Homologous recombination deficiency test validation in patients with high-grade advanced ovarian cancer by Angelica Nogueira Rodrigues, Andreza Karine de Barros Almeida Souto, Diocésio Alves Pinto de Andrade, Larissa Müller Gomes, Sandra Satie Koide, Renata de Godoy e Silva, Bruno Batista de Souza, Juliana Doblas Massaro, Andréia Cristina de Melo, Andrea Morais Borges, Camila Giro, Carlos Augusto Vasconcelos de Andrade, Cesar Martins da Costa, Daniel Luiz Gimenes, Eduardo Caminha Bandeira de Mello, Fernanda Cesar de Oliveira, Frederico Müller de Toledo Lima, Gabriel Lima Lopes, Gustavo de Oliveira Bretas, Gustavo Guerra Jacob, Herika Lucia da Costa Silva, Juliana Ferrari Notaro, Lara Ladislau Alves, Marcos Veloso Moitinho, Mirian Cristina da Silva, Roberto Abramoff, Thais Amaral da Cunha Rauber, Rodrigo Dienstmann, Fernanda Christtanini Koyama

“…In this scenario, access to a validated diagnostic HRD test can optimize treatment selection and increase the effectiveness of the intervention.ObjectiveTo technically validate an in-house next-generation sequencing (NGS)-based HRD test, QIAseq Custom Panel (QIAGEN), by comparing it with the reference assay, MyChoice CDx® Plus HRD (Myriad Genetics), which is used in routine care.MethodsThis is a prospective cohort study conducted at the Oncoclínicas Precision Medicine (OCPM) laboratory using samples from patients with advanced or relapsed platinum-sensitive ovarian cancer eligible for HRD testing in a diagnostic clinical setting at Oncoclínicas and Co. …”
Get full text

Longitudinal maternal glycemia during pregnancy and placental epigenetic age acceleration by Tesfa Dejenie Habtewold, Prabhavi Wijesiriwardhana, Richard J. Biedrzycki, Cuilin Zhang, Katherine L. Grantz, Jagteshwar Grewal, Fasil Tekola-Ayele

Get full text

Comparison of effectiveness in smoking cessation using nicotine replacement therapy and electronic cigarettes by Adrianna Kopaczyńska, Katarzyna Szafrańska, Szymon Niemirka, Aleksandra Janiak, Kinga Dominiczak, Łukasz Grądalski, Filip Dębicki

“…The impact of electronic cigarettes on smoking cessation also remains controversial, taking into consideration how little today's medicine does know about the long-term side effects of using e-cigarettes. …”
Get full text

Caution when using network partners for target identification in drug discovery by Dandan Tan, Yiheng Chen, Yann Ilboudo, Kevin Y.H. Liang, Guillaume Butler-Laporte, J. Brent Richards

Get full text

Outcomes and Complications of Minimally Invasive Glaucoma Surgeries (MIGS) in Primary Angle Closure and Primary Angle Closure Glaucoma: A Systematic Review and Meta-Analysis by Paik B, Chua CH, Yip LW, Yip VC

“…Benjamin Paik,1 Chun Hau Chua,2 Leonard W Yip,1,2 Vivien CH Yip1,2 1Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; 2Department of Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, SingaporeCorrespondence: Vivien CH Yip, TTSH Medical Centre, 11 Jalan Tan Tock Seng, Level 1, Singapore, 308433, Singapore, Email vyip82@yahoo.co.ukTopic: To analyse the safety and efficacy of minimally invasive glaucoma surgeries (MIGS) in lowering IOP and medication burden in primary angle closure (PAC) or primary angle closure glaucoma (PACG).Clinical Relevance: MIGS is off-label in angle closure, as implantation of the device is difficult when there is iridotrabecular contact. …”
Get full text

Protocol of the Nurses’ Mental Health Study (NMHS): a nationwide hospital multicentre prospective cohort study by Jiaxin Yang, Chongmei Huang, Shuiyuan Xiao, Xuting Li, Meng Ning, Zengyu Chen, Yusheng Tian, Qiang Yu, Yamin Chen, Ya-Min Li

Get full text

The impact of food-based incentive behaviors on oral health among Saudi children: a cross-sectional study by Yasir Dilshad Siddiqui, Saud Hamdan Almaeen, Ahmed Shawkat Hashem, Ahmed Ali Ahmed Almuntashiri, Mohammed Nadeem Baig, Abdullah Hammad Alshammari, Rital Jamal Alwaqid, Haifa Ali Almutairi, Raha Ahmed, Rakhi Issrani, Farooq Ahmad Chaudhary

Get full text

Ультразвуковой мониторинг легких при COVID-19 пневмониях в ОРИТ: межэкспертная повторяемость при выполнении врачами анестезиологами-реаниматологами: ретроспективное двухцентровое к... by Иван Сергеевич Щепарев, Б. А. Теплых, Д. Н. Проценко, А. Н. Кузовлев

Get full text

Variability and performance of NHS England’s ‘reason to reside’ criteria in predicting hospital discharge in acute hospitals in England: a retrospective, observational cohort study... by Elizabeth Sapey, Simon Ball, David McNulty, Felicity Evison, Suzy Gallier, Katherine Reeves

Get full text

Prescription pattern, glycemic control status, and predictors of poor glycemic control among diabetic patients with comorbid chronic kidney disease in Ethiopia: a facility-based cr... by Oumer Sada Muhammed, Minimize Hassen, Samuel Mamusha

Get full text

Clinical Practice Guidelines of the Russian Scientific Liver Society, Russian Gastroenterological Association, Russian Association of Endocrinologists, Russian Association of Geron... by V. T. Ivashkin, M. V. Maevskaya, M. S. Zharkova, Yu. V. Kotovskaya, O. N. Tkacheva, E. A. Troshina, M. V. Shestakova, I. V. Maev, V. V. Breder, N. I. Gheivandova, V. L. Doshchitsin, E. N. Dudinskaya, E. V. Ershova, Kh. B. Kodzoeva, K. A. Komshilova, N. V. Korochanskaya, A. Yu. Mayorov, E. E. Mishina, M. Yu. Nadinskaya, I. G. Nikitin, N. V. Pogosova, A. I. Tarzimanova, M. Sh. Shamkhalova

Get full text

Influencing factors for delay in healthcare-seeking, definitive diagnosis, identification in patients with pulmonary tuberculosis in Minhang District by MA Qiongjin, YAN Huiqin, WU Yunhua, GUO Xu, YANG Lijia, TANG Lihong, YANG Shengyuan

Get full text

Comparison of phenotypic and genetic traits of ESBL-producing UPEC strains causing recurrent or single episode UTI in postmenopausal women by Michelle Kalu, Peter Jorth, Annie Wong-Beringer

Get full text

Predictors of survival rates among breast cancer patients in Ethiopia: a systematic review and meta-analysis 2024 by Chalie Mulugeta, Tadele Emagneneh, Getinet Kumie, Assefa Sisay, Nigusie Abebaw, Mulat Ayele, Abebaw Alamrew

Get full text

Antimicrobial and ADME properties of methoxylated, methylated and nitrated 2-hydroxynaphthalene-1 carboxanilides by Lucia Vrablova, Tomas Gonec, Tereza Kauerova, Michal Oravec, Izabela Jendrzejewska, Peter Kollar, Alois Cizek, Josef Jampilek

Get full text

Patellofemoral Joint Loading During the Performance of the Forward and Side Lunge with Step Height Variations by Rafael Escamilla, Naiquan Zheng, Toran D MacLeod, Rodney Imamura, Kevin E. Wilk, Shangcheng Wang, Irv Rubenstein, Kyle Yamashiro, Glenn S. Fleisig

Get full text

Respiratory pathogen spectrum and epidemiological trends in Hainan Province: a retrospective analysis from 2017 to 2023 by Lvying Wu, Jianan Zhang, Zhiming Wu, Hua Pei, You Zhang

Get full text

Incidence and influencing factors of occupational pneumoconiosis: a systematic review and meta-analysis by Xiao Yu, Xinri Zhang, Xuesen Su, Xiaomei Kong

Get full text

A minimally invasive animal model of atherosclerosis and neointimal hyperplasia for translational research by Max L. A. Ebert, Vanessa F. Schmidt, Osman Öcal, Anne von Thaden, Olaf Dietrich, Bastian Popper, Sandra Elges, Max Seidensticker, Jens Ricke, Melanie A. Kimm, Astrid Jeibmann, Moritz Wildgruber

Get full text

Efficacy of Esophageal Protector in Treating Gastroesophageal Reflux Disease with Extraesophageal Symptoms: a Multicenter, Open-Label, Observational Study by Yu. A. Kucheryavy, D. N. Andreyev, E. Yu. Eryomina, A. A. Gilmanov, O. V. Nazarova, Ye. A. Sidneva, Yu. G. Topalova

Get full text