …”
Get full text

Effect of Meridian Massage combined with Swallowing Rehabilitation Training on Elderly Patients with Dysphagia after Stroke by Hui FAN, Zhongqin XU, Chunxia MA, Lei DONG, Yao ZHOU

“…Objective:To observe the effect of meridian massage combined with swallowing rehabilitation training on elderly patients with dysphagia after stroke.Methods:A total of 65 elderly patients with dysphagia after stroke who were treated in the department of geriatrics of the Affiliated Hospital of Nanjing University of Chinese Medicine from March 2019 to June 2020, which were randomly divided into the control group and the observation group, with 33 cases and 32 cases in each group respectively. …”
Get full text

Parental Mental Health and Child Maltreatment in the COVID-19 Pandemic: Importance of Sampling in a Quantitative Statistical Study by Lara Engelke, Claudia Calvano, Steffi Pohl, Sibylle Maria Winter, Babette Renneberg

“…Specifically, we aimed to (1) investigate if outcomes on parental health and child maltreatment during the COVID-19 pandemic from a convenience sample differ from those of a specific representative sample and (2) investigate reasons for differences in the results. MethodsIn 2020, we simultaneously conducted 2 studies: (1) a web-based survey using a convenience sample of 4967 parents of underage children, primarily recruited via social media, and (2) a study using a quota sample representative of the German adult population with underage children (N=1024), recruited through a combination of telephone interviews and computer-assisted web interviews. …”
Get full text

Long-term results of irritable bowel syndrome treatment by A. I. Ulyanin, Yu. M. Poluektov, Ye. A. Poluektova, Ch. S. Pavlov, V. T. Ivashkin

“…To estimate duration of remission of irritable bowel syndrome after treatment by multistrain probiotic drug, motility regulator or antispasmodic medication. Material and methods. Original study included overall 87 patients with irritable bowel syndrome (IBS) or IBS in combination with functional dyspepsia (FD) in whom the diagnosis was confirmed according to compliance of symptoms to the Rome-III criteria and absence of organic diseases according to laboratory and instrumental investigation. …”
Get full text

A population-based study on the burden of hospitalized pediatric pneumococcal disease in Taiwan before and after the introduction of 13-valent pneumococcal conjugate vaccine into t... by Ting-An Yen, Jhong-Lin Wu, Chi-Chuan Wang, Ling-Ya Huang, See-Hwee Yeo, Dony Patel, Cindy Thiow Koon Lim, Hung-Wei Lin, Eriko Yamada, Isaya Sukarom

“…Abstract Background To estimate the burden of invasive pneumococcal disease, non-bacteremic pneumococcal pneumonia, and acute otitis media before and after inclusion of the 13-valent pneumococcal vaccine (PCV13) into Taiwan’s Childhood Immunization Program in 2015. Methods Episodes of eligible children aged < 18 years hospitalized with invasive pneumococcal disease, non-bacteremic pneumococcal pneumonia, or acute otitis media between 1 January 2011 and 31 December 2019 were identified from the National Health Insurance Research Database. …”
Get full text

Construction and evaluation of the prediction model for advanced disease in well-differentiated colorectal neuroendocrine neoplasms less than 2 cm in diameter by Hongda Yin, Yanan Chen, Wei Zhao, Fuqiang Zhao, Zhijun Huang, Aimin Yue, Zhijie Wang

“…Objective: Advanced lesions are often ignored in well-differentiated colorectal neuroendocrine neoplasms (NENs) smaller than 2 cm, and we aimed to develop an effective nomogram for these lesions. Methods: We extracted data from the Surveillance, Epidemiology, and End Results (SEER) database and used a logistic regression model to identify independent risk factors for advanced disease. …”
Get full text

Efficacy and safety of PCSK9 inhibitors, potent statins, and their combinations for reducing low-density lipoprotein cholesterol in hyperlipidemia patients: a systematic network me... by Yuhua Jiang, Yingying Wang, Sijia Ma, Linlin Qian, Yeteng Jing, Xi Chen, Jinsheng Yang

“…BackgroundThe objective of this study is to assess the relative efficacy of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, such as alirocumab, evolocumab, and inclisiran, in conjunction with potent statins like atorvastatin and rosuvastatin, in patients presenting with hyperlipidemia or heightened cardiovascular risk attributable to elevated low-density lipoprotein cholesterol (LDL-C).MethodsA systematic search was conducted across databases including PubMed, Embase, and the Cochrane Library to explore lipid-lowering therapies in hyperlipidemia from their inception to 7 November 2023. …”
Get full text

Sprachpraxis im Migrationskontext – Sprachprofile am Beispiel Albanisch sprechender Migranten und Migrantinnen der dritten Generation in Deutschland und der Schweiz by Naxhi Selimi, Naxhi Selimi

“…Abstract (English) This paper presents data-based language profiles that have been developed in an interdisciplinary multi-method approach. It also proposes the use of a multilevel profiling model and a language analysis grid that have been newly developed. …”
Get full text

Comparing efficacy and safety of low-dose versus standard-dose antiplatelet therapy in stroke patients: a meta-analysis by Zhao Ren, Chunxing Li, Xin Zhang, Lichaoyue Sun, Hui Zhu, Dongxiao Wang, Yumin Wang, Shuo Liang, Guanchun Wang

“…This requires careful dosage adjustments to balance thrombosis and bleeding risks.ObjectiveThis study compared the efficacy and safety of low-dose versus standard-dose antiplatelet therapy in stroke patients.MethodsWe conducted a comprehensive search across multiple databases, including PubMed, Embase, the Cochrane Library, ClinicalTrials.gov, CNKI, and the Wanfang Medical Database, up to March 2024. …”
Get full text

The Influence of Overnight Orthokeratology on Ocular Surface and Meibomian Gland Dysfunction in Teenagers with Myopia by Xiu Wang, Jing Li, Rui Zhang, Na Li, Yi Pang, Yan Zhang, Ruihua Wei

“…The aim of this study was to investigate the effect of overnight orthokeratology (OOK) on ocular surface and meibomian gland dysfunction in teenagers with myopia. Methods. A total of 59 subjects were recruited in this prospective study. …”
Get full text

Association between the triglyceride-glucose index and contrast-induced nephropathy in chronic total occlusion patients undergoing percutaneous coronary intervention by Serdar Söner, Adem Aktan, Raif Kılıç, Hamdullah Güzel, Ercan Taştan, Metin Okşul, Adnan Duha Cömert, Mehmet Sait Coşkun, Hülya Tosun Söner, Tuncay Güzel

“…In this study, we aimed to investigate the relationship between the TyG index and CIN and mortality in patients who underwent PCI due to chronic total coronary occlusion (CTO). Methods Two hundred eighteen individuals from three separate medical centers who underwent procedural PCI between February 2010 and April 2012 and had a CTO lesion in at least one coronary artery were recruited. …”
Get full text

High tumor mutational burden predicts favorable response to anti-PD-(L)1 therapy in patients with solid tumor: a real-world pan-tumor analysis by Sehhoon Park, Jaeyun Jung, You Jeong Heo

“…TruSight Oncology 500 (TSO500) is currently used globally as a routine assay for TMB.Methods Between 2019 and 2021, 1744 patients with cancer received TSO500 assay as part of a real-world clinical practice at the Samsung Medical Center, and 426 received anti-PD-(L)1 treatment. …”
Get full text

Financial crisis and its association with parental stress and children’s mental health in Lebanon by Ramona Nasr, Samantha Abi Saab, Nada Nasr, Chadia Haddad, Eman Swaidan, Sara Abou Ibrahim, Joanne Karam

“…Accordingly, this study aimed to assess the effect of financial insecurities on parents in Lebanon amid the multiple crises, and the impact of parents’ mental health on their children’s emotional and behavioral wellbeing. Methods A cross-sectional study including 589 parents in Lebanon was performed using convenience sampling of parents of any gender with children aged 4 to 18 from the five Lebanese governorates. …”
Get full text

Characterization of β-Actin Promoter from Nile Tilapia (Oreochromis niloticus) by . Alimuddin, A. Octavera, O.Z. Arifin, K. Sumantadinata

“…Sequence of tiBP promoter was isolated by using PCR method. Sequencing was performed using ABI PRISM 3100 machine. …”
Get full text

Association Between Metabolic Syndrome and Cardiac Autonomic Nervous Function and Cardiorespiratory Fitness in Older Adults: A Retrospective Observational Study with Propensity Sco... by Cui N, Li Q, Cheng J, Xing T, Shi P, Wang Y, Luo M, Dun Y, Liu S

“…The present study aimed to investigate the association between MetS and HRRs at 1, 2, 3 and 6 minutes after exercise and cardiorespiratory fitness (CRF) in Chinese dwelling older adults.Methods: This retrospective, observational study consecutively enrolled participants aged 60 years or older who underwent physical examinations in Shenzhen District Yantian People’s Hospital from September 2019 to July 2021. …”
Get full text

Effect of glucagon-like peptide-1 receptor agonists on vascular risk factors among adults with type 2 diabetes and established atherosclerotic cardiovascular disease by Aaron King, Xi Tan, Neil Dhopeshwarkar, Rhonda Bohn, Katherine Dea, Charles E. Leonard, Adam de Havenon

“…Introduction: Limited data exist on the cardiovascular effectiveness of once-weekly (OW) glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in real-world practice. Methods: We assessed the OW GLP-1 RA effects on vascular risk factors in adults with type 2 diabetes and atherosclerotic cardiovascular disease using data from a large-scale US electronic health record database (index date = first prescription of OW GLP-1 RA). …”
Get full text

Evaluating risk factors for Trastuzumab-Deruxtecan Pneumonitis in patients with metastatic breast cancer by Jonathan Henricks, Tyler Haddad, Omair Ahmed, Jonathan Schoenhals, Pavnesh Kumar, Ryan Wilson, Jianing Ma, Jing Gennie Wang, Michael Wert, Vincent Esguerra, Ian Bentley, Kai Johnson, Daniel Stover, Sachin R. Jhawar, Margaret Gatti-Mays, Kevin Ho

“…Currently, there is limited understanding of pre-treatment risk factors for pneumonitis associated with T-DXd. Methods Consecutive breast cancer patients who received at least one dose of T-DXd at a single academic cancer study between January 1, 2019, and February 20, 2024, were identified for analysis. …”
Get full text

Baccaurea ramiflora fruit peel powder supplementation prevented inflammatory cell infiltration, oxidative stress, and fibrosis in carbon tetrachloride (CCl4) administered ovariecto... by Tahsin Zahan, Mirza Alimullah, Ishrat Jahan, Md. Borhan Uddin, Khondker Ayesha Akter, Md. Junaeid Rahman, Shahnaz Siddiqua, Kamrun Nahar Ela, Sakil Amin, Khondoker Shahin Ahmed, Hemayet Hossain, Ferdous Khan, Md Ashraful Alam, Nusrat Subhan

“…This study explored the impact of Baccaurea ramiflora fruit peel powder on oxidative stress and fibrosis in hepatic damage induced by carbon tetrachloride (CCl4) in ovariectomized rats. Methods: High-performance liquid chromatography (HPLC) analysis was done on Baccaurea ramiflora fruit peel powder extract to confirm the presence of phenolic antioxidants. …”
Get full text