Comprehensive Analysis of m5C RNA Methylation Regulator Genes in Clear Cell Renal Cell Carcinoma by Jiajin Wu, Chao Hou, Yuhao Wang, Zhongyuan Wang, Pu Li, Zengjun Wang

“…However, the function and mechanism of m5C RNA methylation regulators in clear cell renal cell carcinoma (ccRCC) remains undiscovered. …”
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Clinical outcome changes in sarcopenic obesity: a meta-analysis of exercise training methods by Lei Chen, Haojing Zhou, Yichen Gong, Yi Tang, Hai Su, Zhongyi Zhang, Peijian Tong, Guoqian Chen

“…This underscores the clinical significance of exercise intervention in treating muscle-reducing obesity, suggesting future studies explore exercise intervention’s role and mechanism, particularly related to IGF-1, IL-6, and other cytokines.…”
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The Multifaceted Roles of Myrrha in the Treatment of Breast Cancer: Potential Therapeutic Targets and Promises by Anwar Shams MD, MSc, PhD, Abdullah Ahmed Alzahrani, Taghreed A Ayash MSc, PhD, Shadi Tamur MD, FRCPC, FAAP, Majed AL-Mourgi MD, FRCS, FCCP, FACS

“…Nonetheless, myrrh’s precise rudimentary mechanisms of action in regulating genes involved in breast cancer evolution and progression remain elusive. …”
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TGF-β induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles by Dorival Mendes Rodrigues-Junior, Chrysoula Tsirigoti, Konstantina Psatha, Dimitris Kletsas, Michalis Aivaliotis, Carl-Henrik Heldin, Aristidis Moustakas

“…Conclusion Hence, we delineated a novel signaling cascade that leads to high rates of EV generation by cancer cells in response to TGF-β, with cholesterol being a key intermediate step in this mechanism. Graphical Abstract • TGF-β increases EV release by activating a MEK-ERK1/2-SREBP2-DHCR7 signaling and transcriptional pathway. • TGF-β-induced DHCR7 expression raises cholesterol abundance that promotes EV release. • EVs carry surface latent TGF-β and MMP9 that can activate TGF-β receptor signaling on the surface of recipient cells.…”
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Whole-genome resequencing landscape of adaptive evolution in Relict gull (Larus relictus) by Chao Yang, Qingxiong Wang, Kuo Sun, Lei Luo, Hao Yuan, Xuejuan Li, Yuan Huang, Hong Xiao

“…The findings identified several genes associated with the correlated changed life-history traits of L. relictus, including BMP4 involved in beak adaptation; HAND2, NEUROG1, COL11A2, and EDNRB involved in the evolution of the palate, soft palate, and tongue; PIGR and PLCB2 involved in an enhanced response to bitter taste by sensing chemical secretions released by staple food substrate insects to activate protective mechanisms. Furthermore, thirty-four genes related to sperm development and activity, including KLHL10 and TEKT3, were identified in the expanded gene family. …”
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29 m6A-RNA Methylation (Epitranscriptomic) Regulators Are Regulated in 41 Diseases including Atherosclerosis and Tumors Potentially via ROS Regulation – 102 Transcriptomic Dataset... by Ming Liu, Keman Xu, Fatma Saaoud, Ying Shao, Ruijing Zhang, Yifan Lu, Yu Sun, Charles Drummer, Li Li, Sheng Wu, Satya P. Kunapuli, Gerard J. Criner, Jianxin Sun, Huimin Shan, Xiaohua Jiang, Hong Wang, Xiaofeng Yang

“…Our findings shed new light on the functions of upregulated m6A-RMRs in 41 diseases and cancers, nine cellular and molecular mechanisms, novel therapeutic targets for inflammatory disorders, metabolic cardiovascular diseases, autoimmune diseases, organ failures, and cancers.…”
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Non-small Cell Lung Cancer Cell Line PC-9 Drug-resistant Mutant Cell Line 
Establishment and Validation of Their Sensitivity to EGFR Inhibitors by Tao HU, Yang LOU, Mingbo SU

“…This study provides a clinically relevant cellular evaluation and mechanism validation system for the development of a new generation of innovative drugs targeting EGFR mutation resistance.…”
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Risk prediction models for feeding intolerance in patients with enteral nutrition: a systematic review and meta-analysis by Huijiao Chen, Jin Han, Jing Li, Jianhua Xiong, Dong Wang, Mingming Han, Yuehao Shen, Wenli Lu

“…The top five predictors included in the model were APACHE II, age, albumin levels, intra-abdominal pressure, and mechanical ventilation. The reported AUC, or area under the curve, exhibited a range of values between 0.70 and 0.921. …”
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Determinants of anemia in school-going adolescents: a case study in Douala, Cameroon by Annick Suzanne Mbazoa Mbou, Godfroy Rostant Pokam Djoko, Alice Ketchaji, Sali Aristide Dama, Florence Irita, Verance Carline Kegha Ngodem, Manuela Tchinda Magne, Alex Kevin Tako Djimefo, Joelle Laure Sobngwi

“…Finally, longitudinal studies and intervention-based research are needed to better understand the causal mechanisms of adolescent anemia in this context.…”
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Pengaruh Valsartan Terhadap Fibrosis Ginjal pada Obstruksi Ureter by Alvarino .

“…Kesimpulan : Pemberian valsartan dengan dosis antihipertensi tidak<br />mengurangi tingkat fibrosis interstisial, degenerasi hidrofik, maupun atrofi tubulus pada obstruksi ureter unilateral<br />pada tikus wistar<br />Kata kunci: obstruksi ureter unilateral, valsartan, fibrosis interstisial<br />Abstract<br />Introduction: Ureteral obstruction is a condition that might happen at any age in any level with the worst<br />complication is permanent renal damage. There are several mechanisms that play role in renal damage in ureteral<br />obstruction. …”
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Therapeutic Potential of Social Chatbots in Alleviating Loneliness and Social Anxiety: Quasi-Experimental Mixed Methods Study by Myungsung Kim, Seonmi Lee, Sieun Kim, Jeong-in Heo, Sangil Lee, Yu-Bin Shin, Chul-Hyun Cho, Dooyoung Jung

“…However, the specific effects and mechanisms through which these chatbots influence mental health remain underexplored. …”
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INCREASED PULMONARY BLOOD FLOW IN NEWBORNS WITH CYANOTIC CONGENITAL HEART DEFECTS AND DUCTUS-DEPENDENT PULMONARY BLOOD FLOW: RESULTS AND FEATURES OF OUTPATIENT POSTOPERATIVE FOLLOW... by Anzhelika Mykhailovska, Olga Borodinova, Raad Tammo

“…(p=0.05), and the duration of mechanical ventilation in the SPAS group was 254 [39.5; 471] hours (from 63 to 751 hours), and in the group of PDA st. was shorter - 134 [92.75; 158.7] (from 39 to 549 hours) (p<0.05). …”
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Process Evaluations of Interventions for the Prevention of Type 2 Diabetes in Women With Gestational Diabetes Mellitus: Systematic Review by Iklil Iman Mohd Sa'id, Natasha Hotung, Madeleine Benton, Iliatha Papachristou Nadal, Anisah Baharom, Matthew Prina, Barakatun Nisak Mohd Yusof, Kimberley Goldsmith, Samantha Birts, Ching Siew Mooi, Angus Forbes, Khalida Ismail, Boon How Chew

“…While diabetes prevention interventions (DPIs) have been developed to delay or prevent the onset of T2DM, few studies have provided process evaluation (PE) data to assess the mechanisms of impact, quality of implementation, or contextual factors that may influence the effectiveness of the intervention. …”
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Inhibition of microRNA-139-5p Improves Fibroblasts Viability and Enhances Wound Repair in Diabetic Rats Through AP-1 (c-Fos/c-Jun) by Mo J, Zhang J, Meng X, Wang F, Tang W, Liu Y, Fu L, Liang F, Mo Z

“…Jiake Mo,1,2,&ast; Jiaqi Zhang,1,2,&ast; Xubiao Meng,3 Fang Wang,1,2 Weian Tang,1,2 Ying Liu,1,2 Lanfang Fu,3 Fang Liang,4 Zhaohui Mo1,2 1Department of Endocrinology, Third Xiangya Hospital of Central South University, Changsha, Hunan Province, People’s Republic of China; 2Diabetic Foot Research Center of Central South University, Changsha, Hunan Province, People’s Republic of China; 3Department of Endocrinology, Haikou People’s Hospital & Haikou Affiliated Hospital of Central South University Xiangya School of Medicine, Haikou, Hainan Province, People’s Republic of China; 4Department of Endocrinology, Xingtai People’s Hospital, Xingtai, Hebei Province, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zhaohui Mo; Fang Liang, Email easd04mzh@126.com; liangfang1024@163.comIntroductions: Diabetic foot ulcers (DFU) are notoriously difficult to heal, however, its underlying molecular mechanisms are unknown. MicroRNA-139-5p participates in various biological processes, including cancer and vascular endothelial injury, while its role in diabetic wound healing has not been reported.Methods: Sprague-Dawley (SD) rats were intraperitoneally injected with streptozotocin and a 1.0 cm full-layer dorsal skin wound was made to establish a diabetic wound model. …”
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PneumoniaCheck, a novel aerosol collection device, permits capture of airborne Mycobacterium tuberculosis and characterisation of the cough aeromicrobiome in people with tuberculos... by Tinaye L. Chiyaka, Georgina R. Nyawo, Charissa C. Naidoo, Suventha Moodley, Jose C. Clemente, Stephanus T. Malherbe, Robin M. Warren, David N. Ku, Leopoldo N. Segal, Grant Theron

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The Influence of Depression, Anxiety, and Stress on Ageism Among Undergraduates: Mediating Roles of Life Satisfaction, Gratitude, and Prosociality by Chen S, Wan Z

“…While considerable research has explored the impact of perceived ageism on older adults’ mental health, limited attention has been given to how negative mental health factors—such as depression, anxiety, and stress (DAS)—influence ageist attitudes among younger populations, along with the psychological mechanisms underlying this relationship.Purpose: This study first investigates the prevalence of ageism among undergraduates and its variation across certain socio-demographic factors at the research site. …”
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Anticancer Activity of Asiatic Acid from Centella Asiatica: A Comprehensive Systematic Review of In Vitro and In Vivo Studies by Fiki Muhammad Ridho, Panggih Fahrudin, Andika Julyanto Syachputra, Iren Angelia Aruan, Kamailiya Ulfah, Alfi Syahri

“…Based on the findings in the reviewed articles, we report that AsA, a triterpene derived from C. asiatica, exhibits anticancer effects demonstrated both in various cancer cell lines and in cancer cell-induced animal model, through several mechanisms, including anti-inflammatory effects, antioxidant effects, inhibition of cell proliferation, inhibition of invasion and migration, and induction of apoptosis and autophagy. …”
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Loss of histone H3K27me3 up-regulates SLC7A11 in diffuse gastric cancer cells by REN Yuanfeng, LIU Wenkang, CHU Zhaole

“…Objective‍　‍To map the genome-wide distribution profile of histone H3K27me3 modification in diffuse gastric cancer tissues， identify target genes regulated by H3K27me3， and primarily explore the potential mechanism of its modification reprogramming in the occurrence and development of the tumor. …”
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Automatic GPR detection of grouting defects behind the tunnel shield segments based on wavelet coherence analysis combined with modified Res-RCNN by Dengyi Wang, Ming Peng, Liu Liu, Xiongyao Xie, Zhenming Shi, Yaoying Liang, Jian Shen, Qiyu Wu

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Impact of First- and Second-Generation Tyrosine Kinase Inhibitors on the Development of Graft-Versus-Host Disease in Individuals with Chronic Myeloid Leukemia: A Retrospective Anal... by Ugo Giordano, Agnieszka Piekarska, Witold Prejzner, Lidia Gil, Jan Maciej Zaucha, Joanna Kujawska, Zuzanna Dybko, Krzysztof Dudek, Sebastian Giebel, Jarosław Dybko

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