Evaluation of Preoperative CA15-3 Level and its Relationship with Clinico-Pathological Characteristics in Primary Breast Cancer Patients by Braihan Hamdi Hameed, Izzat Abdulsatar Al-Rayahi, Salwa S. Muhsin

“…Furthermore, the present study showed that higher preoperative CA15-3 level was significantly associated with a larger tumor size and lymph node metastasis. This means that elevated CA15-3 is correlated with an increased tumor burden, suggesting its predictive value. …”
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Recurrent Giant Malignant Phyllodes Tumor of the Breast by Erik Kudela, Karol Kajo, Erik Kozubik, Tomas Rokos, Terezia Pribulova, Jan Danko, Eva Kudelova, Igor Homola, Pavol Slavik, Barbora Macurova, Kamil Biringer

“…In addition, they are associated with an increased risk of local recurrence and distant metastasis. The authors hereby present a case report of a 34-year-old woman with recurrent malignant PT with an increasing aggressiveness. …”
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Impact of interferon-free regimens in patients with chronic HCV and successfully ablated HCC by Amr Maged Mahmoud Rasheed, Maissa E. L. Raziky, Mohammad El Sayed, Mai Mehrez, Gamal Esmat

“…Results Four patients with distant metastasis, three dying from liver-related incidents, received surgical resection, TACE, and RFA treatment, while one patient survived with compensated chronic liver disease. …”
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Hypoxia Promotes Glioma Stem Cell Proliferation by Enhancing the 14-3-3β Expression via the PI3K Pathway by Weidong Cao, Qiang Zhou, Hongwei Wang, Wei Rao, Gang Cheng, Peng Wang, Shengli Guo, Bin Ren, Jianning Zhang

“…Hypoxia induced by using CoCl2 application and 14-3-3β protein knockdown by specific small interfering RNA transfection were performed in GSCs both in vitro and in vivo to observe their role in glioma progression and metastasis occurrence by using western blot analysis and MTT assay. …”
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Small Cell Neuroendocrine Carcinoma of the Urinary Tract Successfully Managed with Neoadjuvant Chemotherapy by Mustapha Ahsaini, Omar Riyach, Mohammed Fadl Tazi, Mohammed Jamal El Fassi, My Hassan Farih, Hind Elfatmi, Afaf Amarti

“…After 24 months of followup, no local or distant metastasis was detected. Conclusion. The purpose of this review is to present a rare case of pure small cell neuroendocrine carcinoma of the urinary tract and review the literature about the place of neoadjuvant chemotherapy in this rare tumors.…”
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Synchronous HPV-Related Cancer of Bilateral Tonsils Detected Using Transoral Endoscopic Examination with Narrow-Band Imaging by Fukuko Shimizu, Kenji Okami, Koji Ebisumoto, Daisuke Maki, Akihiro Sakai, Go Ogura, Naoya Nakamura, Masahiro Iida

“…Early diagnosis without the inspection under general anesthesia is beneficial for the patients with lymph node metastasis from unknown primary lesion.…”
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Liposarcoma of the Nasopharynx: Diagnosis and Management of a Rare Diagnostic Entity by George X. Papacharalampous, Dimitrios Kikidis, Alexios Vasileiou, Aggeliki Bousiotou, Aristeidis Chrysovergis

“…However, there is no adequate evidence that the combination of surgery and radiotherapy lowers the possibility of distant metastasis of the head and neck liposarcomas. The role of adjuvant or neoadjuvant chemotherapy still remains controversial.…”
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A new strategy for the treatment of advanced ovarian cancer: utilizing nanotechnology to regulate the tumor microenvironment by Zixuan Xiong, Yichun Huang, Shulong Cao, Xuqun Huang, Haiyuan Zhang

“…In the non-immune TME, mechanisms such as apoptosis inhibition, DNA damage response (DDR), and epithelial-mesenchymal transition (EMT) can promote tumor growth, metastasis, and drug resistance. Despite the challenges posed by the TME in the treatment of AOC, the unique biological advantages of nanoparticles (NPs) make it possible to regulate the TME. …”
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Unraveling the PVTGlu-mPFCGlu circuit: A new frontier in chronic pain management for bone cancer pain by Liqun Duan, Qianliang Wang, Jianpeng Chen, Zelin Fan, Wenzhi Zhang, Jun Yan

“…Bone cancer pain (BCP) is a type of ongoing or breakthrough pain caused by a primary bone tumor or bone metastasis. BCP impairs patients’ quality of life. Depending upon clinical observations, the administration of centrally acting analgesic has been associated with the alleviation of pain symptoms BCP patients. …”
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Do Not Miss the Tumor: A Novel Presentation of Osteosarcoma by Michael DePalma, Sachin Gupta, Jie Nguyen, Divya Talwar, Alexandre Arkader, Lawrence Wells

“…Because primary-care physicians and pediatricians may be the first medical providers to encounter patients with osteosarcoma, it is imperative that such clinicians are familiar with the signs and symptoms associated with osteosarcomas in order to reduce the risk of metastasis and disease progression and prevent treatment delays. …”
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Adjuvant Radiochemotherapy with a 23-Month Overall Survival Time in a Patient after a Surgery due to Splenic Hemangiosarcoma Rupture: A Case Report with the Literature Review by M. Bilski, D. Surdyka, I. Paśnik, M. Bilska, P. Cisek, P. Korona, J. Szumiło, L. Grzybowska-Szatkowska

“…Treatment of choice is surgical splenectomy, which rarely gives good results due to the aggressive course of the disease as well as the high potential for metastasis. Overall survival in primary spleen sarcomas as described by various authors is between 4 and 14 months. 80% of patients after spleen rupture do not survive 6 months. …”
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Impact of Surgeon Experience in the Resection of Basal Cell Carcinoma of the Head and Neck Region by Carlos Gonzalo Acosta Mayorga, Piedad Elizabeth Acurio Padilla, Guido Nino Guida Acevedo

“…<strong>Foundation:</strong> surgical excision with adequate margins is considered the standard treatment for cutaneous basal cell carcinoma, due to its association with lower rates of recurrence and postoperative metastasis. <br /><strong>Objective:</strong> to evaluate the impact of surgical experience in a high-volume head and neck surgery department in relation to margin status in basal cell carcinoma resection. …”
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Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition by Antonino Glaviano, Hannah Si-Hui Lau, Lukas M. Carter, E. Hui Clarissa Lee, Hiu Yan Lam, Elena Okina, Donavan Jia Jie Tan, Wency Tan, Hui Li Ang, Daniela Carbone, Michelle Yi-Hui Yee, Muthu K. Shanmugam, Xiao Zi Huang, Gautam Sethi, Tuan Zea Tan, Lina H. K. Lim, Ruby Yun-Ju Huang, Hendrik Ungefroren, Elisa Giovannetti, Dean G. Tang, Tullia C. Bruno, Peng Luo, Mads Hald Andersen, Bin-Zhi Qian, Jun Ishihara, Derek C. Radisky, Salem Elias, Saurabh Yadav, Minah Kim, Caroline Robert, Patrizia Diana, Kurt A. Schalper, Tao Shi, Taha Merghoub, Simone Krebs, Anjali P. Kusumbe, Matthew S. Davids, Jennifer R. Brown, Alan Prem Kumar

“…Abstract The tumor microenvironment (TME) is integral to cancer progression, impacting metastasis and treatment response. It consists of diverse cell types, extracellular matrix components, and signaling molecules that interact to promote tumor growth and therapeutic resistance. …”
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Overexpression of Notch3 and pS6 Is Associated with Poor Prognosis in Human Ovarian Epithelial Cancer by Zhaoxia Liu, Rongna Yun, Xiaolin Yu, Hui Hu, Genhua Huang, Buzhen Tan, Tingtao Chen

“…In tumor tissues, Notch3 expression and pS6 expression were negatively associated with age (p>0.05) but positively associated with clinical stage, pathological grading, histologic type, lymph node metastasis, and ascites (p<0.05 or p<0.01). A follow-up survey of 64 patients with ovarian epithelial cancer showed that patients with high Notch3 and pS6 expression had a shorter survival time (p<0.01), in which the clinical stage (p<0.05) and Notch3 expression (p<0.01) played important roles. …”
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Immunohistochemical evaluation of P53 in squamous cell carcinoma of the esophagus by Kala K, Sarumathy G, Nithya I, Prathiba A

“…There were no significant associations between p53 expression and site, lymph node metastasis (N classification) and stage. Conclusion: In conclusion, the expression of p53 in ESCC patients significantly correlates with age, betel nut chewing and histological grade. p53 play an important role in tumor progression and an independent variable affecting the survival. …”
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Metastatic Extrapulmonary Small Cell Carcinoma to the Cerebellopontine Angle: A Case Report and Review of the Literature by Debebe Theodros, C. Rory Goodwin, Genevieve M. Crane, Jason Liauw, Lawrence Kleinberg, Michael Lim

“…We present the first documented case of skull base metastasis of a poorly differentiated small cell carcinoma involving the CPA.…”
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Synchronous Gastric Gastrointestinal Stromal Tumor and Colon Adenocarcinoma: A Case Report by Thivi Vasilakaki, Kalliroi Koulia, Aikaterini Tsavari, Elissavet Arkoumani, Efstratios Kouroumpas, Anargiros Pavlis, Georgios Christopoulos, Konstantinos Stamatiou, Kassiani Manoloudaki, Dimitrios Zisis

“…Two years later the patient showed no evidence of recurrence or metastasis.…”
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Allelic and Genotypic Analysis of LncRNA ANRIL rs4977574 A/G Mutations in Oral Squamous Cell Carcinoma Patients: Insights into Tumor Characteristics and Genotypic Correlations by Mohammad Amin Amiri, Delara Amiri, Mohammad Javad Mokhtari, Fatemeh Lavaee, Mohammad Javad Fattahi, Abbas Ghaderi, Bijan Khademi

“…Furthermore, the association of the genotypes with the lymph node metastasis and the tumors stage was not found to be significant (p>0.05). …”
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Winging of Scapula due to a Sinister Etiology by Shania Niromi Gunasekera, Priyanka Yogananda, Harindra Karunatilaka, Bimsara Senanayake

“…Histology of a biopsy of the cervical lymph node confirmed metastasis from a poorly differentiated adenocarcinoma of the lung. …”
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Differences in Pain Intensity of Tumors Spread to the Anterior versus Anterolateral/Lateral Portions of the Vertebral Body Based on CT Scans by Hui-Ching Hsu, Tzu-Yao Liao, Long-Sun Ro, Yu-Hsiang Juan, Chuang-Chi Liaw

“…The selection criteria were as follows: (1) advanced or metastatic solid tumor; (2) radicular pain without extremity weakness; (3) malignant lesions anteriorly, anterolaterally, or laterally located at the vertebral body either spread locoregionally or over a greater distance via metastasis based on CT scan diagnosis; and (4) patient needs to use opioids for pain relief. …”
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