Anlotinib Inhibits Cisplatin Resistance in Non-Small-Cell Lung Cancer Cells by Inhibiting MCL-1 Expression via MET/STAT3/Akt Pathway by Lile Wang, Lu Xu, Shuhua Han, Xiaoli Zhu

“…Our data showed that anlotinib inhibited the DDP resistance of NSCLC cells by regulating cell proliferation and metastasis. Moreover, MET and MCL-1 expression could be decreased by anlotinib treatment. …”
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Brentuximab Vedotin Treatment for Primary Refractory Hodgkin Lymphoma by Hung-Bo Wu, Shyh-An Yeh, Huei-Yung Chen

“…Salvage radiotherapy to the mediastinal tumor, obtained no remission but was followed by rapid in-field progression and then lung metastasis. She declined stem cell transplantation and received salvage brentuximab vedotin (BV) therapy, which induced dramatic shrinkage of tumor without significant side effects. …”
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Papillary Endolymphatic Sac Tumor: A Case Report by S. Arava, R. M. Soumya, S. Chitragar, R. Safaya, S. H. Chandrashekhar, Alok Thakar

“…These tumors do not metastasize but there is single case report of drop metastasis to the spine in the literature. Hence this tumor must be distinguished from other benign tumors of the middle ear. …”
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Metastatic Lesion of the Tibia from Renal Cell Carcinoma by Piotr Młodożeniec, Krzysztof Balawender, Mateusz Zasadny

“…Additionally, in patients with osseous metastasis, only 3% occur within the tibia. Rarely, a patient presents with a primary complaint of lower limb pain in advanced metastatic renal cell carcinoma. …”
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Neoadjuvant immunotherapy for DNA mismatch repair proficient/microsatellite stable non-metastatic rectal cancer: a systematic review and meta-analysis by Huan Zhang, Jing Huang, Huanji Xu, Nanhao Yin, Nanhao Yin, Liyan Zhou, Liyan Zhou, Jianxin Xue, Jianxin Xue, Jianxin Xue, Min Ren

“…Interestingly, RC patients with lymph node metastasis showed a higher pooled pCR than those without lymph node metastasis (43% vs 35%).ConclusionNIT was linked to favorable response rates and anal preservation, alongside an acceptable safety profile. …”
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Small Renal Masses: Incidental Diagnosis, Clinical Symptoms, and Prognostic Factors by F. M. Sánchez-Martín, F. Millán-Rodríguez, G. Urdaneta-Pignalosa, J. Rubio-Briones, H. Villavicencio-Mavrich

“…The great majority of malign SRMs have good prognosis (low stage and grade, no metastasis) with open or laparoscopic surgical treatment (nephron sparing techniques). …”
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Successful Management of Pheochromocytoma Detected in Pregnancy by Interval Adrenalectomy in a VHL Patient by V. T. S. Kaluarachchi, Uditha Bulugahapitiya, Maulee Arambewela, Sonali Gunathilake

“…CECT abdomen with adrenal protocol confirmed a right-sided pheochromocytoma without any evidence of metastasis. Uncomplicated laparoscopic right adrenalectomy led to a clinical and biochemical recovery of the patient while histology confirmed the pheochromocytoma without any evidence of invasion. …”
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Interplay between Inflammation and Stemness in Cancer Cells: The Role of Toll-Like Receptor Signaling by Da-Wei Yeh, Li-Rung Huang, Ya-Wen Chen, Chi-Ying F. Huang, Tsung-Hsien Chuang

“…These cells contribute to cancer metastasis, treatment resistance, and relapse following therapy; therefore, they may cause malignancy and reduce the success of cancer treatment. …”
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Mitotically Active Plexiform Fibrohistiocytic Tumor by Ebru Zemheri, Şeyma Özkanlı, Serkan Şenol, Filiz Ozen, Cigdem Ulukaya Durakbaşa, İlkin Zindancı, Hamit Okur

“…Clinically it is usually a slow-growing mass of upper extremities with frequent local recurrence and rare regional lymphatic and systemic metastasis (Fletcher et al. (2002), Enzinger and Zhang (1988), Remstein et al. (1999)).…”
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Molecular Insights in the Anticancer Activity of Natural Tocotrienols: Targeting Mitochondrial Metabolism and Cellular Redox Homeostasis by Raffaella Chiaramonte, Giulia Sauro, Domenica Giannandrea, Patrizia Limonta, Lavinia Casati

“…Cancer cells maintain moderate levels of ROS to promote tumorigenesis, metastasis, and drug resistance; indeed, once the cytotoxicity threshold is exceeded, ROS trigger oxidative damage, ultimately leading to cell death. …”
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Paediatric extra-axial myxopapillary ependymoma: what to expect? Case report and literature review by Roberto Lo Piccolo, Roberto Lo Piccolo, Maria Chiara Cianci, Iacopo Sardi, Marco Di Nicola, Anna M. Buccoliero, Chiara Caporalini, Antonino Morabito, Antonino Morabito

“…MPEs are considered low-grade tumours, but relapse with distant metastasis is frequent. Therefore, therefore a proper diagnosis and subsequent follow-up are warranted. …”
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Comparative evaluation of TNM staging systems (eighth vs. ninth edition) for the non-surgical treatment of localized and locally advanced anal squamous cell carcinoma: Prognostic s... by Aihong Zheng, Hong'en Xu, Yiming Tao, Bingchen Chen, Jieni Ding, Tao Song, Yanwei Lu

“…This study aims to compare the survival discrimination of the Tumor-Node-Metastasis (TNM) eighth and ninth editions for patients with localized and locally advanced (LLA) anal squamous cell carcinoma (ASCC) treated non-surgically and to evaluate the prognostic impact of T classification and lymph node (LN) status with data from the Surveillance, Epidemiology, and End Results database. …”
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A 15-year pheochromocytoma and paraganglioma experience in a single centre: a Singapore perspective by Yingshan Lee, Leon Yuan Rui Tan, Shaikh Abdul Kader Kamaldeen Abdul Shakoor

“…Disease recurrences and metastasis occurred in up to one-fifth of the patients. …”
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Leiomyosarcoma after Total Laparoscopic Hysterectomy with Power Morcellation by Tsukasa Takahashi, Tomohisa Ugajin, Noriaki Imai, Atsushi Hayasaka, Nobuo Yaegashi, Takeo Otsuki

“…Since there was no metastasis, she was followed-up without additional treatment. …”
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Case report: Patients with positive HER-2 amplification locally advanced gastroesophageal junction cancer achieved pathologic complete response with the addition of pembrolizumab t... by Huanhuan Li, Chao Ren, Donghai Cui, Tao Wu, Zhiyong Nie

“…Therefore, addition of PD-1 to chemotherapy plus trastuzumab may lead to a better response in patients with G/GEJ cancer.Case presentationA 66-year-old man was diagnosed with stage III GEJ adenocarcinoma with celiac lymph node metastasis. Immunohistochemical results indicated HER-2(3+) and PD-L1 CPS=5. …”
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Osteosarcoma of the Mandible in an Elderly Patient by Isao Hoshi, Ryosuke Abe, Kei Onodera, Yu Ohashi, Tadashi Kawai, Ikuya Miyamoto, Toshimi Chiba, Yasunori Takeda, Hiroyuki Yamada

“…There was no evidence of tumor recurrence or metastasis 4 years after surgery. This case showed that it was not necessary to exclude surgical treatment merely because the patient was 90 years old. …”
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Extended Distal Pancreatectomy with En Bloc Resection of the Celiac Axis for Locally Advanced Pancreatic Cancer: A Case Report and Review of the Literature by Patrick H. Alizai, Andreas H. Mahnken, Christian D. Klink, Ulf P. Neumann, Karsten Junge

“…The patient underwent laparoscopy to exclude hepatic and peritoneal metastasis. Subsequently, a selective embolization of the common hepatic artery was performed to enlarge arterial flow to the hepatobiliary system and the stomach via the pancreatoduodenal arcades from the superior mesenteric artery. …”
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Evaluation of C-X-C chemokine receptor type 4 (CXCR4) and Peroxisome proliferator-activated receptor gamma (PPAR-γ) expression in colorectal carcinoma: Relation to the available cl... by Asmaa E. Bedeer, Nehal Abd El-Ghaffar Heabah

“…High CXCR4 expression showed significant associations with the depth of tumor invasion (P = 0.024), lymph node metastasis (P = 0.009), advanced tumor stage (P = 0.001) and the presence of vascular invasion (P = 0.035). …”
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Heterogeneity in polyamine metabolism dictates prognosis and immune checkpoint blockade response in hepatocellular carcinoma by Jianyan Pan, Zhong Lin, Qinchun Pan, Tao Zhu

“…In vitro experiments suggested that FIRRE, the gene with the greatest impact on the PAscore, significantly contributed to HCC proliferation and metastasis. This study underscores the potential of our polyamine-related signature in predicting the prognosis and immunotherapy response in HCC patients, and also reveals the polyamine metabolic heterogeneity among HCC cells that influences their crosstalk with infiltrating myeloid cells.…”
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The neuroscience in breast cancer: Current insights and clinical opportunities by Jia-feng Wang, Meng-chuan Wang, Lei-lei Jiang, Neng-ming Lin

“…Interaction between the nervous system and breast cancer can influence tumor initiation, growth, invasion, metastasis, reverse resistance to drugs, promote inflammation in tumors, and impair the immune system's ability to combat cancer. …”
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