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  1. 5301

    La gestion de l’eau à Bibracte (Saône-et-Loire), avant et après la Conquête romaine by Laetitia Borau

    Published 2020-12-01
    “…This is therefore an example of an organised water storage system throughout the whole oppidum, which was needed not only to meet the daily needs of the population, but also for others purposes such as fire-fighting. …”
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  2. 5302

    Should the Food and Drug Administration Limit Placebo-Controlled Trials? by Max Goodman, Connor Pedersen

    Published 2022-07-01
    “…Extreme care must be taken to avoid abuse of this option.[4] The FDA has largely ignored this and deemed placebo controls the gold standard, stating that “PCTs are necessary to control for placebo effect of investigational medicinal product.”[5] The FDA has even refused to approve drugs that are tested against established treatments instead of against placebos, notably atenolol.[6] By stretching the “methodological” exception and failing to define harm reasonably, the FDA does not meet the spirit behind Helsinki’s conditions for allowing PCTs. …”
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  3. 5303

    Development of a clinical decision support tool for Primary care Management of lower Urinary tract Symptoms in men: the PriMUS study by Adrian Edwards, Ridhi Agarwal, Janine Bates, Alison Bray, Sarah Milosevic, Emma Thomas-Jones, Michael Drinnan, Marcus Drake, Peter Michell, Bethan Pell, Haroon Ahmed, Natalie Joseph-Williams, Kerenza Hood, Yemisi Takwoingi, Chris Harding

    Published 2025-01-01
    “…Objective 6: potential National Health Service costs involved in the new pathway We were unable to meet this objective as originally intended. Up-to-date data on referral rates are required (identified to have risen to 30% of men presenting with LUTS in primary care at the time of commissioning PriMUS study, 2017). …”
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  4. 5304

    Multi-cancer early detection tests for general population screening: a systematic literature review by Ros Wade, Sarah Nevitt, Yiwen Liu, Melissa Harden, Claire Khouja, Gary Raine, Rachel Churchill, Sofia Dias

    Published 2025-01-01
    “…Technologies that appeared to be at a very early stage of development did not meet the inclusion criteria for the review. Individual MCED tests and technologies claimed to detect from 3 to over 50 different types of cancer. …”
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