Characterization of the bioaccumulation and toxicity of copper pyrithione, an antifouling compound, on juveniles of rainbow trout by Bourdon, Charlotte, Cachot, Jérôme, Gonzalez, Patrice, Couture, Patrice

“…Among them, copper pyrithione (CuPT) is used, but its mechanisms of toxicity remain little known. This project aimed to identify and measure the impacts of aqueous exposure to CuPT, an organic compound, and compare it to ionic Cu2+ added in the form of its inorganic salt CuSO4, in equivalent Cu2+ molar concentrations, on rainbow trout (Oncorhynchus mykiss) juveniles under controlled laboratory conditions. …”
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Single-cell profiling reveals a reduced epithelial defense system, decreased immune responses and the immune regulatory roles of different fibroblast subpopulations in chronic atro... by Lin Lin, Tingxuan Huang, Lizhi Li, Yang Lin, Feng Chen, Ziyi Zheng, Jie Zhou, Yizhe Wang, Weihao You, Yujie Duan, Yawen An, Shiwei He, Weimin Ye

“…Abstract Purpose To identify key cellular changes and molecular events in atrophic mucosa, we aimed to elucidate the molecular mechanisms driving the occurrence of chronic atrophic gastritis (CAG). …”
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Overcoming barriers to the development of clean and digital energy start-ups: access to credit and protection of minority investors' rights by Artyukhov Artem, Oleksii Havrylenko, Olena Churikanova, Kseniia Mohylna

“…The study's primary aim is to analyse how financial mechanisms and governance safeguards influence start-up development in the clean and digital energy sectors. …”
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Role of sphingolipid metabolism signaling in a novel mouse model of renal osteodystrophy based on transcriptomic approach by Yujia Wang, Yan Di, Yongqi Li, Jing Lu, Bofan Ji, Yuxia Zhang, Zhiqing Chen, Sijie Chen, Bicheng Liu, Rining Tang, Yuanyuan Ji

“…ROD increases the risk of fracture and mortality in CKD patients. The underlying mechanisms of ROD remain elusive, partially due to the absence of an appropriate animal model. …”
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A method for evaluating the accessibility of underground auxiliary transportation vehicles in coal mines based on multi feature fusion by Fan JIANG, Yifan LIU, Zhencai ZHU, Chaofan ZHANG, Gongbo ZHOU, Yuxing PENG

“…Progressive probability Hough transform and Catmull Rom spline curve with improved feature point selection are used to fit the straight track and curved track separately, forming a railway track detection method based on a switchable model; Secondly, based on the color attributes of coal mine underground tunnel wall pipelines, a pipeline feature detection strategy is constructed through HSV color space transformation, edge detection, and least squares fitting algorithms; Once again, a weighted fusion method based on pipeline and rail feature points is proposed to extract the centerline trajectory of auxiliary transportation vehicles, and to construct rules for generating safe passage areas for auxiliary transportation vehicles; Then, for the over-segmentation problem in the traditional watershed algorithm, two-dimensional edge and area feature extraction of static obstacles is carried out by using improved watershed segmentation based on markers and GraphCut algorithm, and a small-sample classification support vector mechanism is selected to build a pedestrian detection model based on the fusion of HOG (Histograms of Oriented Gradients)features and LBP(Local Binary Pattern) features for underground coal mine, so as to realize the comprehensive detection of dynamic and static obstacles in front of auxiliary transportation vehicles; Finally, the positional relationship between obstacles and safe passage area is judged by Euclidean distance to determine the obstacle invasion, and the results of auxiliary transportation vehicle passability assessment are obtained. …”
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Differentiation status determines the effects of IFNγ on the expression of PD-L1 and immunomodulatory genes in melanoma by Teitur Sævarsson, Adrián López García de Lomana, Ólafur Sánchez, Veerle van Esch, Gunnar Bjarni Ragnarsson, Siggeir Fannar Brynjólfsson, Eiríkur Steingrímsson, Berglind Ósk Einarsdóttir

“…Inhibition of the JAK kinases, NF-κB and STAT3 with small molecule inhibitors, and siRNA mediated knockdown of STAT1 and IRF1 was applied to investigate the molecular mechanism behind IFNγ induced PD-L1 expression in dedifferentiated melanoma cells. …”
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The interaction of tPA with NMDAR1 drives neuroinflammation and neurodegeneration in α-synuclein-mediated neurotoxicity by Daniel Torrente, Enming J. Su, Alí Francisco Citalán-Madrid, Gerald P. Schielke, Daniel Magaoay, Mark Warnock, Tamara Stevenson, Kris Mann, Flavie Lesept, Nathalie Delétage, Manuel Blanc, Erin H. Norris, Denis Vivien, Daniel A. Lawrence

“…To characterize the mechanism of tPA action in α-synuclein-mediated pathology in the SN and to identify possible therapeutic pathways, we performed RNA-seq analysis of the SN and used multiple transgenic mouse models. …”
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Spatial-Temporal Variation and Driving Forces of Carbon Storage at the County Scale in China Based on a Gray Multi-Objective Optimization-Patch-Level Land Use Simulation-Integrated... by Gui Chen, Qingxia Peng, Qiaohong Fan, Wenxiong Lin, Kai Su

“…This study deepened, to a certain extent, the research on spatiotemporal dynamics simulation of carbon storage and its driving mechanisms under land-use changes in mountainous forest ecosystems. …”
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Impact of a positive end-expiratory pressure on oxygenation, respiratory compliance, and hemodynamics in obese patients undergoing laparoscopic surgery in reverse Trendelenburg pos... by Gulfairus A. Yessenbayeva, Aizhan M. Meyerbekova, Sergey I. Kim, Murat B. Zhumabayev, Gulbanu S. Berdiyarova, Sanzhar B. Shalekenov, Dinara S. Zharlyganova, Irina Y. Mukatova, Yekaterina A. Yukhnevich, Dmitriy A. Klyuyev, Andrey I. Yaroshetskiy

“…Abstract Background High and individual positive end-expiratory pressure (PEEP) during laparoscopic surgery may improve oxygenation and respiratory mechanics. Methods We searched RCTs in PubMed, Cochrane Library, Web of Science, and Google Scholar from from from January 2000 to December 2023 comparing the different intraoperative PEEP (low PEEP (LPEEP): 0–5 mbar; moderate PEEP (MPEEP): 6–9 mbar; high PEEP (HPEEP): >=10 mbar; individualized PEEP (iPEEP): PEEP set by special physiological technique) on arterial oxygenation, respiratory compliance (Cdyn) or driving pressure, mean arterial pressure (MAP), and heart rate (HR) in patients during laparoscopic surgery in reverse Trendelenburg position. …”
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A Meta analysis on effect of auricular point sticking and pressing therapy in the treatment of hyperemesis gravidarum (耳穴贴压法治疗妊娠恶阻临床疗效的Meta分析) by TIAN Tian (田恬), XIE Wei (谢薇), DENG Yunyan (邓云燕), LI zhongqing (李忠琴), ZHANG yang (张杨), ZHAO Su (赵苏)

“…Conclusion Auricular point sticking and pressing therapy is better than basic therapy in the treatment of hyperemesis gravidarum. However, the mechanism of auricular plaster therapy is not clear and needs to be studied. …”
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Molecular characterization of ST15 carbapenem-resistant Klebsiella pneumoniae isolated in a single patient by Yongjin Hu, Rong Tang, Shanshan Jin, Jiahao Guan, Xiaoxiao Meng, Zengpeijie Dan, Ruilan Wang, Hong-Yu Ou, Jian Lu

“…In this study, we analysed the clinical and molecular characteristics of drug resistance changes in KP strains isolated from a single patient, and the potential mechanisms underlying these resistance changes. Methods: Antimicrobial susceptibility test and string test were conducted to evaluate the resistant and virulent characterization of the strains. …”
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CCAAT/Enhancer-Binding Protein β Mediates Oxygen-Induced Retinal Neovascularization via Retinal Vascular Damage and Vascular Endothelial Growth Factor by Tingting Li, Xuan Cai, Xiangning Wang, Xueyan Zhang, Hui Zhang, Biwei Xu, Shiwei Li, Jianyan Hu, Qiang Wu

“…C/EBP β shRNA inhibits RNV in OIR. A potential mechanism may be that the activity of C/EBP β increases with its overexpression, which in turn aggravates the amount of the retinal vascular damage and promotes transcription of VEGF. …”
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Yeast cell wall polysaccharides accelerate yet in-feed antibiotic delays intestinal development and maturation via modulating gut microbiome in chickens by Fangshen Guo, Jianing Qiao, Zeqiong Hu, Jia Huang, Ruichen Bi, Waseem Abbas, Wenrui Zhen, Yuming Guo, Zhong Wang

“…This study aimed to investigate the effects of dietary yeast cell wall polysaccharides (YCWP) addition on intestinal development and maturation of chickens and its potential action mechanism. Methods 180 one-day-old male Arbor Acres broilers were randomly assigned to three groups containing control (basal diets without any antibiotics or anticoccidial drug), bacitracin methylene disalicylate (BMD)-treated group (50 mg/kg) and YCWP-supplemented group (100 mg/kg). …”
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Adherence to a digital therapeutic mediates the relationship between momentary self-regulation and health risk behaviors by Enzo G. Plaitano, Enzo G. Plaitano, Daniel McNeish, Sophia M. Bartels, Sophia M. Bartels, Kathleen Bell, Jesse Dallery, Michael Grabinski, Michaela Kiernan, Hannah A. Lavoie, Hannah A. Lavoie, Shea M. Lemley, Michael R. Lowe, David P. MacKinnon, Stephen A. Metcalf, Stephen A. Metcalf, Lisa Onken, Judith J. Prochaska, Cady Lauren Sand, Cady Lauren Sand, Emily A. Scherer, Luke E. Stoeckel, Haiyi Xie, Lisa A. Marsch

“…Self-regulation is one fundamental behavior change mechanism often incorporated within digital therapeutics as it varies momentarily across time and contexts and may play a causal role in improving these health behaviors. …”
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An analysis of the Policy of Increasing the Salaries of Government Employees Based on the Framework of Kingdon's Multiple Streams (Case Study of Budget Law 1401) by Seyyed Mojtaba Shahraeini, Heidar Najafi, Seyyedamir Abbaszade, Mahdi Khosravi, Iman Akbari

“…These concerns are also a continuous focus for government employees. Consequently, the mechanism and amount of salary increases for government employees, in a fair and proportionate manner, remain a challenging aspect of the interactions between the government, parliament, and other stakeholders. …”
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Screening and Identification of Cold-Tolerant Phosphorus and Potassium Solubilizing Bacteria and Their Growth-Promoting Effects on Soybean in Cold Regions by Hao Yan, Tianyi Wang, Haocheng Wang, Nan Sun, Xuebing Wang, Xingbo Zhao, Zhongbao Yao, Hao Tian, Shengjie Chen, Songyan Tang, Chenyang Li

“…We analyzed the strain’s phosphorus/potassium solubilizing capacity, as well as its organic acid secretion ability, to reveal its mechanism of detoxification of phosphorus and potassium. …”
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Gut microbiota drives colon cancer risk associated with diet: a comparative analysis of meat-based and pesco-vegetarian diets by Carlotta De Filippo, Sofia Chioccioli, Niccolò Meriggi, Antonio Dario Troise, Francesco Vitali, Mariela Mejia Monroy, Serdar Özsezen, Katia Tortora, Aurélie Balvay, Claire Maudet, Nathalie Naud, Edwin Fouché, Charline Buisson, Jacques Dupuy, Valérie Bézirard, Sylvie Chevolleau, Valérie Tondereau, Vassilia Theodorou, Claire Maslo, Perrine Aubry, Camille Etienne, Lisa Giovannelli, Vincenzo Longo, Andrea Scaloni, Duccio Cavalieri, Jildau Bouwman, Fabrice Pierre, Philippe Gérard, Françoise Guéraud, Giovanna Caderni

“…An inverse correlation between nonconjugated bile acids and bacterial genera mainly belonging to the Lachnospiraceae and Prevotellaceae families (representative of the PVD group) was present, suggesting a potential mechanism of action for the protective effect of these genera against CRC. …”
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Clinical Characteristics of COVID-19 in Neonates and Infants Younger Than 3 Months by Fatemeh Varshoei, Mohammad Sadegh Rezai, Roya Farhadi, Azin Hajialibeig, Saeid Mohammadi, Masoud Moradi, Fatemeh Hosseinzadeh

“…Twenty-nine patients (19.1%) required intensive care unit (ICU) admission, and 6(3.9%) underwent mechanical ventilation (P=0.463 and P=0.126, respectively). …”
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The compensatory enrichment of sphingosine-1-phosphate on HDL in FSGS enhances the protective function of glomerular endothelial cells compared to MCD by Yunfeng Xiong, Qiuping Ye, Lifang Liu, Wanjun Lin, Yonggen Liao, Ruiyu Gao, Jiaming Xu, Xinyu Zhang, Ruoyan Chen, Sihui Chen, Qiaoling Chen, Lixin Wei

“…Knockdown of S1PR1 using siRNA reduced the expression of p-eNOS and NO release. The mechanism underlying the regulation of p-eNOS expression by rHDL was associated with the PI3K-AKT signaling pathway. …”
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Neuropsychiatric profile in tuberous sclerosis complex patients with epilepsy by Mahmoud Fawzi Osman, Mahmoud Fawzi Osman, Faisal Hadid, Tawfeg ben Omran, Tawfeg ben Omran, Tawfeg ben Omran, Munira Aden, Fatima Al-Maadid, Sondos Altaraqji, Khalid Mohamed, Ruba Benini, Ruba Benini

“…Further research is required to clarify the mechanisms underlying these associations and to develop targeted interventions for improving the quality of life for individuals with TSC and epilepsy.…”
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