Epithelioid Trophoblastic Tumor: A Case Report and Review of the Literature by Eirwen M. Scott, Ashlee L. Smith, Mohamed Mokhtar Desouki, Alexander B. Olawaiye

“…ETT can be a sequela of any gestational event and can present in both intrauterine and extrauterine sites. Metastasis and death have been reported. We present a case of a 44-year-old female incidentally diagnosed with ETT following laparoscopic-assisted vaginal hysterectomy. …”
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The interpretation of Use of Adjuvant Bisphosphonates and Other Bone-Modifying Agents in Breast Cancer: ASCO-OH (CCO) Guideline Update by LU Yujie, ZHU Siji

“…Bone-modifying agents (BMAs), including bisphosphonate (BP) and denosumab, can reduce bone-related events caused by breast cancer bone metastasis. “Use of Adjuvant Bisphosphonates and Other Bone-Modifying Agents in Breast Cancer: ASCO-OH (CCO) Guideline Update” was published in Journal of Clinical Oncology in January 2022. …”
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Epithelial Tight Junctional Changes in Colorectal Cancer Tissues by Xuexuan Wang, Owen Tully, Benjamin Ngo, Marc Zitin, James M. Mullin

“…It has become increasingly evident that TJs play a crucial role in maintaining cell-cell integrity, and the loss of cell junctional sealing could involve itself in the processes of carcinoma and cancer metastasis. If correlations between altered TJ proteins and CRC presence or invasiveness could be established, they may serve as important markers and guidelines for prophylactic and prognostic purposes, along with other screening methods. …”
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Metastatic Squamous Cell Carcinoma of the Anus to the Lung Confirmed with Allelotyping by Rachel Roth, Susan Moffatt-Bruce, Marino E. Leon

“…Additionally, allelotyping for loss of heterozygosity displayed similar findings and confirmed the histopathological impression of anal SCC metastasis to the lung. The patient was treated with palliative chemotherapy instead of additional surgical treatment. …”
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Hypoxia-inducible factor in cancer: from pathway regulation to therapeutic opportunity by Brian M Ortmann

“…HIF’s dysregulation is frequently observed in various cancer types and correlates with increased aggressiveness, metastasis, resistance to therapy and poor patient prognosis. …”
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The amount of DNA and RNA in primary cancer cells and their metastases by Oleksandr Herasymenko, Kostyantyn Gerasymenko, Olha Herasymenko

“…Considering the significant impact of oncopathology on global morbidity and mortality, as well as changes in its prevalence and typology, research into the molecular-genetic mechanisms of oncogenesis and metastasis, particularly the role of nucleic acids, becomes crucial. …”
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Massive Fetomaternal Hemorrhage Caused by an Intraplacental Choriocarcinoma: A Case Report by Anna-Karina Aaris Henningsen, Lisa Leth Maroun, Hanne Havsteen, Jens Svare

“…When found near term the risk of maternal metastasis is high because of the late diagnosis. Case. …”
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Co-Expression of Plexin-B1 and Met in Human Breast and Ovary Tumours Enhances the Risk of Progression by Guido Valente, Giuseppina Nicotra, Marisa Arrondini, Roberta Castino, Lorena Capparuccia, Maria Prat, Simonetta Kerim, Luca Tamagnone, Ciro Isidoro

“…Background: Plex-B1, the receptor of Sema4D, has been implicated in tumour growth, angiogenesis and metastasis. The binding of Sema4D to Plex-B1 can trigger the activation of Met tyrosine kinase, thereby promoting cell dissociation and invasive growth. …”
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Natural History of Invasive Papillary Breast Carcinoma Followed for 10 Years: A Case Report and Literature Review by Yong Joon Suh, Hyukjai Shin, Tae Jung Kwon

“…However, a whole-body bone scan and 18F-FDG PET/CT showed no evidence of distant metastasis. Immunohistochemistry results, corresponding to biopsies taken at subsequent examinations, have remained unaltered since 2006. …”
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Tumor-Induced Local and Systemic Impact on Blood Vessel Function by J. Cedervall, A. Dimberg, A-K. Olsson

“…The vessel wall serves as a barrier for metastatic tumor cells, and the integrity and activation status of the endothelium serves as an important defense mechanism against metastasis. In addition, leukocytes, such as cytotoxic T-cells, have to travel across the vessel wall to enter the tumor tissue where they contribute to killing of cancer cells. …”
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The Rare Malignancy of the Hepatobiliary System: Ampullary Carcinoid Tumor by Mustafa Ozsoy, Yucel Ozsoy, Aras Emre Canda, Olcay Ak Nalbant, Fatih Haskaraca

“…On pathological examination of the mass, a tumoral mass was detected in ampulla vateri localization, 1.5 × 1 × 0.8 cm in size, which, in immunohistochemical staining, was evaluated as a neuroendocrine tumor. Also, Metastasis was observed. Conclusion. The rarest type of carcinoid tumor is ampullary located carcinoid tumor, and tumor size is not a reliable indicator for tumor aggressivity in ampullary carcinoid tumors.…”
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Debt, sleep deprivation and psychological distress among online ride-hailing drivers: evidence from China by Meng Tian, Yi Lu, Han Zhang, Yinan Zhang, Wanjie Tang, Jingyue Chen, Simiao Wang, Xianglan Jiang, Siqi Wu, Luyu Yang, Jiuping Xu, Zeyuan Sun

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Preclinical advance in nanoliposome-mediated photothermal therapy in liver cancer by Lixuan Tang, Xiao Yang, Liwen He, Chaogeng Zhu, Qingshan Chen

“…This article reviews the latest preclinical research progress of nanoliposome-based PTT for liver cancer and its metastasis, discusses the preclinical challenges in this field, and proposes directions for improvement, with the aim of improving the effectiveness of liver cancer treatment.…”
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Prognostic Parameters for the Primary Care of Melanoma Patients: What Is Really Risky in Melanoma? by Daniela Göppner, Martin Leverkus

“…Even more, is it not well known precisely what kind of molecular changes predispose the primary melanoma for metastasis. The identification of morphological surrogates and prognostic parameters in tumors with such genetic alteration seems therefore crucial when differentiating and classifying this heterogeneous tumor entity in more detail and thus facilitates the stratification of prognosis as well as therapy. …”
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Vertebral Column Metastases from an Esthesioneuroblastoma: Chemotherapy, Radiation, and Resection for Recurrence with 15-Year Followup by Ali S. Shirzadi, Doniel G. Drazin, Allison S. Strickland, Serguei I. Bannykh, J. Patrick Johnson

“…Although local invasion to the sinuses is common, spinal metastasis of ENB is rare with only 28 documented cases involving the spine spinal cord, or leptomeninges. …”
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Adderall Induced Acute Liver Injury: A Rare Case and Review of the Literature by Rohini R. Vanga, Bikram Bal, Kevin W. Olden

“…She had a past history of partial hepatic resection secondary to metastasis from colon cancer which was under remission at the time of presentation. …”
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Potential Use of Bisphosphonates in Invasive Extramammary Paget’s Disease: An Immunohistochemical Investigation by Taku Fujimura, Sadanori Furudate, Yumi Kambayashi, Setsuya Aiba

“…Recent reports also suggested that BPs might have a direct antitumor effect through several pathways beyond their beneficial effect on bone metastasis. Among them, the abrogation of immunosuppressive cells, myeloid derived suppressor cells (MDSC), by BPs might be one of the optimal methods to induce an antitumor immune response both locally and at sites remote from the tumor. …”
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Granulomatosis with Polyangiitis (Wegener’s Granulomatosis) Accompanied by Dysuria by Hisashi Takeuchi, Isao Kuroda, Issei Takizawa, Teiichiro Aoyagi, Masaaki Tachibana

“…Prostatic tumor with lung metastasis was suspected from computed tomography and magnetic resonance imaging. …”
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Acute Hydrocephalus due to Secondary Leptomeningeal Dissemination of an Anaplastic Oligodendroglioma by Andreas M. Stark, Heinz-Herrmann Hugo, H. Maximilian Mehdorn, Friederike Knerlich-Lukoschus

“…Surgical treatment consisted in (1) placement of an ommaya reservoir for daily CSF puncture, (2) Spinal dural biopsy confirming leptomeningeal oligodendroglioma metastasis, and (3) ventriculo-peritoneal shunt placement after CSF protein has decreased to 1500–2000 mg/l.…”
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Maintenance Therapy with Trastuzumab in Her2 Positive Metastatic Parotid Ductal Adenocarcinoma by Muhammad Shahid Iqbal, Ghazia Shaikh, Sanjoy Chatterjee, Helen Cocks, Josef Kovarik

“…Our case also highlights that isolated brain metastasis should be managed aggressively to allow optimal local control when systemic disease is under remission with trastuzumab. …”
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