Adipose Tissue-Derived Stem Cells Differentiate into Carcinoma-Associated Fibroblast-Like Cells under the Influence of Tumor-Derived Factors by Constantin Jotzu, Eckhard Alt, Gabriel Welte, Jie Li, Bryan T. Hennessy, Eswaran Devarajan, Srinivasalu Krishnappa, Severin Pinilla, Lilly Droll, Yao-Hua Song

“…Carcinoma-associated fibroblasts (CAF) are considered to contribute to tumor growth, invasion and metastasis. However, the cell type of origin remains unknown. …”
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Classifications of triple-negative breast cancer: insights and current therapeutic approaches by Ziqi Chen, Yumeng Liu, Minchuan Lyu, Chi Ho Chan, Meiheng Sun, Xin Yang, Shuangying Qiao, Zheng Chen, Sifan Yu, Meishen Ren, Aiping Lu, Ge Zhang, Fangfei Li, Yuanyuan Yu

“…TNBC has a high risk of recurrence and distant metastasis, resulting in lower survival rates. Additionally, TNBC exhibits significant heterogeneity at histopathological, proteomic, transcriptomic, and genomic levels, further complicating the development of effective treatments. …”
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Endoscopic Nipple- or Skin-Sparing Mastectomy and Immediate Breast Reconstruction with Endoscopic Harvesting of the Latissimus Dorsi Flap: A Preliminary Experience of an Innovative... by Yu Feng, Nan Wen, Faqing Liang, Jiao Zhou, Xiangquan Qin, Xinran Liu, Juan Li, Mengxue Qiu, Huanzuo Yang, Zhenggui Du

“…No tumor recurrence or metastasis was found until the last follow-up. In the BREAST-Q evaluation, although they gave a lower score beginning at 1-month post-operation than preoperatively (P>0.05, except for physical well-being: chest and physical well-being: back and shoulder, P<0.01), there was an uptrend at 3 months postoperatively. …”
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Case report: Unraveling a unique case of male occult breast cancer with axillary intricacies and a comprehensive literature dive by Xintong Xie, Xiangyi Kong, Xiangyi Kong, Hongnan Jiang, Jidong Gao, Jidong Gao

“…Notably, this is the first documented case of male occult breast cancer with distant metastasis that was successfully treated with surgery and radiotherapy following systemic therapy. …”
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Single component organic photosensitizer for tumor Photodynamic/Photothermal immunotherapy via apoptosis and pyroptosis by Miao-Yan Xu, Jie Zeng, Xin-Hao Han, Duo-Duo Wei, Bing Fan, Xin‑Hui Qu, Shaorong Huang, Xiao-Jian Han

“…Moreover, JNC NPs + Laser can induce immunogenic cell death (ICD) to improve the maturation of dendritic cells (DCs) and present antigens to T cells, which high-effectively eliminate tumor lung metastasis. This finding provided a single component organic photosensitizer for tumor photodynamic/photothermal immunotherapy via apoptosis and pyroptosis.…”
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RETRACTED ARTICLE: LRPPRC regulates malignant behaviors, protects mitochondrial homeostasis, mitochondrial function in osteosarcoma and derived cancer stem-like cells by Ziyi Zhao, Yingwei Sun, Jing Tang, Yuting Yang, Xiaochao Xu

“…However, the exact role and mechanisms by which LRPPRC acts in osteosarcoma and osteosarcoma-derived cancer stem-like cells (CSCs), which potentially critically contribute to recurrence, metastasis and chemoresistance, are still largely unclear. …”
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The systematic analysis of genes related to butyrate metabolism suggests that CDKN3 could serve as a promising therapeutic target for lung adenocarcinoma treatment by Yanchao Luan, Chao Liang, Qingsong Han, Xueqin Zhou, Na Yang, li Zhao

“…Finally, we determined that knockdown CDKN3 inhibited the proliferation and metastasis of LUAD cells. Conclusion We identify and validate a novel BMR-related prognostic signature comprising 5 DEGs for LUAD patients. …”
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Aberrant Expression of MicroRNA-15a and MicroRNA-16 Synergistically Associates with Tumor Progression and Prognosis in Patients with Colorectal Cancer by Guangfa Xiao, Huihuan Tang, Wei Wei, Jian Li, Liandong Ji, Jie Ge

“…In addition, miR-15a and/or miR-16 downregulation were all significantly associated with advanced TNM stage (all P<0.05), poorly histological grade (all P<0.05), and positive lymph node metastasis (all P<0.05). Moreover, the survival analysis identified miR-15a expression, miR-16 expression, and miR-15a/miR-16 combination as independent predictors of both unfavorable overall survival and disease-free survival. …”
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The association between pretransplant malignancy and post-transplant survival and cancer recurrence in bilateral lung transplantation: An analysis of 23,291 recipients by Wongi Woo, MD, Hye Sung Kim, MD, Ankit Bharat, MBBS, Young Kwang Chae, MD, PhD, MBA

“…If patients with pre-TM are free from recurrence or metastasis for a significant time, there could be some who can benefit from BLT. …”
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PAK5 Induces EMT and Promotes Cell Migration and Invasion by Activating the PI3K/AKT Pathway in Ovarian Cancer by Diyou Li, Yinglin Pan, Yating Huang, Ping Zhang, Xuhong Fang

“…It was initially found that PAK5 was highly expressed in ovarian cancer tissues, particularly in patients with distant metastasis. Higher expression of PAK5 predicted poor survival fates in patients with ovarian cancer (p=0.008). …”
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Endoscopic Removal of Gastrointestinal Stromal Tumors in the Stomach: A Single-Center Experience by Yingjie Guo, Xue Jing, Jian Zhang, Xueli Ding, Xiaoyu Li, Tao Mao, Zibin Tian

“…The moderate-risk cases were treated with imatinib mesylate after ER. No recurrence or metastasis was observed during the follow-up period of 23±8 months (range: 3-48 months). …”
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Targeted generative data augmentation for automatic metastases detection from free-text radiology reports by Maede Ashofteh Barabadi, Xiaodan Zhu, Wai Yip Chan, Amber L. Simpson, Richard K. G. Do

“…This observation suggests that Llama3, which has not been specifically tailored to this task or clinical data in general, can generate high-quality synthetic data through paraphrasing in the clinical context. We also compare metastasis identification accuracy between models utilizing institutionally standardized reports vs. non-structured reports, which complicate the extraction of relevant information, and show how including patient history with a customized model architecture narrows the gap between those two setups from 7.3 to 4.5 points on F1-score under LoRA tuning. …”
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The prognostic value of boost dose in residual cervical lymph nodes in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy: a retrospective study by Mengting Xu, Liuling Wang, Jianming Ding, Yiying Xu, Zhaodong Fei

“…Results Patients with positive RCLN findings exhibited considerably lower 3-year relapse-free survival (RRFS), overall survival (OS), progression-free survival (PFS), and distant metastasis-free survival (DMFS) rates compared to those with negative findings (98.0% vs. 92.8%; 93.5% vs. 85.0%; 87.0% vs. 68.4%; 92.8% vs. 81.9%, all P < 0.001). …”
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Inguinal Lymph Node Dissection for Advanced Stages of Plantar Melanoma in a Low-Income Country by Ollo Roland Somé, Malick Diallo, Damien Konkobo, Nassirou Yabré, Valentin Konségré, Issouf Konaté, Sidy Ka

“…We included all documented cases of advanced stage plantar melanoma with clinically detectable inguinal lymph node metastasis. Twenty-two of 27 patients identified—with mean age 56 years—underwent ILND. …”
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Ir-6: A Novel Iridium (III) Organometallic Derivative for Inhibition of Human Platelet Activation by Ren-Shi Shyu, Themmila Khamrang, Joen-Rong Sheu, Chih-Wei Hsia, Marappan Velusamy, Chih-Hsuan Hsia, Duen-Suey Chou, Chao-Chien Chang

“…Platelet activation has been reported to play a major role in arterial thrombosis, cancer metastasis, and progression. Recently, we developed a novel Ir(III)-based compound, [Ir(Cp∗)1-(2-pyridyl)-3-(4-dimethylaminophenyl)imidazo[1,5-a]pyridine Cl]BF4 or Ir-6 and assessed its effectiveness as an antiplatelet drug. …”
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Perianal Paget’s Disease: The 17-Year-Experience of a Single Institution in Taiwan by Yu-Chen Wang, Anna Fen-Yau Li, Shung-Haur Yang, Hsiu-Hsun Ma, Wen-Yih Liang

“…The colorectal cancers (CRCs) in secondary PPD cases were located in anorectal area for 9 patients while 4 were located in the rectum; 5, 2, 4, and 2 were in stages I, II, III, and in uncertain stage, respectively. The distant metastasis rates of CRC in the secondary PPD patients during follow-up were 40% (2/5), 0% (0/2), and 50% (2/4) for stages I, II, and III, respectively. …”
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Cancer Stem Cells from Tumor Cell Lines Activate the DNA Damage Response Pathway after Ionizing Radiation More Efficiently Than Noncancer Stem Cells by Heriberto Abraham Valencia-González, Graciela Ruíz, Elizabeth Ortiz-Sánchez, Alejandro García-Carrancá

“…CSC are proposed to repair DNA damage more efficiently than the rest of tumor cells, resisting chemotherapy or radiotherapy and causing clinical recurrence and metastasis. We aimed to determine the molecular basis of radioresistance and first compared the response to ionizing radiation (IR) between cancer stem cell-enriched cultures grown as spheres and conventional tumor cell line cultures grown as monolayer, from HeLa and MCF-7 cancer cell lines. …”
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Tumor-Infiltrating Lymphocytes and Neutrophils and Their Location in Canine Mammary Neoplasms with a Solid Arrangement: A Prognostic Factor? by Mayra C. Flecher, Marina P. Reys, Débora Balabram, Karen Y. R. Nakagaki, Geovanni D. Cassali

“…High infiltration of intratumoral BCD79⁺ lymphocytes was related to nodal metastasis (<i>p</i> = 0.03). Intratumoral TILs and TCD3⁺ were associated with shorter survival time. …”
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Meta-analysis of the association between overexpression of RAD51 family genes and prognosis and clinical features in breast cancer by Yong-Cheng Liu, Jun Shen

“…High expression of RAD51 family genes was associated with poorer overall survival (OS) [HR = 1.305, 95%CI (1.145–1.488), P < 0.01], disease-free survival/distant metastasis-free survival (DFS/DMFS) [HR = 1.588, 95%CI (1.208–2.089), P < 0.01], and disease-specific survival (DSS) [HR = 1.403, 95%CI (1.066–1.846), P = 0.02]. …”
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The Role of Pentacyclic Triterpenoids in Non-Small Cell Lung Cancer: The Mechanisms of Action and Therapeutic Potential by Young-Shin Lee, Ryuk Jun Kwon, Hye Sun Lee, Jae Heun Chung, Yun Seong Kim, Han-Sol Jeong, Su-Jung Park, Seung Yeon Lee, Taehwa Kim, Seong Hoon Yoon

“…Pentacyclic triterpenoids, such as lupeol, betulinic acid, betulin, oleanolic acid, ursolic acid, glycyrrhetinic acid, glycyrrhizin, and asiatic acid, have demonstrated the ability to inhibit cell proliferation and angiogenesis, induce apoptosis, suppress metastasis, and modulate inflammatory and immune pathways in NSCLC cell line models. …”
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