Cancer-associated fibroblast-derived COL17A1 promotes gemcitabine resistance and tumorigenesis in pancreatic cancer cells by interacting with ACTN4 by Rongyu Shi, Ning Zhang, Han Li, Hu Zhong, Chengcheng Zhong, Wei Du, Xi Yang

“…Here, this study focused on investigating whether CAFs affected GEM resistance in PC by secreting COL17A1 and its associated mechanisms. Methods In total, 60 newly diagnosed PC patients only with GEM-based chemotherapy were recruited. …”
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A conserved element in the first intron of Cd4 has a lineage specific, TCR signal-responsive, canonical enhancer function that matches the timing of cell surface CD4 upregulation r... by Gregory A. Swan, Gregory A. Swan, Chika Fujii, Mia E. Guzynski, Sheridan M. Page, Isabelle V. Meyers, Yordan P. Penev, Sejiro Littleton, Sejiro Littleton, Adinda Azzahra, Christine Richardson, Sophia D. Sarafova, Sophia D. Sarafova

“…IntroductionThe regulation of Cd4 expression during T-cell development and immune responses is essential for proper lineage commitment and function in the periphery. However, the mechanisms of genetic and epigenetic regulation are complex, and their interplay not entirely understood. …”
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Gαi1/3 signaling mediates IL-5-induced eosinophil activation and type 2 inflammation in eosinophilic chronic rhinosinusitis by Huanxia Xie, Jiang Ji, Zhichen Liu, Ning Lu, Yuqian Wei, Aina Zhou, Jisheng Liu, Qingqing Jiao, Qingqing Jiao

“…Whether Gαi1/3 proteins have a role in the development of eCRS remains unknown.ObjectivesTo investigate the association between Gαi1/3 expression levels and CRS and the underlying mechanismsMethodsWestern blotting and immunohistology were used to detect Gαi1/3 expression. …”
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Oxidative balance score was negatively associated with the risk of metabolic syndrome, metabolic syndrome severity, and all-cause mortality of patients with metabolic syndrome by Zhixiao Xu, Xiong Lei, Weiwei Chu, Luoqi Weng, Chengshui Chen, Chengshui Chen, Chengshui Chen, Ran Ye

“…BackgroundThe oxidative balance score (OBS), an encompassing scoring mechanism for assessing oxidative stress, is formulated based on nutritional and lifestyle components. …”
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Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD by Shaowei Wang, Boyang Li, Jie Li, Zhiheng Cai, Cristelle Hugo, Yi Sun, Lu Qian, Julia TCW, Helena C. Chui, Dante Dikeman, Isaac Asante, Stan G. Louie, David A. Bennett, Zoe Arvanitakis, Alan T. Remaley, Bilal E. Kerman, Hussein N. Yassine

“…Cholesterol accumulation is known to drive cellular senescence; however, its underlying mechanisms are not fully understood. ATP-binding cassette transporter A1 (ABCA1) plays an important role in cholesterol homeostasis, and its expression and trafficking are altered in APOE4 and AD models. …”
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Identifying subgroup of severe community-acquired pneumonia based on clinical metagenomics, a multicenter retrospective cohort study by Mingqiang Wang, Mingqiang Wang, Yue Jin, Yue Jin, Wenxiao Zhang, Wenxiao Zhang, Ling Ye, Ling Ye, Huanzhang Shao, Huanzhang Shao

“…We hypothesize that subtyping sCAP based on simple inflammatory markers, organ dysfunction, and clinical metagenomics results is feasible.MethodIn this study, we retrospectively enrolled immunocompetent sCAP patients requiring invasive mechanical ventilation, who underwent clinical metagenomics from 17 medical centers. …”
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Targeting BRD4 ameliorates experimental emphysema by disrupting super-enhancer in polarized alveolar macrophage by Difei Li, Xing Shi, Yuqiong Yang, Yao Deng, Dandan Chen, Shuyu Chen, Jinyong Wang, Guanxi Wen, Zhenyu Liang, Fengyan Wang, Jiaqi Gao, Yuanyuan Liu, Danna Wang, Ruifang Liang, Haizhao Xu, Rongchang Chen, Shanze Chen, Lingwei Wang

“…Conclusion This study suggested that downregulation of BRD4 might suppress airway inflammation and emphysema through disrupting the SEs of IRF4 and alveolar macrophages polarization, which might be a potential target of therapeutic intervention in COPD. A diagram of the mechanism by which BRD4 mediated super-enhancer of IRF4 in M2 AMs. …”
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Clinical Features of COVID‐19 Associated Pulmonary Aspergillosis: A Multicenter, Retrospective Study by Yasheng Zhan, Guojun He, Cheng Zhong, Yake Yao, Jiangying Zhou, Tong Li, Hua Zhou

“…Results In the total of 197 patients, 36 were admitted to the intensive care unit (ICU), 13 received mechanical ventilation; among them, nine received extracorporeal membrane oxygenation (ECMO). …”
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The association of Helicobacter pylori infection with the risk of anemia in children: systematic review and meta-analysis by Muluken Walle, Addisu Tesfaye, Melaku Mekonnen Agidew, Muluken Semaw, Surafel Mekuria, Fasil Getu

“…Future research need to focus on the mechanisms by which H. pylori infection contributes to anemia, as well as the potential benefits of targeted interventions in reducing both H. pylori prevalence and anemia rates in children.…”
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Klotho enhances stability of chronic kidney disease atherosclerotic plaques by inhibiting GRK2/PLC-β-mediated endoplasmic reticulum stress in macrophages via modulation of the ROS/... by Zhe Li, Jing Li, Lin Li, Qian Wang, Qian Zhang, Ling Tian, Chenchen Li

“…This study investigates the mechanism by which Klotho enhances the stability of atherosclerotic plaques in chronic kidney disease. apoE-/- knockout mice and C57BL/6 mice underwent 5/6 nephrectomy and then klotho-NC and klotho-mimic groups were set up to be fed a high-fat chow diet and a dummy group was created to be fed a normal chow diet. qPCR detected relative mRNA expression of klotho. …”
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Bio-ecological characteristics of Malus genus species in the context of prospective directions in horticulture and landscape forestry by Tetiana Moskalets, Oleksandr Kratiuk, Mariana Ivankiv, Sergii Shevchenko, Nataliia Shevchuk

“…The study aimed to conduct a comparative assessment of representatives of the genus Malus based on morphological traits, biological characteristics, physiological mechanisms of resistance to fungal pathogens, ornamental value, and significance within the frameworks of horticulture, landscape forestry, and shelterbelt afforestation. …”
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A systematic analysis of the contribution of genetics to multimorbidity and comparisons with primary care dataResearch in context by Olivia Murrin, Ninon Mounier, Bethany Voller, Linus Tata, Carlos Gallego-Moll, Albert Roso-Llorach, Lucía A. Carrasco-Ribelles, Chris Fox, Louise M. Allan, Ruby M. Woodward, Xiaoran Liang, Jose M. Valderas, Sara M. Khalid, Frank Dudbridge, Sally E. Lamb, Mary Mancini, Leon Farmer, Kate Boddy, Jack Bowden, David Melzer, Timothy M. Frayling, Jane A.H. Masoli, Luke C. Pilling, Concepción Violán, João Delgado

“…Interpretation: Most pairs of chronic conditions show evidence of shared genetics, and co-occurrence in primary care, suggesting shared mechanisms. The identified patterns of shared genetics, negative correlations and discordance between genetic and observational data provide a foundation for future multimorbidity research. …”
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Cyanoacrylate glue in breast surgery: the GLUBREAST Trial by Emanuela Esposito, Claudio Siani, Ivana Donzelli, Anna Crispo, Sergio Coluccia, Piergiacomo Di Gennaro, Assunta Luongo, Franca Avino, Alfredo Fucito, Ugo Marone, Maria Teresa Melucci, Ruggero Saponara, Raimondo di Giacomo

“…The glue is a synthetic sealant (N-Butyl-2-CyanoAcrylate+Metacryloxisulfolane) biocompatible, CE approved for internal human uses and surgical procedures. The assumed mechanism of action in breast surgery is that the glue would create a seal coating in the operative field to occlude lymphatic leaks and limit seroma formation.Materials and methodsThe trial included 180 patients scheduled for breast-conserving surgery or for radical modified mastectomy without reconstruction. …”
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Identification of WDR74 and TNFRSF12A as biomarkers for early osteoarthritis using machine learning and immunohistochemistry by Yiwei Chen, Yiwei Chen, Jiali Lin, Detong Shi, Yu Miao, Yu Miao, Feng Xue, Feng Xue, Kexin Liu, Kexin Liu, Xiaotao Wang, Changqing Zhang, Changqing Zhang

“…The potential intercellular communication mechanisms were explored using the CellChat R package. …”
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Thyroid function during COVID-19 and post-COVID complications in adults: a systematic review by Anisha Panesar, Palma Gharanei, Natasha Khovanova, Lawrence Young, Dimitris Grammatopoulos, Dimitris Grammatopoulos

“…Several studies have reported that COVID-19 can induce thyroid dysfunction, leading to conditions such as thyroiditis and alterations in thyroid hormone levels. The mechanisms through which SARS-CoV-2 affects the thyroid include direct viral infection of thyroid cells, leading to viral thyroiditis, which causes inflammation and transient or sustained thyroid dysfunction, as well as an excessive systemic immune response (cytokine storm). …”
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HMGB1 lactylation drives neutrophil extracellular trap formation in lactate-induced acute kidney injury by Li Zhu, Li Zhu, Qiang Zheng, Xiaodong Liu, Xiaodong Liu, Hao Ding, Mengqing Ma, Jiaxin Bao, Yawen Cai, Changchun Cao

“…Elevated lactate levels are implicated in sepsis-induced AKI; however, it remains unclear whether increased lactate directly induces AKI or elucidates the underlying mechanisms.MethodsFor human, the measurement of lactate in arterial blood gas is performed using the direct determination of L-lactate through an electrode oxidation method by a blood gas analyzer. …”
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Role of IPF genetic risk loci in post-COVID-19 lung abnormalities: a cohort study by James Johnston, Christopher Carlsten, Christopher J Ryerson, Alyson W Wong, Cameron J Hague, Julia Yang, Janice Leung, Daniel-Costin Marinescu, Aditi Shah, Darra Murphy

“…Mean age was 63±16 years, 62% were male, 31% were ever-smokers and median hospital length of stay was 9±11 days, with 23% requiring mechanical ventilation. The MUC5B risk allele was associated with a significant decrease in ground glass (β=−0.8, 95% CI −1.5 to –0.1, p=0.02) at 3 months, and this finding was paralleled by a concurrent but non-significant trend towards increased diffusion capacity for carbon monoxide (DLCO) (β=8.8, 95% CI −1.2 to 18.8, p=0.08) compared with patients without this risk allele. …”
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Screening and identification of two novel phosphate-solubilizing Pyrenochaetopsis tabarestanensis strains and their role in enhancing phosphorus uptake in rice by Xiaozhe Bao, Haifei Lu, Jinyao Zhao, Taotao Yang, Longmei Wu, Jixiang Zou, Qingchun Chen, Bin Zhang

“…This study aimed to isolate and characterize fungal strains from the rice rhizosphere and assess their phosphate solubilization capabilities, plant-growth-promoting (PGP) traits, and mechanisms involved. An initial comparative sequence analysis of the hypervariable regions of the ITS rDNA and morphological analysis identified two strains belonging to the genus Pyrenochaetopsis, designated Pyrenochaetopsis tabarestanensis WFY-1 (PtWFY-1) and WFY-2 (PtWFY-2). …”
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Affecting of Glyphosate Tolerance and Metabolite Content in Transgenic <i>Arabidopsis thaliana</i> Overexpressing <i>EPSPS</i> Gene from <i>Eleusine indica</i> by Jingchao Chen, Zhiling Li, Haiyan Yu, Hailan Cui, Xiangju Li

“…Overproducing of the target of glyphosate 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) is one of the resistance mechanisms in weeds. However, few studies have measured the effects on tolerance levels and metabolite content in model plant species overexpressing <i>EPSPS</i> from weeds. …”
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Social learning activities to improve community engagement in waste management program by S. Sunarti, R.S.Y. Zebua, J.H. Tjakraatmadja, A. Ghazali, B. Rahardyan, K. Koeswinarno, S. Suradi, N. Nurhayu, R.H.A. Ansyah

“…Further path model analysis demonstrated that without “Affective Factors” being nurtured, learning activities and Facilities would not be able to improve behavior significantly, as all paths directing to Behavioral Domain (Intention and WMB) had an insignificant effect (P value > 0.05).CONCLUSION: This study offered empirical evidence, showing the mechanism of social learning to improve waste management behavior. …”
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