Integrating bulk and single-cell RNA sequencing data: unveiling RNA methylation and autophagy-related signatures in chronic obstructive pulmonary disease patients by Shi-Xia Liao, Lan-Ying Zhang, Ling-Mei Shi, Huai-Yu Hu, Yan-Hui Gu, Ting-Hua Wang, Yao Ouyang, Peng-Peng Sun

“…These findings provide novel genetic insights into the epigenetic mechanisms of COPD and suggest potential avenues for developing diagnostic and therapeutic strategies.…”
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The Effects of Mesenchymal Stem Cells on Antimelanoma Immunity Depend on the Timing of Their Administration by Dragana Miloradovic, Dragica Miloradovic, Bojana Simovic Markovic, Aleksandar Acovic, Carl Randall Harrell, Valentin Djonov, Nebojsa Arsenijevic, Vladislav Volarevic

“…Although several possible explanations have been proposed, including different numbers of injected and engrafted MSCs, heterogeneity in phenotype, and function of tumor cells, the exact molecular mechanisms responsible for opposite effects of MSCs in modulation of antitumor immunity are still unknown. …”
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Reservoir water level decline accelerates ground subsidence: InSAR monitoring and machine learning prediction of surface deformation in the Three Gorges Reservoir area by Jiaer Yang, Jiaer Yang, Pinglang Kou, Pinglang Kou, Xu Dong, Xu Dong, Ying Xia, Qinchuan Gu, Yuxiang Tao, Jiangfan Feng, Qin Ji, Weizao Wang, Ram Avtar

“…Despite existing studies, systematic exploration of long-term deformation characteristics and their driving mechanisms remains limited. This study combines SBAS-InSAR technology and machine learning to analyze and predict surface deformation in Fengjie County, Chongqing, China, between 2020 and 2022, focusing on riverside urban ground, riverside road slopes, and ancient landslides in the reservoir area.MethodsSBAS-InSAR technology was applied to 36 Sentinel-1A images to monitor surface deformation, complemented by hydrological and meteorological data. …”
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Spatial Distribution Characteristics of Micronutrients and Their Deficiency Effect on the Root Morphology and Architecture in Citrus Rootstock by Gaofeng Zhou, Yiping Fu, Mei Yang, Yanhong Li, Jing Zhang

“…To clarify the spatial distribution characteristics of essential nutrients in citrus roots and the influence mechanism of micronutrient deficiency on citrus root morphology and architecture, especially the effects on lateral root (LR) growth and development, two commonly used citrus rootstocks, trifoliate orange (<i>Poncirus trifoliata</i> L. …”
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Kangtaizhi Granule Alleviated Nonalcoholic Fatty Liver Disease in High-Fat Diet-Fed Rats and HepG2 Cells via AMPK/mTOR Signaling Pathway by Jiaxin Zhang, Haixia Du, Menglan Shen, Zhengqi Zhao, Xinmiao Ye

“…However, the underlying mechanisms under this efficacy are rather elusive. In the present study, network pharmacology and HPLC analysis were performed to identify the chemicals of KTZG and related target pathways for NAFLD treatment. …”
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Reciprocal regulation between DNMT3A/3B and microRNAs miRs-299-3p/-30e is a causal factor for the downregulation of microRNAs targeting androgen receptor in prostate cancer by Kavya Ganapathy, Christian F. Harrs, Samuel Harris, Stephen J. Staklinski, Ayman Khatib, Jong Y. Park, Ratna Chakrabarti

“…This study establishes a feedback regulation between AR targeting miRNAs and DNMTs in PCa cells and provides an insight into the mechanism of the aberrant expression of AR in advanced PCa that is potentially mediated through the downregulation of miRs-299-3p, −34c and −30e and stabilization of expression and activities of DNMTs.…”
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End-to-End Stroke Imaging Analysis Using Effective Connectivity and Interpretable Artificial Intelligence by Wojciech Ciezobka, Joan Falco-Roget, Cemal Koba, Alessandro Crimi

“…This elucidates the effective connectivity biomarker&#x2019;s contribution to stroke classification, fostering insights into disease mechanisms and treatment responses. This transparent analytical framework not only enhances clinical interpretability but also instills confidence in decision-making processes, crucial for translating research findings into clinical practice. …”
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Atmospheric oxidation of 1,3-butadiene: influence of seed aerosol acidity and relative humidity on SOA composition and the production of air toxic compounds by M. Jaoui, K. Nestorowicz, K. Nestorowicz, K. J. Rudzinski, M. Lewandowski, T. E. Kleindienst, J. Torres, E. Bulska, W. Danikiewicz, R. Szmigielski

“…Although the terms “acidified” and “non-acidified” are true for the solutions from which the seeds were atomized, there are far more fundamental differences between the phase states in which species partition to or from (aqueous/solid), which considerably affects their partitioning and formation mechanisms. SOA mass and most SOA products (i) were higher under acidified seed conditions, where the aerosol particles were deliquescent, than under non-acidified seed conditions, where the aerosol particles did not contain any aqueous phase; (ii) increased with the acidity of the aerosol aqueous phase in the experiments under acidified seed conditions; and (iii) decreased with increasing RH. …”
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Systemic and mammary inflammation and mammary gland development of Holstein dairy cows around dry-off and calving by J. Gao, T.N. Marins, J.O.S. Calix, Z. Qi, C.G. Savegnago, A.M. Roper, M.W. Woldemeskel, J.K. Bernard, S. Tao

“…Our data also suggested that the increased mammary growth during the late gestation and early dry periods was mediated by different mechanisms. The concurrent increases in immune cell infiltration and mammary cell proliferation in the mammary gland following dry-off suggest an association between mammary immune responses and growth during the early dry period.…”
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The protein composition of human adenovirus replication compartments by Paloma Hidalgo, Amada Torres, Pierre M. Jean Beltran, Gamaliel López-Leal, Luca D. Bertzbach, Thomas Dobner, S. J. Flint, Ileana M. Cristea, Ramón A. González

“…We conducted quantitative proteome analyses of RC-enriched subnuclear fractions at different times post-infection with human adenovirus species C type 5, revealing a multifaceted network of proteins that participate in the regulation of gene expression, DNA damage response, RNA metabolism, innate immunity, and other cellular antiviral defense mechanisms. Furthermore, we validated the localization of several host proteins to viral RCs using immunofluorescence microscopy and immunoblotting and identified cellular HMGB1 as a proviral factor late during infection. …”
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Resveratrol contributes to NK cell-mediated breast cancer cytotoxicity by upregulating ULBP2 through miR-17-5p downmodulation and activation of MINK1/JNK/c-Jun signaling by Bisha Ding, Jie Li, Jia-Lin Yan, Chun-Yan Jiang, Ling-Bo Qian, Jie Pan

“…This study aims to investigate how RES affects the expression of ULBP2 and the sensitivity of breast cancer (BC) cells to NK cell cytotoxicity, along with the underlying mechanisms.MethodsThe effects of RES on ULBP2 expression were detected with qRT-PCR, western blot, flow cytometry analysis and immunohistochemistry. …”
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Emodin protects against severe acute pancreatitis-associated acute lung injury by activating Nrf2/HO-1/GPX4 signal and inhibiting ferroptosis in vivo and in vitro by Gang Shen, Haiyun Wen, Huijuan Li, Xuetao Zhang, Bowen Lan, Xuanchi Dong, Peng Ge, Yalan Luo, Hailong Chen

“…However, its protection mechanism in SAP-ALI needs to be further clarified. …”
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Immunological and autonomic profile of ischemic stroke in lowlands by Nargiza T. Chekeeva, Svetalana G. Shleifer, Bolot B. Kulov, Begimai B. Kadyrova, Asel T. Jusupova, Elena V. Andrianova

“…Research objective was to study immunological and autonomic parameters in patients with primary IS of varying severity in low-mountain conditions and clarify the pathogenesis and mechanisms underlying stroke severity. Methods: An observational cohort study was conducted involving 52 patients with primary IS divided into three groups: mild stroke (n = 12), moderate stroke (n = 28), and severe stroke (n = 12). …”
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Treatment-related Hypertension as a Prognostic Factor for De Novo Metastatic Hormone-sensitive Prostate Cancer: A Retrospective Real-world Evidence Study by Giuseppe Salfi, Martino Pedrani, Selin Candan, Vasile Urechie, Sara Merler, Lorenzo Ruinelli, Amos Colombo, Luis Castelo-Branco, Irene Testi, Fabio Turco, Luigi Tortola, Ursula Vogl, Luca Gabutti, Silke Gillessen, Ricardo Pereira Mestre

“…Larger studies are needed to validate these findings and explore the potential underlying mechanisms. Patient summary: In this report, we examined the outcomes of patients with metastatic hormone-sensitive prostate cancer and their correlation with hypertension toxicities. …”
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Prevalence and associated factors of multidimensional poverty among rural households in East Gojjam zone, Northern Ethiopia: a community-based cross-sectional study by Amare Wubishet Ayele, Yeshiwas Ewinetu, Asefa Delesho, Yirsie Alemayehu, Hayimro Edemealem

“…To address this issue, stakeholders should prioritize to promote climate-resilient agriculture and strengthening drought coping mechanisms. Furthermore, it is essential to account for the variations in poverty levels across different administrative units and ecological zones to effectively eradicate poverty among rural households.…”
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Whole-genome sequencing and metagenomics reveal diversity and prevalence of Listeria spp. from soil in the Nantahala National Forest by Jia Wang, Claire N. Schamp, Lauren K. Hudson, Harleen K. Chaggar, Daniel W. Bryan, Katie N. Garman, Mark Radosevich, Thomas G. Denes

“…Additionally, examining the ecological niches and survival mechanisms of Listeria in natural habitats provides insights into its persistence and adaptability, informing risk assessments and public health interventions. …”
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Roles of Rufy3 in experimental subarachnoid hemorrhage-induced early brain injury via accelerating neuronal axon repair and synaptic plasticity by Yang Wang, Jianguo Xu, Wanchun You, Haitao Shen, Xiang Li, Zhengquan Yu, Haiying Li, Gang Chen

“…In addition, we investigated the relevant brain-protective mechanisms. Oxyhemoglobin (OxyHb) stimulation of cultured primary neurons simulated vitro SAH condition. …”
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Temperature Sensitivity Response of Soil Enzyme Activity to Simulated Climate Change at Growth Stages of Winter Wheat by Yaokun Jiang, Bingbing Lu, Meng Liang, Yang Wu, Yuanze Li, Ziwen Zhao, Guobin Liu, Sha Xue

“…This study is of great significance in exploring the effects of global warming on food production and the mechanism of soil ecosystem functional stability under future climate change.…”
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Engineering a live-attenuated porcine reproductive and respiratory syndrome virus vaccine to prevent RNA recombination by rewiring transcriptional regulatory sequences by Liwei Li, Jinxia Chen, Zhengda Cao, Ziqiang Guo, Jiachen Liu, Yanjun Zhou, Guangzhi Tong, Fei Gao

“…The results have enriched our understanding of the critical role of TRS circuits in PRRSV recombination mechanisms and indicate a successful redesign that can endow PRRSV live vaccines with recombination-resistant capabilities.IMPORTANCEPorcine reproductive and respiratory syndrome viruses (PRRSVs) are genetically diverse, and this is due in part to their extensive recombination. …”
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Allelopathic Properties of the Species Comprising Communities of Invasive <i>Impatiens</i> spp. and Antioxidant System of Invaders’ Populations by Eugenija Kupcinskiene, Ruta Budreviciute, Vaida Jasionyte, Laura Simanaviciute, Lina Jociene, Edvina Krokaite-Kudakiene, Tomas Rekasius, Vitas Marozas

“…Allelopathy has been proposed as one of the possible invasion mechanisms of exotic plants. <i>Impatiens parviflora</i> and <i>Impatiens glandulifera</i> are among the widely spread invasive plant species in the Baltic region. …”
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