Clinical Impact of Sphingosine-1-Phosphate in Breast Cancer by Junko Tsuchida, Masayuki Nagahashi, Kazuaki Takabe, Toshifumi Wakai

“…It is difficult to cure the breast cancer patients with distant metastasis due to resistance to drug therapies. Elucidating the underlying mechanisms of breast cancer metastasis and drug resistance is expected to provide new therapeutic targets. …”
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Plasma Iron Levels at Early Breast Cancer Diagnosis Are Associated With Development of Secondary Metastases: A Single-Center Retrospective Cohort Study by Jasmine De Troy, Sarah-Maria Fendt, Sigrid Hatse, Patrick Neven, Ann Smeets, Annouschka Laenen, Hans Wildiers

“…Cox proportional hazard models were applied to determine the association between iron levels and risk of metastasis. Results: In total, 1113 patients were included, 10% of them developed distant metastasis over a median follow-up period of 7 years. …”
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The Role of TAMs in Tumor Microenvironment and New Research Progress by Yawei Feng, Zhiqiang Ye, Furong Song, Yufeng He, Jun Liu

“…Tumor-associated macrophages (TAMs) are an important part of tumor microenvironment (TME) and play a key role in TME, participating in the process of tumor occurrence, growth, invasion, and metastasis. Among them, metastasis to tumor tissue is the key step of malignant development of tumor. …”
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Thigmotropism of Malignant Melanoma Cells by Pascale Quatresooz, Claudine Piérard-Franchimont, Fanchon Noël, Gérald E. Piérard

“…During malignant melanoma (MM) progression including incipient metastasis, neoplastic cells follow some specific migration paths inside the skin. …”
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The CD4/CD8 ratio is associated with T lymphocyte functions in long-term virally suppressed patients with HIV by Qing Xiao, Fengting Yu, Liting Yan, Xiaojie Lao, Xuelei Liang, Hongxin Zhao, Liuyue Zhai, Zailin Yang, Xiaomei Zhang, Yao Liu, Fujie Zhang

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Cell Counts, rather than Proportion, of CD8/PD-1 Tumor-Infiltrating Lymphocytes in a Tumor Microenvironment Associated with Pathological Characteristics of Chinese Invasive Ductal... by Qingkun Song, Feng Shi, Maya Adair, Hong Chang, Xiudong Guan, Yanjie Zhao, Yuchen Li, Guangjiang Wu, Jiangping Wu

“…The proportion of CD8+/PD-1- TILs was 16% among patients with axillary lymph node metastasis, significantly lower than those without metastasis (24%). …”
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miR-370-3p as a Novel Biomarker Promotes Breast Cancer Progression by Targeting FBLN5 by Jiahui Mao, Lingxia Wang, Junying Wu, Yichun Wang, Huiyan Wen, Xueming Zhu, Bo Wang, Huan Yang

“…Our results demonstrated that miR-370-3p significantly promoted proliferation, metastasis, and stemness of breast cancer in vitro and in vivo. …”
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HIF-3α-Induced miR-630 Expression Promotes Cancer Hallmarks in Cervical Cancer Cells by Forming a Positive Feedback Loop by Qiaohui Gao, Zhenghua Ren, Shengyuan Jiao, Juan Guo, Xia Miao, Jin Wang, Junye Liu

“…Hypoxia has crucial functions in the development and metastasis of cervical cancer by inducing the expression of numerous genes, including microRNA genes. …”
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The Function of SUMOylation and Its Role in the Development of Cancer Cells under Stress Conditions: A Systematic Review by Qi Zhao, Ying Ma, Zugui Li, Kexin Zhang, Minying Zheng, Shiwu Zhang

“…Malignant tumors still pose serious threats to human health due to their high morbidity and mortality. Recurrence and metastasis are the most important factors affecting patient prognosis. …”
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Outcomes of Recurrent Head and Neck Cutaneous Squamous Cell Carcinoma by Nichole R. Dean, Larissa Sweeny, J. Scott Magnuson, William R. Carroll, Daniel Robinson, Renee A. Desmond, Eben L. Rosenthal

“…Distant metastasis was a strong indicator of poor overall survival (P<.001). …”
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Primary leiomyosarcoma of the scalp: a case report and review of the literature by Shuo Gao, Pule Liu, Jixing Liu, Wenzhen Yang, Shude Yang

“…Background and importanceLeiomyosarcoma is a rare and aggressive malignant tumor with a high potential for relapse and metastasis. Correct and timely diagnosis is critical for effective treatment, yet it is often challenging due to the diverse clinical presentations. …”
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Obscure Gastrointestinal Bleeding from an Ampullary Tumour in a Patient with a Remote History of Renal Cell Carcinoma: A Diagnostic Conundrum by Rhonda M Janzen, Alnoor S Ramj, Julia DA Flint, Charles H Scudamore, Eric M Yoshida

“…Metastasis of renal cell carcinoma to the ampulla of Vater is a rare occurrence. …”
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Multiple Cutaneous Metastases as Initial Presentation in Advanced Colon Cancer by Sudheer Nambiar, Asha Karippot

“…Of all the tumors, breast cancer most commonly spreads as cutaneous metastasis is followed by lung, colorectal, renal, ovarian, and bladder cancers. …”
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Membrane Proteins Involved in Epithelial-Mesenchymal Transition and Tumor Invasion: Studies on TMPRSS4 and TM4SF5 by Semi Kim, Jung Weon Lee

“…The EMT is believed to be an important step in metastasis and is implicated in cancer progression, although the influence of the EMT in clinical specimens has been debated. …”
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A Case Report of a Metastatic Gastrointestinal Stromal Tumor Occurring in Femur by Chang-kun Zheng, Wu-Sheng Kan, Peng Li

“…To the best of our knowledge, few cases have been reported in the literature about the femur metastasis of GIST. This paper describes a metastasis of a gastrointestinal stromal tumour (GIST) to the femur in a 62-year-old male, 2 years after treatment for a gastric primary. …”
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Epigenetics of cancer drug resistance by Sayandeep Mukherjee, Ronit Dey, Subhabrata Guha, Nabendu Murmu, Gaurav Das

“… One of the major causes due to cancer-related death is metastasis. The major factors contributing to metastasis of cancer cells are epithelial–mesenchymal transition and cancer stem cells. …”
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Tumor Cells and Tumor-Associated Macrophages: Secreted Proteins as Potential Targets for Therapy by Marc Baay, Anja Brouwer, Patrick Pauwels, Marc Peeters, Filip Lardon

“…Inflammatory pathways, meant to defend the organism against infection and injury, as a byproduct, can promote an environment which favors tumor growth and metastasis. Tumor-associated macrophages (TAMs), which constitute a significant part of the tumor-infiltrating immune cells, have been linked to the growth, angiogenesis, and metastasis of a variety of cancers, most likely through polarization of TAMs to the M2 (alternative) phenotype. …”
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Endoscopic Mucosal Resection for Esophageal and Gastric Mucosal Cancers by Haruhiro Inoue

“…In absolutely indicated cases there has been no local or distant metastasis during the longest period of follow-up (nine years). …”
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The Role of PPARs in the Endothelium: Implications for Cancer Therapy by David Bishop-Bailey, Karen E. Swales

“…The growth and metastasis of cancers intimately involve the vasculature and in particular the endothelial cell layer. …”
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Metastatic Ureteral Involvement of Non-Small Cell Lung Cancer by Koichi Kodama, Tetsuya Imao, Kazuto Komatsu

“…After excluding the presence of other primary tumors and metastases, we reached a final diagnosis of solitary retroperitoneal metastasis of adenocarcinoma of the lung. Although rare, in patients of non-small cell lung cancer, presence of hydronephrosis should alert the physician to the possibility of metastasis.…”
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