Exosomal circRNAs: Deciphering the novel drug resistance roles in cancer therapy by Xi Li, Hanzhe Liu, Peiyu Xing, Tian Li, Yi Fang, Shuang Chen, Siyuan Dong

“…These stable, non-coding RNAs encapsulated in exosomes participated in cancer progression, tumor growth, metastasis, drug sensitivity and the tumor microenvironment (TME). …”
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Carcinoma de corteza suprarrenal. Presentación de un caso y revisión de la literatura by Dayana Calzada Urquiola, Ana Lourdes Vasallo Díaz, Bernardo Heredia Martínez

“…Entre el 40 y el 70 % de los pacientes tienen metástasis cuando se inicia el estudio. Se presenta de manera general en adultos, aunque también afecta a los niños. …”
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Very Late Relapse of Testicular Tumour in Combination with Renal Cancer and Their Retroperitoneoscopic Removal by Mihály Murányi, Morshed Ali Salah, Béla Tállai, Mátyás Benyó, Tibor Flaskó

“…Retroperitoneoscopy is feasible approach for the removal of retroperitoneal lymph node metastasis and resection of renal tumor.…”
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An Acute Jejunojejunal Intussusception Revealing a Metastatic Combined Lung Cancer by Feryel Letaief-Ksontini, Ryma Boujnah, Yosra Yahiaoui, Yosra Zaimi, Meriem Ksentini, Raoudha Aloui, Khedija Meddeb, Amel Mezlini

“…He underwent an en bloc resection, and pathological findings concluded to a metastasis of a pulmonary combined small cell carcinoma and adenocarcinoma. …”
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Safety and Efficacy of Combined Yttrium 90 Resin Radioembolization with Aflibercept and FOLFIRI in a Patient with Metastatic Colorectal Cancer by Andre De Souza, Kevin Pelham Daly, James Yoo, Muhammad Wasif Saif

“…A 56-year-old female with history of bilateral breast cancer and metastatic colon cancer with prior hemicolectomy and 4 previous chemotherapy regimens developed liver metastasis. She was started on aflibercept and FOLFIRI and concurrently underwent two treatments of radioembolization with Y90, initially targeting the largest right lobe tumor, and then a subsequent treatment targeting the smaller left lobe tumor with retreatment of the right lobe tumor. …”
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Poorly Differentiated Thyroid Carcinoma Arising in Struma Ovarii by Surapan Khunamornpong, Jongkolnee Settakorn, Kornkanok Sukpan, Prapaporn Suprasert, Sumalee Siriaunkgul

“…Despite FIGO stage IA by optimal staging procedure and the absence of identifiable lymphovascular invasion, the patient developed pulmonary metastasis 15 months after surgery and died from the progression of the disease 7 years after the diagnosis. …”
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Complete PSA Remission without Adjuvant Therapy after Secondary Lymph Node Surgery in Selected Patients with Biochemical Relapse after Radical Prostatectomy and Pelvic Lymph Node D... by Alexander Winter, Jens Uphoff, Rolf-Peter Henke, Friedhelm Wawroschek

“…Results. 9 of 10 patients with histologically confirmed LNM showed a PSA response. 4 of 9 patients with single LNM had a complete permanent PSA remission (mean followup 31.8, range 1–48 months). Of metastasis-suspicious LNs (14) 12 could be histologically confirmed. …”
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Aggressive Multimodal Approach for Anaplastic Thyroid Cancer and Long-Term Survival by Nasir Hussain, Usman Mustafa, Su Hyeon Jung, Alan D. Gilman

“…Aggressive multimodal approach of combining radicle surgery with chemoradiation treatment in select patients of ATC with no distant metastasis helps improve prognosis.…”
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Cutaneous Neuroendocrine Metastases of Visceral Origin Responsive to Surgical Resection and Targeted Radionuclide Therapy by Eleanor Tung-Hahn, Ghassan El-Haddad, Jonathan Strosberg

“…While NETs are known to frequently metastasize to lymph nodes, liver, and lungs, spread to the skin is extremely rare and is often a late finding. Because cutaneous metastasis from a visceral site represents distant tumor dissemination, prompt histologic diagnosis is critical in terms of selecting further treatment options and ultimately impacts subsequent prognosis. …”
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Nonalpine Thyroid Angiosarcoma in a Patient with Hashimoto Thyroiditis by Nadia Innaro, Elena Succurro, Giuseppe Tomaino, Franco Arturi

“…After total thyroidectomy and right cervical lymphadenectomy, postoperative histological examination revealed the presence of a thyroid angiosarcoma with positive staining for CD31 and for both Factor VIII-related antigen and Vimentin and only partially positive for staining pancytokeratin and presence of metastasis in cervical, supraclavicular, mediastinal and paratracheal lymph nodes. …”
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Whole-Body 18FDG-PET in an Arthritis Paraneoplastic Syndrome Revealed an Underlying Hematological Neoplasm by Serge Cammilleri, Marie Caroline Guzian, Jean-Pierre Mattei, Olivier Mundler, Sandrine Guis

“…About 4% of patients with lymphoma or leukemia suffered from rheumatologic paraneoplastic symptoms like arthralgia and about 10% of the patients with rheumatologic or neurologic clinical symptoms develop a solid cancer or hematological neoplasm. 18FDG-PET is an interesting exam to identify an underlying malignancy when a paraneoplastic syndrome is suspected; it can detect the primitive lesion and/or the metastasis lesions. The use of the 18FDG-PET can help to detect earlier hematological neoplasm in cases of paraneoplastic syndrome without a determined cause and to treat more rapidly and specifically the patient.…”
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Detection of Cancer Stem Cells from Patient Samples by Sofia Hakala, Anna Hämäläinen, Sanne Sandelin, Nikolaos Giannareas, Elisa Närvä

“…The existence of cancer stem cells (CSCs) in various tumors has become increasingly clear in addition to their prominent role in therapy resistance, metastasis, and recurrence. For early diagnosis, disease progression monitoring, and targeting, there is a high demand for clinical-grade methods for quantitative measurement of CSCs from patient samples. …”
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Anti-programmed death-1 inhibitors and nimotuzumab in combination with induction chemotherapy for locoregionally advanced nasopharyngeal carcinoma: a propensity score-matched analy... by Ya-Ni Zhang, Yu-Pei Chen, Pu-Yun OuYang, Tai-Xiang Lu, Fang-Yun Xie, Fei Han, Chun-Yan Chen

“…Background: The poor prognosis of locoregionally advanced nasopharyngeal carcinoma (LANPC) due to the high incidence of metastasis necessitates effective treatment strategies. …”
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A Case of GATA3 Positive Pleomorphic Liposarcoma, Epithelioid Variant: A Diagnostic Pitfall by Makoto Abe, Nobuo Hoshi, Sayuri Hoshi, Kaoru Hirabayashi, Kazutaka Kikuta, Toru Hirozane, Rumi Nakagawa, Tsukasa Mizuno, Hiroshi Nakamura, Koichi Inoue, Takehiko Yamaguchi

“…It is sometimes difficult to distinguish from carcinoma metastasis. Immunohistochemical panel is very important for differential diagnosis; however, there is a risk that unexpected staining could lead to misinterpretation. …”
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Clinical Characteristics of Cutaneous Melanoma and Second Primary Malignancies in a Dutch Hospital-Based Cohort of Cutaneous Melanoma Patients by Haike M. J. van der Velden, Michelle M. van Rossum, Willeke A. M. Blokx, Jan B. M. Boezeman, Marie-Jeanne P. Gerritsen

“…We collected data on patients who visited the Department of Dermatology at the Radboud University Nijmegen Medical Centre and were newly diagnosed with cutaneous melanoma or metastasis of melanoma with unknown primary localization between 2002 and 2006. …”
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Twist-Induced Epithelial-to-Mesenchymal Transition Confers Specific Metabolic and Mitochondrial Alterations by Haleigh N. Parker, Kayla L. Haberman, Tolulope Ojo, Juli Watkins, Adhwaitha Nambiar, Kayla Morales, Bernd Zechmann, Joseph H. Taube

“…Cells undergo significant epigenetic and phenotypic change during the epithelial-to-mesenchymal transition (EMT), a process observed in development, wound healing, and cancer metastasis. EMT confers several advantageous characteristics, including enhanced migration and invasion, resistance to cell death, and altered metabolism. …”
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Uterine Tumor Resembling Ovarian Sex-Cord Tumors Initially Diagnosed as a Prolapsed Fibroid by Fernando Augusto Rozário Garcia, Vanessa Pereira Gaigher, Rodrigo Neves Ferreira, Antônio Chambô Filho

“…Discussion. Reports of metastasis or recurrence are rare. UTROSCT are considered of uncertain malignant potential and no particular form of treatment is formally recommended, with hysterectomy currently being the treatment of choice. …”
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Investigation of survival and prognostic factors in triple negative molecular subtype male breast cancer patients: A population-based study by Ahmet Necati Sanli, Bilal Turan

“…Mean follow-up time was 25.76±25.02, and overall survival was 50.5% and cancer specific survival was 59.6%. Grade, metastasis status, and surgical status were found to be independent risk factors for survival. …”
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En Masse Resection of Pancreas, Spleen, Celiac Axis, Stomach, Kidney, Adrenal, and Colon for Invasive Pancreatic Corpus and Tail Tumor by Koray Kutluturk, Abdul Hamid Alam, Cuneyt Kayaalp, Emrah Otan, Cemalettin Aydin

“…Providing a more comfortable life and a longer survival for pancreatic corpus/tail tumors without metastasis depends on the complete resection. Recently, distal pancreatectomy with celiac axis resection was reported as a feasible and favorable method in selected pancreatic corpus/tail tumors which had invaded the celiac axis. …”
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HOXA-AS3 Promotes Proliferation and Migration of Hepatocellular Carcinoma Cells via the miR-455-5p/PD-L1 Axis by Cheng Zeng, Shaojun Ye, Yu Chen, Qu Zhang, Yan Luo, Liang Gai, Bo Luo

“…The effect of HOXA-AS3 expression on tumor growth and metastasis was assessed using a mouse xenograft model. …”
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