Modules Identification in Gene Positive Networks of Hepatocellular Carcinoma Using Pearson Agglomerative Method and Pearson Cohesion Coupling Modularity by Jinyu Hu, Zhiwei Gao

“…Finally, the biological significance of the two types of modules is analyzed and explained, which shows that these modules are closely related to the proliferation and metastasis of liver cancer. This discovery of the new modules may provide new clues and ideas for liver cancer treatment.…”
Get full text

Low-Grade Malignant Triton Tumor of the Neck: A Case Report and Review of the Literature by Taissir Omar, Hanaa Raslan, Sahar El Sheikh, Moataz Rizq, Awatef Draz

“…After 4 years there were no signs of recurrence or distant metastasis. The clinical, microscopic, and long-term follow-up of this case are consistent with those of a low-grade malignancy.…”
Get full text

Nonlethal Levels of Zeaxanthin Inhibit Cell Migration, Invasion, and Secretion of MMP-2 via NF-κB Pathway in Cultured Human Uveal Melanoma Cells by Ming-Chao Bi, Nicole Hose, Cai-Lian Xu, Chen Zhang, Jodi Sassoon, E. Song

“…These results suggest that zeaxanthin might be a potentially therapeutic approach in the prevention of metastasis in uveal melanoma.…”
Get full text

Gelatin-based biomaterials as a delivery strategy for osteosarcoma treatment by Qifan Yang, Xingpeng Chen, Jing Liu, Yeteng He

“…However, the high recurrence and metastasis rate of osteosarcoma and bone defects caused by surgery are still the main problems faced by osteosarcoma. …”
Get full text

Poorly Differentiated Uterine or Cervical Sarcoma in a Young Dog by Michelle C. Cora, Jennifer A. Neel

“…Via histopathology and immunohistochemistry, a diagnosis of poorly differentiated sarcoma originating from the uterus or cervix with widespread intra-abdominal dissemination and metastasis was made. Sarcomas of any type are rare in young dogs with only sporadic cases of poorly or undifferentiated sarcomas reported. …”
Get full text

The Importance of CD44 as a Stem Cell Biomarker and Therapeutic Target in Cancer by Ranjeeta Thapa, George D. Wilson

“…CD44 is a cell surface HA-binding glycoprotein that is overexpressed to some extent by almost all tumors of epithelial origin and plays an important role in tumor initiation and metastasis. CD44 is a compelling marker for cancer stem cells of many solid malignancies. …”
Get full text

Endometrioid Adenocarcinoma Metastatic to the Thyroid, Presenting Like Anaplastic Thyroid Cancer by Natasha Pollak, Gregory J. Renner, Ronald Miick, Shellaine R. Frazier

“…Metastasis of uterine cancer to the head and neck is extremely rare. …”
Get full text

Regulators of Actin Dynamics in Gastrointestinal Tract Tumors by Konrad Steinestel, Eva Wardelmann, Wolfgang Hartmann, Inga Grünewald

“…Accordingly, expression and activity of these actin-binding proteins have been linked to enhanced metastasis and poor prognosis in a variety of malignancies. …”
Get full text

Research Progress on Tumor Treatment Strategies Targeting TGF-β by Jian ZHANG, Binyue LYU, Xiao ZHAO

“…The TGF-β signaling pathway affects various biological processes of cancers, including proliferation, invasion, metastasis, angiogenesis, and immune escape. Currently, multiple drugs targeting this pathway are in clinical trial stage, which involve three aspects of TGF-β, namely, production, activation, and signal transduction. …”
Get full text

Duodenal Obstruction as First Presentation of Metastatic Breast Cancer by Sami Khairy, Ayman Azzam, Shamayel Mohammed, Kausar Suleman, Abdurahman Khawaji, Tarek Amin

“…The tumor presents again as brain metastasis after stop of Herceptin due to cardiac toxicity.…”
Get full text

Squamous Cell Carcinoma Developing from a Testicular Epidermal Cyst: A Case Report and Literature Review by Ryo Kasahara, Ryosuke Tajiri, Kota Kobayashi, Masahiro Yao, Kazuo Kitami

“…He is alive without recurrence or metastasis six months after surgery. Testicular SCC is an extremely rare tumor. …”
Get full text

Beta-HCG Secretion by a Pulmonary Choriocarcinoma in a Male Patient by Brecht Devos, Cedric Willemse, Mira Sterckx, Johan Debruyne, Inge Stappaerts, Tom Van den Mooter, Marjan Hertoghs, Pascale Abrams

“…MRI of the brain showed a solitary brain metastasis, while on a subsequent 18F-FDG PET/CT, no other metastatic lesions were seen. …”
Get full text

Neuroendocrine Tumor, Well Differentiated, of the Breast: A Relatively High-Grade Case in the Histological Subtype by Shogo Tajima, Hajime Horiuchi

“…In the lymph nodes, the morphology of the tumor was similar to the primary site. No distant metastasis and no relapse was seen for one year after surgery. …”
Get full text

Primary Small-Cell Carcinoma of the Palate with Cushing’s Syndrome: A Case Report by Yingqiu Song, Zhenyu Lin, Lingjuan Chen, Gang Wu

“…There was no evidence of recurrence or metastasis for more than three years. Small cell carcinoma originating in the head and neck region has been reported to be highly aggressive and has a poor prognosis. …”
Get full text

Autophagy in brain tumors: molecular mechanisms, challenges, and therapeutic opportunities by Jiarui Zhang, Jinan Zhang, Chen Yang

“…Autophagy mechanisms can influence metastasis and drug resistance in glioblastoma, and there is a complex interplay between autophagy and cellular responses to stress like hypoxia and starvation. …”
Get full text

Mesenteric Lymph Node Recurrence of a Primary Colorectal Leiomyosarcoma by Amélie Beauchamp, Roy Hajjar, Sharmila Khullar, Mathieu Latour, Frank Schwenter, Herawaty Sebajang

“…The mesenteric lymph node was resected and histopathology confirmed a leiomyosarcoma metastasis. This case opens the controversy on the management of rare lymph node recurrences in colorectal leiomyosarcoma.…”
Get full text

Progress in immune microenvironment, immunotherapy and prognostic biomarkers in pediatric osteosarcoma by Lin Zhang, Haoming Jiang, Haichao Ma

“…Despite advances in treatment, including multi-agent chemotherapy, survival rates remain suboptimal, with metastasis, particularly to the lungs, contributing significantly to mortality. …”
Get full text

Modulating lipid metabolism improves tumor immunotherapy by Yi Zhang, Yu Ping, Qiuqing Fan

“…Abnormal lipid metabolism, which is frequently observed in cancers, promotes tumor proliferation, invasion, and metastasis. Li et al from the Medical Oncology Department of Chongqing University Cancer Hospital constructed a lipid metabolism scoring system and reported that MK1775 inhibited fatty acid oxidation in tumor-associated macrophages and reduced T-cell infiltration, further enhancing the efficacy of immunotherapy. …”
Get full text

Complex Liver Resections for Colorectal Metastases: Are They Safe in the Low-Volume, Resource-Poor Caribbean Setting? by Shamir O. Cawich, Dexter A. W. Thomas, Chunilal Ramjit, Roderick Bhagan, Vijay Naraynsingh

“…A 50-year-old woman with a solitary colorectal metastasis invading the inferior vena cava underwent an extended left hepatectomy with caval resection and reconstruction. …”
Get full text

Advances in sodium-glucose transporter protein 2 inhibitors and tumors by Jiaqi Wang, Wenyong Yang

“…SGLT2 has been found to be overexpressed in many tumors and involved in tumorigenesis, progression and metastasis, suggesting that SGLT2i has a wide range of applications in tumor therapy. …”
Get full text