(5E,7E)-4,5,6 Trihydroxy-3-(hydroxymethyl)tetrahydro-2H-pyran-2-ylheptadeca-5,7-dienoate from Euclea crispa (L.) Inhibits Ovarian Cancer Cell Growth by Controlling Apoptotic and Me... by Chella Perumal Palanisamy, Bo Cui, Hongxia Zhang, Selvaraj Jayaraman, Ponnulakshmi Rajagopal, Vishnu Priya Veeraraghavan

“…CXCR4, HER2, and Akt proteins involved in cell proliferation and metastasis were found to be significantly reduced (p<0.05). …”
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The Role of Intraarterial Chemotherapy in the Management of Retinoblastoma by Aleksandra Pekacka

“…The studies evaluated the technical success rate of IAC, globe salvage rate, and ocular and systemic complications, as well as the occurrence of deaths, metastasis, and secondary neoplasms. In total, 1827 eyes with retinoblastoma were analysed. …”
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Somatostatin Treatment for Ectopic ACTH Syndrome due to Pancreatic Neuroendocrine Tumors: Review of the Literature by Da Zhang, Lin Lu, Hui-Juan Zhu, Yu Xiao, Xian-Lin Han, Shun-Da Du, Hua-Dan Xue, Qing-Xing Liu, Zhao-Hui Zhu, Ming-Ming Hu, Xiao Zhai, Xiao-Ping Xing, Zhao-Lin Lu

“…As a supplemental therapy, SSA treatment led to clinical and biochemical improvement with a good safety profile in patients exhibiting EAS-p-NET with metastasis. However, tumor progression was inhibited by SSA treatment in only a few patients. …”
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Plasma lncRNA GAS8-AS1 as a Potential Biomarker of Papillary Thyroid Carcinoma in Chinese Patients by Dongxue Zhang, Xin Liu, Bojun Wei, Guoliang Qiao, Tao Jiang, Zhenwen Chen

“…A low level of plasma GAS8-AS1 expression was correlated with lymph node metastasis (LNM) (P<0.001). Multivariate analysis showed that a reduced GAS8-AS1 level in plasma was associated with LNM (P<0.05). …”
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A Metastasizing Squamous Cell Carcinoma Arising in a Solitary Epidermal Nevus by Masami Toya, Yuichiro Endo, Akihiro Fujisawa, Miki Tanioka, Yoshiaki Yoshikawa, Takao Tachibana, Yoshiki Miyachi

“…A biopsy of the tumor showed that a well-differentiated squamous cell carcinoma (SCC) arose from the epidermal nevus. As a lymph node metastasis was found by sentinel lymph node biopsy, the patient received surgical excision of the lesion, axillary lymph node dissection, and postoperative radiation. …”
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Update on the Progress of Musashi-2 in Malignant Tumors by Yiting Niu, Tao Zhou, Yanjun Li

“…A substantial body of evidence has demonstrated that it is closely related to the development, metastasis, migration, and drug resistance of malignant tumors. …”
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The Clinical and Pathological Presentation of Thyroid Nodules in Children and the Comparison with Adult Population: Experience of a Single Institution by Tamas Solymosi, Gyula Lukacs Toth, Laszlo Budai, Istvan Gal

“…The ratio of follicular adenoma to hyperplastic nodules (3 : 1 to 1 : 1.67), the proportion of follicular variant (77.8% versus 26.7%), T4 tumors (77.8% versus 33.3%), and tumors with lymph node metastasis (88.9% versus 66.7%) were significantly higher among younger papillary carcinoma patients. …”
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Implicative Statistical Analysis to Identify Prognostic Factors for Mortality from Lymphomas in Children and Adolescents by Mayelyn Rodríguez Estenger, Nelsa María Sagaró del Campo, Larisa Zamora Matamoros, Evelyn Yolanda Fundichely Vázquez

“…The state of the deceased or alive patient at the time of the study was analyzed as the dependent variable and the following were taken as covariates: poor prognosis stage, presence of B symptoms, histological subtype, presence of three or more extranodal sites, metastasis, age and presence of tumor mass. Two statistical techniques were applied: binary logistic regression and implicative statistical analysis. …”
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Association of Peripheral Monocyte Count with Soluble P-Selectin and Advanced Stages in Nasopharyngeal Carcinoma by Adi Surya Komala, Andhika Rachman

“…Fifty-five patients with nasopharyngeal carcinoma were divided into three groups according to nodal and distant metastasis (group of stages I-IVA, IVB, and IVC). Monocyte count was calculated from routine peripheral blood examination, while sP-selectin level was measured using commercial ELISA kit. …”
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Successful Resection of Isolated Para-Aortic Lymph Node Recurrence from Advanced Sigmoid Colon Cancer following 156 Courses of FOLFIRI Regimen by Kaoru Takeshima, Kazuo Yamafuji, Atsunori Asami, Hideo Baba, Nobuhiko Okamoto, Hidena Takahashi, Chisato Takagi, Kiyoshi Kubochi

“…As PLN enlarged to 15 mm in the minor axis on a CT scan in 2014 after receiving a total of 156 courses of the FOLFIRI regimen, we considered the enlarged PLN to represent an isolated metastasis. Accordingly, lymph node resection was performed with microscopically negative margins. …”
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Impact of Body Mass Index on Surgical and Oncological Outcomes in Laparoscopic Total Mesorectal Excision for Locally Advanced Rectal Cancer after Neoadjuvant 5-Fluorouracil-Based C... by Yanwu Sun, Pan Chi

“…With a median follow-up time of 55 months (ranging 20–102 months), oncological outcome was comparable in terms of overall survival, local recurrence, and distant metastasis. Conclusions. Obesity does not affect surgical or oncological outcome of laTME after nCRT. …”
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The Role of Chemokines in Breast Cancer Pathology and Its Possible Use as Therapeutic Targets by M. Isabel Palacios-Arreola, Karen E. Nava-Castro, Julieta I. Castro, Eduardo García-Zepeda, Julio C. Carrero, Jorge Morales-Montor

“…In cancer, although chemokines are associated primarily with the generation of a protumoral microenvironment and organ-directed metastasis, they also mediate other phenomena related to disease progression, such as angiogenesis and even chemoresistance. …”
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Lipid metabolic reprogramming and associated ferroptosis in osteosarcoma: From molecular mechanisms to potential targets by Zhiyang Yin, Guanlu Shen, Minjie Fan, Pengfei Zheng

“…Key enzymes such as adenosine triphosphate-citrate lyase (ACLY), acetyl-CoA synthetase 2 (ACSS2), fatty acid synthase (FASN) and stearoyl-CoA desaturase-1 (SCD1) are overexpressed in OS and associated with poor prognosis.Based on specific changes in metabolic processes, this review highlights potential therapeutic targets in the lipid metabolism and ferroptosis pathways, and in particular the HMG-CoA reductase inhibitor simvastatin has shown potential in inducing apoptosis and inhibiting OS metastasis. Targeting these pathways provides new strategies for the treatment of OS. …”
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Identification and Validation of a Potential Stemness-Associated Biomarker in Hepatocellular Carcinoma by Yangyang Zhang, Ruike Zhang, Lingxiu Zeng, Haizhou Wang, Ruyi Peng, Meng Zhang, Hailin Zhang, Zhenwei Yang, Liping Gao, Meng Wang, Jing Liu

“…Cancer stem cells (CSCs) are typically related to metastasis, recurrence, and drug resistance in malignant tumors. …”
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Evaluating the Influence of Hashimoto’s Thyroiditis on Clinico-Pathological Characteristics and Prognostic Outcomes of Middle Eastern Differentiated Thyroid Carcinoma by Sandeep Kumar Parvathareddy, Abdul K. Siraj, Nabil Siraj, Saeeda O. Ahmed, Saif S. Al-Sobhi, Fouad Al-Dayel, Khawla S. Al-Kuraya

“…In contrast, HT demonstrated a negative association with several aggressive clinical features, including extrathyroidal extension, distant metastasis, recurrent/persistent disease and high-risk categorization by the American Thyroid Association (ATA) guidelines. …”
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Mechanisms of Cancer-Induced Bone Pain by Wang X, Li L, Wang Y

“…Xuejuan Wang, Li Li, Yun Wang Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Yun Wang, Department of anesthesiology, Beijing Friendship Hospital, Capital Medical University, No. 95, Yong’an Road, Xicheng District, Beijing, 100050, People’s Republic of China, Email wangyun129@ccmu.edu.cnAbstract: Bone is a common site of advanced cancer metastasis, second only to the lungs and liver. Cancer-induced bone pain (CIBP) is a persistent and intense pain that is caused by a combination of inflammatory and neuropathic factors. …”
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Follicular Thyroid Carcinoma Metastatic to the Kidney: Report of a Case with Cytohistologic Correlation by Vikas Nath, Mithra Baliga, Jack Lewin, Frederico Souza, Israh Akhtar

“…The differential diagnoses of renal metastasis of FTC include the encapsulated follicular variant of papillary thyroid carcinoma (PTC), which possesses some of the nuclear features seen in conventional PTC but may occasionally be indistinguishable from FTC in cytologic preparations, and renal lesions such as benign thyroidization of the kidney and thyroid-like follicular carcinoma of the kidney, which mimic FTC in histologic appearance but do not stain with thyroid markers.…”
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Targeting Invasion: The Role of MMP-2 and MMP-9 Inhibition in Colorectal Cancer Therapy by Alireza Shoari, Arghavan Ashja Ardalan, Alexandra M. Dimesa, Mathew A. Coban

“…Gelatinases, specifically MMP-2 and MMP-9, play critical roles in the processes of tumor growth, invasion, and metastasis. Their expression and activity are significantly elevated in CRC, correlating with poor prognosis and lower survival rates. …”
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Duodenal Gangliocytic Paraganglioma Requiring a Pancreaticoduodenectomy: A Case Report and Review of the Literature by Laurie Adams, Theodore M. Friedman, Timothy R. Shaver, George Younan

“…Duodenal GPs were initially viewed as benign tumors of the duodenum; however, there have been increasing incidence reports of hematogenous and lymphatic metastasis. Appropriate treatment of duodenal GPs is still controversial and ranges from local endoscopic submucosal resection to major radical surgery. …”
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Intracranial Metastatic Neuroblastoma Treated with Gamma Knife Stereotactic Radiosurgery: Report of Two Novel Cases by Nathan C. Rowland, Jennifer Andrews, Daxa Patel, David V. LaBorde, Adam Nowlan, Bradley George, Claire Mazewski, Andrew Reisner, Howard M. Katzenstein

“…Intracranial metastasis of neuroblastoma (IMN) is associated with poor survival. …”
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