Spontaneous Retroperitoneal Bleeding as a Complication of Unusual Renal Paraganglioma by Tawfeeq I. Sangey, Hamim Abdul Rusheke, Ansaar I. Sangey, Nimishkumar Chaya, Advera Ngaiza

“…Abdominal contrast CT scan was helpful in locating the tumor, estimating tumor size and extent of bleeding, visualizing the interaction between the tumor and the surroundings, and ruling out any potential metastasis; however, it lacked specificity in identifying the origin of the mass, needing histologic investigation for a conclusive diagnosis. …”
Get full text

Early epidermoid carcinoma. A case presentation by Lidia Torres Ajá, Julian Viera Llanes

“…At present the patient has no metastasis and receives treatment at the outpatient. …”
Get full text

A Case Report of Melanoma as Acute Mastoiditis in a 10-Month-Old Female Child by Konstantina Chrysouli, Michael Tsakanikos, Sofia Stamataki

“…A full radiological assessment showed no sign of metastasis. The child remained without treatment. Complete remission of bone metastatic lesion has been confirmed by follow-up; now, the child is 4 years old, alive, and without evidence of disease.…”
Get full text

Cyclooxygenase-2 Mediated Regulation of E-Cadherin Occurs in Conventional But Not Early-Onset Gastric Cancer Cell Lines by R. Sitarz, R. J. Leguit, W. W. J. de Leng, F. H. M. Morsink, W. P. Polkowski, R. Maciejewski, G. J. A. Offerhaus, A. N. Milne

“…Background: COX-2 and E-cadherin, involved in invasion and metastasis, are molecules critical for gastric carcinogenesis. …”
Get full text

RANKL-Targeted Therapies: The Next Frontier in the Treatment of Male Osteoporosis by Alicia K. Morgans, Matthew R. Smith

“…Denosumab is also associated with delayed time to first skeletal-related event and an increase in bone metastasis-free survival in these men. It is reasonable to investigate the use of RANKL-targeted therapy in male osteoporosis in the general population.…”
Get full text

Urothelial Bladder Cancer with Cavitary Lung Metastases by Anil Kurian, Jason Lee, Abraham Born

“…Patterns of pulmonary metastasis include multiple nodules, a solitary mass or interstitial micronodule. …”
Get full text

David Slays Goliath: Exceptional Efficacy of Oral Vinorelbine in Conquering Metastatic Finger Angiosarcoma by Te-Lin Hsu, San-Chi Chen

“…The recurrence rate is high, and metastasis occurs in about half of the cases. The National Comprehensive Cancer Network guidelines recommend anthracycline-based, gemcitabine-based, and paclitaxel regimens as preferred first-line treatments for metastatic AS. …”
Get full text

To construct and validate a risk score model of angiogenesis-related genes to predict the prognosis of hepatocellular carcinoma by Duangui Gao, Yuan Lu, Tianpeng Jiang, Qinghong Duan, Zhi Huang

“…Angiogenesis is essential for HCC progression and metastasis. Some angiogenesis-related genes promote this process, whereas other antiangiogenic genes inhibit HCC growth and metastasis. …”
Get full text

Evolution of Treatment Outcomes and Prognostic Factors in Esophageal Cancer Surgery: A Retrospective Analysis of 1500 Consecutive Esophagostomies by Yasue Kimura, MD, PhD, Eiji Oki, MD, PhD, Tomonori Nakanoko, MD, PhD, Qingjiang Hu, MD, PhD, Keita Natsugoe, MD, Sho Nanbara, MD, PhD, Ryota Nakanishi, MD, PhD, Yuichiro Nakashima, MD, PhD, Mitsuhiko Ota, MD, PhD, Tomoharu Yoshizumi, MD, PhD

“…However, for recent surgeries (groups D and E), only the depth of invasion, lymph node metastasis, and curative resection were significant independent prognostic factors. …”
Get full text

Hypofractionated image-guided radiotherapy with 70 Gy in 28 fractions for prostate cancer confined to the pelvis: a single institute experience in Taiwan by Hui-Lei Mu, Mau-Shin Chi, Hui-Ling Ko, Guang-Dar Juang, Thomas I-Sheng Hwang, Kwan-Hwa Chi, Kai-Lin Yang

“…Event-free survival, overall survival, prostate cancer-specific survival, biochemical failure, locoregional recurrence, and distant metastasis were evaluated using the Kaplan–Meier method. …”
Get full text

Engineered bacterial membrane biomimetic covalent organic framework as nano-immunopotentiator for cancer immunotherapy by Qi-Chao Yang, Yuan-Yuan Wang, Shuo Wang, An Song, Wen-Da Wang, Liang Zhang, Zhi-Jun Sun

“…Consequently, the response rate of αPD-L1 immunotherapy was drastically promoted to efficiently prevent tumor metastasis and recurrence, causing 84.6 % distant tumor inhibition and complete suppression of tumor metastasis. …”
Get full text

An Update of the Appropriate Treatment Strategies in Anaplastic Thyroid Cancer: A Population-Based Study of 735 Patients by Nai-si Huang, Xiao Shi, Bo-wen Lei, Wen-jun Wei, Zhong-wu Lu, Peng-cheng Yu, Yu Wang, Qing-hai Ji, Yu-long Wang

“…Patients with very locally advanced disease or distant metastasis could not benefit from TT as well. Conclusions. …”
Get full text

AGD1/USP10/METTL13 complexes enhance cancer stem cells proliferation and diminish the therapeutic effect of docetaxel via CD44 m6A modification in castration resistant prostate can... by Hong Wang, Chunli Cui, Weiyi Li, Hui Wu, Jianjun Sha, Jiahua Pan, Wei Xue

“…The effects of AGD1 and METTL13 on CRPC development and metastasis under docetaxel treatment were analyzed using a xenograft mouse model and an organoid model. …”
Get full text

Circular RNA circBNC2 inhibits tumorigenesis by modulating ferroptosis and acts as a nanotherapeutic target in prostate cancer by Xiang Pan, Kailai Chen, Wei Gao, Meiqi Xu, Fanlong Meng, Mengyuan Wu, Zi Qi Wang, Yun Qi Li, Wanhai Xu, Manjie Zhang, Yakun Luo

“…Abstract Background Metastasis is a leading cause of cancer-related death in castration-resistant prostate cancer (CRPC) patients. …”
Get full text

CircPRMT5, a Potential Salivary Biomarker, Facilitates the Progression of Head and Neck Squamous Cell Carcinoma via the IGF2BP3-SERPINE1 Pathway by Jiang S, Ou L, Wang Y, Su K, Chen Z, He L, Xu X, Cheng B, Xia J, Fan Z

“…Finally, salivary exosomes were isolated, and the expression levels of circPRMT5 were assessed using qRT-PCR.Results: The upregulation of circPRMT5 in HNSCC tissues was identified to be correlated with cervical lymph node metastasis and advanced clinical T stage. Both in vitro and in vivo experiments manifested that circPRMT5 promoted the proliferation and metastasis of HNSCC. …”
Get full text

Prognostic significance of p27 in colorectal cancer: a meta-analysis and bioinformatics analysis by Jing Zou, Dong Wang, Gaoping Yin, Kexiang Lu, Kaibin Chang, He Li

“…The results from GEPIA and UALCAN showed that p27 had no effect on TNM staging, lymph node metastasis, DFS, and OS; moreover, there was no expression difference between tumor tissues and normal tissues. …”
Get full text

Upregulated SAE1 Drives Tumorigenesis and Is Associated with Poor Clinical Outcomes in Breast Cancer by Hong Liu, Jing Wang, Yunhai Li, Feng Luo, Lei Xing

“…Patients with SAE1 overexpression had a worse overall survival (OS), recurrence-free survival (RFS), and distant metastasis-free survival compared with lower expression patients. …”
Get full text

Preoperative Butyrylcholinesterase Level as an Independent Predictor of Overall Survival in Clear Cell Renal Cell Carcinoma Patients Treated with Nephrectomy by Takuya Koie, Chikara Ohyama, Jotaro Mikami, Hiromichi Iwamura, Naoki Fujita, Tendo Sato, Yuta Kojima, Ken Fukushi, Hayato Yamamoto, Atsushi Imai, Shingo Hatakeyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Masato Kitayama, Kazuyoshi Hirota

“…Multivariate analysis revealed that preoperative BChE levels and distant metastasis status were significantly associated with OS. …”
Get full text

Health promoting activities and corresponding mechanism of (–)-epicatechin-3-gallate by Zhiliang Li, Changchun Feng, Hongjin Dong, Weibin Jin, Wenying Zhang, Jianfeng Zhan, Shuzhen Wang

“…The antineoplastic mechanism contains inhibition of phase 1 CYP enzymes, induction of phase II detoxification and antioxidant enzymes, high anti-inflammatory efficacy, arrest of cell cycle progression, regulation of apoptosis, as well as mediation of metastasis processes. In particular, the gallate moiety of ECG is critical for mediating inhibitory effects towards cancer cells. …”
Get full text

Metastatic Renal Cell Carcinoma Presenting as Gastric Ulcer: Case Report and Literature Review by Alhareth Al Juboori, Satinder Kaur, Atigadda Reddy

“…Herein we describe a case of delayed metastasis to gastric wall occurring more than a decade after previously curative nephrectomy for RCC. …”
Get full text