Toxicity of Low-dose Graphene Oxide Nanoparticles in an in-vivo Wild Type of Caenorhabditis elegans Model by Ming-Hsien Tsai, How-Ran Chao, Jheng-Jie Jiang, Yu-Hsieh Su, Mariene-syne P. Cortez, Lemmuel L. Tayo, I-Cheng Lu, Hao Hsieh, Chih-Chung Lin, Sheng-Lun Lin, Wan Nurdiyana Wan Mansor, Ching-Kai Su, Sen-Ting Huang, Wen-Li Hsu

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Hyaluronic Acid-Based Hybrid Nanoparticles as Promising Carriers for the Intranasal Administration of Dimethyl Fumarate by Serri C, Piccioni M, Guarino V, Santonicola P, Cruz-Maya I, Crispi S, Di Cagno MP, Ferraro L, Dalpiaz A, Botti G, Giunchedi P, Rassu G, Gavini E

“…Lipid-polymer hybrid nanoparticles (LPNs) were developed to improve DMF stability, limiting gastrointestinal side effects and increasing brain bioavailability by nose-to-brain targeting application.Methods: DMF-loaded and unloaded LPNs with or without hyaluronic acid (HA) were prepared using the nanoprecipitation via magnetic/mechanical stirring technique. Particle morphology and surface properties were evaluated; drug content, viscosity, and mucoadhesion were determined. …”
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The Prognostic Value and Overexpression of Cyclin A Is Correlated with Gene Amplification of both Cyclin A and Cyclin E in Breast Cancer Patient by A. Husdal, G. Bukholm, I. R. K. Bukholm

“…In this study we wanted to evaluate the mechanisms behinde overexpression of cyclin A, as well as the impact of other cyclins, both at the gene level and at the protein level, on prognosis of breast cancer patients. …”
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Combination Fractional Carbon Dioxide Laser Treatment and Bone Marrow Mesenchymal Stem Cell Therapy Enhances the Treatment of Skin Photoaging in a Murine Model System by Li L, He Z, Yu C, Zhang C, Yu Y, Li Y, Xu X

“…Li Li,1– 3,* Zeyu He,3– 5,* Chengqian Yu,3– 5 Chao Zhang,3– 5 Yanqiu Yu,6 Yuanhong Li,3– 5 Xuegang Xu3– 5 1ShanXi Medical University, Taiyuan, People’s Republic of China; 2Department of Dermatology, The First Hospital of ShanXi Medical University, Taiyuan, 030001, People’s Republic of China; 3Department of Dermatology, The First Hospital of China Medical University, Shenyang, 030001, People’s Republic of China; 4Key Laboratory of Immunodermatology (China Medical University), Ministry of Education, Shenyang, 110001, People’s Republic of China; 5NHC Key Laboratory of Immunodermatology (China Medical University), Shenyang, 110001, People’s Republic of China; 6Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang, 110122, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xuegang Xu, Department of Dermatology, The First Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping District, Shenyang, Liaoning Province, 110001, People’s Republic of China, Email xuxuegang2749290@163.com Li Li, Department of Dermatology, The First Hospital of ShanXi Medical University, No. 85 South Jiefang Road, Yingze District, Taiyuan, Shanxi Province, 030001, People’s Republic of China, Email lilizaimu0807@163.comBackground: Fractional carbon dioxide lasers and bone marrow mesenchymal stem cells (BMSCs) are commonly employed in the treatment of skin photoaging.Objective: This study was developed to explore the effects of combination carbon dioxide laser treatment and BMSC injection on skin photoaging and the underlying molecular mechanisms.Methods & Materials: In total, 24 mice with experimentally photoaged skin were separated into control, carbon dioxide fractional laser treatment, combination therapy, and BMSC injection groups. …”
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A STUDY OF THE INFLUENCE OF EXTRACELLULAR VESICLES ON THE MORPHOFUNCTIONAL STATE OF THE ENDOMETRIUM IN VITRO by Оксана Александровна Мелкозерова, Ирина Викторовна Крутинь, Александра Юрьевна Храмцова, Мария Валерьевна Улитко, Алсу Фармутовна Мустафина

“…The resulting tissue fragments were placed in a phosphate-saline solution with the addition of penicillin-streptomycin, gentamicin and amphotericin for transportation. A combination of mechanical and chemical methods was used to isolate primary cells. …”
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Factors Affecting Negative Symptoms in Schizophrenia and Their Relationship with Anxiety and Depression by Zeng G, Liang R, Xiao L, Cao W, Zhou W, Wang W, Liu C, Zhou H, Shi X, Chen B, Chen W

“…Meanwhile, these symptoms are closely linked to anxiety and depression, further complicating prognosis. The mechanisms underlying these relationships remain unclear. …”
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Mobile Apps and Visual Function Assessment: A Comprehensive Review of the Latest Advancements by Caius Goh, Marilyn Puah, Zhi Hong Toh, Joewee Boon, Debbie Boey, Ryan Tay, Ashita A. Sule, Renee Liu, Xing-Er Ong, Aditya Kalra, Satvik Gupta, Andres Rousselot, William Rojas-Carabali, Bryan Ang, Rupesh Agrawal

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New Insights into the Role of Inflammatory Pathways and Immune Cell Infiltration in Sleep Deprivation-Induced Atrial Fibrillation: An Integrated Bioinformatics and Experimental Stu... by Liang J, Tang B, Shen J, Rejiepu M, Guo Y, Wang X, Shao S, Guo F, Wang Q, Zhang L

“…Analyses focusing on functional enrichment, such as Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG), were conducted to pinpoint crucial biological mechanisms and pathways. Furthermore, we utilized immunofluorescence and Western blot techniques to evaluate YBX1 expression and its role in activating NLRP3 inflammasomes in a rat model induced by SD.Results: A total of 540 common DEGs were precisely identified between the AF and SD data collections. …”
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Machine Learning–Based Risk Factor Analysis and Prediction Model Construction for the Occurrence of Chronic Heart Failure: Health Ecologic Study by Qian Xu, Xue Cai, Ruicong Yu, Yueyue Zheng, Guanjie Chen, Hui Sun, Tianyun Gao, Cuirong Xu, Jing Sun

“…With the abundance of medical data and the rapid development of machine learning (ML) technologies, new opportunities are provided for in-depth investigation of the mechanisms of CHF and the construction of predictive models. …”
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Hubungan Kadar Profil Lipid dengan Kejadian Hipertensi pada Masyarakat Etnik Minangkabau di Kota Padang Tahun 2012 by Rahmat Feryadi, Delmi Sulastri, Husnil Kadri

“…Lipid profile can lead hypertension through a variety of mechanism, either directly or indirectly. This study aims to investigate the lipid profile relation with the incident of hypertension. …”
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Exhaustion of CD8pos central memory regulatory T cell differentiation is involved in renal allograft rejection by Florian Kälble, Jonas Leonhard, Jonas Leonhard, Martin Zeier, Oliver Zivanovic, Matthias Schaier, Andrea Steinborn

“…The pathogenesis of graft deterioration in case of rejection involves the exhaustive differentiation of both CD8pos T cell subsets, but the causal mechanisms have not yet been identified.MethodsIn this study, we separately investigated the differentiation of CD8posTregs/Tresps in 134 stable KTR with no evidence of renal graft rejection, in 41 KTR diagnosed with biopsy-confirmed rejection at enrolment and in 5 patients who were unremarkable at enrolment, but developed rejection within three years of enrolment. …”
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Risk factors and prognosis analysis of dysphagia after occipitocervical fusion surgery: a retrospective study of 43 cases by Yufan Chen, Weihong Xu

“…Abstract Objectives To analyze the risk factors for developing dysphagia after occipitocervical fusion (OCF) and investigate possible mechanisms and prognosis. Methods The case data of 43 patients who underwent OCF were retrospectively reviewed. …”
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The Legionella pneumophila effector PieF modulates mRNA stability through association with eukaryotic CCR4−NOT by Harley O'Connor Mount, Malene L. Urbanus, Francesco Zangari, Anne-Claude Gingras, Alexander W. Ensminger

“…Collectively, this work reveals a new, highly conserved target of L. pneumophila effectors and suggests a mechanism by which the pathogen may be modulating host mRNA stability and expression during infection.IMPORTANCEThe intracellular bacterial pathogen Legionella pneumophila targets conserved eukaryotic pathways to establish a replicative niche inside host cells. …”
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Innovative Model of Socio-Professional Development of a Student’s Personality by E. F. Zeer, V. S. Tretyakova, M. V. Zinnatova

“…The content of each module is focused on the final result of educational activity: professional, diagnostic, competence, technological, functional. The mechanism of the model implementation is to build an individual student professional perspective aimed at practical action in order to improve the level of qualification, ability to work, enrichment of professional and personal qualities and behavioural patterns.Scientific novelty of the present research consists in the formation of interdisciplinary scientific knowledge (at the intersection of psychology, pedagogy, philosophy, occupational studies) on the methodology of the modelling, organisation and content of professional education taking into account modern challenges and demands of the digital economy. …”
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Possible linking and treatment between Parkinson’s disease and inflammatory bowel disease: a study of Mendelian randomization based on gut–brain axis by Beiming Wang, Xiaoyin Bai, Yingmai Yang, Hong Yang

“…Thus, we aimed to identify the causal relationships and novel therapeutic targets shared between them based on their common pathophysiological mechanisms in gut–brain-axis (GBA). Methods A meta-analysis on bidirectional Mendelian randomization (MR) utilizing various datasets was performed to estimate their causal relationship. …”
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Release Profile and Antibacterial Activity of <i>Thymus sibthorpii</i> Essential Oil-Incorporated, Optimally Stabilized Type I Collagen Hydrogels by Caglar Ersanli, Ioannis Skoufos, Konstantina Fotou, Athina Tzora, Yves Bayon, Despoina Mari, Eleftheria Sarafi, Konstantina Nikolaou, Dimitrios I. Zeugolis

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Exploring cement Production's role in GDP using explainable AI and sustainability analysis in Nepal by Ramhari Poudyal, Biplov Paneru, Bishwash Paneru, Tilak Giri, Bibek Paneru, Tim Reynolds, Khem Narayan Poudyal, Mohan B. Dangi

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Two-Dimensional Transition Metal Dichalcogenide: Synthesis, Characterization, and Application in Candlelight OLED by Dipanshu Sharma, Sanna Gull, Anbalagan Ramakrishnan, Sushanta Lenka, Anil Kumar, Krishan Kumar, Pin-Kuan Lin, Ching-Wu Wang, Sinn-Wen Chen, Saulius Grigalevicius, Jwo-Huei Jou

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INSTITUTIONAL GLOBALIZATION AS A SYSTEM OF INTEGRATION THE PHENOMENON OF THE POSTMODERN DEVELOPMENT by V. V. Zinchenko

“…In the social sphere the subjectivity is expressed in the individualization of the social existence of man and the personification of public relations and it is implemented through the mechanisms of liberal institutions. It seems that the civilizational unity of the economy, democratic state and liberal society has the value of a scientific paradigm. …”
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Integrated Three-Dimensional Structural and Petrophysical Modeling for Assessment of CO2 Storage Potential in Gas Reservoir by Syed Yasir Ali Shah, Jiangfeng Du, Sayed Muhammad Iqbal, Linze Du, Umair Khan, Baoyi Zhang, Jingqiang Tan

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