Acid-Unlocked Two-Layer Ca-Loaded Nanoplatform to Interfere With Mitochondria for Synergistic Tumor Therapy by Zheng Y, Williams GR, Hu R, Tong S, Xu J, Wang T, Zhang Y, Wu J, Li F, Cai Y, Zhu LM

“…Yilu Zheng,1 Gareth R Williams,2 Ran Hu,1 Sen Tong,3 Jianxiang Xu,1 Tong Wang,1 Yanyan Zhang,1 Junzi Wu,3 Fan Li,4 Yingyu Cai,4 Li-Min Zhu1 1College of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, People’s Republic of China; 2UCL School of Pharmacy, University College London, London, WC1N 1AX, UK; 3The Key Laboratory of Microcosmic Syndrome Differentiation, Education Department of Yunnan, Yunnan University of Chinese Medicine, Kunming, 650500, People’s Republic of China; 4Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, People’s Republic of ChinaCorrespondence: Yingyu Cai, Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, People’s Republic of China, Email yingyu.cai@shgh.cn Li-Min Zhu, College of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, People’s Republic of China, Email lzhu@dhu.edu.cnBackground: The development of selective formulations able to target and kill tumor cells without the application of external energy has shown great promise for anti-tumor therapy.Methods: Here, we report a “nanobomb” that explosively increases Ca content within cells. …”
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Implementation of model-informed precision dosing for tamoxifen therapy in patients with breast cancer: A prospective intervention study by Ruben Y.M. van Nijnatten, Sanne M. Buijs, Bram C. Agema, Raphaël M.J. Fischer, Inge Ghobadi Moghaddam-Helmantel, Caroline M.E. Contant, Felix E. de Jongh, Auke M.T. Huijben, Manon Kop, Annemieke van der Padt-Pruijsten, Hanneke J.M. Zuetenhorst, Ron H.N. van Schaik, Birgit C.P. Koch, A. Jager, Stijn L.W. Koolen, Ron H.J. Mathijssen

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Impact of prior CAR T-cell therapy on mosunetuzumab efficacy in patients with relapsed or refractory B-cell lymphomas by Elise A. Chong, Elicia Penuel, Ellen B. Napier, Rachel K. Lundberg, Lihua E. Budde, Mazyar Shadman, Matthew J. Matasar, Nancy L. Bartlett, Ian W. Flinn, Francesc Bosch, Keith Fay, Andre Goy, Anita Kumar, Loretta J. Nastoupil, Michael C. Wei, Mei Wu, Shen Yin, Joseph A. Fraietta, Emeline R. Chong, Stephen J. Schuster

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Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes by Kazuhiro Kakimi, Hirokazu Matsushita, Masaaki Komatsu, Eiryo Kawakami, Mikako Nishida, Nahoko Yamashita, Taisaku Ogawa, Keita Koseki, Eiji Warabi, Tomoyuki Ohue, Katsuyuki Shiroguchi, Heiichiro Udono

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Disparities in the uptake of HPV-related cancer prevention strategies among women by HIV status in Puerto Rico by Marievelisse Soto-Salgado, Melisa Ramos-Sepúlveda, Jeslie M. Ramos-Cartagena, Maribel Tirado-Gómez, Humberto M. Guiot, Cristina Muñoz-Masso, Lorena González-Sepúlveda, Ana Patricia Ortiz

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Incidence of constrained condylar and hinged knee implants and mid- to long-term survivorship: a register-based study from the Nordic Arthroplasty Register Association (NARA) by Jake von Hintze, Ville Ponkilainen, Annette W-Dahl, Nils P Hailer, Ove Furnes, Anne M Fenstad, Mona Badawy, Alma B Pedersen, Martin Lindberg-Larsen, Mika J Niemeläinen, Keijo Mäkelä, Antti Eskelinen

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Individualized prediction of multi-domain intelligence quotient in bipolar disorder patients using resting-state functional connectivity by Xiaoyu Li, Wei Wei, Linze Qian, Xiaojing Li, Mingli Li, Ioannis Kakkos, Qiang Wang, Hua Yu, Wanjun Guo, Xiaohong Ma, George K. Matsopoulos, Liansheng Zhao, Wei Deng, Yu Sun, Tao Li

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Blood Flow Restriction: Cause for Optimism, But Let’s Not Abandon The Fundamentals by Dan Lorenz

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Sports Physiotherapy for All by Kristian Thorborg, Luciana Mendonça

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Making the Case for Modalities: The Need for Critical Thinking in Practice by Phil Page

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Vibration Therapy – A Clinical Commentary by Lewis Lupowitz

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Editorial: Two Steps Forward by Michael M Reinold

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The Need for Critical Thinking in Rehabilitation Research by Phil Page

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Data-Driven Prognosis and Improved Outcomes Part 2: The Opportunity of Grading Risk by Gray Cook

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We are Ready for 2024! by International Journal of Sports Physical Therapy

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To Reconstruct the Anterior Cruciate Ligament or Not? – Put into Panther Perspective by Kristian Thorborg

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The Effect of Vitamin D3 on Serum Creatine Phosphokinase Level in Patients with Multiple Trauma: A Pilot Randomized Clinical Trial by Mehran Kouchek, Niloufar Taherpour, Mahya Farasat, Mirmohammad Miri, Sara Salarian, Seyedpouzhia Shojaei, Rezvan Hassanpour, Hossein Amini, Mohammad Sistanizad

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A model based cost-utility analysis of Embedding referral to structured self-management education into standard practice (Embedding) compared to usual care for people with type 2 d... by Melanie J Davies, Alan Brennan, Danielle H Bodicoat, Daniel John Pollard, Anju Keetharuth, Michelle Hadjiconstantinou, Agnieszka Glab, Joesph P Mensa, Alison Northern

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Carbapenem-resistant Enterobacterales (CRE) colonisation as a predictor for subsequent CRE infection: A retrospective surveillance study by Courtney M. Tubb, Marco Tubb, Jonathan Hooijer, Rispah Chomba, Jeremy Nel

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Palpitations, Shortness of Breath, Weakness in Limbs, Edema, and Dyspnea: A Rare Inflammatory Myopathy with Positive Aniti-mitochondrial Antibodies and Cardiac Involvement by LIANG Chunsu, ZHANG Xuchang, ZHANG Ning, KANG Lin, LIU Xiaohong, YU Jiaqi, LIU Yingxian, QIAO Lin, YANG Yanli, ZHAO Xiaoyi, ZHAO Ruijie, NIU Na, YAN Xuelian

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