Safety and tolerability of the M2 muscarinic acetylcholine receptor modulator BAY 2413555 in heart failure with reduced ejection fraction in the REMOTE-HF study by Marat Fudim, Muhammad Shahzeb Khan, Dominik Linz, JoAnn Lindenfeld, Calum MacRae, Nina Kimmeskamp-Kirschbaum, Michaela Meyer, Thomas Mondritzki, Hanna Tinel, Wilfried Dinh, Robert J. Mentz

“…There were promising signs of target engagement, providing grounds for further exploration of the mechanism…”
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Exosome‐derived long non‐coding RNA AC010789.1 modified by FTO and hnRNPA2B1 accelerates growth of hair follicle stem cells against androgen alopecia by activating S100A8/Wnt/β‐cat... by Shaojun Chu, Lingling Jia, Yulong Li, Jiachao Xiong, Yulin Sun, Qin Zhou, Dexiang Du, Zihan Li, Xin Huang, Hua Jiang, Baojin Wu, Yufei Li

“…However, the molecular mechanism of HFSCs against AGA remains elusive. Methods The expression and prognosis of lncRNA AC010789.1 in AGA hair follicle tissues were assessed by qRT‐PCR analysis. …”
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Standardised packaging, minimum excise tax, and RYO focussed tax rise implications for UK tobacco pricing. by Rosemary Hiscock, Nicole H Augustin, J Robert Branston, Anna B Gilmore

“…The main limitations are first that because we do not know the exact mechanism by which Nielsen scales up sample data to provide UK estimates, we could only use data for a set three year period during which the same adjustments are made. …”
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HIF-1α and VEGF Immunophenotypes as Potential Biomarkers in the Prognosis and Evaluation of Treatment Efficacy of Atherosclerosis: A Systematic Review of the Literature by Dimitra P. Vageli, Panagiotis G. Doukas, Dimitrios Georgiou, Michailangelos P. Prokopiou, Nefeli E. Ladaki, Androniki Papadopoulou, Sotirios G. Doukas, Konstantina Zacharouli, Konstantinos P. Makaritsis, Maria Ioannou

“…Exploring pathogenetic mechanisms and therapeutic options, we included several studies using variable methods to evaluate HIF-1α/VEGF immunophenotypes with controversial and innovative results. …”
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Discussion: acoustic density and ocular structures rigidity in healthy individuals and patients with primary open-angle glaucoma (response to the article by Kazemi A., Zhou B., Zha... by I.N. Koshits, O.V. Svetlova, A.A. Ryabtseva, M.G. Guseva, M.B. Egemberdiev, P.P. Bakshinsky, M.V. Zaseeva

“…</p> <p> <b>Keywords: </b>scleral functions, rigidity, fluctuation, intraocular pressure, key branches in glaucoma pathogenesis, errors in measurement techniques, laws of mechanics. </p> <p> <b>For citation</b>: Koshits I.N., Svetlova O.V., Ryabtseva A.A., Guseva M.G., Egemberdiev M.B., Bakshinsky P.P., Zaseeva M.V. …”
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Cloning, Characterization and Expression Regulation in Response to High-Temperature Stress of TRAF7 Gene in the Sea Cucumber Apostichopus japonicus by Yanfeng ZHAO, Meijie LIAO, Jianlong GE, Jinjin WANG, Yingeng WANG, Xiaojun RONG, Bin LI, Yanting TAN

“…The results indicated that AjTRAF7 might be involved in regulating expression in response to high-temperature stress in sea cucumbers, and the results provide a scientific basis for analyzing the molecular mechanism of high-temperature stress in sea cucumbers.…”
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Changes of Narrative: Osvald Sirén’s Photographic Modeling of Modern Research on Chinese Garden by Jiuwen GU, Yuanfeng SHI, Shan JIA

“…As an emerging image material and a way to understand and review gardens, photography has driven a shift in gardening research, with the underlying mechanisms being investigated in this research. In addition, the research also explores the interaction between photography’s technical characteristics and gardens’ spatial characteristics.MethodsThis research adopts the case study of Osvald Sirén’s photographic images of Chinese gardens. …”
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Growth, physical, and cognitive function in children who are born HIV-free: School-age follow-up of a cluster-randomised trial in rural Zimbabwe. by Joe D Piper, Clever Mazhanga, Marian Mwapaura, Gloria Mapako, Idah Mapurisa, Tsitsi Mashedze, Eunice Munyama, Maria Kuona, Thombizodwa Mashiri, Kundai Sibanda, Dzidzai Matemavi, Monica Tichagwa, Soneni Nyoni, Asinje Saidi, Manasa Mangwende, Dzivaidzo Chidhanguro, Eddington Mpofu, Joice Tome, Gabriel Mbewe, Batsirai Mutasa, Bernard Chasekwa, Handrea Njovo, Chandiwana Nyachowe, Mary Muchekeza, Kuda Mutasa, Virginia Sauramba, Ceri Evans, Melissa J Gladstone, Jonathan C Wells, Elizabeth Allen, Melanie Smuk, Jean H Humphrey, Lisa F Langhaug, Naume V Tavengwa, Robert Ntozini, Andrew J Prendergast

“…Further research is needed to define the biological and psychosocial mechanisms underlying these differences to inform future interventions that help CBHF thrive across the life-course.…”
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The Effect of Different Ratio of Methionine-Zinc and Zinc Oxide on Performance Indicators and Diarrhea in Suckling Holstein Calves by Morteza Rezapour, Yadollah Chashnidel, Asadollah Teimoury Yansary, Essa Dirandeh

“…It is thought that the mechanisms of anti-diarrheal effect of zinc element are due to regulation of intestinal fluid transfer and mucosal integrity, strengthening of immunity and modulation of oxidative stress. …”
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Expression Analysis and SNP Mining of the Parkin Co-Regulated Gene (PACRG) and parkin in Penaeus vannamei Against White Spot Syndrome Virus by Qian XUE, Xupeng LI, Yang LI, Sheng LUAN, Kun LUO, Jie KONG, Qun XING, Xianhong MENG

“…This study provides a theoretical reference for future research on the molecular mechanisms underlying P. vannamei's resistance to WSSV.…”
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Exploring the Interaction between Local Communities and Environmental Policies: A Qualitative Study of Conflicts between Natives and Rangers around the Protected Areas of Bojaq Nat... by Yaser Khoshsirat Salimi, Ali Ruhani, Hossein Afrasiabi, Sadegh Salehi

“…The interview protocol included questions about the causes of resistance among local hunters and their lifestyle, as well as mechanisms of conflict and adaptation. It also explored the advantages and disadvantages of their way of life in relation to the environmental and fisheries organizations, as well as significant social structures. …”
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Human Capital, Economic Growth and Environmental Quality with Special Emphasis on Public Education Expenditures: An Application of DSGE Models by Yahya Mohaghegh, hashem zare, Mehrzad Ebrahimi

“…Theoretical studies emphasize different mechanisms through which education affects economic growth. (1) Education increases the human capital of the labor force, thereby increasing labor productivity and shifting growth toward a higher equilibrium level of output. (2) In endogenous growth theories, education increases the economy's capacity to innovate new technologies, products, and processes, thereby promoting growth. …”
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Jiangu Granules Regulates Endoplasmic Reticulum Stress-Induced Apoptosis in UMR-106 Cells by Modulating the PERK/eIF2α/ATF4/CHOP Pathway by CHEN Sainan, ZHOU Fen, HUANG Yunmei, LIN Yanping

“…ObjectiveTo observe and analyze the mechanism by which Jiangu Granules containing serum alleviate endoplasmic reticulum stress (ERS)-induced apoptosis in UMR-106 osteoblast-like cells.MethodsUMR-106 osteoblast-like cells were selected for the study, and various concentrations (0, 0.01, 0.02, 0.03, 0.04, 0.05 μmol/L) of GSK2606414 (PERK inhibitor) were employed to intervene in the cells. …”
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Topological Analysis of Brain Glucose Metabolic Connectivity Networks of Patients with Type 2 Diabetes Mellitus Combined with Mild Cognitive Impairment by LIANG Shengxiang, YANG Junchao, ZHANG Yusi, YIN Xiaolong, HUANG Li, LI Zuanfang

“…The nodal local efficiencies of left hippocampal (<italic>r</italic>=-0.363, <italic>P</italic>=0.002) and left parahippocampal gyrus (<italic>r</italic>=-0.362, <italic>P</italic>=0.002) were negatively correlated with EcogSPMem score.ConclusionThe abnormal topological structure of brain glucose metabolic connectivity network in patients with T2DM&amp;MCI might be one of the reasons for the decline in memory, which could provide a reference for the exploring of the neural mechanism of patients with T2DM&amp;MCI.…”
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Potentially commercializable nerve guidance conduits for peripheral nerve injury: Past, present, and future by Chundi Liu, Mouyuan Sun, Lining Lin, Yaxian Luo, Lianjie Peng, Jingyu Zhang, Tao Qiu, Zhichao Liu, Jun Yin, Mengfei Yu

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Effects of Exercise Preconditioning Mediating Oxidative Stress to Regulate PI3K/Akt and Nrf2/HO-1 Pathways to Alleviate Cognitive and Learning Disorders in Rats by KONG Haijun, LI Xinlong, WANG Fenghua, CHEN Xiaoan

“…ObjectiveTo explore the basic mechanism of exercise preconditioning regulating PI3K/Akt and Nrf2/HO-1 signa-ling pathways and oxidative stress to alleviate cognitive and learning disabilities in rats with hypoxic exposure.MethodsA total of sixty 6-week-old SPF male SD rats were divided into control group, exercise group, exposure group and exercise + exposure group according to random number table method, with 15 rats in each group. …”
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Characteristics of Traditional Human Settlement Landscapes on Bedrock Islands in Guangdong Based on the “Ao” Unit by Ying PAN, Linxi CHEN, Ying SHI

“…This combination of research paradigms and advanced analytical tools aims to uncover the mechanisms that have shaped the traditional human settlement landscape on Nan’ao Island over time.ResultsResearch results are summarized as follows. 1) The components and basic attributes of the Ao unit, the fundamental human settlement unit for the development of Bedrock Island, have been clarified. …”
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Analyzing Expressions of the Design Argument and Answering Doubts Attributed to it Based on the Type of Logical Reasoning by Shokoh Monazzam, Abbas Abbaszadeh, Naser Forouhi

“…Therefore, real believers would not conclude the existence of a contriver creature in the design argument based on knowing the world as a mechanical one but perceive an intelligent cause based on definite and obvious rules like causality and cause-effect suitability.…”
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Vibration therapy as an intervention for trochanteric hip fractures – A randomized double-blinded, placebo-controlled trial by Ronald Man Yeung Wong, Pui Yan Wong, Chaoran Liu, Chun Sing Chui, Wing Hong Liu, Ning Tang, James Griffith, Ning Zhang, Wing Hoi Cheung

“…Low-magnitude high-frequency vibration (LMHFV) is a biophysical intervention that provides non-invasive, systemic mechanical stimulation. The objectives of this study were to investigate the efficacy of LMHFV in trochanteric hip fracture elderly patients to (i) accelerate trochanteric fracture healing and (ii) improve clinical and functional outcomes. …”
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An exploratory study of INPP4B, a biomarker of gemcitabine chemoresistance in pancreatic cancer by REN Jiaqiang, WU Shuai, SU Tong, LI Jie, HAN Liang, WU Zheng

“…The use of gemcitabine as a first-line chemotherapeutic agent has not significantly improved patient prognosis, primarily due to the development of chemoresistance. The precise mechanisms underlying gemcitabine resistance in pancreatic cancer remain unclear. …”
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