Painting a portrait: Analysis of national health survey data for cancer genetic counseling by Monica H. Stamp, Ora K. Gordon, Christopher P. Childers, Kimberly K. Childers

“…Study findings to date are contradictory, making it unclear what, if any, disparities in receipt of cancer genetic counseling exist. Methods Utilizing the 2015 National Health Interview Survey (NHIS)—a cross‐sectional, in person interview survey collecting self‐reported health data for the US population—geographic and sociodemographic factors were compared between those receiving genetic counseling and the national sample. …”
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How efficient are specialized public health services in China? A data envelopment analysis and geographically weighted regression approach by Qian Bai, Qian Bai, Lieyu Huang, Yan Guo, Xin Xu, Zhouyixin Zhang, Yuan Wang, Hao Chen, Ying Bian, Ying Bian

“…Meanwhile, in the context of restricted public health resources, how to efficiently utilize these resources becomes a paramount concern.ObjectiveThis study aimed to evaluate the technical efficiency of specialized public health facilities, the major providers of public health services in China, then discuss its temporal and spatial distribution characteristics and finally investigate its influencing factors.MethodsThe super slacks-based measure data envelopment model was constructed to calculate the efficiency of specialized public health facilities of 31 provinces from 2017 to 2019. …”
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Factors Influencing the Development of Metachronous Fractures in Patients with Osteoporotic Vertebral Fractures Treated with Conservative Management or Vertebroplasty by Fernando Ruiz Santiago, Lucía Bueno Caravaca, Francisco Garrido Sanz, Paula María Jiménez Gutiérrez, David Luengo Gómez, Mario Rivera Izquierdo, José Manuel Benítez, Antonio Jesús Láinez Ramos-Bossini

“…<b>Objectives:</b> We aimed to analyze potential predictors for the development of metachronous fractures (MFs) after osteoporotic vertebral fractures (OVFs), with particular focus on radiological variables obtained at initial X-rays and computed tomography (CT) examinations, treatment applied (conservative management [CM] versus percutaneous vertebroplasty [PV]), and fractures located at the thoracolumbar junction (T11-L2). <b>Methods:</b> We conducted a two-center, observational retrospective study, including patients with single-level OVFs treated with CM or VP. …”
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The immune landscape of fetal chorionic villous tissue in term placenta by Brianna M. Doratt, Heather E. True, Heather E. True, Suhas Sureshchandra, Suhas Sureshchandra, Qi Qiao, Qi Qiao, Monica Rincon, Nicole E. Marshall, Ilhem Messaoudi

“…Recent studies have characterized the transcriptional profile of the first trimester (T1) placenta; however, the phenotypic and functional diversity of chorionic villous immune cells at term (T3) remain poorly understood.MethodsTo address this knowledge gap, immune cells from human chorionic villous tissues obtained from full-term, uncomplicated pregnancies were deeply phenotyped using a combination of flow cytometry, single-cell RNA sequencing (scRNA-seq, CITE-seq) and chromatin accessibility profiling (snATAC-seq).ResultsOur results indicate that, relative to the first trimester, the frequency of fetal macrophages (HBC, proliferating HBC) is significantly reduced, whereas that of infiltrating maternal monocytes/macrophages (PAMM1b, PAMM1a, PAMM2, MAC_1) increased in T3. …”
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A longitudinal cohort study on dispensed analgesic and psychotropic medications in older adults before, during, and after the COVID-19 pandemic: the HUNT study by Tanja Louise Ibsen, Ekaterina Zotcheva, Sverre Bergh, Debby Gerritsen, Gill Livingston, Hilde Lurås, Svenn-Erik Mamelund, Anne Marie Mork Rokstad, Bjørn Heine Strand, Richard C. Oude Voshaar, Geir Selbæk

“…Secondarily, we explored individual characteristics associated with changes in medication prescriptions. Methods A prospective cohort study using baseline data from 10,464 participants (54% females, mean age 76 years [SD 5.8]) from the Norwegian Trøndelag Health Study (HUNT4 70+) linked with the Norwegian Prescription Database. …”
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Predictive role of SLC1A5 in neuroblastoma prognosis and immunotherapy by Jian Cheng, Miaomiao Sun, Xiao Dong, Yang Yang, Xiaohan Qin, Xing Zhou, Yongcheng Fu, Yuanyuan Wang, Jingyue Wang, Da Zhang

“…However, its contributions to neuroblastoma biology remain largely unexplored. Methods This study utilized clinical neuroblastoma samples from 20 patients and 1310 cases from four public datasets to investigate SLC1A5 expression, biological function, and prognostic significance. …”
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A Novel Immune-Related lncRNA-Based Model for Survival Prediction in Clear Cell Renal Cell Carcinoma by Zedan Zhang, Yanlin Tang, Yanjun Liu, Hongkai Zhuang, Enyu Lin, Lu Xie, Xiaoqiang Feng, Kaiwen Tian, Jiayi Zeng, Jiumin Liu, Yuming Yu

“…Identifying immune-related lncRNAs and constructing a model would probably provide new insights into biomarkers and immunotherapy for ccRCC and aid in the prognosis prediction. Methods. The transcription profile and clinical information were obtained from The Cancer Genome Atlas (TCGA). …”
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Optical Coherence Tomography Guided Intravascular Lithotripsy in the Peripheral Vasculature: Technique and Case Series Analysis by Rohit Mehra, Vikram Patra, Rishi Dhillan, Rahul Merkhed, C V N M Dattatraya

“…This study was an endeavor to utilize optical coherence tomography (OCT) as a therapeutic imaging modality in in vivo human arterial vasculature, in amalgamation with IVL for producing realistic intraoperative evidence of calcium fragmentation and luminal expansion, stent bed preparation, and ascertain utility without the usage of contrast. Patients and Methods: A prospective, observational, two-center study case series analysis, which enrolled 24 patients with peripheral arterial disease requiring the usage of IVL. …”
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Visual analysis of research hotspots and trends in traditional Chinese medicine for depression in the 21st century: A bibliometric study based on citespace and VOSviewer by Chengcheng Song, Kelong Chen, Yongxi Jin, Ling Chen, Zuxiu Huang

“…Therefore, the present study aimed to summarise the research trends and progress in this field, providing relevant information and presenting potential future research directions for subsequent researchers. Methods: Literature in this field was searched from January 1, 2000 to April 20, 2024 in the Web of Science Core Collection database, to analyse the current status of the literature and publication trends. …”
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Computer-guided identification of novel inhibitors of apoptosis-signaling kinase 1 from Spondia mombim bioactive compounds against colorectal cancer by Olusola Olalekan Elekofehinti, Hannah Oluwaseun Popoola, Adedotun Olayemi Oluwatuyi, Opeyemi Iwaloye, Moses Orimoloye Akinjiyan, Oluwamodupe Cecilia, Frank Abimbola Ogundolie, Olalekan Isaac Olatunde, Oussama Abchir, Samir Chtita, Joao Batista Texeira Rocha

“…The use of natural compounds in human cancer treatment continues to gain significant attention in the scientific community due to their therapeutic efficacy. Method In this study, computational models such as flexible docking, induced fit docking, and binding free energy calculation were employed to identify small molecule inhibitors from known bioactive compounds of Spondias mombin in reference to 5-fluorouracil (Colorectal cancer standard drug) targeting apoptosis-signaling kinase 1. …”
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Utilization and quality of primary and specialized palliative homecare in nursing home residents vs. community dwellers: a claims data analysis by Juliane Poeck, Franziska Meissner, Bianka Ditscheid, Markus Krause, Ulrich Wedding, Cordula Gebel, Ursula Marschall, Gabriele Meyer, Werner Schneider, Antje Freytag

“…We want to add evidence by comparing nursing home residents (who had been living in a nursing home for at least one year) and nursing-care-dependent community dwellers in terms of utilization and quality of palliative homecare. Methods We conducted a population-based study with nationwide claims data from deceased beneficiaries of a large German health insurance provider. …”
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Implementation of prehospital point-of-care ultrasound using a novel continuous feedback approach in a UK helicopter emergency medical service by Salman Naeem, Shadman Aziz, Thomas Hirst, Johannes Strobel, Jamin M. Mulvey, Ailidh Lang, Jankee Patel, Alexander Smith, Ka Jun Cheng, Michael Palmer, Jonas Schlautmann, Michael D. Christian, Daniel Nevin

“…This paper describes a novel approach to implementation of prehospital PoCUS and clinical governance framework in a UK HEMS. Methods A retrospective database review was undertaken at London’s Air Ambulance (LAA) from 1st September 2021 to 31st March 2023. …”
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Meta-analysis of efficacy and safety of pembrolizumab for the treatment of advanced or recurrent cervical cancer by Xue Zhang, Wen-Jie Yin, Ai-Li Zhang, Xiao-Xiao Zhang, Li-Juan Ding, Jiao Zhang, Shu-Ting He, Jie-Ping Yan

“…Background This meta-analysis seeks to assess the efficacy and safety of pembrolizumab in individuals with advanced or recurrent cervical cancer.Methods Databases from PubMed, Embase, and the Cochrane Library were all thoroughly searched for pertinent research. …”
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Aspergillus fumigatus Influences Gasdermin-D-Dependent Pyroptosis of the Lung via Regulating Toll-Like Receptor 2-Mediated Regulatory T Cell Differentiation by Wei Yan, Yi-si Zhao, Ke Xie, Yu Xing, Fang Xu

“…The aim of this study was to explore whether A. fumigatus influences Gasdermin-D-dependent pyroptosis of the lung by regulating Toll-like receptor 2-mediated regulatory T cell differentiation. Methods. Collect peripheral blood from patients with A. fumigatus. …”
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Traditional Chinese Mind and Body Exercises for Neck Pain: A Meta-Analysis of Randomized Controlled Trials by Yu-Hua Xie, Man-Xia Liao, Mao-Yuan Wang, W. C. Hewith A. Fernando, Yue-Ming Gu, Xue-Qiang Wang, Lin-Rong Liao

“…The aim of this study was to investigate the effectiveness of TCMBE on pain intensity, functional mobility, and QOL in individuals with neck pain. Methods. The PubMed, MEDLINE, PEDro, and Embase databases were systematically searched for relevant studies. …”
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NOX4 modulates breast cancer progression through cancer cell metabolic reprogramming and CD8+ T cell antitumor activity by Yingying Xiong, Yiming Weng, Shan Zhu, Jian Qin, Jia Feng, Xiaopeng Jing, Chao Luo, Wei Gong, Rui Sun, Min Peng

“…Although NADPH oxidase 4 (NOX4) has been implicated in various oncogenic processes, its exact function in breast cancer progression, metabolic reprogramming, and immune modulation remains unclear.MethodsWe used murine 4T1 and EO771 breast cancer models to generate NOX4 knockout (KO) cell lines via CRISPR/Cas9. …”
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Assessment of Chaves Low-Temperature CO2-Rich Geothermal System (N-Portugal) Using an Interdisciplinary Geosciences Approach by J. M. Marques, P. M. Carreira, L. A. Aires-Barros, F. A. Monteiro Santos, M. Antunes da Silva, P. Represas

“…The Chaves low-temperature CO2-rich geothermal waters present similar 87Sr/86Sr ratios (between 0.728035 and 0.716713) to those of the plagioclases from granitic rocks (between 0.72087 and 0.71261) suggesting that water mineralization is strongly ascribed to Na-plagioclase hydrolysis. Geophysical methods (e.g., resistivity and AMT soundings) detected conductive zones concentrated in the central part of the Chaves graben as a result of temperature combined with the salinity of the Chaves low-temperature CO2-rich geothermal waters in fractured and permeable rock formations. …”
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iRGD-Targeted Biosynthetic Nanobubbles for Ultrasound Molecular Imaging of Osteosarcoma by Liu T, Liang X, Liu W, Yang S, Cui T, Yan F, Li Z

“…Here, we selected it as the imaging target and fabricated iRGD-sGVs acoustic probe for the early-stage diagnosis of osteosarcoma.Materials and Methods: Biological nanoscale gas vesicles (sGVs) were extracted from Serratia 39006. …”
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A Magnetic Photocatalytic Composite Derived from Waste Rice Noodle and Red Mud by Qing Liu, Wanying Ying, Hailing Gou, Minghui Li, Ke Huang, Renyuan Xu, Guanzhi Ding, Pengyu Wang, Shuoping Chen

“…WRN was processed via a hydrothermal method to produce a solution containing carbon quantum dots (CQDs). …”
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Residents as learning facilitators inside and outside of interprofessional education: a faculty development program in postgraduate pediatric training by Philipp A. Müller, Christine Straub, Christine Straub, Andrea Heinzmann, Thorsten Langer, Sebastian F. N. Bode, Jan Griewatz, Christian Kimmig, Sebastian Friedrich

“…To bridge the gap between IPE and non-IPE learning facilitation for the other residents, we developed the resident-as-teachers course “How to teach pediatrics.”Methods“How to teach pediatrics” was implemented as a 4-week blended learning program based on the framework of Core Competencies for Medical Teachers (KLM). …”
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