4-1BB agonist targeted to fibroblast activation protein α synergizes with radiotherapy to treat murine breast tumor models by Ignacio Melero, Alvaro Teijeira, Christian Klein, Maria E Rodriguez-Ruiz, Christina Claus, Pablo Umana, Tamara Tanos, Carlos E De Andrea, Carlos Luri-Rey, Paloma Sanchez-Mateos, Leticia Fernández-Rubio, María Collantes, Irantzu Serrano-Mendioroz, Celia Barrio-Alonso, Antonio Rullan, Jon Ander Simon, Eneko Garate-Soraluze, Claudia del Pilar Herrero

“…Selective monoclonal antibody (mAb)-mediated depletions of immune cell populations, neutralizing interferon alpha/beta receptor 1 (IFNAR-I) IFNAR and interferon (IFN)-γ mAbs and gene-modified mice (4-1BB−/−) were used to delineate the immune cell subsets and mechanisms required for efficacy. 67Ga labeled muFAP-4-1BBL tracked by SPECT-CT was used to study biodistribution. …”
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Target Groups for a Short Dexamethasone Course among Critically Ill COVID-19 Patients by Armen Oganesyan, Ruslan Menzulin, Yury Surovoy, Andrei Nikiforchin, Kirill Zykov

“…Subgroup analysis was performed to assess the impact of dexamethasone on mortality in patients with invasive mechanical ventilation (IMV). Results. Of 233 patients, 220 (median age: 65 years, 38% female) were included: 83 patients received dexamethasone and 137 received usual care. …”
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Relationship between internet gaming disorder, interpersonal needs, loneliness, and depression among adolescents using a chain mediation model by GAO-QU Yige, MUZAI Baier, DONG Jingwen, ZHAO Yuxi, ZHU Pengyu, GU Xicheng, LIU Shangbin, CAI Yong, YUAN Dong, WANG Ying

“…ObjectiveTo explore the relationships between internet gaming disorder (IGD), interpersonal needs, loneliness, and depression in adolescents through the construction of a chain mediation model, to clarify the underlying mechanisms of these associations, and to provid a theoretical basis for depression prevention and intervention.MethodsBased on the data of the 7th Population Census, using convenient sampling method 1 106 adolescents aged between 10‒19 years in South China (176), North China (147), Central China (332), and East China (451) were selected to conduct a cross-sectional survey, with a ratio of 1∶1∶1.5∶2.5. …”
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Mamá Empoderada: study protocol for a pilot trial of a novel parenting and mental health prevention intervention for migrant mothers with young children at the Mexico-US border by Gudelia Rangel, Shira M Goldenberg, Eileen Pitpitan, Kaylee Ramage, Ietza Bojorquez-Chapela, Cecilia Martinez-Torteya, Katherine Rosenblum, Chelsie Hernandez, Monica Alvarez

“…The aim of this study is to pilot-test a novel parenting and mental health prevention intervention for migrant mothers with young children (MMC) in Tijuana, Mexico, including (a) assessing acceptability; (b) estimating effect sizes on symptoms of depression, anxiety, and parenting stress; (c) identifying which theory-based mechanisms of action predict changes in outcomes; and (d) identifying factors associated with differential intervention response.Methods and analysis ‘Mamá Empoderada’ (Mom Power) is a theory-based, trauma-informed group intervention to promote mental health and responsive parenting among mothers with young children (0–5 years). …”
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AGD1/USP10/METTL13 complexes enhance cancer stem cells proliferation and diminish the therapeutic effect of docetaxel via CD44 m6A modification in castration resistant prostate can... by Hong Wang, Chunli Cui, Weiyi Li, Hui Wu, Jianjun Sha, Jiahua Pan, Wei Xue

“…To uncover the underlying mechanisms of AGD1, RNA pull-down assay, RIP, co-Immunoprecipitation (co-IP), mass spectrometry (MS), Methylated RNA immunoprecipitation (MeRIP) and single-base elongation and ligation-based qPCR amplification method (SELECT) were performed. …”
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MAZ-mediated tumor progression and immune evasion in hormone receptor-positive breast cancer: Targeting tumor microenvironment and PCLAF+ subtype-specific therapy by Gaofeng Ni, Yuwei Sun, Hongling Jia, Zhikai Xiahou, Yumeng Li, Fu Zhao, Hongyan Zang

“…Understanding the molecular mechanisms behind this resistance, including tumor heterogeneity and changes in the tumor microenvironment, was crucial for overcoming resistance, identifying new therapeutic targets, and developing more effective personalized treatments. …”
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Species Diversity, Biomass Production and Carbon Sequestration Potential in the Protected Area of Uttarakhand, India by Geetanjali Upadhyay, Lalit M. Tewari, Ashish Tewari, Naveen Chandra Pandey, Sheetal Koranga, Zishan Ahmad Wani, Geeta Tewari, Ravi K. Chaturvedi

“…Further, comprehending the carbon storage mechanisms of these forests will be critical for developing environmental management strategies aimed at alleviating the impacts of climate change in the years to come.…”
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Canopy structure modulates the sensitivity of subalpine forest stands to interannual snowpack and precipitation variability by M. Berkelhammer, G. F. M. Page, G. F. M. Page, F. Zurek, C. Still, C. Still, M. S. Carbone, M. S. Carbone, W. Talavera, L. Hildebrand, J. Byron, K. Inthabandith, A. Kucinski, M. Carlson, K. Foss, W. Brown, R. W. H. Carroll, A. Simonpietri, M. Worsham, I. Breckheimer, I. Breckheimer, A. Ryken, R. Maxwell, R. Maxwell, D. Gochis, M. S. Raleigh, E. Small, K. H. Williams, K. H. Williams

“…Using the sap velocity data along with supporting measurements of soil moisture and snow depth, we propose three mechanisms that lead to stand density modulating the tree-level response to changing seasonality of precipitation: </p><ol><li> <p id="d2e396"><span id="page702"/>Topographically mediated convergence zones have consistent access to recharge from snowmelt which supports denser stands with high water demands that are more reliant and sensitive to changing snow.…”
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Prevalence of carbapenemase-encoding genes carriage in patients admitted to multidisciplinary hospital in Moscow by Ni O.G., Shifman E.M., Yakovlev S.V., Bykov A.O., Gorbacheva A.A., Kruglov A.N., Belotserkovskiy B.Z., Matyushkov N.S., Galata A.A., Protsenko D.N.

“…Additional lower respiratory tract samples were collected from patients who were undergoing mechanical ventilation. The collected samples were tested by polymerase chain reaction using AmpliSens reagent kits to identify crabapenemase-encoding genes: blaOXA-58, blaOXA-51, blaOXA-40, blaOXA-23, blaVIM, blaIMP, blaOXA-48, blaNDM and blaKPC. …”
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Natural Product Identification and Molecular Docking Studies of Leishmania Major Pteridine Reductase Inhibitors by Moses N. Arthur, George Hanson, Emmanuel Broni, Patrick O. Sakyi, Henrietta Mensah-Brown, Whelton A. Miller, Samuel K. Kwofie

“…A 100 ns MD combined with molecular mechanics Poisson–Boltzmann surface area (MM/PBSA) calculations confirmed the robust binding interactions and provided insights into the dynamics and stability of the protein–ligand complexes.…”
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Proof of concept for multirotor systems with vortex-generating modes for regenerative wind energy: a study based on numerical simulations and experimental data by F. Avila Correia Martins, A. van Zuijlen, A. van Zuijlen, C. Simão Ferreira

“…The results indicate that, when the ABL-control strategy is employed, vertical momentum flux may become the dominant mechanism for wake recovery. In configurations with two or four ABL-control wings, the total wind power in the wake recovers to 95 % of the free-stream value at positions as early as <span class="inline-formula"><math xmlns="http://www.w3.org/1998/Math/MathML" id="M1" display="inline" overflow="scroll" dspmath="mathml"><mrow><mi>x</mi><mo>/</mo><mi>D</mi><mo>≈</mo><mn mathvariant="normal">6</mn></mrow></math><span><svg:svg xmlns:svg="http://www.w3.org/2000/svg" width="42pt" height="14pt" class="svg-formula" dspmath="mathimg" md5hash="f1f50c65a676d34319b7e018d39c81d7"><svg:image xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="wes-10-41-2025-ie00001.svg" width="42pt" height="14pt" src="wes-10-41-2025-ie00001.png"/></svg:svg></span></span> downstream of the multirotor system, representing a recovery rate that is approximately an order of magnitude faster than that observed in the baseline wake without ABL-control capabilities. …”
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Integrated bioinformatics analysis to explore potential therapeutic targets and drugs for small cell carcinoma of the esophagus by Maofei Zhu, Maofei Zhu, Yueming Chu, Yueming Chu, Qiang Yuan, Qiang Yuan, Junfeng Li, Silin Chen, Lin Li, Lin Li, Lin Li

“…Therefore, a deeper understanding of the therapeutic targets and the mechanisms underlying its occurrence and development is of great importance for early diagnosis, identification of potential therapeutic agents and improvement of the prognosis for patients.MethodsFirstly, the dataset of SCCE was downloaded from the GEO database and GEO2R tool was employed for the analysis of differentially expressed genes (DEGs). …”
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Risk factors associated with in-hospital mortality during yellow fever outbreak in Brazil by Max McClure, Izabela Maurício de Rezende, Leonardo Soares Pereira, Maria Rita Teixeira Dutra, Jordana Rodrigues Barbosa Fradico, Rodrigo Macedo, Marcelle Cardoso Marçal, Lívia Soares Coelho Fonte Boa, Alexandre Maurício Castro Bragato, Flávio Augusto de Almeida Faria, Livia Pamplona, Rodrigo Fabiano do Carmo Said, Carlos Eduardo Calzavara-Silva, Dario Brock Ramalho, Cintia Lopes de Brito Magalhães, Pedro Augusto Alves, Thaysa Drummond Palmeira Gama, Gláucia Fernandes Cota, Thomas P. Monath, Olindo Assis Martins-Filho, Marcelo Antônio Pascoal-Xavier, Andrea Teixeira-Carvalho, Betânia Paiva Drumond, A. Desiree LaBeaud, Yellow Fever Collaborative Group, Argus Leão Araújo, Barbara Lenoir, Bruno Dala Vedova Gomes Beato, Carolina Lins Rodrigues Vieira, Daniel Vitor de Vasconcelos Santos, Flavia Mansur Starling, Gabriela Miana de Mattos Paixão, Indiara Penido, Izabela Aparecida Coelho, Leandro Henrique Malta Cunha, Letícia Menezes, Livia Frota Rabelo, Letícia Lemos Jardim, Lívia Fulgêncio da Cunha Melo, Lívia Zignago Moreira dos Santos, Ludmila de Paula, Luísa Lages de Abre Paladino, Natalia Soares Albuquerque, Simone Lopes Oliveira Lemos, Tayrine Araújo

“…In-hospital mortality (hypothesis formulated after data collection), demographic factors and clinical and laboratory assessments were used.ResultsStudy patients were mainly men (87.6%), with a median age of 46.0 (IQR 36.5, 57.0). 131 (46.3%) patients were admitted to the ICU, and 62 (22.0%) used invasive mechanical ventilation for a median of 2 days (IQR 1, 3). …”
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Effect of colloidal particle size on physicochemical properties and aggregation behaviors of two alkaline soils by Y. Yan, X. Zhang, C. Xu, C. Xu, J. Liu, F. Hu, F. Hu, Z. Geng, Z. Geng

“…The purposes of the present study are to clarify how particle size affects the physicochemical properties and aggregation kinetics of soil colloids and to further reveal the underlying mechanisms. Soil colloidal fractions, from two alkaline soils – Anthrosol and Calcisol – were subdivided into three ranges: <span class="inline-formula"><i>d</i>&lt;2</span> <span class="inline-formula">µ</span>m, <span class="inline-formula"><i>d</i>&lt;1</span> <span class="inline-formula">µ</span>m and <span class="inline-formula"><i>d</i>&lt;100</span> nm. …”
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Prevalence and determinants of faecal carriage of carbapenem- and third-generation cephalosporin-resistant Enterobacterales: a cross-sectional household survey in northern VietnamR... by Max van Wijk, Hoang Huy Tran, Bich Ngoc Thi Vu, Costanza Tacoli, Tu Cam Thi Nguyen, Quynh Dieu Pham, Thương Hong Thi Nguyen, Trang Thu Nguyen, Hien Anh Thi Nguyen, Tung Son Trinh, Thai Duy Pham, Huong Kieu Thi Tran, Dung Tien Viet Vu, Duc Anh Dang, Tien Dac Tran, Duong Thanh Nguyen, H. Rogier van Doorn, Thomas Kesteman, Sonia Lewycka

“…Further research is required to understand the mechanisms behind these associations. Funding: This work was supported by Oxford University Clinical Research Unit internal grants in Vietnam from the Wellcome Trust Africa Asia Programme core grants (2015-2022—106680/Z/14/Z, and 2022-2029—225167/Z/22/Z).…”
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PD-L1/TLR7 dual-targeting nanobody-drug conjugate mediates potent tumor regression via elevating tumor immunogenicity in a host-expressed PD-L1 bias-dependent way by Wei Huang, Ji Zhou, Jia Li, Yakun Wan, Chao Hu, Meng Liu, Pan Xu, Feng Tang, Jianhua Sun, Xiaolu Yu, Yiru Long, Binfan Chen, Yongliang Tong, Mengwen Shan, Xiaomin Jia, Henglei Lu, Runqiu Chen, Jin Ren, Guangyi Jin, Likun Gong

“…Immunophenotyping, immune cell depletion, tumor rechallenge, RNA sequencing and PD-L1-deficient models were combined to determine the mechanism for NDCs function. The dynamics of the in vivo behaviors of NDCs were assessed based on multiorgan changes in PD-L1 levels.Results The screened PD-L1 nanobodies were characterized as tumor-targeting and alleviated T-cell immunosuppression. …”
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m6A demethylase CpALKBH regulates CpZap1 mRNA stability to modulate the development and virulence of chestnut blight fungus by Lijiu Zhao, Xiangyu Wei, Fengyue Chen, Baoshan Chen, Ru Li

“…Collectively, our findings highlight the essential role of CpALKBH as an m6A demethylase in the development and virulence of C. parasitica, while also elucidating the molecular mechanisms through which m6A modification impacts CpZap1 mRNA stability.IMPORTANCEN6-methyladenosine (m6A) is the most abundant eukaryotic mRNA modification and is involved in various biological processes. …”
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Sdd3 regulates the biofilm formation of Candida albicans via the Rho1-PKC-MAPK pathway by Li Mei Pang, Guisheng Zeng, Eve Wai Ling Chow, Xiaoli Xu, Ning Li, Yee Jiun Kok, Shu Chen Chong, Xuezhi Bi, Jiaxin Gao, Chaminda Jayampath Seneviratne, Yue Wang

“…Understanding the molecular mechanisms governing biofilm formation is crucial for developing anti-biofilm therapies. …”
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Potential diagnostic tools for intensive care unit acquired weakness: A systematic review by Chen Xin, Yubiao Gai, Lili Wei, Yanqiu Wang, Yuhong Luo, Binru Han

“…Background: Intensive care unit-acquired weakness is a prevalent complication among critically ill patients, associated with heightened mortality rates, extended durations of mechanical ventilation and hospital stays, as well as diminished mobility and unfavorable prognoses. …”
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Social vulnerability and genetic service utilization among unaffected BRIDGE trial patients with inherited cancer susceptibility by Jemar R. Bather, Melody S. Goodman, Adrian Harris, Guilherme Del Fiol, Rachel Hess, David W. Wetter, Daniel Chavez-Yenter, Lingzi Zhong, Lauren Kaiser-Jackson, Rachelle Chambers, Richard Bradshaw, Wendy Kohlmann, Sarah Colonna, Whitney Espinel, Rachel Monahan, Saundra S. Buys, Ophira Ginsburg, Kensaku Kawamoto, Kimberly A. Kaphingst, on behalf of the BRIDGE research team

“…Conclusions These results underscore the importance of investigating social and structural mechanisms as potential pathways to increasing genetic testing uptake among patients with increased inherited risk of cancer. …”
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