Hyperthermic intraperitoneal chemotherapy: Ideal and reality by Fan-He Dong, Yu-Qiang Shan, Wen-Cheng Kong, Hao-Ran Wei, Lin-Po Zhou, Ye-Bin Yang, Jing Shi, Cheng-Hao Ji, Yi-Jia Zhang

“…The HIPEC technique can effectively kill residual lesions in the abdominal cavity through the synergistic sensitization effect of thermal chemotherapy and the circulating perfusion and washing effect of large volume perfusion fluid, thereby reducing the occurrence of malignant ascites and reducing the risk of postoperative recurrence and metastasis. However, there are still many problems in the practical operation of HIPEC, such as non-uniform distribution of perfusate temperature, inadequate perfusion due to the presence of ‘dead space’, incomplete cytoreductive surgery (CRS), instances of catheter obstruction during perfusate circulation, the lack of a uniform standard for selecting appropriate HIPEC techniques, occupational exposure of medical personnel during the HIPEC procedure, and the selection of HIPEC chemotherapy regimens for patients with various types of tumors. …”
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miR-224 activates cancer-associated fibroblasts to enhance lung cancer cell migration and invasion by targeting Akirin1 by Seonyeong Oh, Sieun Lee, Inyoung Cheon, Young-Ho Ahn

“…In a mouse orthotopic injection model, miR-224 overexpression in LFs increased lung cancer metastasis. Using target prediction tools and subsequent 3′-UTR luciferase assay, Akirin1 was validated as a direct target gene of miR-224. …”
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Prognostic factors for survival in patients with advanced cholangiocarcinoma treated with percutaneous transhepatic drainage by Tomas Rohan, Barbora Cechova, Peter Matkulcik, Matej Straka, Jan Zavadil, Michal Eid, Michal Uher, Marek Dostal, Tomas Andrasina

“…A multivariate analysis showed that mass forming tumor with mass larger than 5 cm and presence of metastasis at the time of PTBD served as a negative prognostic factor (p = 0.002), better survival was associated with lower preprocedural bilirubin and lower CRP (p = 0.003). …”
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Multiomic machine learning on lactylation for molecular typing and prognosis of lung adenocarcinoma by Mengmeng Hua, Tao Li

“…In the subsequent prognosis validation, the high-risk group included more patients with stage T3 + 4, N1 + 2 + 3, M1, and III + IV cancer; higher recurrence/metastasis rates; and lower 1, 3, and 5 year overall survival rates. …”
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Identification of Crotonylation Metabolism Signature Predicting Overall Survival for Clear Cell Renal Cell Carcinoma by Jie Zheng, Yingqing Liu, Kai Wei, Jiewu Shi, Lin Li, Xuefeng Jiang, Lingsong Tao

“…Reducing KAT2A expression hindered ccRCC cell growth and metastasis. Conclusion. Our study highlights the critical role of crotonylation metabolism in cancer development and progression, particularly its link to poor prognosis. …”
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To study the expression of estrogen, progesterone receptor and p53 immunohistochemistry markers in subtyping endometrial carcinoma by Anuja Yadav, Anuradha Sistla, Meenakshi Swain, Swarnalata Gowrishankar, Michelle de Padua, Tejal Modi, Rallabandi Himabindu, Neha Agarwal, Aditya Kulkarni, Trilok Bhandari, Hemanth Vudayaraju, Chinnababu, Vijay A. Reddy

“…There was a statistical association between ER and PR status and lymph node metastasis. p53 did not show a statistical significance. …”
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Regulatory Role of the RUNX2 Transcription Factor in Lung Cancer Apoptosis by Camila Bernal, Andrea Otalora, Alejandra Cañas, Alfonso Barreto, Karol Prieto, Martin Montecino, Adriana Rojas

“…Current studies have confirmed that RUNX2 is closely related to the proliferation, invasion, and bone metastasis of multiple cancer types, such as osteosarcoma, breast cancer (BC), prostate cancer, gastric cancer, colorectal cancer, and lung cancer. …”
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Unraveling the Molecular Nexus between GPCRs, ERS, and EMT by Niti Kumari, Somrudee Reabroi, Brian J. North

“…The epithelial-mesenchymal transition (EMT) is a fundamental process in promoting cancer cell invasion and tumor dissemination leading to metastasis, an often intractable state of the disease. …”
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CRIP1 inhibits cutaneous melanoma progression through TFAM-mediated mitochondrial biogenesis by Jianqiang Wu, Lixia Chen, Peijun Wen

“…Abstract Metastasis is the leading cause of death in patients with cutaneous melanoma. …”
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Result of Surgery to Patients with Brain Tumor in Cienfuegos by Jorge Luis Acevedo Cardoso, Samuel Sánchez Sánchez, Yoniel Suárez Guerrero, Tamara García Alfonso de Armas, Wendy Gómez Menéndez

“…<br /><strong>Conclusion:</strong> a greater survival was associated with meningothelial meningioma, emphasizing lethality in grade IV astrocytomas and lung metastasis. The most frequent and associated mortality complication was postoperative neurological deterioration.…”
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To describe the subsets of malignant epithelial cells in gastric cancer, their developmental trajectories and drug resistance characteristics by Tingting Xu, Tianying Zhang, Yan Sun, Sijia Wu

“…Cell–cell communication analysis uncovered a dynamic network of interactions within the tumor microenvironment, potentially influencing tumor growth and metastasis. Differential gene expression analysis identified key genes (LDHA, GPC3, MIF, CD44, and TFF3) that were used to construct a prognostic risk score model. …”
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Prognostic and Diagnostic Significance of circRNA Expression in Esophageal Cancer: A Meta-analysis by Hong Lin, Jinpeng Yuan, Guoxi Liang, Yanxuan Wu, Liming Chen

“…Upregulated expression of oncogenic circRNA was correlated with poor clinicopathological features, including lymph node metastasis, tumor size, and T classification, while downregulation of tumor-suppressor circRNA was contributed to worse TNM stage. …”
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The Influence of Radiological “Disappearing Lesions” on the Efficacy and Prognosis of Patients with Colorectal Liver Metastases Undergoing Conversion Therapy by Zhi-yang Song, Dong Yang, Yang Liu, Yong Cheng

“…The purpose of the current study was to analyze the influence of radiological “disappearing liver metastasis” (DLM) on the efficacy and prognosis of patients with colorectal liver metastases (CRLM) undergoing conversion therapy. …”
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Clear Cell Carcinoma Arising in Vulvar Endometriosis by Pranom Buppasiri, Pilaiwan Kleebkaow, Chantip Tharanon, Apiwat Aue-aungkul, Chumnan Kietpeerakool

“…Computed tomography of the abdominopelvic region showed an ulcerative mass at the right labia majora and nodal metastasis at the external iliac and inguinal regions. …”
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Durable Effect of Radioactive Iodine in a Patient with Metastatic Follicular Thyroid Carcinoma by Aubrey A. Carhill, Rena Vassilopoulou-Sellin

“…Traditionally, differentiated thyroid cancer (DTC) carries a good prognosis when diagnosed early, but increasingly patients are presenting with late-stage disease and bone metastasis which carries a poor prognosis. Treatment of DTC involves surgical resection followed by radioactive iodine (RAI), which conventionally is thought to reach maximal effectiveness between 6 and 12 months following treatment. …”
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Primary Malignant Melanoma of the Rectum: Report of Two Cases by Kodai Tomioka, Hitoshi Ojima, Makoto Sohda, Akiko Tanabe, Yasuyuki Fukai, Akihiko Sano, Takahiro Fukuda, Masahiko Murakami

“…The clinical diagnosis for each was rectal carcinoma at stage IIIc according to the tumor-node-metastasis classification (6th edition), and the patients underwent abdominoperineal resection with dissection of lymph nodes. …”
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Intraosseous Mucoepidermoid Carcinoma in the Mandible by George Borja de Freitas, Arthur José Barbosa de França, Stefanny Torres dos Santos, Miqueias Oliveira de Lima Júnior, Adilis Stepple da Fonte Neto, Paula Bernardon

“…The main modality of treatment for patients with this neoplasm is radical surgical resection, offering a greater chance of cure than the more conservative procedures, such as enucleation or curettage, due to the great possibility of recurrence and tumor metastasis. This paper reports a rare case of intraosseous mucoepidermoid carcinoma occasionally discovered after panoramic radiography of the jaws, which was treated with segmental resection through hemimandibulectomy.…”
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Immunotherapy for Hepatocellular Carcinoma: Current Advances and Future Expectations by Yingjun Xie, Yien Xiang, Jiyao Sheng, Dan Zhang, Xiaoxiao Yao, Yongsheng Yang, Xuewen Zhang

“…In recent years, tumor immunotherapy has emerged as a promising method owing to its safety and efficacy with respect to delaying the progression of advanced tumors and protecting postoperative patients against tumor relapse and metastasis. Immune tolerance and suppression in tumor microenvironments are the theoretical basis of immunotherapy. …”
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Phoenix dactylifera L. (date palm) fruit extracts and fractions exhibit anti-proliferative activity against human pancreatic cancer cell lines by Reem A. Al Alawi, Jörg D. Hoheisel, Mohamed Saiel Saeed Alhamdani, Younis Baqi

“…Pancreatic cancer has a very poor prognosis due to its high resistance to chemotherapeutic drugs, late diagnosis, and early metastasis, making it the most aggressive and lethal cancer. …”
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Antioxidant Peptide Derived from Spirulina maxima Suppresses HIF1α-Induced Invasive Migration of HT1080 Fibrosarcoma Cells by Won Suk Kim, Won Kyo Jung, Sun Joo Park

“…The initiation of tumor metastasis requires invasive cell migration. Here, we show that an antioxidant peptide derived from Spirulina maxima suppresses hypoxia-induced invasive migration of HT1080 human fibrosarcoma cells. …”
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