Differential expression of CD175 and CA19-9 in pancreatic adenocarcinoma by Jane J. Cheng, Yasuyuki Matsumoto, Gabrielle E. Dombek, Kathryn A. Stackhouse, Ana Sofia Ore, Jonathan N. Glickman, Jamie Heimburg-Molinaro, Richard D. Cummings

“…In addition, two other TACAs are CA19-9 (sialyl-Lewis a), which is used as a prognostic serum marker for pancreatic cancer, and its isomer sialyl-Lewis x (SLex, CD15s), which is overexpressed in many cancer types and associated with metastasis. While CD175 and other TACAs may be expressed by many human carcinomas, little is known about their differential expression patterns in tumors, thus limiting their use as tissue biomarkers or therapeutic targets. …”
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Preclinical Evaluation of Oncolytic Δγ134.5 Herpes Simplex Virus Expressing Interleukin-12 for Therapy of Breast Cancer Brain Metastases by James J. Cody, Pietro Scaturro, Alan B. Cantor, G. Yancey Gillespie, Jacqueline N. Parker, James M. Markert

“…The metastasis of breast cancer to the brain and central nervous system (CNS) is a problem of increasing importance. …”
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A case report of successful treatment of advanced thymic squamous cell carcinoma with poor performance status using multimodal therapy by Xianhua Xu, Xiang Yan, Yang Qin, Dan Kou, Qi Huang, Qiongcheng Chen, Yejin Li

“…Computed tomography (CT) and positron emission tomography/computed tomography (PET/CT) scans demonstrated a significant mass in the chest, accompanied by metastasis to adjacent lymph nodes. Vascular ultrasound and CT angiography both indicated thrombosis in the jugular, innominate, and left subclavian veins. …”
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The Therapeutic Targets of miRNA in Hepatic Cancer Stem Cells by Sabrina Bimonte, Maddalena Leongito, Antonio Barbieri, Vitale del Vecchio, Michela Falco, Aldo Giudice, Raffaele Palaia, Vittorio Albino, Raimondo Di Giacomo, Antonella Petrillo, Vincenza Granata, Francesco Izzo

“…Several studies demonstrated that hepatic cancer stem cells (HCSCs), also called tumor-initiating cells, are involved in regulation of HCC initiation, tumor progression, metastasis development, and drug resistance. Despite the extensive research, the underlying mechanisms by which HCSCs are regulated remain still unclear. …”
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Suppression of Migration and Invasion by 4-Carbomethoxyl-10-Epigyrosanoldie E from the Cultured Soft Coral Sinularia sandensis through the MAPKs Pathway on Oral Cancer Cells by Rou-Yi Fang, Yueh-Wen Liu, Yih-Gang Goan, Jen-Jie Lin, Jui-Hsin Su, Wen-Tung Wu, Yu-Jen Wu

“…The primary reason for cancer-related fatalities is metastasis. The compound 4-carbomethoxyl-10-epigyrosanoldie E, derived from the Sinularia sandensis soft coral species grown in cultures, exhibits properties that counteract inflammation. …”
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Research Progress on Natural Products That Regulate miRNAs in the Treatment of Osteosarcoma by Lin Wang, Xinyu Liu, Haoze Lv, Han Zhang, Rimei Lin, Shan Xu, Chaojing Zhang, Shilei Lou, Zhidong Qiu, Cong Sun, Ning Cui

“…Osteosarcoma, a malignant neoplasm predominantly occurring during adolescence and later in life, is characterized by a high propensity for metastasis. This review explores the role of miRNAs in the initiation and progression of cancer, highlighting their potential as predictive biomarkers for disease. …”
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Mass resection as a candidate treatment for uterine PEComas of uncertain malignant potential: a case report and literature review by Haijuan Shi, Yan Yin, Shoujun Liang, Chuanzhong Liu, Yibao Huang, Bingfeng Lu, Liying Zhang

“…Except for the patients who were lost to follow-up, 11 patients were free of any recurrence or metastasis at their last follow-up. Patients with group A tumours (abundant HMB45 expression) had a longer disease-free survival than those with group B tumours.ConclusionsSurgery alone may be appropriate for uterine PEComas of uncertain malignant potential. …”
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The patterns of presentation, management and outcomes of breast cancer patients at a tertiary health facility in Sierra Leone by Constance Cummings-John, Abdulai Jawo Bah, Isaac Olufemi Smalle, Caesar Cho Challe, Babatunde Duduyemi, Temidayo Ogundiran

“…The left breast of 130 (51.2%) patients was the most commonly affected; approximately 119 (47%) patients presented with stage III B disease, and 35 (13.8%) presented with metastasis. With respect to treatment modalities, surgery, chemotherapy, and hormonal therapy were provided to patients — with 120 (48%) mastectomies, 73 (29.2%) neoadjuvant chemotherapy, 84 (33.6%) adjuvant chemotherapy, 98 (39.2%) hormonal therapy, 35 (14.0%) palliative care and approximately 38 (15.2%) refused or did not initiate any treatment. …”
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Influence of Mesalazine on Ferroptosis-Related Gene Expression in In Vitro Colorectal Cancer Culture by Joanna Słoka, Barbara Strzałka-Mrozik, Sebastian Kubica, Ilona Nowak, Celina Kruszniewska-Rajs

“…Despite medical advances, CRC continues to present a high risk of recurrence, metastasis and low survival rates. Consequently, significant emphasis has been directed towards exploring novel types of cell death, particularly ferroptosis. …”
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Clinical Outcome of Third-Line Pazopanib in a Patient with Metastatic Renal Cell Carcinoma by Michela Roberto, Maria Bassanelli, Elsa Iannicelli, Silvana Giacinti, Chiara D’Antonio, Anna Maria Aschelter, Paolo Marchetti

“…Thus, he underwent a multimodality treatment with pazopanib, as third-line therapy, to control systemic disease and radiosurgery directed on the new brain metastasis. To date, the patient is still receiving pazopanib, with progression-free survival and overall survival of 43 and 103 months, respectively. …”
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Identification of multicohort-based predictive signature for NMIBC recurrence reveals SDCBP as a novel oncogene in bladder cancer by Chen Zhang, Hubin Yin, Tinghao Li, Junrui Chen, Weiyang He, Ke Ren, Bo Li, Xudong Liu

“…Gene Set Variation Analysis and Gene Set Enrichment Analysis unveiled SDCBP exerted cancer-promoting biological processes, such as angiogenesis, EMT, metastasis and proliferation. Experimental procedures demonstrated that silencing SDCBP attenuated cell growth, glucose metabolism and extracellular acidification rate, accompanied by decreased expression of p-AKT, p-ERK1/2, LDHA and Vimentin.Conclusions The established 8-gene signature holds promise as a tool for predicting NMIBC recurrence, while targeting SDCBP may represent a potential strategy for delaying disease relapse.…”
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Submucosal Tunnel Endoscopic Resection for Esophageal Submucosal Tumors: A Multicenter Study by Sufang Tu, Silin Huang, Guohua Li, Xiaowei Tang, Haitao Qing, Qiaoping Gao, Jingwen Fu, Guoping Du, Wei Gong

“…During the mean 15-month follow-up, there were no cases of recurrence and distant metastasis. Conclusions. STER is a safe and feasible technique for treating esophageal SMTs originating from the muscularis propria layer.…”
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Gamma Knife Radiosurgery Treatment for Metastatic Melanoma of the Trigeminal Nerve and Brainstem: A Case Report and a Review of the Literature by Halloran E. Peterson, Erik W. Larson, Robert K. Fairbanks, Wayne T. Lamoreaux, Alexander R. Mackay, Jason A. Call, John J. Demakas, Barton S. Cooke, Christopher M. Lee

“…This case illustrates the use of repeated SRS, specifically Gamma Knife radiosurgery (GKRS) for management of a unique brainstem metastasis. Clinical Presentation. This patient presented 5 years after the removal of a lentigo maligna melanoma from her left cheek with left sided facial numbness and paresthesias with no reported facial weakness. …”
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High Intensity Focused Ultrasound versus Brachytherapy for the Treatment of Localized Prostate Cancer: A Matched-Pair Analysis by Fouad Aoun, Ksenija Limani, Alexandre Peltier, Quentin Marcelis, Marc Zanaty, Alexandre Chamoun, Marc Vanden Bossche, Thierry Roumeguère, Roland van Velthoven

“…No statistically significant difference in metastasis-free, cancer specific, and overall survivals was observed between the two groups. …”
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Lack of Anatomical Concordance between Preablation and Postablation CT Images: A Risk Factor Related to Ablation Site Recurrence by Petra G. Kele, Eric J. Van der Jagt, Paul F. M. Krabbe, Koert P. de Jong

“…Variation in the position of the liver between preablation and postablation CT images hampers assessment of treatment of colorectal liver metastasis (CRLM). The aim of this study was to test the hypothesis that discordant preablation and postablation imaging is associated with more ablation site recurrences (ASRs). …”
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Conjugated Linoleic Acid Treatment Attenuates Cancerous features in Hepatocellular Carcinoma Cells by Zohre Miri-Lavasani, Shukoofeh Torabi, Roya Solhi, Bahareh Shokouhian, Parvaneh Afsharian, Zahra Heydari, Abbas Piryaei, Zahra Farzaneh, Nikoo Hossein-khannazer, Hamidreza Aboulkheyr Es, Ensieh Zahmatkesh, Andreas Nussler, Moustapha Hassan, Mustapha Najimi, Massoud Vosough

“…The concept of differentiation therapies (DT) relies on inducing differentiation in HCC cells in order to inhibit recurrence and metastasis. Hepatocyte nuclear factor 4 alpha (HNF4α) is the key hepatogenesis transcription factor and its upregulation may decrease the invasiveness of cancerous cells by suppressing epithelial-mesenchymal transition (EMT). …”
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Automated skin melanoma diagnostics based on mathematical model of artificial convolutional neural network by D. A. Gavrilov, E. I. Zakirov, E. V. Gameeva, V. Yu. Semenov, O. Yu. Aleksandrova

“…In the proposed project, we will focusour a en on on the diagnosis of human skin diseases.At the moment, melanoma is one of the most dangerous types of malignant tumors of the skin with a lot of deaths due to rapid metastasis, which is difficult to treat. The development of computer vision technology has allowed the development of technical vision systems that allow detec on and classifi ca on of skin diseases with a quality that is comparable and in some cases exceeds the values a ained by man.In this paper, the authors propose an algorithm for the primary diagnosis of skin melanoma based on deep neural networks, achieving an accuracy of 91% for melanoma in dermatoscopic images. …”
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Pancreatic Cancer: Molecular, Biochemical, Chemopreventive, and Therapeutic Aspects by Juan Iovanna, José Luis Neira

“…Yet, understanding and stopping metastasis may prove to be one of the great potential strategies of treating PC. …”
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Primary Neuroendocrine Tumor of the Parotid Gland: A Case Report and a Comprehensive Review of a Rare Entity by Olga Martínez-Sáez, Javier Molina-Cerrillo, Carmen Moreno García del Real, Rafael Barberá Durban, Juan J. Díez, Teresa Alonso-Gordoa, Enrique Grande Pulido

“…Regardless of their low frequency, it is imperative to accurately differentiate these tumors from the much more common squamous cell carcinomas and from metastasis from another primary tumor due to the completely different therapeutic approaches and prognosis. …”
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Chordoma Spontaneous Regression After COVID-19 by Luis Fernando Moura da Silva Junior, Gyl Eanes Barros Silva, Marcos Adriano Garcia Campos, Antonio Augusto Lima Teixeira Júnior, Ramon Moura Santos, Orlando José dos Santos, Natalino Salgado Filho

“…Chordomas are a low-to-intermediate-grade slow-growing subtype of sarcoma, but show propensity to grow and invade locally with recurrence and metastasis in 10–40% of cases. We describe the first case of spontaneous regression of a solid tumor (histologically and immunohistochemically proven chordoma) after COVID-19. …”
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